`
`(12) United States Patent (cid:9)
`Scarrott et al. (cid:9)
`
`(10) Patent No.: (cid:9)
`(45) Date of Patent: (cid:9)
`
`US 8,662,075 B2
`Mar. 4, 2014
`
`(54) DISPENSING DEVICE
`
`(75) Inventors: Peter Mycola Scarrott, London (CA);
`Jerry R. Grychowski, Lake Zurich, IL
`(US); James Nick Schmidt, London
`(CA); Martin P. Foley, London (CA)
`
`Assignee: Trudell Medical International, London
`(CA)
`
`Notice: (cid:9)
`
`Subject to any disclaimer, the term of this
`patent is extended or adjusted under 35
`U.S.C. 154(b) by 20 days.
`
`Appl. No.: 13/313,840
`
`Filed: (cid:9)
`
`Dec. 7, 2011
`
`Prior Publication Data
`
`US 2012/0222672 Al (cid:9)
`
`Sep. 6, 2012
`
`Related U.S. Application Data
`
`(63) Continuation of application No. 12/835,275, filed on
`Jul. 13, 2010, now Pat. No. 8,074,643, which is a
`continuation of application No. 11/639,175, filed on
`Dec. 14, 2006, now Pat. No. 7,757,688, which is a
`continuation of application No. 11/370,748, filed on
`Mar. 8, 2006, now Pat. No. 7,516,738, which is a
`continuation of application No. 11/289,050, filed on
`Nov. 29, 2005, now Pat. No. 7,341,057, which is a
`continuation of application No. 11/136,044, filed on
`May 24, 2005, now Pat. No. 7,568,481, which is a
`continuation of application No. 10/876,005, filed on
`Jun. 24, 2004, now Pat. No. 6,926,002, which is a
`continuation of application No. 10/409,247, filed on
`Apr. 8, 2003, now Pat. No. 6,953,039, which is a
`continuation of application No. 10/039,744, filed on
`Oct. 26, 2001, now Pat. No. 6,761,161, which is a
`continuation of application No. 09/303,043, filed on
`Apr. 30, 1999, now Pat. No. 6,336,453, and a
`continuation-in-part of application No. 09/603,427,
`filed on Jun. 26, 2000, now Pat. No. 6,328,037, which
`is a continuation of application No. 09/073,275, filed
`on May 5, 1998, now Pat. No. 6,082,358.
`
`(2006.01)
`
`(51) Int. Cl.
`A61M 11/00 (cid:9)
`(52) U.S. Cl.
` 128/200.23; 128/200.14; 116/307
`USPC (cid:9)
`(58) Field of Classification Search
`USPC (cid:9)
` 128/200.14, 200.18, 200.23, 203.15,
`128/203.12, 205.23, 203.23; 222/32, 36,
`222/162; 116/311-315, 317, 318
`See application file for complete search history.
`References Cited
`
`(56)
`
`U.S. PATENT DOCUMENTS
`
`165,054 A
`498,851 A
`
`6/1875 Baldwin
`6/1893 Jones
`(Continued)
`
`FOREIGN PATENT DOCUMENTS
`
`AU
`CA
`
`6/1990
`598250 B2 (cid:9)
`1/1957
`535518 A (cid:9)
`(Continued)
`OTHER PUBLICATIONS
`
`International Search Report in International Application No. PCT/
`IB03/01032, dated Aug. 19, 2003, 10 pages.
`
`(Continued)
`
`Primary Examiner - Steven Douglas
`(74) Attorney, Agent, or Firm - Brinks Gilson & Lione
`(57)
`ABSTRACT
`An indicating device for indicating the number of dosages of
`medicament dispensed from a container includes a housing, a
`single indicator member nested the housing, an actuator and
`a drive mechanism. The drive mechanism is periodically
`engageable with the single indicator member. The drive
`mechanism is operable to advance the single indicator mem-
`ber an incremental amount when the drive mechanism is
`engaged with the single indicator member. The single indica-
`tor member remains stationary and is free of engagement
`from the drive mechanism for at least some reciprocal move-
`ments of the actuator. A dispensing device and a dispensing
`system are also provided.
`26 Claims, 15 Drawing Sheets
`
`RPC-1001
`RPC v Trudell
`Page 1 of 32
`
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`
`
`(56) (cid:9)
`
`References Cited
`
`U.S. PATENT DOCUMENTS
`
`1,219,858
`2,455,962
`2,580,292
`2,587,147
`2,630,027
`2,644,452
`2,767,680
`2,770,711
`2,883,086
`2,939,597
`2,943,730
`2,953,242
`3,001,524
`3,073,468
`3,085,745
`3,119,557
`3,120,318
`3,148,801
`3,151,599
`3,170,597
`3,187,963
`3,189,232
`3,191,867
`3,240,389
`3,334,731
`3,344,951
`3,361,306
`3,402,863
`3,419,187
`3,446,179
`3,477,561
`3,495,567
`3,511,409
`3,549,057
`3,568,629
`3,572,282
`3,589,563
`3,612,349
`3,654,890
`3,655,952
`3,688,945
`3,753,417
`3,757,732
`3,766,882
`3,789,843
`3,792,242
`3,796,348
`3,797,748
`3,802,608
`3,831,808
`3,831,812
`3,845,883
`3,848,774
`3,886,879
`3,887,099
`3,921,568
`3,926,326
`3,950,939
`3,960,713
`3,977,554
`3,994,421
`4,011,829
`4,029,033
`4,034,757
`4,037,719
`4,069,935
`4,069,942
`4,074,831
`4,078,661
`4,094,408
`4,117,952
`4,162,746
`4,164,301
`4,171,753
`4,188,984
`
`3/1917 Patterson
`12/1948 Wheeler et al.
`12/1951 Geary et al.
`2/1952 Guion et al.
`3/1953 Wunderlich
`7/1953 Brown
`10/1956 Lermer
`11/1956 Baranowski
`4/1959 Davison et al.
