EXHIBIT 1009
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`
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`aK‘Ffiw‘vvrmfimwmw‘wwwcwiwnnN,
`
`EDITION
`
`THE
`
`MERCK INDEX
`
`AN ENCYCLOPEDIA OF
`
`CHEMICALS, DRUGS, AND BIOLOGICALS
`
`FOURTEENTH EDITION
`
`Maryadele J. O’Neil, Editor
`
`Patricia E. Heckelman, Senior Associate Editor
`
`Cherie B. Koch, Associate Editor
`
`Kristin J. Roman, Assistant Editor
`
`Catherine M. Kenny, Editorial Assistant
`
`Maryann R. D’Arecca, Administrative Associate
`
`Published by
`Merck Research Laboratories
`
`Division of
`
`MERCK & C0,, INC.
`Whitehouse Station, NJ, USA
`
`2006
`
`

`

`Library of Congress Catalog Card Number 89-6000l
`ISBN Number 0-911910-00-x
`ISBN Number 978-0-9l 1910-00-1
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`Copyright © 2006 by MERCK & CO., INC., Whitehouse Station, NJ, USA
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`All rights reserved. No part of this book or electronic product may be reproduced or used in any form or by any means.
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`Printed in the USA
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`

`6033
`
`224°C. Soly in water: 4.8 g/100 g. Soly of water in methyl I-butyl
`ether: 1.5 g/100 g. Unstable in acid soln. Volatile; lipophilic.
`Flammable. LC“, in mice (15 min): 1.6 mmol/liter of atmosphere
`(Marsh).
`Caution: Potential symptoms of overexposure by inhallation are
`coughing. burning sensation in nose and throat, headache. nausea.
`vomiting. dizziness. feeling of spaciness and disorientation (P897-
`121016).
`USE: Octane booster in gasoline. Chromatographic eluent esp in
`HPLC.
`THERAP CAT: Cholelitholytic agent.
`
`[591v78-6] 2-Hexanone. C6-
`6033. Methyl Butyl Ketone.
`HIZO: mol wt 100.16. C 71.95%. H 12.08%. 015.97%. CHJCO—
`C. Hg. Toxicity study: H. F. Smyth at al., Arch. Ind. Hyg. 0(‘(‘llp.
`Med, 10, 61 (1954). Review of toxicology: P. M. .1. Bus etal.. Am.
`J. Ind. Med. 20, 175-194 (1991); and human exposure: Toxicolog-
`ical Profilefor Z-Hat'anoiw (PB93-l 10773. 1992) l 16 pp.
`Colorless liquid. (10.830. bp 127°. Slightly soluble in water;
`sol in alcohol. ether. LDSD orally in rats: 2.59 g/kg (Smyth).
`Caution: Potential symptoms 01‘ overexposure arc irritation of
`eyes and nose; peripheral neuropathy; weakness. paresthesia: der~
`matitis; headache; drowsiness. See NIOSH Pocket Guide to Chem-
`iral Hazards (DHHS/NIOSH 97—140. 1997) p 164.
`
`Methyl Butyl Ketone
`l 129 (I960). Toxicity data: Smyth, J. Ind. Hyg.
`dar. Ber. 93,
`Toxicol. 23. 259 (1941); Werner. ibid. 25, 157 (1943). Series of
`articles on toxicology: Environ. Health Perspect. 57, 1—275 (1984).
`Liquid. Poisonous! hp“... 124.43°; hp:0 34.41°. d3" 0.9663.
`Flash pt 115°F.
`in," 1.4028. Miscible with water. alcohol ether.
`glycerol. acetone. dimethylfonnamide. LDSO in rats. guinea pigs
`(mg/kg): 2460. 950 orally (Smyth). LC50 (7 hr in air) in mice: 4.6
`mg/l (Wemer).
`Caution: Potential symptoms of overexposure are irritation of
`eyes. nose. throat: headache. drowsiness. weakness; ataxia. tremor.
`somnolence: anemic pallor. See NIOSH Pocket Guide to Chemical
`Hazards (DHHS/NIOSH 97-140. 1997) p 202. Exerts principle
`toxic effects on brain. blood. kidneys. thymus. testes. Appreciably
`toxic when inhaled. Absorbed through skin; direct contact may
`cause skin irritation. Embryotoxic and teratogenic in exptl animals.
`Sr? Patty's Industrial Hygiene and Toxirology vol. 21), G. D. Clay—
`ton. F. E. Clayton. Eds. (Wiley-lntcrscicnce. New York, 4th ed..
`1994) pp 2764-2776.
`USE: Solvent for low-viscosity cellulose acetate. natural resins.
`some synthetic resins and some alcohol-soluble dyes: in dyeing
`leather. sealing moistureproot‘ cellophane: in nail polishes, quick-
`drying varnishes and enamels. wood stains.
`In modified Karl
`Fischer reagent: Peters. Jungnickel. Anal. Chem. 27. 450 (1955).
`
`New York. 4th ed.. 1975) pp 5
`R. Cronn. D. E. Harsch. Anal. 1
`study: D. W. Lindle at (1].. Ph.
