`
`CURRICULUM VITAE
`
`
`RAYMOND ROBERT R. ROWLAND, PH.D.
`Department of Diagnostic Medicine/Pathobiology
`1800 Denison Ave
`College of Veterinary Medicine
`Kansas State University
`Manhattan, KS 66506
`Office: 785-532-4631
`Email: browland@vet.k-state.edu
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`PROFESSIONAL HISTORY AND APPOINTMENTS
`July 2007: Professor, Department of Diagnostic Medicine/ Pathobiology, Kansas State
`University.
`July 2001-June 2007: Associate Professor, Department of Diagnostic Medicine/ Pathobiology,
`Kansas State University.
`August 1998-June, 2001: Associate Professor, Department of Biology-Microbiology, South
`Dakota State University.
`August 1994-July 1998: Assistant Professor, Department of Biology-Microbiology, South
`Dakota State University.
`November 1990-July 1994: Postdoctoral Fellow, Department of Microbiology, University of
`Minnesota.
`October 1989-October 1990: Postdoctoral Fellow, Department of Pharmacology, University of
`Minnesota.
`September 1985-September 1989: University of New Mexico (graduate school)
` Graduate Research Assistant, Department of Microbiology
` Graduate Teaching Assistant, Department of Biology
` Instructor, Department of Biology
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`PROFESSIONAL ACTIVITIES AND AWARDS
`2014-
`Member, External Stakeholder Board, STEC-CAP
`2013-
`Executive director, North American PRRS Symposium, Chicago
`2013
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`Executive director and co-chair, International PRRS Symposium, Beijing
`2012
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`Distinguished Graduate Faculty Award, Kansas State University
`2012
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`Recognized as Professor of the Week at the Kansas State-Texas football game
`2011
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`Genome Canada- Phenomic Resources for Genomics of Swine Health
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` Project Management Committee
`2011
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`Guest editor, PLoS Pathogens
`2010 Member, Planning Committee International Nidovirus Symposium
`2010
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`U.S. representative, MAF Expert Working Group on PRRS Risk
`2010
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`Guest editor, special issue of Virus Research on PRRS
`2010-2012
`Executive director, International PRRS Symposium
`2010-2014 Associate director, Center of Excellence for Emerging and Zoonotic Animal
` Diseases (CEEZAD)
`Advisory board member, Midwest Research Center of Excellence (MRCE)
`2010-
`2010 Panel member, USDA National Needs Fellowship Program
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`External advisory board member, PoRRSCon
`2010-
`Panel member, AI CAP proposal review
`2009-2010
`Panel member, USDA Animal Health and Well-being
`2009
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`Co-director, PRRS Host Genetics Consortium
`2009-
`2008-2013 Director, USDA PRRS Coordinated Agricultural Project (PRRS CAP)
`2008-2009
`Proceedings editor, International PRRS Symposium
`2007
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`Pfizer Researcher of the Year Award, College of Veterinary Medicine
`2006-2007
`Chair, 2007 International PRRS Symposium
`2006-2007
`Chair, USDA North Central Committee on PRRS, NC-229
`2005-2006 NIH study section IDM-G90 (viral diseases)
`2004-2005
`Secretary, USDA North Central Committee on PRRS, NC-229
`2004
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`Guest editor, special issue of Veterinary Immunology and Immunopathology
`2004
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`Member, USDA study panel on CAP funding
`2004
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`Elected member of Phi Zeta Veterinary Research Honor Society
`1993-1994 American Cancer Society Postdoctoral Fellow
`1990-1993 NIH National Cancer Institute Postdoctoral Training Fellowship
`1989
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`Phi Kappa Phi Honor Society member
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`Ad hoc reviewer: Brain, Behavior, and Immunity; Immunopharmacology; Journal of
`Neuroimmunology; Proceedings of the Society for Experimental Biology and Medicine; Swine
`Practitioner, Journal of Clinical Microbiology, Journal of Veterinary Diagnostics Investigation,
`National Pork Board PRRS Initiative, USDA NRI Competitive Grants Program, NIH, Arid
`Lands Consortium, Journal of General Virology, Journal of Viral Immunology, Virus Research,
`Immunology, Clinical and Experimental Immunology, FEBS Letters, Journal Swine Health and
`Production, Journal of Veterinary Medicine, Journal of Virology, Virus Genes, Veterinary
`Microbiology, Sensors and Actuators, Clinical and Vaccine Immunology, BMC Veterinary
`Research, USDA National Needs Fellowship Program, Animal Health Research Reviews, PLoS,
`Hong Kong Research Grants Council, Midwest Research Center of Excellence, NSF BREAD
`Program.
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`EDUCATION
`December 1989: Ph.D., Microbiology, University of New Mexico School of Medicine. Title of
`dissertation: Effect of met-enkephalin on in vitro immunity.