`6/1960 Greene
`7/1960 Tregilgas
`9/1960 Shaw
`9/1961 Maison et al.
`1/1963 Arneson
`4/1963 Auberger
`1/1964 Chapman
`2/1964 Rigor
`9/1964 Radeloff et al.
`10/1964 Livingston
`2/1965 Reichenberger
`6/1965 Anderson
`6/1965 Joffe
`6/1965 Helms
`3/1966 Genua
`8/1967 Dale
`10/1967 Gervais
`1/1968 Grim
`9/1968 Green
`12/1968 Bazarnic
`5/1969 Bender
`11/1969 Espinal
`2/1970 Hayes et al.
`5/1970 Huck
`12/1970 Perez
`3/1971 Porter
`3/1971 Trump et al.
`6/1971 Carragan et al.
`10/1971 Thomas
`4/1972 Rigney et al.
`4/1972 Johnson et al.
`9/1972 Harman, Jr. et al.
`8/1973 Garby
`9/1973 Frey et al.
`10/1973 Babbitt, III
`2/1974 Armstrong et al.
`2/1974 Hanson
`3/1974 Zipper
`3/1974 Nozawa et al.
`4/1974 Gullett
`8/1974 Bender
`8/1974 Dolan
`11/1974 Johnson et al.
`11/1974 Schimke
`6/1975 Frost et al.
`6/1975 Gillman et al.
`11/1975 Fish
`12/1975 Grau
`4/1976 Meisner
`6/1976 Carey
`8/1976 Costa
`11/1976 Hansen
`3/1977 Wachsmann et al.
`6/1977 Kerwin et al.
`7/1977 Glover
`7/1977 Perlmutter
`1/1978 Hampel
`1/1978 Marshall et al.
`2/1978 Roach
`3/1978 Thomas
`6/1978 Ford
`10/1978 Grimes
`7/1979 Anderson et al.
`8/1979 Thayer
`10/1979 Vreede
`2/1980 Lyall
`
`US 8,662,075 B2
`Page 2
`
`4,220,247
`4,291,688
`4,300,548
`4,319,128
`4,345,541
`4,347,804
`4,347,853
`4,350,265
`4,354,621
`4,357,192
`4,365,722
`4,368,381
`4,405,045
`4,419,016
`4,432,300
`4,436,223
`4,440,306
`4,489,834
`4,500,005
`4,501,370
`4,511,150
`4,523,933
`4,528,933
`4,534,345
`4,538,744
`4,548,157
`4,562,933
`4,565,302
`4,599,508
`4,634,012
`4,637,528
`4,641,759
`4,646,936
`4,662,520
`4,664,107
`4,666,051
`4,668,218
`2,841,190
`4,677,975
`4,693,399
`4,705,182
`4,722,729
`4,723,673
`4,727,886
`4,736,871
`4,749,093
`4,753,189
`4,756,423
`4,782,966
`4,792,664
`4,817,822
`4,890,572
`4,934,358
`4,934,568
`4,947,875
`4,955,371
`4,969,578
`4,973,250
`4,984,158
`5,009,338
`5,011,032
`5,020,527
`5,027,806
`5,027,808
`5,038,972
`5,056,454
`5,060,643
`5,069,204
`5,082,129
`5,082,130
`5,115,929
`5,174,473
`5,184,761
`5,188,251
`5,190,643
`5,209,375
`5,215,079
`5,217,004
`5,224,474
`
`9/1980 Kramer
`9/1981 Kistler
`11/1981 Jones
`3/1982 Dow, Jr. et al.
`8/1982 Villa-Real
`9/1982 Villa-Real
`9/1982 Gereg et al.
`9/1982 Griffiths et al.
`10/1982 Knickerbocker
`11/1982 Moser
`12/1982 Kramer
`1/1983 Ishiyama
`9/1983 Villa-Real
`12/1983 Zoltan
`2/1984 Lyss
`3/1984 Wilson
`4/1984 Van Buskirk et al.
`12/1984 Thackrey
`2/1985 Forrester
`2/1985 Kelley
`4/1985 Seguenot
`6/1985 Laush et al.
`7/1985 Allen
`8/1985 Wetterlin
`9/1985 Weissenborn
`10/1985 Hevoyan
`1/1986 Dennis
`1/1986 Pfeiffer et al.
`7/1986 Smetaniuk
`1/1987 Kelley
`1/1987 Wachinski et al.
`2/1987 Kelley
`3/1987 Frazier et al.
`5/1987 Griffin
`5/1987 Wass
`5/1987 Trick
`5/1987 Virtanen
`7/1987 Sheck
`7/1987 Edgar et al.
`9/1987 Hickman et al.
`11/1987 Newel-Lewis
`2/1988 Dettbarn et al.
`2/1988 Tartaglia et al.
`3/1988 Conrardy et al.
`4/1988 Luciani et al.
`6/1988 Trick
`6/1988 Mastman et al.
`7/1988 Holtsch
`11/1988 Thackrey
`12/1988 Schwab
`4/1989 Rand et al.
`1/1990 Huang
`6/1990 Nilsson et al.
`6/1990 Fuchs
`8/1990 Brooks et al.
`9/1990 Zamba et al.
`11/1990 Gander et al.
`11/1990 Milman
`1/1991 Hillsman
`4/1991 Barker
`4/1991 Rollman
`6/1991 Dessertine
`7/1991 Zoltan et al.
`7/1991 Rich et al.
`8/1991 Muderlak et al.
`10/1991 Turner
`10/1991 Rich et al.
`12/1991 Smith et al.
`1/1992 Kramer
`1/1992 Weinstein
`5/1992 Buono
`12/1992 Marelli
`2/1993 Lee
`2/1993 Kusz
`3/1993 Duncan et al.
`5/1993 Fuchs
`6/1993 Fine et al.
`6/1993 Blasnik et al.
