2/20/2014
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`Michael Elliott Weinblatt - Department of Medicine
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`Michael Elliott Weinblatt
`
` View Physician Profile
`
`Senior Physician, Brigham and Women's Hospital
`John R. Riedman Professor of Medicine, Harvard Medical School
`
`Brigham and Women's Hospital
`Department of Medicine
`Rheumatology, Immunology
`75 Francis Street
`Boston, MA 02115
`
`Keywords (MeSH):
`
`
`
`Immunoglobulin G
`Receptors, Tumor Necrosis Factor
`Antirheumatic Agents
`Arthritis, Rheumatoid
`Methotrexate
`
`Publications (Pulled from Harvard Catalyst Profiles):
`
`1. Yoshida K, Sung YK, Kavanaugh A, Bae SC, Weinblatt ME, Kishimoto M, Matsui K, Tohma S, Solomon
`DH. Response to: 'Biologic discontinuation studies: a systematic review of methods' by van der Maas et al.
`Ann Rheum Dis. 2014 Jan 1; 73(1):e5.
`
`2. Yoshida K, Radner H, Kavanaugh A, Sung YK, Bae SC, Kishimoto M, Matsui K, Okada M, Tohma S,
`Weinblatt ME, Solomon DH. Use of data from multiple registries in studying biologic discontinuation:
`challenges and opportunities. Clin Exp Rheumatol. 2013 Jul-Aug; 31(4 Suppl 78):S28-32.
`
`3. Schiff M, Weinblatt ME, Valente R, van der Heijde D, Citera G, Elegbe A, Maldonado M, Fleischmann R.
`Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: two-
`year efficacy and safety findings from AMPLE trial. Ann Rheum Dis. 2014 Jan 1; 73(1):86-94.
`
`4. Lin C, Karlson EW, Canhao H, Miller TA, Dligach D, Chen PJ, Perez RN, Shen Y, Weinblatt ME, Shadick
`NA, Plenge RM, Savova GK. Automatic prediction of rheumatoid arthritis disease activity from the
`electronic medical records. PLoS One. 2013; 8(8):e69932.
`
`5. Iannaccone CK, Fossel A, Tsao H, Cui J, Weinblatt M, Shadick N. Factors associated with attrition in a
`longitudinal rheumatoid arthritis registry. Arthritis Care Res (Hoboken). 2013 Jul; 65(7):1183-9.
`
`6. Weinblatt ME, Moreland LW, Westhovens R, Cohen RB, Kelly SM, Khan N, Pappu R, Delaet I, Luo A,
`Gujrathi S, Hochberg MC. Safety of Abatacept Administered Intravenously in Treatment of Rheumatoid
`Arthritis: Integrated Analyses of up to 8 Years of Treatment from the Abatacept Clinical Trial Program. J
`Rheumatol. 2013 Jun; 40(6):787-97.
`
`7. Centola M, Cavet G, Shen Y, Ramanujan S, Knowlton N, Swan KA, Turner M, Sutton C, Smith DR, Haney
`DJ, Chernoff D, Hesterberg LK, Carulli JP, Taylor PC, Shadick NA, Weinblatt ME, Curtis JR. Development of
`a multi-biomarker disease activity test for rheumatoid arthritis. PLoS One. 2013; 8(4):e60635.
`
`8. Lillegraven S, Paynter N, Prince FH, Shadick NA, Haavardsholm EA, Frits ML, Iannaccone CK, Kvien TK,
`Weinblatt ME, Solomon DH. Performance of matrix-based risk models for rapid radiographic progression
`in a cohort of patients with established rheumatoid arthritis. Arthritis Care Res (Hoboken). 2013 Apr;
`65(4):526-33.
`
`9. Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao
`C, Okada Y, Wedrén S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T,
`Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP,
`Crusius JB, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PL, van de Laar M, Guchelaar HJ, Shadick
`NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL, Criswell LA, Moreland LW, Fonseca JE, de
`http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=3972
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`1/11
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`ANTARES Exhibit 1031
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`Michael Elliott Weinblatt - Department of Medicine
`2/20/2014
`NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL, Criswell LA, Moreland LW, Fonseca JE, de
`Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Barton A,
`Padyukov L, Coenen MJ, Karlson EW, Plenge RM. Genome-Wide Association Study and Gene Expression
`Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis. PLoS
`Genet. 2013 Mar; 9(3):e1003394.
`
`10. Weinblatt ME, Kremer J, Cush J, Rigby W, Teng LL, Devenport J, Singh N, Lepley D, Genovese MC.
`Tocilizumab as monotherapy or in combination with nonbiologic disease-modifying antirheumatic drugs:
`Twenty-four-week results of an open-label, clinical practice study. Arthritis Care Res (Hoboken). 2013
`Mar; 65(3):362-71.