`June 1983: M.A., Microbiology, San Francisco State University. Title of thesis:
`Radioimmunoassay of porcine fibrinopeptide A.
`June 1977: B.A., Biology, California State University, Fresno. Graduated Magna Cum Laude.
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`TEACHING
`Kansas State University (2001- present)
` Undergraduate
` DMP 680- Problems in Pathobiology
` Graduate Course
` DMP 910-Viral Pathogenesis (course coordinator)
` Veterinary Curriculum
` DMP 722-Veterinary Virology (6 lectures on introductory virology)
` Online Curriculum
` Course coordinator for proposed online course in Veterinary Virology
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`Undergraduate and Graduate Courses (1994-2001, South Dakota State University)
` Immunology- Lecture and Laboratory
` Molecular Microbial Genetics-Laboratory
` Medical Microbiology- Lecture and Laboratory
` Microbial Pathogenesis-Lecture and Laboratory
` Introductory Microbiology Laboratory
` Graduate technique courses in molecular biology
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`POSTDOCTORAL FELLOWS
`Mofazzal Hosain 2013-
`Maria Murgia, 2012-
`Rachel White, 2011-2012
`Adam Stephenson, 2012
`Jessica Green, 2010-2011
`Kyle Horlen, 2006-2008
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`GRADUATE STUDENTS
`Masters Students
`Mollie Burton, 2014-
`Matthew Olcha, 2014-
`Rebecca Ober, 2014-
`Jamie Thompson, 2014-
`Jessica Hessman, 2014-
`Rachael Gortowski, 2014-
`Wenjing Sang, 2010-2012, Title of research: Differential expression of type I interferons in fetal
`tissues and the maternal-fetal interface in response to PRRSV infection.
`Yu (Britney) Wang, 2011-2013, Title of research: Development of a multiplex fluorescent
`immunoassay for the simultaneous detection of serum antibodies to multiple swine
`pathogens.
`Benjamin Trible, 2008-2011, Title of research: Expression of recombinant porcine PCV2 capsid
`polypeptides for use in mapping epitopes.
`Paula Schneider, 2005-2007, Title of research: Genetic sequence analysis of North American
`Type 1 strains of porcine reproductive and respiratory syndrome virus.
`Luna Agurrie, 2003-2005, Title of research: Cloning and expression of porcine ISG-20.
`Elliot Stevens, 1999-2001, Title of research: Analysis of functional domains in PRRSV GP5.
`Ying Fang, 1997-1999, Title of research: Characterization of a nucleolar localization signal motif
`in PRRSV N protein.
`Rachel Farwell. 1998-2000. Title of research: The 2b protein of PRRSV.
`Taeg Su Kim, 1998-2000.Title of research: Cytokine production and apoptosis during PRRSV
`infection.
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`Ph.D. Students
`Izabela Ragan, 2014-
`Giselle Cino, 2013-
`Luca Popescu, 2013-
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`Michelle Mazur, 2013-
`Rachel Palinski, 2013-
`Megan Neiderwerder, 2012-
`Nanhua Chen, 2012-
`Benjamin Trible, 2012-
`Ranjni Chand, 2009-2014, Title of research: Study of recombination in porcine reproductive and
`respiratory syndrome virus (PRRSV) using a novel in-vitro system.
`Dal-Young Kim, 2002-2007, Title of research: The application of a PRRSV reverse genetic
`system for the study of nonstructural protein (nsp) function.
`Vinita Chauhan, 2003-2006, Title of research: Characterization of severe acute respiratory
`syndrome (SARS) nucleocapsid protein.
`Ying Fang, 2001-2004. Title of research: Heterogeneity and evolution of PRRSV NSP2.
`Bobbi Kervin, 1995-1997. Title of research: Nucleolar localization of the PRRSV N protein.