`7/1993 Bloomfield
`
`RPC-1001 / Page 2 of 32
`
`
`
`US 8,662,075 B2
`Page 3
`
`5,826,571 A (cid:9)
`5,829,434 A (cid:9)
`5,845,777 A (cid:9)
`5,852,590 A (cid:9)
`5,871,007 A (cid:9)
`5,873,995 A (cid:9)
`5,882,507 A (cid:9)
`5,896,855 A (cid:9)
`5,896,990 A (cid:9)
`5,899,201 A (cid:9)
`5,904,139 A (cid:9)
`5,957,896 A (cid:9)
`5,961,495 A (cid:9)
`5,979,698 A (cid:9)
`5,988,496 A (cid:9)
`6,000,159 A (cid:9)
`6,001,082 A (cid:9)
`6,003,467 A (cid:9)
`6,012,450 A (cid:9)
`6,029,659 A (cid:9)
`6,032,609 A (cid:9)
`6,059,133 A (cid:9)
`6,062,214 A (cid:9)
`6,076,521 A (cid:9)
`6,082,358 A (cid:9)
`6,089,180 A (cid:9)
`6,096,010 A (cid:9)
`6,119,684 A (cid:9)
`6,138,669 A (cid:9)
`6,142,339 A (cid:9)
`6,148,815 A (cid:9)
`6,149,054 A (cid:9)
`6,152,067 A (cid:9)
`6,155,251 A (cid:9)
`6,161,724 A (cid:9)
`6,164,494 A (cid:9)
`6,182,655 B1 (cid:9)
`6,186,364 B1 (cid:9)
`6,202,642 B1 (cid:9)
`6,221,053 B1 (cid:9)
`6,223,744 B1 (cid:9)
`6,234,168 B1 (cid:9)
`6,283,365 B1 (cid:9)
`6,328,037 B1 (cid:9)
`6,336,453 B1 (cid:9)
`6,360,739 B1 (cid:9)
`6,405,727 B1 (cid:9)
`6,415,785 B1 (cid:9)
`6,425,392 B1 (cid:9)
`6,431,168 B1 (cid:9)
`6,435,372 B1 (cid:9)
`6,446,627 B1 (cid:9)
`6,474,331 B1 (cid:9)
`6,481,438 B1 (cid:9)
`6,484,717 B1 (cid:9)
`6,516,799 B1 (cid:9)
`6,523,688 B1 (cid:9)
`6,529,446 B1 (cid:9)
`6,561,384 B2 (cid:9)
`6,601,582 B2 (cid:9)
`6,615,827 B2 (cid:9)
`6,659,307 B1 (cid:9)
`6,679,251 B1 (cid:9)
`6,701,917 B2 (cid:9)
`6,718,972 B2 (cid:9)
`6,729,330 B2 (cid:9)
`6,752,153 B1 (cid:9)
`6,761,161 B2 (cid:9)
`6,766,799 B2 (cid:9)
`6,769,601 B2 (cid:9)
`6,796,267 B2 (cid:9)
`6,907,876 B1 (cid:9)
`6,926,002 B2 (cid:9)
`6,938,796 B2 (cid:9)
`6,997,349 B2 (cid:9)
`7,004,164 B2 (cid:9)
`7,100,530 B2 (cid:9)
`7,107,986 B2 (cid:9)
`7,137,391 B2 (cid:9)
`
`10/1998 Casper et al.
`11/1998 Ambrosio et al.
`12/1998 Najmi
`12/1998 de la Huerga
`2/1999 Clark, Jr.
`2/1999 Huang et al.
`3/1999 Tanner et al.
`4/1999 Hobbs
`4/1999 Barzana
`5/1999 Schultz et al.
`5/1999 Hauser
`9/1999 Bendek et al.
`10/1999 Walters et al.
`11/1999 Deal
`11/1999 Bruna
`12/1999 Hornung
`12/1999 Dair et al.
`12/1999 Shelton-Ferrelle et al.
`1/2000 Rubsamen
`2/2000 O'Connor
`3/2000 Luoma
`5/2000 Lai
`5/2000 Howlett
`6/2000 Lindahl et al.
`7/2000 Scarrott et al.
`7/2000 Nichols, Jr.
`8/2000 Walters et al.
`9/2000 Nohl et al.
`10/2000 Rocci, Jr. et al.
`11/2000 Blacker et al.
`11/2000 Wolf
`11/2000 Cirrillo
`11/2000 Mathison
`12/2000 Hauser
`12/2000 Blacker et al.
`12/2000 Marelli
`2/2001 Keller et al.
`2/2001 Dobbs
`3/2001 McKinnon et al.
`4/2001 Walters et al.
`5/2001 Garon
`5/2001 Bruna
`9/2001 Bason
`12/2001 Scarrott et al.
`1/2002 Scarrott et al.
`3/2002 Rand et al.
`6/2002 MacMichael et al.
`7/2002 Stage
`7/2002 Sosiak
`8/2002 Rand et al.
`8/2002 Blacker et al.
`9/2002 Bowman et al.
`11/2002 Rand et al.
`11/2002 Gallem et al.
`11/2002 Dagsland et al.
`2/2003 Greenwood et al.
`2/2003 Palmieri
`3/2003 de la Huerga
`5/2003 Blacker et al.
`8/2003 Rand et al.
`9/2003 Greenwood et al.
`12/2003 Stradella
`1/2004 Gallem et al.
`3/2004 O'Leary
`4/2004 O'Leary
`5/2004 Scarrott et al.
`6/2004 Eckert
`7/2004 Scarrott et al.
`7/2004 Edwards et al.
`8/2004 Haikarainen et al.
`9/2004 Dubarry
`6/2005 Clark et al.
`8/2005 Scarrott et al.
`9/2005 Blacker et al.
`2/2006 Blacker et al.
`2/2006 Scarrott
`9/2006 Lu
`9/2006 Rand et al.
