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`U800828296682
`
`(12) United States Patent
`Baldassarre et at.
`
`[10) Patent No.:
`(45) Date of Patent:
`
`US 8,282,966 32
`*Oet. 9, 2012
`
`(54) METHODS OF REDUCING TIIE RISK OF
`OCCURRENCE OF PULMONARY EDEMA IN
`CHILDREN IN NEED OF TREATMENT WITH
`INHALED NITRIC OXIDE
`
`(75)
`
`Inventors: James S. Baldassarre. Doylestown. PA
`(US); Ralf Rosskamp. Chester. NJ (US)
`
`(73) Assignee:
`
`INO Therapeutics LLC. Hampton. NJ
`(US)
`
`( "‘ ) Notice:
`
`Subject to any disclaimer. the term of this
`patent is extended or adjusted under 35
`U.S.C. 15401) by 0 days.
`
`This patent is subject to a terminal dis-
`clailtler.
`
`[21) Appl.No.: 121821320
`
`(22)
`
`Filed:
`
`Jun. 22. 2010
`
`((15)
`
`Prior Publication Data
`US 201010330207 Al
`DEC. 30. 2010
`
`Related U.S. Application Data
`
`(63) Continuation of application No. 12I494.598_. filed on
`Jun. 30. 2009. now abandoned.
`
`(51)
`
`Int. Cl.
`(2006.01)
`AOIN 59/00
`(2006.01)
`A61K 33/00
`(2006.01 )
`C013 2.924
`(2006.01)
`21(le 1'6/00
`424.1718: 125920024: 4231405
`(52) U.S. Cl.
`(58) Field ofClassificatinn Search
`None
`See application tile for complete search history.
`
`(56)
`
`References Cited
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`1 [-2006
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`(Continued)
`
`lirnst Arnold
`Priiinriy Iixuritiner
`(74) Attornet’. Agent. or I‘i‘rm -— liislt & Richardson PC.
`
`ABSTRACT
`[57)
`The invention relates methods of reducing the risk or prevent—
`ing the occurrence of an adverse event (Ali) or a serious
`adverse event (SAIE) associated with a medical treatment
`comprising inhalation of nitric oxide.
`
`29 Claims, No Drawings
`
`001
`
`PRAXAIR 1001
`
`001
`
`

`

`US 8,282,966 BZ
`Page 2
`
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