BRCA2 [Homo sapiens] - Protein - NCBI
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`Page 1 of 3
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`Display Settings: GenPept
`
`BRCA2 [Homo sapiens]
`GenBank: AAB07223.1
`FASTA Graphics
`
`Go to:
`
`LOCUS AAB07223 3418 aa linear PRI 03-SEP-1996
`DEFINITION BRCA2 [Homo sapiens].
`ACCESSION AAB07223
`VERSION AAB07223.1 GI:1161384
`DBSOURCE locus HSU43746 accession U43746.1
`KEYWORDS .
`SOURCE Homo sapiens (human)
` ORGANISM Homo sapiens
` Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
` Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
` Catarrhini; Hominidae; Homo.
`REFERENCE 1 (sites)
` AUTHORS Teng,D.H., Bogden,R., Mitchell,J., Baumgard,M., Bell,R., Berry,S.,
` Davis,T., Ha,P.C., Kehrer,R., Jammulapati,S., Chen,Q., Offit,K.,
` Skolnick,M.H., Tavtigian,S.V., Jhanwar,S., Swedlund,B., Wong,A.K.
` and Kamb,A.
` TITLE Low incidence of BRCA2 mutations in breast carcinoma and other
` cancers
` JOURNAL Nat. Genet. 13 (2), 241-244 (1996)
` PUBMED 8640236
`REFERENCE 2 (residues 1 to 3418)
` AUTHORS Tavtigian,S.V., Rommens,J.M., Couch,F.J., Neuhausen,S., Bell,R.,
` Berry,S., Bogden,R., Chen,Q., Davis,T., Frye,C., Hattier,T.,
` Jammulapati,S., Janecki,T., Jiang,P., Kehrer,R., Schroeder,M.,
` Snyder,S., Stringfellow,M., Stroup,C., Swedlund,B., Teng,D.,
` Thomas,A., Tran,T., Weaver-Feldhaus,J., Wong,A., Leblanc,J.-F.,
` Belanger,C., Tranchant,M., Samson,C., Dumont,M.,
` McArthur-Morrison,J., McSweeney,D., Peng,Y., Shizuya,H., Slepak,T.,
` Simon,M.I., Labrie,F., Shattuck-Eidens,D., Skolnick,M., Goldgar,D.,
` Weber,B.L., Simard,J. and Kamb,A.
` TITLE Direct Submission
` JOURNAL Submitted (21-DEC-1995) Sean Tavtigian, Myriad Genetics Inc.,
` Department of Research, 390 Wakara Way, Salt Lake City, 84106, USA
`COMMENT On Jan 19, 1996 this sequence version replaced gi:1131427.
` Tavtigian,S.V., Bell,R., Berry,S., Bogden,R., Chen,Q., Davis,T.,
` Frye,C., Hattier,T., Jammulapati,S., Janecki,T., Jiang,P.,
` Kehrer,R., Schroeder,M., Snyder,S., Stringfellow,M., Stroup,C.,
` Swedlund,B., Shattuck-Eidens,D., Skolnick,M., and Kamb,A.
` Myriad Genetics Inc.
` 390 Wakara Way
` Salt lake City, Utah 84106
` Rommens,J.M., McArthur-Morrison,J., and McSweeney,D.
` Department of Genetics, Research Institute
` The Hospital for Sick Children
` Toronto, Canada
` Couch,F.J., Peng,Y. and Weber,B.L.
` Division of Hematology and Oncology
` Department of Medicine
` University of Pennsylvania Medical School
` Shizuya,H., Slepak,T., and Simon,M.I.
` Division of Biology 157-75
` California Institute of Technology
` Dumont,M., Leblanc,J.-F., Belanger,C., Tranchant,M., Samson,C,.
` Labrie,F., and Simard,J.
` CHUL Research Center and Laval University
` Department of Molecular Endocrinology
` Quebec, Canada
` Neuhausen,S. and Goldgar,D.