`11/2006 Bruna
`
`(56) (cid:9)
`
`References Cited
`
`U.S. PATENT DOCUMENTS
`
`7/1993 Cheng
`7/1993 Umemoto
`7/1993 Fuchs
`9/1993 Garby et al.
`9/1993 Ambrosio et al.
`11/1993 Barker et al.
`11/1993 Altermatt et al.
`2/1994 Burns et al.
`3/1994 Fuchs
`4/1994 Barker et al.
`4/1994 Kossoff et al.
`4/1994 Burke et al.
`7/1994 Boldt, Jr. et al.
`7/1994 Andersson et al.
`8/1994 Fuchs et al.
`9/1994 Chippendale et al.
`9/1994 Wass et al.
`10/1994 Tang et al.
`10/1994 Schraga
`11/1994 Mishelevich et al.
`12/1994 Schroeder
`1/1995 Haber et al.
`1/1995 Dunn et al.
`1/1995 Mulholland
`2/1995 Muderlak et al.
`2/1995 Mulhauser et al.
`2/1995 Johansson et al.
`3/1995 Ritson et al.
`3/1995 Jesadanont
`5/1995 Weinstein
`6/1995 Garby et al.
`8/1995 Braithwaite
`9/1995 Bacon
`9/1995 Robinson et al.
`11/1995 Schraga
`1/1996 Klein
`1/1996 Hoffman
`3/1996 Vallelunga et al.
`4/1996 Samiotes et al.
`4/1996 Wolf et al.
`4/1996 Michel
`5/1996 Robinson et al.
`5/1996 Ritson et al.
`6/1996 Ritson et al.
`6/1996 Haber et al.
`8/1996 Jewett et al.
`8/1996 Trofast et al.
`10/1996 Walker et al.
`11/1996 Herman et al.
`11/1996 Tucker
`12/1996 Pawelka et al.
`3/1997 Garby et al.
`4/1997 King
`4/1997 Jewett et al.
`4/1997 Compton
`4/1997 Sears
`5/1997 Petersen et al.
`6/1997 Garby et al.
`8/1997 Braithwaite
`10/1997 Rocci, Jr. et al.
`11/1997 Ambrosio et al.
`12/1997 Bruna et al.
`12/1997 Marshall
`12/1997 Schraga
`2/1998 Garby et al.
`2/1998 Price
`3/1998 Rubsamen et al.
`3/1998 Barker et al.
`4/1998 Ashley et al.
`6/1998 Kreamer
`6/1998 Dial et al.
`8/1998 Wachter et al.
`9/1998 Garby et al.
`9/1998 Barker et al.
`9/1998 Wolf
`
`5,226,539
`5,227,764
`5,228,586
`5,242,067
`5,243,970
`5,261,548
`5,263,475
`5,284,133
`5,289,946
`5,299,701
`5,300,042
`5,301,873
`5,328,597
`5,331,953
`5,335,823
`5,349,944
`5,349,945
`5,356,012
`5,356,406
`5,363,842
`5,370,267
`5,378,233
`5,379,804
`5,382,243
`RE34,847
`5,388,572
`5,392,768
`5,394,866
`5,397,028
`5,411,173
`5,421,482
`5,437,270
`5,447,150
`5,448,042
`5,468,233
`5,482,030
`5,482,163
`5,498,243
`5,505,192
`5,505,195
`5,509,905
`5,519,197
`5,520,166
`5,522,378
`5,524,613
`5,544,647
`5,549,101
`5,564,414
`5,574,268
`5,577,335
`5,584,815
`5,611,444
`5,617,844
`5,622,163
`5,625,334
`5,625,659
`5,626,566
`5,638,970
`5,657,748
`5,676,129
`5,687,710
`5,692,492
`5,694,882
`5,697,916
`5,718,355
`5,720,392
`5,724,957
`5,732,836
`5,740,792
`5,758,638
`5,772,074
`5,794,612
`5,799,651
`5,803,283
`5,809,997
`
`r71
`
`RPC-1001 / Page 3 of 32
`
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`
`
`(56) (cid:9)
`
`References Cited (cid:9)
`
`U.S. PATENT DOCUMENTS (cid:9)
`
`12/2006 Dagsland et al. (cid:9)
`7,143,764 B1 (cid:9)
`12/2006 Blacker et al. (cid:9)
`7,143,908 B2 (cid:9)
`1/2007 Eckert (cid:9)
`7,156,258 B2 (cid:9)
`3/2007 Ouyang et al. (cid:9)
`7,191,918 B2 (cid:9)
`3/2007 Ouyang et al. (cid:9)
`7,195,134 B2 (cid:9)
`8/2008 Ouyang et al. (cid:9)
`7,407,066 B2 (cid:9)
`7/2009 Stump et al. (cid:9)
`7,555,995 B1 (cid:9)
`8/2009 Blacker et al. (cid:9)
`7,575,130 B2 (cid:9)
`9/2010 Stradella et al. (cid:9)
`7,793,798 B2 (cid:9)
`1/2002 Schuler et al. (cid:9)
`2002/0000225 Al (cid:9)
`10/2002 Scarrott et al. (cid:9)
`2002/0153005 Al (cid:9)
`2003/0183225 Al 10/2003 Knudsen (cid:9)
`2003/0200964 Al 10/2003 Blakley et al. (cid:9)
`2003/0205227 Al 11/2003 Hodson (cid:9)
`2003/0209239 Al 11/2003 Rand et al. (cid:9)
`2004/0065326 Al (cid:9)
`4/2004 Macmichael et al. (cid:9)
`2004/0069301 Al (cid:9)
`4/2004 Bacon (cid:9)
`2004/0094147 Al (cid:9)