`
`11. Weinblatt ME, Kavanaugh A, Genovese MC, Jones DA, Musser TK, Grossbard EB, Magilavy DB. Effects
`of Fostamatinib (R788), an Oral Spleen Tyrosine Kinase Inhibitor, on Health-related Quality of Life in
`Patients with Active Rheumatoid Arthritis: Analyses of Patient-reported Outcomes from a Randomized,
`Double-blind, Placebo-controlled Trial. J Rheumatol. 2013 Apr; 40(4):369-78.
`
`12. Weinblatt ME, Schiff M, Valente R, van der Heijde D, Citera G, Zhao C, Maldonado M, Fleischmann R.
`Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis:
`Findings of a phase IIIb, multinational, prospective, randomized study. Arthritis Rheum. 2013 Jan;
`65(1):28-38.
`
`13. Desai SP, Lu B, Szent-Gyorgyi LE, Bogdanova AA, Turchin A, Weinblatt M, Coblyn J, Greenberg JO,
`Kachalia A, Solomon DH. Increasing pneumococcal vaccination for immunosuppressed patients: A cluster
`quality improvement trial. Arthritis Rheum. 2013 Jan; 65(1):39-47.
`
`14. Weinblatt ME. Methotrexate in rheumatoid arthritis: a quarter century of development. Trans Am Clin
`Climatol Assoc. 2013; 124:16-25.
`
`15. Burmester GR, Weinblatt ME, McInnes IB, Porter D, Barbarash O, Vatutin M, Szombati I, Esfandiari E,
`Sleeman MA, Kane CD, Cavet G, Wang B, Godwood A, Magrini F. Efficacy and safety of mavrilimumab in
`subjects with rheumatoid arthritis. Ann Rheum Dis. 2013 Sep 1; 72(9):1445-52.
`
`16. Curtis JR, van der Helm-van Mil AH, Knevel R, Huizinga TW, Haney DJ, Shen Y, Ramanujan S, Cavet G,
`Centola M, Hesterberg LK, Chernoff D, Ford K, Shadick NA, Hamburger M, Fleischmann R, Keystone E,
`Weinblatt ME. Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity.
`Arthritis Care Res (Hoboken). 2012 Dec; 64(12):1794-803.
`
`17. Dervieux T, Weinblatt ME, Kivitz A, Kremer JM. Methotrexate polyglutamation in relation to infliximab
`pharmacokinetics in rheumatoid arthritis. Ann Rheum Dis. 2013 Jun; 72(6):908-10.
`
`18. Winthrop KL, Weinblatt ME, Daley CL. You can't always get what you want, but if you try sometimes
`(with two tests--TST and IGRA--for tuberculosis) you get what you need. Ann Rheum Dis. 2012 Nov;
`71(11):1757-60.
`
`19. Weinblatt ME, Fleischmann R, Huizinga TW, Emery P, Pope J, Massarotti EM, van Vollenhoven RF,
`Wollenhaupt J, Bingham CO, Duncan B, Goel N, Davies OR, Dougados M. Efficacy and safety of
`certolizumab pegol in a broad population of patients with active rheumatoid arthritis: results from the
`REALISTIC phase IIIb study. Rheumatology (Oxford). 2012 Dec; 51(12):2204-14.
`
`20. Weinblatt ME, Bingham CO, Mendelsohn AM, Kim L, Mack M, Lu J, Baker D, Westhovens R. Intravenous
`golimumab is effective in patients with active rheumatoid arthritis despite methotrexate therapy with
`responses as early as week 2: results of the phase 3, randomised, multicentre, double-blind, placebo-
`controlled GO-FURTHER trial. Ann Rheum Dis. 2013 Mar; 72(3):381-9.
`
`21. Prince FH, Bykerk VP, Shadick NA, Lu B, Cui J, Frits M, Iannaccone CK, Weinblatt ME, Solomon DH.
`Sustained rheumatoid arthritis remission is uncommon in clinical practice. Arthritis Res Ther. 2012;
`14(2):R68.
`
`22. Chang HH, Tai TS, Lu B, Iannaccone C, Cernadas M, Weinblatt M, Shadick N, Miaw SC, Ho IC.
`PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis. PLoS
`One. 2012; 7(3):e33067.
`
`23. Ercan A, Cui J, Hazen MM, Batliwalla F, Royle L, Rudd PM, Coblyn JS, Shadick N, Weinblatt ME,
`Gregersen P, Lee DM, Nigrovic PA. Hypogalactosylation of serum N-glycans fails to predict clinical
`response to methotrexate and TNF inhibition in rheumatoid arthritis. Arthritis Res Ther. 2012; 14(2):R43.