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`Undergraduate Students (1994 to present)
`Jill Haven, Brandon Warrick, Joseph Steffanick, Melissa Steffen, Ann Sperlich, Bridget
`Robinson, Jack Alexander, Toby Ackermann, Rachel Bierman, Scott Smit, Ryan Gruber, Karla
`Severson, Quincy Jones, Kristin Kallesen, Diane Stoick, Chris Kuckleburg, Penney Mairose,
`Marc Finley, Keith Reddy, Jill Iverson, Sarah Englebrecht, Mary Wendel, Heather Waxdahl,
`Natasha Gaudreault, Ben Trible, Brandy Struth, David Weinstein, Maggie Rudolph, Jonathan
`Nevins, Sarah Thompson, Luca Popescu, Becky Wical, Jessica Otradovec, Jennifer Wellner,
`Nick Crossland, Ruth Hester, Laura Dare, Shelby DeNoya, Curtis Concannon, Alexia Sampson,
`Bobbie Jo Horocofsky, Emma Faulkner, Katie Hope, Michelle Zajac, Nicole Eberhart, Priscilla
`De Los Santos, Robby Haynes, Sam Redmond, Sarah Abatti, Swathi Bujuru, Traci Rathburn,
`Angie Lundberg, Kassidy Simmons, Latrice Wilson, Maura Cornell, Gina Callari, Shanna
`Clifford, Joe Darocha, Mollie Burton, Stephanie Martin, Micke Ramirez, Tyler Eaves, Rachel
`Eisen-McGinn, Lindsey Pease, Hannah Seger, Mackenzie Wahl, Michaela Sievers, Taylor Scott,
`Taylor Shulse, Hailey Clemons, Whitney Jones, Katie MacKinnon, Megan Wheeler, Hope
`Gates, Bianca Broeckelman, Eric Varenhorst, Victoria Ayers, Brecka Waugh, Kristine Kemmet,
`Hunter Sbisa, Kirby Crownover, Brett Fisher, Cody Dressler, Eun Gi Jung, Jason Banning
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`COMMITTEES
`2011-
`CVM Research Committee
`2011-2012
`CVM Master Planning Committee
`2011-
`Chair, DVM/PhD Degree Program
`2008-2010 University Graduate Council Assessment and Review Committee
`2008-2010 Chair, College of Veterinary Medicine Faculty Council
`2008-2010 DMP Representative for University Graduate Council
`2005-2006 DMP Representative, Academic Standards and Re-Admissions Committee
`2006-2009 Academic Standards and Re-Admissions Committee
`2008-2011 Member, Technology Advisory Committee
`2006-2009 Member, University Pandemic Flu Committee
`2004-2014
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`Member, DMP Graduate Program Committee
`Faculty mentoring committees, K Chang, A Nguyen, J Kastner, D van der Merwe, C Wyatt
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`RESEARCH FUNDING
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`Current Funding
`NBAF Transition Funding for the study of ASF,RVF and CSF, 2013-2014, $1.5 million.
`Yoo, Rowland, USDA NIFA 2013-2017, Immune evasion of PRRS virus and a novel strategy
`for vaccine development, 2013-2017, approximately $60,000 to the Rowland lab.
`Dekkers, Rowland, Lunney, et al., USDA NIFA, 2012-2017, Genetically Improving Resistance
`of Pigs to PRRS Virus Infection, $3 million, approximately $800,000 to the Rowland lab.
`Patience et al., 2010-2015, USDA NIFA, Improving biological nutrient use and thus feed
`efficiency in the U.S. pork industry through innovative scientific and extension approaches
`for a more sustainable production, $65,000.
`Richt et al., 2010-2016, CEEZAD-KBA matching funds, Education and training for a Kansas
`workforce, $230,000.
`Rowland et al., 2010-2015, Specific Cooperative Agreement: KSU and USDA-ARS-ABADRU,
`$400,000.
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`Completed Funding
`Gabler, Rowland, NPB, 2012-2013, The effects of PRRSV infection in commercial pigs on
`growth performance, energy and nutrient digestibility, $13,000.
`Rowland, NPB, 2012-2013, Characterization of neutralizing antibody responses to PRRSV and
`association with host factors, $64,000.
`Rowland, Wilson, DHS-FAZD, 2012-2013, Development of a fluorescent microsphere
`immunoassay platform for diagnosis and surveillance of Rift Valley fever, approx. $200,000.
`Rowland, Zimmerman, Opriessnig, Fang, NPB, 2011-2012, Multi-institutional development and
`validation of a multiplex fluorescent microsphere immunoassay for the diagnosis of multiple
`agents in serum and oral fluid samples, $152,000.
`Hesse, Rowland, USDA APHIS, 2011-2013, Oral fluid as a sample for the immunological
`detection of pseudorabies virus infection, $124,000.
`Rowland, Hesse, Novartis Animal Health, 2011-2012, PRRS Virus Vaccine Discovery
`Challenge Study, $106,636.
`Rowland, Institute for Pig Genetics, 2011-2012, PRRSV Challenge Study, $106,000.
`Plastow et al., 2011-2015, Genome Canada, Project 2209, Application of genomics to improving
`swine health and welfare, Rowland lab $800,000.
`Rowland and Blecha, 2010-2013, NIH R15, A model for developmental IFN gene regulation in
`the virus-infected fetus, $300,000 (direct costs).
`Rowland and Lunney, et al., NPB, 2007-2012, PRRS host genetics consortium: A proposal to
`develop a consortium to study the role of host genetics and resistance to PRRSV, $800,000.
`Rowland et al., USDA NRI Coordinated Agricultural Program (CAP), 2008-2012, Integrated
`strategies to control and reduce the impact of PRRS virus control, $4.9 million.
`Rowland and Hesse, 2009-2012, USDA NRI 2009-35204-05290, Mapping host protective
`immunity in the PCV2 capsid protein, $240,000.