`5/2004 Schyra et al. (cid:9)
`2004/0144798 Al (cid:9)
`7/2004 Ouyang et al. (cid:9)
`2004/0149772 Al (cid:9)
`8/2004 Ouyang (cid:9)
`2004/0149773 Al (cid:9)
`8/2004 Ouyang et al. (cid:9)
`2004/0221840 Al 11/2004 Stockman-Lamb (cid:9)
`2004/0255935 Al 12/2004 Bruna (cid:9)
`2004/0255936 Al 12/2004 Urbanus (cid:9)
`2005/0011515 Al (cid:9)
`
`1/2005 Lee et al. (cid:9)
`3/2005 Schuler et al. (cid:9)
`2005/0056276 Al (cid:9)
`
`2005/0268905 Al 12/2005 Rasmussen et al. (cid:9)
`2005/0284471 Al 12/2005 Bruna (cid:9)
`2006/0254581 Al 11/2006 Genova et al. (cid:9)
`2007/0084462 Al (cid:9)
`4/2007 Allen et al. (cid:9)
`2009/0173346 Al (cid:9)
`7/2009 Stuart et al. (cid:9)
`
`FOREIGN PATENT DOCUMENTS
`
`CA
`CA
`CA
`CA
`CA
`CA
`CA
`CA
`CA
`DE
`DE
`DE
`DE
`DE
`EP
`EP
`EP
`EP
`EP
`EP
`EP
`EP
`EP
`EP
`EP
`EP
`EP
`FR
`GB
`
`2 152 088 A
`2 181 789 C
`2 486 892 Al
`2 315 777 Al
`2 331 179 Al
`2 383 425 Al
`2 388 958 Al
`2 414 118 Al
`2 420 171 Al
`6 603 758 U
`27 02 539 Al
`33 36 486 Al
`85 90 143.1
`86 02 238.5
`0 028 929 A2
`0 098 939 A2
`0 114 617 A2
`0 063 599 Bl
`0 230 323 Bl
`0 236 871 A2
`0 269 496 A2
`0 280 104 Bl
`0 488 609 Al
`0 559 757 Bl
`0 949 584 A2
`1 369 139 Al
`1 220 802 Bl
`2 743 055 Al
`998 148 A
`
`7/1994
`6/1996
`12/1998
`7/1999
`11/1999
`3/2001
`3/2001
`1/2002
`3/2002
`7/1969
`1/1977
`4/1984
`10/1985
`5/1986
`5/1981
`1/1984
`8/1984
`6/1986
`7/1987
`9/1987
`6/1988
`8/1988
`6/1992
`9/1993
`10/1999
`12/2003
`2/2004
`7/1997
`7/1965
`
`US 8,662,075 B2
`Page 4
`
`2/1967
`1 058 636 A (cid:9)
`GB (cid:9)
`9/1972
`1 290 484 A (cid:9)
`GB (cid:9)
`5/1973
`1 317 315 A (cid:9)
`GB (cid:9)
`7/1980
`2 036 695 A (cid:9)
`GB (cid:9)
`6/1981
`2 063 075 A (cid:9)
`GB (cid:9)
`8/1982
`2 092 991 A (cid:9)
`GB (cid:9)
`3/1983
`2 104 393 A (cid:9)
`GB (cid:9)
`12/1987
`2 191 032 A (cid:9)
`GB (cid:9)
`4/1988
`2 195 544 A (cid:9)
`GB (cid:9)
`10/2000
`2 348 928 A (cid:9)
`GB (cid:9)
`11/2005
`2 414 187 A (cid:9)
`GB (cid:9)
`4/1986
`61-055759 U (cid:9)
`JP (cid:9)
`8/1987
`62-121670 U (cid:9)
`JP (cid:9)
`4/1992
`04-050059 A (cid:9)
`JP (cid:9)
`4/1994
`06-026891 A (cid:9)
`JP (cid:9)
`4/1986
`WO 86/02275 Al (cid:9)
`WO (cid:9)
`8/1987
`WO 87/04354 Al (cid:9)
`WO (cid:9)
`9/1990
`WO 90/10470 Al (cid:9)
`WO (cid:9)
`5/1991
`WO 91/06334 Al (cid:9)
`WO (cid:9)
`5/1992
`WO 92/07600 Al (cid:9)
`WO (cid:9)
`6/1992
`WO 92/09324 Al (cid:9)
`WO (cid:9)
`9/1992
`WO 92/15353 Al (cid:9)
`WO (cid:9)
`WO 92/17231 Al 10/1992
`WO (cid:9)
`WO 93/24167 Al 12/1993
`WO (cid:9)
`WO 94/11272 Al (cid:9)
`5/1994
`WO (cid:9)
`WO 94/14492 A2 (cid:9)
`7/1994
`WO (cid:9)
`WO 95/34874 Al 12/1995
`WO (cid:9)
`WO 96/16686 Al (cid:9)
`6/1996
`WO (cid:9)
`WO 96/16687 Al (cid:9)
`6/1996
`WO (cid:9)
`WO 96/39337 Al 12/1996
`WO (cid:9)
`WO 98/01822 Al (cid:9)
`1/1998
`WO (cid:9)
`WO 98/56444 Al 12/1998
`WO (cid:9)
`WO 98/56445 Al 12/1998
`WO (cid:9)
`WO 99/36115 Al (cid:9)
`7/1999
`WO (cid:9)
`WO 99/57019 A2 11/1999
`WO (cid:9)
`WO 00/09187 A2 (cid:9)
`2/2000
`WO (cid:9)
`WO 00/59806 Al 10/2000
`WO (cid:9)
`WO 01/28887 Al (cid:9)
`4/2001
`WO (cid:9)
`WO 01/29765 Al (cid:9)
`4/2001
`WO (cid:9)
`WO 01/37909 Al (cid:9)
`5/2001
`WO (cid:9)
`WO 03/101514 Al 12/2003
`WO (cid:9)
`WO 03/103759 Al 12/2003
`WO (cid:9)
`WO (cid:9) WO 2004/089451 Al 10/2004
`WO (cid:9)
`WO 2005/060535 A2 (cid:9)
`7/2005
`WO (cid:9) WO 2006/110080 Al 10/2006
`
`OTHER PUBLICATIONS
`
`Written Opinion of the International Searching Authority in Interna-
`tional Application No. PCT/CA2004/001884, dated Mar. 4, 2005, 6
`pages.
