`
`Claims 3, 5, 8, 10, 14, 16, 17, 19, 22, and 24 of the ʼ163 patent are unpatentable
`under 35 U.S.C. § 103(a) as Obvious Over Bernasconi in View of INOMAX
`label, Loh, Goyal, and Macrae.
`
`
`
`U.S. Pat. No.
`8,431,163
`CLAIM 3
`The method of claim
`1, wherein the
`patient's left
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`CLAIM 5
`The method of claim
`4,
`wherein
`the
`patient's
`left
`ventricular
`dysfunction
`attributable
`congenital
`disease.
`
`is
`to
`heart
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 1.
`
`Macrae teaches left ventricular dysfunction (“LVD”) can be
`attributable to congenital heart disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 4.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`
`
`
`1
`
`
`
`
`
`U.S. Pat. No.
`8,431,163
`CLAIM 8
`The method of claim
`6, wherein the left
`ventricular
`dysfunction of the
`first patient is
`attributable to
`congenital heart
`disease.
`
`CLAIM 10
`The method of claim
`9, wherein the left
`ventricular
`dysfunction of
`first
`patient
`attributable
`congenital
`disease.
`
`the
`is
`to
`heart
`
`CLAIM 14
`The method of claim
`12, wherein the left
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 6.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 9.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 12.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`2
`
`
`
`U.S. Pat. No.
`8,431,163
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 15.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 13.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 18.
`
`
`3
`
`CLAIM 16
`The method of claim
`15, wherein the left
`ventricular
`dysfunction of the
`patient is attributable
`to congenital heart
`disease.
`
`
`
`
`
`
`CLAIM 17
`The method of claim
`13, wherein the left
`ventricular
`dysfunction of the
`patient is attributable
`to congenital heart
`disease.
`
`
`
`
`
`
`CLAIM 19
`The method of claim
`18, wherein the left
`ventricular
`dysfunction of the
`
`
`
`
`
`U.S. Pat. No.
`8,431,163
`patient is attributable
`to congenital heart
`disease.
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 20.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1039 in Claim 23.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`CLAIM 22
`The method of claim
`20, wherein the left
`ventricular
`dysfunction of the
`first patient is
`attributable to
`congenital heart
`disease.
`
`CLAIM 24
`The method of claim
`23, wherein the left
`ventricular
`dysfunction of
`first
`patient
`attributable
`congenital
`disease.
`
`the
`is
`to
`heart
`
`
`
`
`
`
`
`Ex. 1008 at 374.
`
`4
`
`