`
`http://www.ncbi.nlm.nih.gov/protein/1161384?sat=13&satkey=6559532
`
`8/6/2014
`
`GeneDX 1028, pg. 1
`
`
`
`Page 1 of 3
`
`Display Settings: GenPept
`
`BRCA2 [Homo sapiens]
`GenBank: AAB07223.1
`FASTA Graphics
`
`Go to:
`
`LOCUS AAB07223 3418 aa linear PRI 03-SEP-1996
`DEFINITION BRCA2 [Homo sapiens].
`ACCESSION AAB07223
`VERSION AAB07223.1 GI:1161384
`DBSOURCE locus HSU43746 accession U43746.1
`KEYWORDS .
`SOURCE Homo sapiens (human)
` ORGANISM Homo sapiens
` Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
` Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
` Catarrhini; Hominidae; Homo.
`REFERENCE 1 (sites)
` AUTHORS Teng,D.H., Bogden,R., Mitchell,J., Baumgard,M., Bell,R., Berry,S.,
` Davis,T., Ha,P.C., Kehrer,R., Jammulapati,S., Chen,Q., Offit,K.,
` Skolnick,M.H., Tavtigian,S.V., Jhanwar,S., Swedlund,B., Wong,A.K.
` and Kamb,A.
` TITLE Low incidence of BRCA2 mutations in breast carcinoma and other
` cancers
` JOURNAL Nat. Genet. 13 (2), 241-244 (1996)
` PUBMED 8640236
`REFERENCE 2 (residues 1 to 3418)
` AUTHORS Tavtigian,S.V., Rommens,J.M., Couch,F.J., Neuhausen,S., Bell,R.,
` Berry,S., Bogden,R., Chen,Q., Davis,T., Frye,C., Hattier,T.,
` Jammulapati,S., Janecki,T., Jiang,P., Kehrer,R., Schroeder,M.,
` Snyder,S., Stringfellow,M., Stroup,C., Swedlund,B., Teng,D.,
` Thomas,A., Tran,T., Weaver-Feldhaus,J., Wong,A., Leblanc,J.-F.,
` Belanger,C., Tranchant,M., Samson,C., Dumont,M.,
` McArthur-Morrison,J., McSweeney,D., Peng,Y., Shizuya,H., Slepak,T.,
` Simon,M.I., Labrie,F., Shattuck-Eidens,D., Skolnick,M., Goldgar,D.,
` Weber,B.L., Simard,J. and Kamb,A.
` TITLE Direct Submission
` JOURNAL Submitted (21-DEC-1995) Sean Tavtigian, Myriad Genetics Inc.,
` Department of Research, 390 Wakara Way, Salt Lake City, 84106, USA
`COMMENT On Jan 19, 1996 this sequence version replaced gi:1131427.
` Tavtigian,S.V., Bell,R., Berry,S., Bogden,R., Chen,Q., Davis,T.,
` Frye,C., Hattier,T., Jammulapati,S., Janecki,T., Jiang,P.,
` Kehrer,R., Schroeder,M., Snyder,S., Stringfellow,M., Stroup,C.,
` Swedlund,B., Shattuck-Eidens,D., Skolnick,M., and Kamb,A.
` Myriad Genetics Inc.
` 390 Wakara Way
` Salt lake City, Utah 84106
` Rommens,J.M., McArthur-Morrison,J., and McSweeney,D.
` Department of Genetics, Research Institute
` The Hospital for Sick Children
` Toronto, Canada
` Couch,F.J., Peng,Y. and Weber,B.L.
` Division of Hematology and Oncology
` Department of Medicine
` University of Pennsylvania Medical School
` Shizuya,H., Slepak,T., and Simon,M.I.
` Division of Biology 157-75
` California Institute of Technology
` Dumont,M., Leblanc,J.-F., Belanger,C., Tranchant,M., Samson,C,.
` Labrie,F., and Simard,J.
` CHUL Research Center and Laval University
` Department of Molecular Endocrinology
` Quebec, Canada
` Neuhausen,S. and Goldgar,D.
`
`http://www.ncbi.nlm.nih.gov/protein/1161384?sat=13&satkey=6559532
`
`8/6/2014
`
`GeneDX 1028, pg. 1
`
`
`
`BRCA2 [Homo sapiens] - Protein - NCBI
`
`Page 2 of 3
`
` Department of Medical Informatics
` University of Utah Medical Center.