`International Search Report in International Application No. PCT/
`IB2004/004062, dated Apr. 6, 2005, 7 pages.
`International Search Report in International Application No. PCT/
`IB2006/000084, dated Jun. 2, 2006, 9 pages.
`Written Opinion of the International Searching Authority in Interna-
`tional Application No. PCT/IB2006/000084, dated Jun. 2, 2006, 8
`pages.
`U.S. Department of Health and Human Services, Food and Drug
`Administration, Center for Drug Evaluation and Research (CDER)—
`Clinical, "Guidance for Industry: Integration of Dose-Counting
`Mechanisms into MDI Drug Products DraftGuidance," datedNov.
`2001, 6 pages.
`Office Action from counterpart Japanese Application No. 2008-
`189362, dated Jun. 14, 2011, 4 pages (with translation).
`Office Action from counterpart Japanese Application No. 2008-
`019458, dated Sep. 29, 2009, 2 pages (with translation).
`
`RPC-1001 / Page 4 of 32
`
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 1 of 15 (cid:9)
`
`US 8,662,075 B2
`
`FIG. I
`
`34
`
`FIG. IA
`
`FIG IR
`
`FIG.
`
`20
`I0
`
`40
`
`34
`72
`
`FIG. 3
`
` 54
`20
`
`HG .3A
`
`542
`
`534
`
`72
`
`94
`
`RPC-1001 / Page 5 of 32
`
`(cid:9)
`
`
`U.S. Patent
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 2 of 15
`
`US 8,662,075 B2
`
`FIG. 4
`
`22
`
`400
`
`74
`
`64
`
`36
`
`92
`
`28
`
`66
`
`64
`
`400
`
`20
`
`21
`
`400
`
`FIG. 5
`
`RPC-1001 / Page 6 of 32
`
`
`
`U.S. Patent
`
`Mar. 4, 2014
`
`Sheet 3 of 15
`
`US 8,662,075 B2
`
`FIG. 6
`
`230
`
`224
`
`226
`
`294
`
`260
`
`RPC-1001 / Page 7 of 32
`
`(cid:9)
`(cid:9)
`(cid:9)
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014
`
`Sheet 4 of 15
`
`US 8,662,075 B2
`
`FIG. 7
`
`226 220
`
`10
`
`236
`
`238 (cid:9)
`
`fir
`
`230
`266
`
`228
`
`226
`
`4
`V;3401 act
`
`/'---SEE FIG. 8
`
`260
`
`230
`
`4011111101,0
`224
`
`232
`
`264
`221
`
`FIG.8
`
`220 (cid:9)
`
`228
`
`FIG. 9
`
`A4141MI
`
`236 der4,
`N, (cid:9)
`
`228
`
`RPC-1001 / Page 8 of 32
`
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 5 of 15 (cid:9)
`
`US 8,662,075 B2
`
`200
`
`228
`
`221
`
`96
`
`FIG. 10
`
`34
`220
`
`228
`
`43
`
`12
`
`44
`
`FIG. I I
`
`12
`
`RPC-1001 / Page 9 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 6 of 15 (cid:9)
`
`US 8,662,075 B2
`
`FIG. 12
`
`220 (cid:9)
`266 (cid:9)
`
`276 (cid:9)
`
`87 262
`238 89
`
`260
`
`264
`
`FIG. 13
`1 (cid:9)
`1 (cid:9)
`1
`
`Aretariwir-%-411!"
`111690/
`,11411k40,1
`ONL 1- L . .11 (cid:9)
`iiiii0
` 41
`igrAn41
`
`40
`
`276
`
`9G
`
`88 82
`
`FIG. 14
`1 I (cid:9)
`I
`
`FIG. 16
`
`FIG. 15
`
`276 (cid:9)
`
`260
`
`260
`220
`
`88 82
`FIG.
`
`60
`
`RPC-1001 / Page 10 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 7 of 15 (cid:9)
`
`US 8,662,075 B2
`
`„FIG. 18
`
`FIG. 20
`
`19
`
`224
`SEE FIG_ 22
`
`266
`232
`230
`224
`264
`
`220
`
`230
`232
`
`224
`266
`226
`
`HG. 19
`
`2
`
`266 260
`4.4 ma*
`61
`
`FIG. 21
`► "VI 03 86
`
`17
`
`:r ,
`12
`A414
`N1/4 15_,1,./
`
`226
`
`220
`
`4
`
`FIG. ?2
`
`276
`
`RPC-1001 / Page 11 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 8 of 15 (cid:9)
`
`US 8,662,075 B2
`
`FIG. 23
`
`FIG. 24
`
`906
`
`FIG. 26
`
`25
`
`372
`
`380 (cid:9)
`320 (cid:9)
`
`FIG. 25
`158 398 360
`300
`392
`156
`
`140
`
`154
`
`152
`
`150
`
`FIG. 27
`
`806
`
`RPC-1001 / Page 12 of 32
`
`(cid:9)
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 9 of 15 (cid:9)
`
`US 8,662,075 B2
`
`RPC-1001 / Page 13 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 10 of 15 (cid:9)
`
`US 8,662,075 B2
`
`FIG. 31
`
`10
`
`92
`
`216
`
`208
`
`214
`
`FIG. 33
`
`FIG. 32
`
`20
`
`40
`
`90
`
`92
`
`20
`
`40
`
`90
`
`204
`
`204
`
`202
`
`12
`
`202
`200
`
`16
`18
`212
`
`216
`206
`
`FIG. 35
`
`FIG. 34
`
`FIG. 36
`
`704
`
`702
`
`760
`
`RPC-1001 / Page 14 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 11 of 15 (cid:9)
`
`US 8,662,075 B2
`
`FIG.37
`
`1062
`
`1514
`
`FIG 39
`
`1036
`
`1600
`
`1052
`
`1300
`
`1302
`
`1310
`
`1061
`
`1060
`
`FIG 41
`
`1153
`
`FIG 40
`
`FIG. 42
`
`1084
`
`1502
`
`FIG.43
`
`1308
`
`87
`
`1306
`
`1107
`
`1304
`
`1109
`
`RPC-1001 / Page 15 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 12 of 15 (cid:9)
`
`US 8,662,075 B2
`
`FIG_ 68
`
`1632
`1600
`
`1092
`1021
`1510
`1514
`
`1273 (cid:9)
`
`"M.2143
`
`1052
`1034
`1020
`
`1300
`
`1302
`