`M. T. Holbrook in Kirk-Otlim
`nology vol. 5 (Wiley-lntersci
`1028-1040. Review of toxic
`Cril. Rev. Toxit‘ol. 6, 283-302
`it'ologiral Profilcfor Chloromc
`Colorless gas of mild odor a1
`mp ~97.7°: bp -23.7°: nu (“1
`water; misc with chloroform. 1
`hol. Soly at 20° (ml/100 mi):
`3756; glacial acetic acid 3679;
`0.48.
`Caution: Potential symptt
`nausea and vomiting: visual di:
`convulsions. coma: liver and it
`atogenic effects; direct conta
`Potential occupational carcin
`Chemical Hazards (DHHS/Nl
`Patty's Industrial Hygiene and
`E. Clayton. Eds. (Wiley—lnters
`3436-3442.
`USE: Manuf of silicones. t:
`butyl rubber. Has been used as
`6042. Methyl Chloroac
`methyl ester. C3H5C102; mol
`32.67%. 0 29.49%. CHZClCC
`Colorless liquid. d3}; 1.238
`water: miscible with alcohol. e‘
`USE: As solvent.
`
`6043. Methyl Chloroca
`dic acid methyl ester; methyl
`94.50. C 25.42%. H 3.20%. .
`Made from phosgene and meth
`Clear liquid. d3“ 1.223.
`gradually (ice by it; miscible
`ether.
`Caution.‘ Vapors strongly ir
`6044.
`3-Methylch01an1
`methylbenzljlaceanthrylcne: 3
`MC. Czll‘lloi"10"“258-3f
`oxycholic acid: Wieland. Sch
`(1925): Wieland. Wicdcrshei
`Dane. ibid. 219, 240 (1933).
`1
`J. Chem. Soc. 1934, 428: Fie:
`2482 (1936): (f. Bachmann. J
`cholanthrene has been produc
`radation of cholesterol deriva
`lich. Angew. Chem. 70, 190 ( l
`Org. Chem. 46, 3429 (1981):
`hadron Lett. 22, 1093 (1981).
`carbons Vol. 1 & 2 (Academit
`
`Pale yellow, slender prisms
`hp... 280°; d" 1.28. Absorpt
`Am. Chem. Soc. 60, 940 (193
`slightly sol in amyl alcohol. 11
`USE: Exptlly in cancer reset
`6045. Methylcobalam:
`methyl deriv. dihydrogen pho
`5,6-dimethyl- 1 -a-D—ribofurar1
`dimethylbenzimidazolylcobal
`Bu; Merl: Algobaz; Hitoco
`C63H91C0NHOHP; mol wt
`
`[115-19-51 2-Hydroxy-2-
`2-Methyl-3-butyn-2-ol.
`6034.
`methyl-3-butyne. C5H,‘O; mol wt 84.12. C 71.39%. H 9.59%. 0
`19.02%. Toxicity data: W. Keil cl 0].. Ar:ncini.-For.rrh. 4. 477
`(1954): K. Soehring or al., ihid. 5. 161 (1955).
`CH3
`
`chl-fi\\\CH
`
`(.133 0.8672. 7.24 lbs/gal. mp 2.6°. hpm, 104.105";
`Liquid.
`15pr 52°; bpn 20°. Flash pl 77°F (25°C). hf," 1.4211. Surface
`tension at 25° = 23.8 dynes/cm: 5% aq soln = 41.7 dynes/cm.
`Miscible with water. acetone. benzene. carbon tetrachloride. Cello-
`solve. cyclohexanone. diethylene glycol. ethyl acetate. kerosine.
`methyl ethyl ketone. mineral spirits. monoethanolamine. neatsl‘oot
`oil. petr ether. soybean oil. Stoddard solvent. Azeotrope with water.
`bp 90.7“. contains 28.4% H20. L050 in mice (mg/kg): 1800 orally
`(Keil): 2340 5.6. (Soehring).
`
`I623-42-7] Butanoic acid methyl
`6035. Methyl Butyrate.
`ester. CSHIUOZ; mol wt 102.13. C 58.80%. H 9.87%. O 31.33%.
`CH3(CH3)2COOCH3.
`Colorless liquid. d3" 0.898. mp about —95°. bp 102°. Flash pt
`14°C.
`11?)” 1.3879. Sol in about 60 parts water: miscible with
`alcohol. ether.
`USE: Manuf artificial rum and fruit essences.
`
`6036. Methyl Carbamate. [59855-0] Urethylane; methyl-
`urethane. C2H5N02; mol wt 75.07. C 32.00%, H 6.71%. N
`18.66%. 0 42.63%. HZNCOOCH... Prepn from silver or mercu-
`ricyanate with [-125 and methanol: Birkenbach, Kolh. Ber. 68, 901
`(1935). From urea and methanol: DE 753127 (1940 to LG. Far-
`benind.).
`White crystals. mp 52<54°. bp 177°. Freely sublimes even at
`room temp. Freely sol in water. alcohol.
`
`6037. Methyl Carbitol®. 1111-77-31 2—(2-Mcthoxyeth-
`oxy)ethanol; dicthylcne glycol monomethyl ether; methyl digol.