`FEATURES Location/Qualifiers
`
` source 1..3418
` /organism="Homo sapiens"
` /db_xref="taxon:9606"
` /chromosome="13"
` /map="13q12-q13"
`
`Protein 1..3418
` /product="BRCA2"
`
`CDS 1..3418
` /gene="BRCA2"
` /coded_by="U43746.1:229..10485"
`ORIGIN
` 1 mpigskerpt ffeifktrcn kadlgpisln wfeelsseap pynsepaees ehknnnyepn
` 61 lfktpqrkps ynqlastpii fkeqgltlpl yqspvkeldk fkldlgrnvp nsrhkslrtv
` 121 ktkmdqaddv scpllnscls espvvlqcth vtpqrdksvv cgslfhtpkf vkgrqtpkhi
` 181 seslgaevdp dmswssslat pptlsstvli vrneeasetv fphdttanvk syfsnhdesl
` 241 kkndrfiasv tdsentnqre aashgfgkts gnsfkvnsck dhigksmpnv ledevyetvv
` 301 dtseedsfsl cfskcrtknl qkvrtsktrk kifheanade ceksknqvke kysfvsevep
` 361 ndtdpldsnv ahqkpfesgs dkiskevvps lacewsqltl sglngaqmek ipllhisscd
` 421 qnisekdlld tenkrkkdfl tsenslpris slpksekpln eetvvnkrde eqhleshtdc
` 481 ilavkqaisg tspvassfqg ikksifrire spketfnasf sghmtdpnfk keteasesgl
` 541 eihtvcsqke dslcpnlidn gswpatttqn svalknagli stlkkktnkf iyaihdetfy
` 601 kgkkipkdqk selincsaqf eanafeaplt fanadsgllh ssvkrscsqn dseeptlslt
` 661 ssfgtilrkc srnetcsnnt visqdldyke akcnkeklql fitpeadsls clqegqcend
` 721 pkskkvsdik eevlaaachp vqhskveysd tdfqsqksll ydhenastli ltptskdvls
` 781 nlvmisrgke sykmsdklkg nnyesdvelt knipmeknqd vcalnenykn vellppekym
` 841 rvaspsrkvq fnqntnlrvi qknqeettsi skitvnpdse elfsdnennf vfqvanernn
` 901 lalgntkelh etdltcvnep ifknstmvly gdtgdkqatq vsikkdlvyv laeenknsvk
` 961 qhikmtlgqd lksdislnid kipeknndym nkwagllgpi snhsfggsfr tasnkeikls
` 1021 ehnikkskmf fkdieeqypt slacveivnt laldnqkkls kpqsintvsa hlqssvvvsd
` 1081 cknshitpqm lfskqdfnsn hnltpsqkae itelstilee sgsqfeftqf rkpsyilqks
` 1141 tfevpenqmt ilkttseecr dadlhvimna psigqvdssk qfegtveikr kfagllkndc
` 1201 nksasgyltd enevgfrgfy sahgtklnvs tealqkavkl fsdienisee tsaevhpisl
` 1261 ssskchdsvv smfkienhnd ktvseknnkc qlilqnniem ttgtfveeit enykrntene
` 1321 dnkytaasrn shnlefdgsd sskndtvcih kdetdllftd qhniclklsg qfmkegntqi
` 1381 kedlsdltfl evakaqeach gntsnkeqlt atkteqnikd fetsdtffqt asgknisvak
` 1441 esfnkivnff dqkpeelhnf slnselhsdi rknkmdilsy eetdivkhki lkesvpvgtg
` 1501 nqlvtfqgqp erdekikept llgfhtasgk kvkiakesld kvknlfdeke qgtseitsfs
` 1561 hqwaktlkyr eackdlelac etieitaapk ckemqnslnn dknlvsietv vppkllsdnl
` 1621 crqtenlkts ksiflkvkvh enveketaks patcytnqsp ysviensala fytscsrkts
` 1681 vsqtslleak kwlregifdg qperintady vgnylyenns nstiaendkn hlsekqdtyl