`
`24. Lillegraven S, Prince FH, Shadick NA, Bykerk VP, Lu B, Frits ML, Iannaccone CK, Kvien TK,
`Haavardsholm EA, Weinblatt ME, Solomon DH. Remission and radiographic outcome in rheumatoid
`arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort. Ann Rheum
`Dis. 2012 May; 71(5):681-6.
`
`25. Curtis JR, Chen L, Luijtens K, Navarro-Millan I, Goel N, Gervitz L, Weinblatt M. Dose escalation of
`certolizumab pegol from 200 mg to 400 mg every other week provides no additional efficacy in
`rheumatoid arthritis: an analysis of individual patient-level data. Arthritis Rheum. 2011 Aug;
`63(8):2203-8.
`
`26. Lee JS, Wang J, Martin M, Germer S, Kenwright A, Benayed R, Spleiss O, Platt A, Pilson R, Hemmings
`A, Weinblatt ME, Kaplowitz N, Krasnow J. Genetic variation in UGT1A1 typical of Gilbert syndrome is
`associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. Pharmacogenet
`Genomics. 2011 Jul; 21(7):365-74.
`
`27. Lee YC, Cui J, Lu B, Frits ML, Iannaccone CK, Shadick NA, Weinblatt ME, Solomon DH. Pain persists in
`DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational
`study. Arthritis Res Ther. 2011; 13(3):R83.
`
`28. Liao KP, Weinblatt ME, Solomon DH. The end of rheumatoid factor as we know it? Arthritis Rheum.
`2011 May; 63(5):1170-2.
`
`29. Todd DJ, Knowlton N, Amato M, Frank MB, Schur PH, Izmailova ES, Roubenoff R, Shadick NA,
`Weinblatt ME, Centola M, Lee DM. Erroneous augmentation of multiplex assay measurements in patients
`with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor. Arthritis Rheum. 2011
`http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=3972
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`Michael Elliott Weinblatt - Department of Medicine
`2/20/2014
`with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor. Arthritis Rheum. 2011
`Apr; 63(4):894-903.
`
`30. Liao KP, Weinblatt ME, Cui J, Iannaccone C, Chibnik LB, Lu B, Coblyn JS, Shadick NA, Solomon DH.
`Clinical predictors of erosion-free status in rheumatoid arthritis: a prospective cohort study.
`Rheumatology (Oxford). 2011 Aug; 50(8):1473-9.
`
`31. Kim SY, Servi A, Polinski JM, Mogun H, Weinblatt ME, Katz JN, Solomon DH. Validation of rheumatoid
`arthritis diagnoses in health care utilization data. Arthritis Res Ther. 2011; 13(1):R32.
`
`32. Genovese MC, Kavanaugh A, Weinblatt ME, Peterfy C, DiCarlo J, White ML, O'Brien M, Grossbard EB,
`Magilavy DB. An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month
`randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not
`respond to biologic agents. Arthritis Rheum. 2011 Feb; 63(2):337-45.
`
`33. Genovese MC, Cohen SB, Wofsy D, Weinblatt ME, Firestein GS, Brahn E, Strand V, Baker DG, Tong SE.
`A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral
`SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis. J
`Rheumatol. 2011 May; 38(5):846-54.
`
`34. Keystone EC, Kavanaugh A, Weinblatt ME, Patra K, Pangan AL. Clinical consequences of delayed
`addition of adalimumab to methotrexate therapy over 5 years in patients with rheumatoid arthritis. J
`Rheumatol. 2011 May; 38(5):855-62.
`
`35. van Vollenhoven RF, Felson D, Strand V, Weinblatt ME, Luijtens K, Keystone EC. American College of
`Rheumatology hybrid analysis of certolizumab pegol plus methotrexate in patients with active rheumatoid
`arthritis: data from a 52-week phase III trial. Arthritis Care Res (Hoboken). 2011 Jan; 63(1):128-34.
`
`36. Weinblatt ME, Keystone EC, Cohen MD, Freundlich B, Li J, Chon Y, Baumgartner SW. Factors
`associated with radiographic progression in patients with rheumatoid arthritis who were treated with
`methotrexate. J Rheumatol. 2011 Feb; 38(2):242-6.
`
`37. Coury FF, Weinblatt ME. Clinical trials to establish methotrexate as a therapy for rheumatoid arthritis.
`Clin Exp Rheumatol. 2010 Sep-Oct; 28(5 Suppl 61):S9-12.