`Rowland, 2010-2011, NPB, Serological approach for diagnosis and surveillance of multiple
`agents in serum and oral fluid samples, $45,000.
`Hesse and Rowland, 2009, Fort Dodge Animal Health, Heterotypic immunity as a platform for a
`new generation of modified live PRRS vaccines, $100,000.
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`Rowland and Hesse, NPB, 2008-2009, The role of maternal antibody in determining PCV2
`vaccine efficacy, $32,000.
`Wyatt et al., NPB, 2008-2009, Mapping T cell epitopes in the PCV2 capsid protein. $58,000.
`Rowland, USDA-NRI Conference Grant, 2007-2008. Support for 2007 International PRRS
`Symposium conference, $6,000.
`Hesse et al., NPB, 2007-2008, PCVAD induced immune dysfunction, $200,000.
`Blecha, et al, USDA NRI, 2006-2009, Porcine antimicrobial peptides and Toll-like receptors in
`PRRS pathogenesis, $340,000.
`Wyatt and Rowland, NPB, 2006-2007, Exploring PRRS virus GP5 peptides for protective cross-
`reactive T cell epitopes, $46,149.
`Yoo et al., NPB, 2006-2007, Development of stable cell lines permissive for PRRSV replication
`and production, $98,000.
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`Rowland, Pfizer Animal Health, 2006-2007, Safety and attenuation evaluation of modified live
`strains of PRRSV in feeder pigs, approximately $50,000.
`Rowland, NPB, 2006-2007, Identification of a peptide sequence in nsp2 that can function as a
`deletion marker for the differentiation of vaccinated from naturally infected pigs, $57,000.
`Rowland and Nietfeld, 2006-2007, NPB, The “Kansas Cluster” of severe PMWS cases:
`characterization of a novel PCV2 as the possible etiological agent, $63,000.
`Rowland and Lunney, 2006-2007, USDA NRI CAP, The PRRSV infected population: The
`contribution of inflammatory cytokines to the appearance of light pigs. $86,000.
`Lunney and Rowland, 2006-2007, USDA NRI CAP, Long term PRRS persistence:
`Understanding the mechanisms involved in controlling, regulating and predicting PRRSV
`persistence, $70,000.
`Wyatt and Rowland, 2005-2007, USDA NRI CAP, Characterization of PRRSV T cell epitopes,
`$200,000.
` Rowland and Wyatt, 2003-2007, USDA-NRI, Mechanisms of short- and long-term
`consequences of fetal PRRSV infection, $240,000.
`Rowland and Pickrell, 2003-2007, USDA Challenge Grant, Student experiential learning in food
`animal infectious disease, $97,000.
`Fang et al, 2005-2006, National Pork Board, Accurate ELISA test development: Evaluation of
`cysteine protease domains of PRRSV non-structural protein 2 as a potential antigen, $10,000.
`Rowland, J, 2005-2006, K-INBRE NIH undergraduate fellowship $3,000.
`Rowland et al., 2006, USDA NRI-CAP, PRRSV diagnostics: creation of a sample resource for
`the research community and identification of diagnostic targets for the analysis of immune
`protection and viral persistence, $350,000.
`Rowland, 2005-2006, Midwest Research Center of Excellence in Biodefense and Emerging
`Diseases (MRCE), Preparation of antibody reagents against SARS N protein, $50,000.
`Rowland, 2003-2006, NIH Structure-Function COBRE, Nucleolar Function of SARSv N protein,
`$170,000.
`Rowland, 2004-2005, Midwest Research Center of Excellence in Biodefense and Emerging
`Diseases (MRCE), SARS N protein association with nucleolar function, $40,000.
`Nelson and Rowland, 2005, National Pork Board, Emerging European-like PRRSV in the U.S.:
`Implications for diagnostic and control strategies, $50,000.
`Jaax and Rowland, 2004-2005, Battelle Rinderpest Monograph, $15,000.
`Rowland and Benfield, 2000-2002, USDA-NRI, Genomic quasispecies associated with PRRSV-
`Consistent with other RNA viruses.
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`Rowland and Benfield 2000-2002, Functional roles for an arterivirus N protein, NIH-R15,
`$106,000.
`Rowland, Benfield and Cafruny, 1997-2001, USDA-NRI, Virological, immunological and
`molecular components of reproductive, $168,000.
`Benfield and Rowland, 2000-2001, NPPC, Genomic quasispecies associated with persistent
`PRRSV, $20,000.
`Benfield and Rowland, 2000-2001, NPPC, Determining pathogenesis of fetal PRRSV infection,
`$20,000.
`Rowland, Chase and Duvall, 1999-2000, USDA NRI Equipment Grant Acquisition of an ABI
`Automated DNA Sequencer, $63,000.