`1500
`
`1502
`
`1066 1076
`_k___----- 1060
`
`1074
`1078
`
`1308
`1306
`
`)6 (cid:9)
`
`ilL__111111111
`
`11/4- ms__111.1111111100 (cid:9)
`areroi
`1270
`1600
`86
`89
`84 1084
`87
`88
`82
`1802
`
`1085
`1083
`
`1304 1109
`
`1106
`107
`
`44
`
`RPC-1001 / Page 16 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 13 of 15 (cid:9)
`
`US 8,662,075 B2
`
`FIG4520,6
`
`2034
`
`2052
`
`2022
`
`2060
`-/
`
`2074
`
`2068
`
`228
`
`2021
`
`2500
`
`2
`2087 2066
`
`
`2074
`
`2236
`
`2400
`
`1802
`2306 136 1801
`
`FIG. 46 2087
`
`2066
`
`
`2109 81
`41
`
`2107
`
`13
`
`2092
`228
`2520
`2502
`
`2076
`2573
`2060
`
`2068
`82 84
`88
`89
`1800
`96 42
`43
`2040
`
`47
`
`2060
`
`2068
`
`2573
`
`FIG 49
`
`2521
`
`2502
`
`8t
`
`2308
`
`2521
`
`2528
`
`2524
`
`2071
`
`2076
`
`FIG. 47
`
`2306
`
`2109
`
`2106
`2107
`
`FIG 48
`
`86
`
`FIG 50
`
`2520
`
`2500
`2514
`2528
`
`2526
`
`RPC-1001 / Page 17 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 14 of 15 (cid:9)
`
`US 8,662,075 B2
`
`226
`
`FIG. 51
`
`2236
`
`FIG_ 52
`
`FIG. 53
`
`2577
`
`2522
`
`2400
`
`2087
`
`81 2066
`84
`
`1800
`
`RPC-1001 / Page 18 of 32
`
`
`
`U.S. Patent (cid:9)
`
`Mar. 4, 2014 (cid:9)
`
`Sheet 15 of 15 (cid:9)
`
`US 8,662,075 B2
`
`FIG. 5520
`
`2069
`i -----2087
`
`2066
`
`1155
`
`2109
`
`-----•-- 1800
`
`2107 J
`
`86
`
`tI52
`1040
`2500 s'------o-
`
`RPC-1001 / Page 19 of 32
`
`(cid:9)
`
`
`US 8,662,075 B2
`
`1
`DISPENSING DEVICE
`
`This application is a continuation of application Ser. No.
`12/835,275, filed Jul. 13, 2010, which is a continuation of
`application Ser. No. 11/639,175, filed Dec. 14, 2006, which is 5
`a continuation of application Ser. No. 11/370,748, filed Mar.
`8, 2006, now issued as U.S. Pat. No. 7,516,738, which is a
`continuation of application Ser. No. 11/289,050, filed Nov.
`29, 2005, now issued as U.S. Pat. No. 7,341,057, which is a
`continuation of application Ser. No. 11/136,044, filed May 10
`24, 2005, now issued as U.S. Pat. No. 7,568,481, which is a
`continuation of application Ser. No. 10/876,005, filed Jun. 24,
`2004, now issued as U.S. Pat. No. 6,926,002, which is a
`continuation of application Ser. No. 10/409,247, filed Apr. 8,
`2003, now issued as U.S. Pat. No. 6,953,039, which is con- 15
`tinuation of application Ser. No. 10/039,744, filed Oct. 26,
`2001, now issued as U.S. Pat. No. 6,761,161, which is a
`continuation of application Ser. No. 09/303,043, filedApr. 30,
`1999, now issued as U.S. Pat. No. 6,336,453, and which also
`is a continuation-in-part of application Ser. No. 09/603,427, 20
`filed Jun. 26, 2000, now issued as U.S. Pat. No. 6,328,037,
`which is a continuation of application Ser. No. 09/073,275,
`filed May 5, 1998, now issued as U.S. Pat. No. 6,082,358, the
`entire disclosures of which are hereby incorporated by refer-
`ence. (cid:9)
`
`25
`
`BACKGROUND OF THE INVENTION
`
`The present invention relates generally to an indicating
`device for indicating the number of metered dosages that have 30
`been dispensed from, or remain in, an aerosol container; and
`in particular, to an indicating device adapted to be mounted to
`the aerosol container.
`Aerosol dispensing devices have been developed that
`include a dose indicating device to indicate the number of 35
`metered doses that have been dispensed from the device, or to
`indicate the number of doses remaining therein. For example,
`patients have certain conditions that can be treated with medi-
`caments dispensed in an aerosol and administered to the
`patient by inhalation. In one format, the aerosol with medi- 40
`caments are contained in a container, and dispensed in
`metered, or measured, dosages with an inhalation device, or
`actuator boot. In such an arrangement, it can be important for
`the patient to be able to ascertain the number of metered doses
`remaining in the container, either by an indication of the 45
`number remaining therein or by knowledge of the number
`already dispensed therefrom, such that the patient is not
`caught unaware with an empty container when in need of the
`medicament. Thus, it may be important for the inhalation
`device to provide an accurate indication of either the number 50
`of doses remaining in the container, or the number of doses
`already dispensed therefrom.