`
`38. Desai SP, Turchin A, Szent-Gyorgyi LE, Weinblatt M, Coblyn J, Solomon DH, Kachalia A. Routinely
`measuring and reporting pneumococcal vaccination among immunosuppressed rheumatology outpatients:
`the first step in improving quality. Rheumatology (Oxford). 2011 Feb; 50(2):366-72.
`
`39. Weinblatt ME, Bathon JM, Kremer JM, Fleischmann RM, Schiff MH, Martin RW, Baumgartner SW, Park
`GS, Mancini EL, Genovese MC. Safety and efficacy of etanercept beyond 10 years of therapy in North
`American patients with early and longstanding rheumatoid arthritis. Arthritis Care Res (Hoboken). 2011
`Mar; 63(3):373-82.
`
`40. Tan W, Wu H, Zhao J, Derber LA, Lee DM, Shadick NA, Conn DL, Smith EA, Gersuk VH, Nepom GT,
`Moreland LW, Furst DE, Thompson SD, Jonas BL, Holers VM, Glass DN, Chen PP, Bridges SL, Weinblatt ME,
`Paulus HE, Tsao BP. A functional RANKL polymorphism associated with younger age at onset of
`rheumatoid arthritis. Arthritis Rheum. 2010 Oct; 62(10):2864-75.
`
`41. Weinblatt ME, Kavanaugh A, Genovese MC, Musser TK, Grossbard EB, Magilavy DB. An oral spleen
`tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N Engl J Med. 2010 Sep 30; 363(14):1303-12.
`
`42. Iannaccone CK, Lee YC, Cui J, Frits ML, Glass RJ, Plenge RM, Solomon DH, Weinblatt ME, Shadick NA.
`Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy:
`data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study. Rheumatology
`(Oxford). 2011 Jan; 50(1):40-6.
`
`43. Sullivan MB, Iannaccone C, Cui J, Lu B, Batra K, Weinblatt M, Shadick NA. Evaluation of selected
`rheumatoid arthritis activity scores for office-based assessment. J Rheumatol. 2010 Dec; 37(12):2466-
`8.
`
`44. Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, O'Donnell CI, Derber LA, Weinblatt
`ME, Shadick NA, Bell DA, Cairns E, Solomon DH, Holers VM, Rudd PM, Lee DM. Aberrant IgG
`galactosylation precedes disease onset, correlates with disease activity, and is prevalent in
`autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2010 Aug; 62(8):2239-48.
`
`45. Curtis JR, Jain A, Askling J, Bridges SL, Carmona L, Dixon W, Finckh A, Hyrich K, Greenberg JD,
`Kremer J, Listing J, Michaud K, Mikuls T, Shadick N, Solomon DH, Weinblatt ME, Wolfe F, Zink A. A
`comparison of patient characteristics and outcomes in selected European and U.S. rheumatoid arthritis
`registries. Semin Arthritis Rheum. 2010 Aug; 40(1):2-14.e1.
`
`46. Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de
`Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedrén S, Ding B, Guiducci C, Wolbink GJ, Crusius JB,
`van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M,
`Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell
`LA, Huizinga TW, Tak PP, Bridges SL, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge
`RM. Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor
`alpha therapy. Arthritis Rheum. 2010 Jul; 62(7):1849-61.
`
`47. Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova
`A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, Barton A, Bowes J, Brouwer E, Burtt NP,
`Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager
`PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin
`P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA,
`Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE,
`van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, Wijmenga C, Karlson EW, Toes RE, de
`Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM. Genome-
`wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet. 2010
`Jun; 42(6):508-14.
`
`48. Boilard E, Lai Y, Larabee K, Balestrieri B, Ghomashchi F, Fujioka D, Gobezie R, Coblyn JS, Weinblatt
`http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=3972
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`Michael Elliott Weinblatt - Department of Medicine
`2/20/2014
`48. Boilard E, Lai Y, Larabee K, Balestrieri B, Ghomashchi F, Fujioka D, Gobezie R, Coblyn JS, Weinblatt
`ME, Massarotti EM, Thornhill TS, Divangahi M, Remold H, Lambeau G, Gelb MH, Arm JP, Lee DM. A novel
`anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis. EMBO Mol
`Med. 2010 May; 2(5):172-87.
`
`49. Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt ME, Massarotti EM, Remold-
`O'Donnell E, Farndale RW, Ware J, Lee DM. Platelets amplify inflammation in arthritis via collagen-
`dependent microparticle production. Science. 2010 Jan 29; 327(5965):580-3.
`
`50. Furst DE, Keystone EC, Fleischmann R, Mease P, Breedveld FC, Smolen JS, Kalden JR, Braun J,
`Bresnihan B, Burmester GR, De Benedetti F, Dörner T, Emery P, Gibofsky A, Kavanaugh A, Kirkham B,
`Schiff MH, