00000001
`
` 100000000
`
`U8008293284B2
`
`(12) United States Patent
`Baldassarre et at.
`
`[10) Patent No.:
`(45) Date of Patent:
`
`US 8,293,284 32
`*Oct. 23, 2012
`
`[54) METHODS OF REDUCING THE RISK OF
`OCCURRENCE OF PULMONARY EDEMA IN
`TERM OR NEAR-TERM NEONATES IN NEED
`OF TREATMENT W'ITH INHALED NITRIC
`OXIDE
`
`(75)
`
`Inventors: James S. Baldassarre. Doylcstown. PA
`(US): Ralf Rosskamp. Chester, NJ (US)
`
`(73) Assignee:
`
`[NO Therapeutics LLC. Hampton. NJ
`(US)
`
`( ’l‘ ) Notice:
`
`Subject to any disclaimer. the term ot'lhis
`patent is extended or adiusled under 35
`use. 1540:) by 0 days.
`
`This patent is subject to a terminal dis-
`claimcr.
`
`(21) Appl. No; 121821.041
`
`(22)
`
`Filed:
`
`Jun. 22, 2010
`
`(65)
`
`Prior Publication Data
`
`US 201070331405 Al
`
`Dec. 30. 2010
`
`Related U.S. Application Data
`
`(63) Continuation of application No. 127494.598. filed on
`Jun. 30. 2009. now abandoned.
`
`(51)
`
`int. (:1.
`(2006.01)
`A01N59x’00
`(2006.01)
`AéIK 33200
`(200601)
`C013 21224
`(2006.01)
`AélM 16/00
`4247718: 128720024; 4237405
`(52) 0.8. CI.
`(58) Field ofCIassification Search
`None
`See application file for complete search history.
`
`[56)
`
`References Cited
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`
`[Continued]
`
`Primarr hit-amine;-
`[74) Attornqu Agent. or I-imi
`
`lirnst Arnold
`l-‘ish & Richardson RC.
`
`OTHER PUBLICATIONS
`
`[57)
`
`A BS TRACT
`
`TheAmericanIllustraled Medical Dictionary(Dorland. 1914.701 Ed.
`p. 113).*
`Bcghctti et al. (Journal of Pediatrics. 1997. p. 8441*
`Macrae eta1.(1rttensive Care Med 2004. 30. pp. 372-380)?“
`Alz el al. (Seminars in Perinatology 1997. 21(5). pp. 441-455)“
`Kinsella et a]. (The Lancet 1999. 354. pp. 1061-1065)“
`
`The invention relates methods of reducing the risk or prevent-
`ing the occurrence of an adverse event (Ali) or a serious
`adverse event (SAE) associated with a medical treatment
`comprising inhalation of nitric oxide.
`
`30 Claims, No Drawings
`
`001
`
`PRAXAIR 1001
`
`001
`
`

`

`US 8,293,284 BZ
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`Page 2
`
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