`Benfield and Rowland, 1998-1999, NPPC, Macrophage attenuated PRRS virus, $17,000.
`Rowland and Benfield, 1997-1998, NPPC, Antigenic drift during persistent infection with PRRS
`virus, $23,000.
`Rowland, 1997-1998, South Dakota Pork Producers, Buffy coat RT-PCR: A sensitive diagnostic
`assay for the detection of PRRS virus infection, $3,000.
`Rowland and Benfield, 1997-1998, NPPC, The importance of persistently-infected (PI) pigs in
`the epidemiology of PRRS virus, $17,400.
`Benfield, Rowland, et al., 1996-1997, NPPC, Development of a quantitative PCR to evaluate the
`risk of boar semen as a source of PRRS virus, $18,000.
`Benfield, Rowland and Collins, 1995-1998, USDA-NRI, Mechanisms of Persistence of Porcine
`Reproductive and Respiratory Syndrome Virus, $210,000.
`Rowland, 1996-1998, NSF (EPSCoR), Membrane and signal transduction alterations as
`determinants of the permissiveness of macrophages for LDV replication, Approximately
`$100,000.
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`South Dakota State University Institutional Funding (1994-2000)
`Clausen, A and RRR Rowland, Summer 2000, NSF Summer Undergraduate Research
`Fellowship.
`Johnson, C and RRR Rowland, Summer 2000, Joseph Nelson Summer Undergraduate Research
`Mentorship Program.
`Sperlich, A, and RRR Rowland, Summer 1999, NSF Summer Undergraduate Research
`Fellowship.
`Warrick, B, and RRR Rowland, Summer 1999, Joseph Nelson Summer Undergraduate Research
`Mentorship Program.
`Waxdahl, H, and RRR Rowland, Summer 1999, NSF Summer Undergraduate Research
`Fellowship.
`Cheesbrough, T and RRR Rowland, 1999, Acquisition of computers and software for DNA and
`gene analyses, SDAES.
`Sperlich, A and RRR Rowland1998, Joseph Nelson Summer Undergraduate Research
`Mentorship Program.
`Bierman, R. and RRR Rowland, 1998, Joseph Nelson Summer Undergraduate Research
`Mentorship Program.
`Robinson, B and RRR Rowland, 1998, NSF Undergraduate Summer research Fellowship.
`Stefanick, J, and RRR Rowland, Summer 1997, Joseph Nelson Undergraduate Mentorship
`Program.
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`Rowland, R, M Hildreth, and T Cheesbrough, 1997, Micro Imaging Facility, South Dakota State
`University College of Agricultural and Biological Science and others, Purchased three
`research grade microscopes including digital imaging hardware, Total funding $79,000.
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`REVIEW ARTICLES, BOOK CHAPTERS, INVITED EDITORIALS
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`Archambault D, UB Balasuriya, RR Rowland, H Yang, D Yoo. 2014. Animal arterivirus
`infections. Biomed Res Int. 2014:303841.
`Hesse, RA, BR Trible, RRR Rowland. 2013. Parvoviridae and Circoviridae, p. 353–362. In
`Veterinary Microbiology, 3rd ed. Wiley-Blackwell, Ames Iowa.
`Trible, BR, RRR Rowland. 2013. Immunologic protection versus immunopathogenesis:
`recognition of the structural form of the PCV2 capsid determines the outcome. In Advances
`in Virus Research. ISBN: 978-1477555-04-0. iConcept Press.
`Rowland, RR, J Lunney, J Dekkers. 2012. Control of porcine reproductive and respiratory
`syndrome (PRRS) through genetic improvements in disease resistance and tolerance. Front
`Genet. 3:260.
`Arceo, ME, CW Ernst, JK Lunney, I Choi, NE Raney, T Huang, CK Tuggle, RR Rowland, JP
`Steibel. 2012. Characterizing differential individual response to porcine reproductive and
`respiratory syndrome virus infection through statistical and functional analysis of gene
`expression. Front Genet 3:321.
`Rowland, JM, RRR Rowland, T Geisbert. 2012. Chapter 14, Ebolaviruses. Diseases of Swine.
`Trible BR, RR Rowland. 2012. Genetic variation of porcine circovirus type 2 (PCV2) and its
`relevance to vaccination, pathogenesis and diagnosis. Virus Res. 164:68-77.
`Zhang, L, CM Huang, YY Go, KS Faaberg, RR Rowland, PJ Timoney, UB Balasuriya. 2012.
`Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of porcine
`reproductive and respiratory syndrome virus do not change the cellular tropism of equine
`arteritis virus. Virology. 432:99-109.
`Chand, R, B Trible, R Rowland. 2012. Pathogenesis of porcine reproductive and respiratory
`syndrome virus. Curr Op Virol. 2:256-263.