`Typically, a conventional aerosol container includes a body
`and a valve stem which can be depressed relative to the body
`so as to emit the metered dose of aerosol and medicament. 55
`The container typically is supplied with a predetermined
`number of metered doses, generally on the order of about 200,
`such that the counting of the number of valve stem depres-
`sions, and corresponding number of dispensed metered
`doses, can be directly correlated with the number of doses 60
`remaining in the container.
`In operation, the container is typically received within a
`housing of the inhalation device, wherein the valve is brought
`into engagement with a support block in the housing. The user
`administers the medicament by moving the container relative 65
`to the housing so as to depress the valve stem and internal
`valve and (cid:9)
`thereby release a metered dose, which is typically
`
`2
`administered to the user through a port or mouthpiece extend-
`ing from the housing. After the dose is administered, the valve
`stem, which is typically spring loaded, biases the container
`away from the support block so as to again move the container
`relative to the housing. In this way, a metered dose of medi-
`cament is administered by each cycle of linear reciprocal
`movement of the container relative to the housing.
`Some actuator boots, or other devices attached to the medi-
`cament container, have indicating devices that convert the
`linear reciprocal movement of the container relative to the
`housing into a one-way, or single-cycle, movement of an
`indicator, wherein the indicator identifies the relative fullness
`of the container, the number of metered doses remaining
`therein or the number of doses already administered.
`Although these actuator boots with indicators, or separate
`indicator devices, have provided the advantage of generally
`being able to keep track of the number of dosages, there
`remains room for improvement. For example, indicating
`devices of this nature may include complex moving parts
`which can be difficult to assemble and expensive to manufac-
`ture. Such devices may also be susceptible to counting inac-
`curacies due to the configuration of the indexing or mating
`parts, or require excessive amounts of space within the hous-
`ing to accommodate the relatively large or numerous moving
`parts. Others still may impede or interfere with the airflow and
`medicament being dispensed from the inhalation device.
`Alternatively, some devices use electrical circuitry to count or
`record the dispersements. Such devices can be relatively
`expensive to manufacture, however, and typically require a
`power source which may be susceptible to damage in various
`environments, such as moist conditions.
`
`SUMMARY OF THE INVENTION
`
`Briefly stated, the invention is directed to an indicating
`device for indicating the number of metered doses that have
`been dispensed from or remain in a container. The container
`has a valve stem extending longitudinally therefrom; the
`valve stem being moveable between a closed position and an
`open position. The container dispenses a metered dosage
`when the valve stem is moved to the open position. The
`indicating device includes a base member adapted to be
`mounted to the container, a cap member moveably connected
`to the base member, an indicator member rotatably mounted
`to the cap member and a drive member adapted to rotate the
`indicator member an incremental amount upon a predeter-
`mined number of axial movements of the cap member relative
`to the base member.
`In a preferred embodiment, the cap member is moveable
`relative to the base member along an axial path. The indicator
`member has a plurality of teeth and is rotatably mounted to
`the cap member about an axis substantially parallel to the
`axial movement of the cap member relative to the base mem-
`ber. A drive mechanism, including the drive member, com-
`prises a ratchet wheel rotatably mounted to one of the base
`member and cap member about an axis substantially perpen-
`dicular to the axis defined by the axial movement of the cap
`member. relative to the base member. The drive member is
`coaxially mounted with the ratchet wheel and a pawl is
`mounted to one of the cap member and base member. The
`pawl is selectively engaged with the ratchet wheel upon each
`axial movement of the cap member relative to the base mem-
`ber so as to rotate the ratchet wheel and drive member an
`incremental amount. The drive member is selectively
`engaged with at least one of the plurality of indicator member
`teeth upon a predetermined number of axial movements of the
`
`RPC-1001 / Page 20 of 32
`
`
`
`US 8,662,075 B2
`
`BRIEF DESCRIPTION OF THE DRAWINGS
`
`35 (cid:9)
`
`4
`3
`and away from the base member and engaging the indicator
`cap member relative to the base member such that the indi-
`member with the drive member so as to rotate the indicator
`cator member is rotated an incremental amount.
`member.
`In another aspect, the indicating device comprises a first
`In yet another aspect, a method is provided for assembling
`and second indicator member, with each of the first and sec-
`5 a dispenser for dispensing metered dosages of medicaments
`ond indicator members mounted to the cap member about an
`from a container. The method includes the steps of providing
`axis substantially parallel to the axial movement of the cap
`a housing, disposing a container in the housing and mounting
`member relative to the base member. The first indicator mem-
`an indicating device to the container.
`ber selectively engages the second indicator member as the
`The present invention provides significant advantages over
`first indicator member completes a usage cycle, representing
`0 other aerosol
Accessing this document will incur an additional charge of $.
After purchase, you can access this document again without charge.
Accept $ ChargeStill Working On It
This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.
Give it another minute or two to complete, and then try the refresh button.
A few More Minutes ... Still Working
It can take up to 5 minutes for us to download a document if the court servers are running slowly.
Thank you for your continued patience.
This document could not be displayed.
We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.
Your account does not support viewing this document.
You need a Paid Account to view this document. Click here to change your account type.
Your account does not support viewing this document.
Set your membership
status to view this document.
With a Docket Alarm membership, you'll
get a whole lot more, including:
- Up-to-date information for this case.
- Email alerts whenever there is an update.
- Full text search for other cases.
- Get email alerts whenever a new case matches your search.
One Moment Please
The filing “” is large (MB) and is being downloaded.
Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.
Your document is on its way!
If you do not receive the document in five minutes, contact support at support@docketalarm.com.
Sealed Document
We are unable to display this document, it may be under a court ordered seal.
If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.
Access Government Site