` 1741 snssmsnsys yhsdevynds gylsknklds giepvlknve dqkntsfskv isnvkdanay
` 1801 pqtvnedicv eelvtssspc knknaaikls isnsnnfevg ppafriasgk ivcvshetik
` 1861 kvkdiftdsf skvikennen kskicqtkim agcyealdds edilhnsldn decsthshkv
` 1921 fadiqseeil qhnqnmsgle kvskispcdv sletsdickc sigklhksvs santcgifst
` 1981 asgksvqvsd aslqnarqvf seiedstkqv fskvlfksne hsdqltreen tairtpehli
` 2041 sqkgfsynvv nssafsgfst asgkqvsile sslhkvkgvl eefdlirteh slhysptsrq
` 2101 nvskilprvd krnpehcvns emektcskef klsnnlnveg gssennhsik vspylsqfqq
` 2161 dkqqlvlgtk vslvenihvl gkeqaspknv kmeigktetf sdvpvktnie vcstyskdse
` 2221 nyfeteavei akafmeddel tdsklpshat hslftcpene emvlsnsrig krrgeplilv
` 2281 gepsikrnll nefdriienq ekslkaskst pdgtikdrrl fmhhvslepi tcvpfrttke
` 2341 rqeiqnpnft apgqeflsks hlyehltlek sssnlavsgh pfyqvsatrn ekmrhlittg
` 2401 rptkvfvppf ktkshfhrve qcvrninlee nrqkqnidgh gsddsknkin dneihqfnkn
` 2461 nsnqaaavtf tkceeepldl itslqnardi qdmrikkkqr qrvfpqpgsl ylaktstlpr
` 2521 islkaavggq vpsacshkql ytygvskhci kinsknaesf qfhtedyfgk eslwtgkgiq
` 2581 ladggwlips ndgkagkeef yralcdtpgv dpklisriwv ynhyrwiiwk laamecafpk
` 2641 efanrclspe rvllqlkyry dteidrsrrs aikkimerdd taaktlvlcv sdiislsani
` 2701 setssnktss adtqkvaiie ltdgwyavka qldppllavl kngrltvgqk iilhgaelvg
` 2761 spdactplea peslmlkisa nstrparwyt klgffpdprp fplplsslfs dggnvgcvdv
` 2821 iiqraypiqw mektssglyi frnereeeke aakyveaqqk rlealftkiq eefeeheent
`
`http://www.ncbi.nlm.nih.gov/protein/1161384?sat=13&satkey=6559532
`
`8/6/2014
`
`GeneDX 1028, pg. 2
`
`
`
`BRCA2 [Homo sapiens] - Protein - NCBI
`
`Page 3 of 3
`
` 2881 tkpylpsral trqqvralqd gaelyeavkn aadpaylegy fseeqlraln nhrqmlndkk
` 2941 qaqiqleirk amesaeqkeq glsrdvttvw klrivsyskk ekdsvilsiw rpssdlysll
` 3001 tegkryriyh latsksksks eraniqlaat kktqyqqlpv sdeilfqiyq preplhfskf
` 3061 ldpdfqpscs evdligfvvs vvkktglapf vylsdecynl laikfwidln ediikphmli
` 3121 aasnlqwrpe sksglltlfa gdfsvfsasp keghfqetfn kmkntvenid ilcneaenkl
` 3181 mhilhandpk wstptkdcts gpytaqiipg tgnkllmssp nceiyyqspl slcmakrksv
` 3241 stpvsaqmts ksckgekeid dqknckkrra ldflsrlplp ppvspictfv spaaqkafqp
` 3301 prscgtkyet pikkkelnsp qmtpfkkfne isllesnsia deelalintq allsgstgek
` 3361 qfisvsestr taptssedyl rlkrrcttsl ikeqessqas teeceknkqd tittkkyi
`//
`
`http://www.ncbi.nlm.nih.gov/protein/1161384?sat=13&satkey=6559532
`
`8/6/2014
`
`GeneDX 1028, pg. 3
`
`
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