`C5H,305; mol wt 120.15. C 49.98%. H 10.07%. 0 39.95%. CH.-
`OCHECH30CH3CHZOH. Toxicity data: Smyth et al.. J. Ind. Hyg.
`Toxicol. 23, 259 (1941 ).
`Liquid. d3“ 1.035. mp <—84°. bp 193°. hi} 1.4264. Flash pl.
`open cup: 200°F (93°C). Miscible with water. alc. glycerol. ether.
`acetone, DMF. L135.) orally in rats: 9.21 g/kg (Smyth).
`USE: Used in the same way as 2-ethoxyethanol where a solvent
`with a higher boiling point is required.
`
`6038. Methyl Cellosolve®. 1109-86-4] 2—Methoxyethanol;
`ethylene glycol monomethyl ether. C3H302; mol wt 76.09. C
`47.35%. H 10.60%. 0 42.05%. HOCHZCHZOCHJ. Prepn from
`ethylene oxide + methanol: Finch. Hagemeyer. US 2748171 (1956
`to Kodak): l'rom ethylene glycol + diazomethane: Hesse. Majum-
`
`[1 10-49-6] 2-Meth-
`6039. Methyl Cellosolve® Acetate.
`oxyethanol acetate; ethylene glycol monomethyl ether acetate. C5-
`H1003; mol wt 118.13. C 50.84%. H 8.53%. O 40.63%. CH3v
`OCHECHZOOCCHJ. Toxicity data: H. F. Smyth e! (11.. J. Ind.
`Hyg. Toxicol. 23. 259 (1941). Series of articles on toxicology:
`Environ. Health Perspect. 57, 1-275 (1984).
`"D
`Colorless liquid.
`d3}; 1.0067. bp 145°. mp -65.1".
`1.4019. Miseible with water. most organic solvents. oils: dissolves
`gums. resins. LDSO orally in rats: 3.4 g/kg (Smyth).
`Caulion: Potential symptoms of overexposure are kidney dam-
`age; brain damage. Direct contact may cause eye. nose and throat
`irritation. Sea NIOSH Pocket Guide 10 Chemical Hazards (DHHS/—
`NIOSH 97—140. 1997) p 202. See also Patty's Industrial Hygiene
`and Toxicology vol. 2D, G. D. Clayton. F. E. Clayton. Eds. (Wiley-
`lnterscience. New York, 4th ed.. 1994) pp 2918-2921.
`USE:
`industrial solvent.
`
`6040. Methylcellulose. [9004-67-5l Cellulose methyl ether:
`Methocel A: Benecel M; Colevac: Cellucon; Citrucel: Cologel:
`Tearisol: Tylose M. Cellulose obtained from fibrous plant material
`and partially etherified with methyl groups. Prepd from cellulose
`fibers heated with caustic solution and treated with methyl chloride.
`Commercial methylccllulose has a methoxyl content of 25—33%
`(degree of substitution 1.5 to 2.0). Review of prepns and properties:
`on. Ccllulnst' and Cellulose Derivatives (Wilcy—lnterscience. New
`York. 2nd ed., 1954/55): G. K. Greminger. A. B. Savage. in Indus-
`trial Gums. R. L. Whistler. Ed. (Academic Press. New York. 2nd ed..
`1973) pp 619-647. Clinical efficacy as laxative:
`.1. W. Hamilton ct
`al.,l)1'g. Dis. Sci. 33. 993 (1988). Evaluation in lens implantation
`surgery:
`.1. R. Rojas er al.. Ann. Ophthalmol. 21. 389 (1989).
`Review of production and uses in the food industry: P. de Muriscal,
`D. A. Bell in Handbook ofFat Replac'crs. S. Roller. S. A. Jones. Eds.
`(CRC Press. Boca Raton FL. 1996) pp 145-159.
`lnsol in
`White granules. Odorless. tasteless. Sol in cold water.
`hot water. An aq soln is best prepd by dispersing the granules in hot
`(but not boiling) water with stirring and chilling to +5°. The soln is
`then stable at room temp. Presence of inorganic salts increases the
`viscosity. The soly is dependent upon degree 01. substitution. Clear
`films may be cast from at} soln.
`USE: As a substitute for water-soluble gums; to render paper
`greaseprool'. in adhesives. as thickening agent in cosmetics. as
`protective colloid in emulsions. as binder and stabilizer in foods.
`As fat replacer in the formulation of dietetic foods. Pharmaceutic
`aid (suspending agent).
`'t't-ttiRAP CAT: Laxative: ocular lubricant.
`THERAP CAT (VET): Laxative.
`
`[74437-31 Chloromethane: Freon
`6041. Methyl Chloride.
`40. CH3C1: mol wt 50.49. C 23.79%, H 5.99%. C1 70.22%.
`Known as early as 1835. large scale production started in 1920‘s.
`Review of mfg processes: Faith, Kaye's & Clark's Industrial Chem-
`icals. F. A. Lowenheim. M. K. Moran. Eds. (Wiley-lnterscience.
`
`Page 1042
`
`Consult the Name Index before using this section.
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