`
`
`
`Claims 4, 10, 12, 18-19, 21, 26-27, and 29 of the ʼ966 patent are Unpatentable
`as Obvious Over Bernasconi, in View of INOMAX label, Loh, Goyal, and
`Macrae.
`
`
`
`U.S. Pat. No.
`8,282,966
`CLAIM 4
`The method of claim
`1, wherein the child's
`left ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in Claim 1.
`
`Macrae teaches left ventricular dysfunction (“LVD”) can be
`attributable to congenital heart disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in Claim 6.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`CLAIM 10
`The method of claim
`6, wherein the left
`ventricular
`dysfunction
`attributable
`congenital
`disease.
`
`is
`to
`heart
`
`Ex. 1008 at 374.
`
`
`1
`
`
`
`
`
`
`
`
`
`U.S. Pat. No.
`8,282,966
`CLAIM 12
`The method of claim
`11, wherein the left
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`CLAIM 18
`The method of claim
`13, wherein the left
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`CLAIM 19
`The method of claim
`13, wherein the left
`ventricular
`dysfunction of the
`first child is
`attributable to
`congenital heart
`disease.
`
`
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in claim 11.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in Claim 13.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in Claim 13.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`2
`
`
`
`
`
`U.S. Pat. No.
`8,282,966
`
`CLAIM 21
`The method of claim
`20, wherein the pre-
`existing left
`ventricular
`dysfunction of the
`first child is
`attributable to
`congenital heart
`disease.
`
`CLAIM 26
`The method of claim
`22, wherein the left
`ventricular
`dysfunction is
`attributable to
`congenital heart
`disease.
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in Claim 20.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in Claim 22.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`
`
`
`
`3
`
`
`
`
`
`
`
`U.S. Pat. No.
`8,282,966
`CLAIM 27
`The method of claim
`22, wherein the pre-
`existing left
`ventricular
`dysfunction of the
`first child is
`attributable to
`congenital heart
`disease.
`
`CLAIM 29
`The method of claim
`28, wherein the pre-
`existing left
`ventricular
`dysfunction of the
`first child is
`attributable to
`congenital heart
`disease.
`
`
`
`
`
`
`
`
`
`Bernasconi, INOMAX label, Loh, Goyal, and Macrae
`
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in Claim 22.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, INOMAX label,
`Loh, and Goyal as outlined in Ex. 1033 in Claim 28.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`Ex. 1008 at 374.
`
`
`
`4
`
`