`
`
`
`Claims 4, 10, 12, 15, 19, 20, 22, 28, and 30 of the ʼ284 patent are unpatentable
`as Obvious Over Bernasconi in View of INOMAX label, Loh, Goyal, and
`Macrae.
`
`
`
`U.S. Pat. No.
`8,293,284
`CLAIM 4
`The method of claim
`1, wherein the
`patient's left
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`CLAIM 10
`The method of claim
`6, wherein the left
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1036 in Claim 1.
`
`Macrae teaches left ventricular dysfunction (“LVD”) can be
`attributable to congenital heart disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1036 in Claim 6.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`CLAIM 12
`The method of claim
`11, wherein the left
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`
`
`
`
`
`1
`
`
`
`
`
`U.S. Pat. No.
`8,293,284
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`CLAIM 15
`The method of claim
`14, wherein the left
`ventricular
`dysfunction
`attributable
`congenital
`disease.
`
`is
`to
`heart
`
`CLAIM 19
`The method of claim
`13, wherein the left
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`Loh, and Goyal as outlined in Ex. 1036 in Claim 11.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1036 in Claim 14.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1036 in Claim 13.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`Ex. 1008 at 374.
`
`2
`
`
`
`
`
`
`
`
`
`U.S. Pat. No.
`8,293,284
`CLAIM 20
`The method of claim
`13, wherein the left
`ventricular
`dysfunction of the
`first patient is
`attributable to
`congenital heart
`disease.
`
`CLAIM 22
`The method of claim
`21, wherein the left
`ventricular
`dysfunction of the
`first patient is
`attributable to
`congenital heart
`disease.
`
`CLAIM 28
`The method of claim
`23, wherein the left
`ventricular
`dysfunction of the
`first patient is
`attributable to
`congenital heart
`disease.
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1036 in Claim 13.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1036 in Claim 21.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1036 in Claim 23.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`3
`
`
`
`
`
`U.S. Pat. No.
`8,293,284
`
`CLAIM 30
`The method of claim
`29, wherein the left
`ventricular
`dysfunction of the
`first patient is
`attributable to
`congenital heart
`disease.
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1036 in Claim 29.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`
`
`4
`
`
`
`
`
`