`Sang Y, RR Rowland, F Blecha.2011. Interaction between innate immunity and porcine
`reproductive and respiratory syndrome virus. Anim Health Res Rev. 12:149-67.
`Lunney JK, DA Benfield DA, RR Rowland. 2010. Porcine reproductive and respiratory
`syndrome virus: an update on an emerging and re-emerging viral disease of swine. Virus Res.
`154:1-6.
`Rowland, RRR. 2007. PCV2: Lessons learned and the future. Pork, invited editorial.
`Rowland, RRR. 2007. The stealthy nature of PRRSV infection: The dangers posed by that ever-
`changing mystery swine disease, invited editorial, Vet J. 174:451.
`Murtaugh, MP, SA Dee, JJ Zimmerman, JK Lunney, RRR Rowland. 2007. Recommendations
`for PRRS vaccine research. J. Swine Health and Production. (Letter to the Editor)
`Rowland, RRR, J Kastner, J Hauser, M Kerrigan. Rinderpest virus-revised monograph.2005.
`Prepared for: Office of Counterproliferation Biological and Chemical Warfare Assessments
`Division Defense Intelligence Agency.
`Rowland, RRR, D Yoo. 2003. Nucleolar-cytoplasmic shuttling of the PRRSV nucleocapsid
`protein: a simple case of molecular mimicry or the complex regulation by nuclear import,
`nucleolar localization and nuclear export signal sequences. Virus Res 95: 23-33.
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`Plagemann, PGW, RRR Rowland, C Even, KS Faaberg. 1995. Lactate dehydrogenase-elevating
`virus: an ideal persistent virus? Springer Seminars Immunopathol. 17: 167-186.
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`PUBLICATIONS
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`Chen, N, JCM Dekkers, CL Ewen, RRR Rowland. Porcine reproductive and respiratory
`syndrome virus replication and amino acid substitutions in pigs that lack adaptive immunity.
`Virus Res. Accepted for publication pending revision.
`Ewen, CL, AG Cino-Ozuna, H He, MA Kerrigan, JCM Dekkers, CK Tuggle, RRR Rowland, CR
`Wyatt. Analysis of blood leukocytes in a naturally occurring immunodeficiency of pigs shows
`the defect is localized to B and T cells. J Vet Immunol Immunopath, Accepted for publication
`pending revision.
`Stephenson, R, B Trible, Y Wang, M Kerrigan, S Goldstein, R Rowland. 2014. Multiplex
`serology for common viral infections in feral pigs in Hawaii between 2007 and 2010.
`Accepted for publication, J Wildlife Dis.
`Sang Y, RR Rowland, F Blecha. 2014. Antiviral regulation in porcine monocytic cells at
`different activation states. J Virol. 88:11395-11410.
`Han, MY, CY Kim, RR Rowland, Y Fang, D Kim, D Yoo. 2014. Biogenesis of non-structural
`protein 1 (nsp1) and nsp1-mediated type I interferon modulation in arteriviruses. Virology.
`458-459:136-150.
`Li X, Galliher-Beckley A, Pappan L, Trible B, Kerrigan M, Beck A, Hesse R, Blecha F, Nietfeld
`JC, Rowland RR, Shi J. 2014. Comparison of host immune responses to homologous and
`heterologous type II porcine reproductive and respiratory syndrome virus (PRRSV) challenge
`in vaccinated and unvaccinated pigs. Biomed Res Int. 2014:416727.
`Giménez-Lirola LG, Gerber PF, Rowland RR, Halbur PG, Huang YW, Meng XJ, Opriessnig T.
`2014. Development and validation of a 4-plex antibody assay for simultaneous detection of
`IgG antibodies against Torque teno sus virus 1 (TTSuV1), TTSuV2, and porcine reproductive
`and respiratory syndrome virus types 1 and 2. Res Vet Sci. 96:543-550.
`Boddicker NJ, Bjorkquist A, Rowland RR, Lunney JK, Reecy JM, Dekkers JC. 2014. Genome-
`wide association and genomic prediction for host response to porcine reproductive and
`respiratory syndrome virus infection. Genet Sel Evol. 46:18.
`Sang Y, Brichalli W, Rowland RR, Blecha F. 2014. Genome-wide analysis of antiviral signature
`genes in porcine macrophages at different activation statuses. PLoS One. 9:e87613.
`Boddicker, NJ, DJ Garrick, RRR Rowland, JK Lunney, JM Reecy, JCM Dekkers. 2014.
`Validation and further characterization of a major quantitative trait locus associated with host
`response to experimental infection with porcine reproductive and respiratory syndrome virus.
`Anim Genet. 45:48-58.
`Islam ZU, Bishop SC, Savill NJ, Rowland RR, Lunney JK, Trible B, Doeschl-Wilson AB. 2013.
`Quantitative analysis of porcine reproductive and respiratory syndrome (PRRS) viremia
`profiles from experimental infection: a statistical modelling approach. PLoS One. 8:e83567
`Prather, RS, RRR Rowland, C Ewen, B Trible, M Kerrigan, B Bawa, JM Teson, J Mao, K Lee,
`MS Samuel, KM Whitworth, CN Murphy, T Egen, JA Green. 2013. An intact sialoadhesin
`(Sn/SIGLEC1/CD169) is not required for attachment/internalization of the porcine
`reproductive and respiratory syndrome virus (PRRSV). J Virol, 87:9538-9546.
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`Cino-Ozuna, AG, RRR Rowland, JC Nietfeld, MA Kerrigan, JC Dekkers, CR Wyatt. 2013.
`Preliminary findings of a previously unrecognized porcine primary immunodeficiency
`disorder. J Vet Pathol 50:144-146.
`Endale Ahanda, ML, ER Fritz, J Estellé, ZL Hu, O Madsen, MA Groenen, D Beraldi, R
`Kapetanovic, DA Hume, RR Rowland, JK Lunney, C Rogel-Gaillard, JM Reecy, E Giuffra.
`2012. Prediction of altered 3'- UTR miRNA-binding sites from RNA-Seq data: the swine
`leukocyte antigen complex (SLA) as a model region. PLoS One. 7:e48607
`Kittawornrat, A, J Prickett, C Wang, C Olsen, C Irwin, Y Panyasing, A Ballagi, A Rice, R Main,
`J Johnson, C Rademacher , M Hoogland , R Rowland, J Zimmerman. 2012. Detection of
`Porcine reproductive and respiratory syndrome virus (PRRSV) antibodies in oral fluid
`specimens using a commercial PRRSV serum antibody enzyme-linked immunosorbent assay.
`J Vet Diagn Invest. 24:262-269
`Basel, MT, S Balivada, AP Beck, MA Kerrigan, MM Pyle, CR Wyatt, RRR Rowland, DE
`Anderson, DL Troyer. 2012. Human xenografts are not rejected in a naturally occurring
`immunodeficient porcine line: a human tumor model in pigs. BMC Med 1:63-68.
`Trible, BR, A Suddith, M Kerrigan, A Cino-Ozuna, R Hesse, RRR Rowland. 2012. Recognition
`of the different structural forms of the capsid protein (CP) determines the outcome following
`infection with porcine circovirus type 2 (PCV2). J Virol. 86:13508-13514
`Lu, Z, J Zhang, CM Huang, YY Go, KS Faaberg, RR Rowland, PJ Timoney, UB Balasuriya.
`2012. Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of
`porcine reproductive and respiratory syndrome virus do not change the cellular tropism of
`equine arteritis virus. Virology. 432:99-109.
`Trible, BR, A Ramirez, A Suddith, A Fuller, M Kerrigan, R Hesse, J Nietfeld, B Guo, E
`Thacker, RRR Rowland. 2012. Antibody responses following vaccination versus infection in
`a porcine circovirus-type 2 (PCV2) disease model show distinct differences in virus
`neutralization and epitope recognition. Vaccine 30:4079-4085.
`Sang, Y, J Shi, W Sang, RR Rowland, F Blecha F. 2012. Replication-competent recombinant
`porcine reproductive and respiratory syndrome (PRRS) viruses expressing indicator proteins
`and antiviral cytokines. Viruses. 4:102-116.
`Boddicker, N, EH Waide, RRR Rowland, JK Lunney, DJ Garrick1, JM Reecy, JCM Dekkers.
`2012. Evidence for a major QTL associated with host response to porcine reproductive and
`respiratory syndrome virus challenge. J Anim Sci. 90:1733-1746.
`Kittawornrat, A, J Prickett, C Wang, C Olsen, C Irwin, Y Panyasing, A Ballagi, A Rice, R Main,
`J Johnson, C Rademacher, M Hoogland, R Rowland, J Zimmerman. 2011. Detection of
`porcine reproductive and respiratory syndrome virus (PRRSV) antibodies in oral fluid
`specimens using a commercial PRRSV serum antibody ELISA. J Vet Diag Invest. 24:262-
`269.
`Cino-Ozuna, AG, S Henry, R Hesse, JC Nietfeld, J Bai, HM Scott, RRR Rowland. 2011.
`Characterization of a new disease syndrome associated with porcine circovirus type 2 (PCV2)
`in previously vaccinated herds. J Clin Micro 49: 2012-2016.
`Trible, BR, M Kerrigan, N Crossland, M Potter, K Faaberg, R Hesse, RRR Rowland. 2011.
`Antibody recognition of porcine circovirus type 2 capsid protein epitopes associated after
`vaccination, infection and disease. Clin Vacc Immunol 18: 749-757.
`Holtkamp, DJ, DP Polson, M Torremorell, DVM, PhD; R Morrison, D Augsburger, L Becton, S
`Henry, M Rodibaugh, R Rowland, H Snelson, B Straw, P Yeske, J Zimmerman. 2011.
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`CEV Exhibit 1015_010
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`Terminology for classifying swine herds by porcine reproductive and respiratory syndrome
`virus status. JSHAP, Vol. 19. No. 1.
`Rowland, RRR. 2010. The interaction between PRRSV and the late gestation pig fetus. Virus
`Res., 154:114-122.
`Ma W, AL Vincent, KM Lager, BH Janke, SC Henry, RR Rowland, RA Hesse, JA Richt. 2010.
`Identification and characterization of a highly virulent triple reassortant H1N1 swine
`influenza virus in the United States. Virus Genes 40:28-36.
`Sang, Y, RR Rowland, F Blecha. 2010. Differential expression and activity of the porcine type I
`interferon family. Physiol Genom. 42:248-258.
`Lunney, JK, ER Fritz, JM Reecy, D Kuhar, E Prucnal, R Molina, J Christopher-Hennings, J
`Zimmermam, RRR Rowland. 2010. Interleukin-8, interleukin-1beta, and interferon-gamma
`levels are linked to PRRS virus clearance. Viral Immunol. 23:127-134.
`Mohammadi, H, S Sharif, RRR Rowland, D. Yoo. 2009. The lactate dehydrogenase-elevating
`virus capsid protein is a nuclear-cytoplasmic protein. Arch Virol. 154:1071-1080.
`Sang, Y, P Ruchala, R Lehrer, CR Ross, RRR Rowland, Frank Blecha. 2009. Antimicrobial Host
`Defense Peptides in an Arteriviral Infection: Differential Peptide Expression and Virus
`Inactivation. Viral Immun. 22:235-242.
`Brown E, S Lawson, C Welbon, J Gnanandarajah, J Li,MP Murtaugh , Nelson EA, RM Molina,
`JJ Zimmerman, RR Rowland, Y Fang. 2009. Antibody response to porcine reproductive and
`respiratory syndrome virus (PRRSV) nonstructural proteins and implications for diagnostic
`detection and differentiation of PRRSV types I and II. Clin Vaccine Immunol. 16:628-635.
`Gaudreault, N, RR Rowland, CR Wyatt. 2009. Factors affecting the permissiveness of porcine
`alveolar macrophages for porcine reproductive and respiratory syndrome virus. Archiv Virol.
`154:133-136.
`Molina, RM, EA Nelson, J Christopher-Hennings R Hesse, RR Rowland, JJ Zimmerman.2008.
`Evaluation of the risk of PRRSV transmission via ingestion of muscle from persistently
`infected pigs. Transbound Emerg Dis. 56:1-8.
`Kim, DY, TJ Kaiser, K Horlen, ML Keith, LP Taylor, R Jolie, JG Calvert, RR Rowland. 2008.
`Insertion and deletion in a non-essential region of the nonstructural protein 2 (nsp2) of
`porcine reproductive and respiratory syndrome (PRRS) virus: effects on virulence and
`immunogenicity. Virus Genes. 38:118-128.
`Ho, C-S, Y-J Lee, JK Lunney, MH Franzo-Romain, GW Martens, J-H Lee, M Wysocki, RRR
`Rowland, DM Smith. 2009. Molecular characterization of swine leukocyte antigen (SLA)
`class I genes in outbred pig populations. Anim Genetics. 40:468-478.
`Molina RM, S Cha, W Chittick, S Lawson, MP Murtaugh, EA Nelson, J Christopher-Hennings,
`K-J Yoon, R Evans, RRR Rowland, J Zimmerman. 2008. Immune response against porcine
`reproductive and respiratory syndrome virus during acute and chronic infection. Vet
`Immunol Immunopathol 126:283-292.
`Patton, JP, RRR Rowland, D Yoo, K-O Chang. 2008. Modulation of CD163 receptor expression
`and replication of porcine reproductive and respiratory syndrome virus in porcine
`macrophages. Virus Res. 140: 161-171.
`Molina, R, W Chittick, E Nelson, J Christopher-Hennings, RRR Rowland, JJ Zimmerman. 2008.
`Diagnostic performance of assays for the detection of anti-porcine reproductive and
`respiratory syndrome virus antibodies in serum and muscle transudate ("meat juice") based on
`samples collected under experimental conditions. J Vet Diagn Invest. 20:735-743.
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`CEV Exhibit 1015_011
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`Sang, Y, C Ross, RR Rowland, F Blecha.2008. Toll-like receptor 3 (TLR3) activation decreases
`porcine arterivirus infection. Viral Immunol 21:303-313.
`Sang, Y, J Yang, C Ross, RRR Rowland, F Blecha, 2008. Molecular identification and
`f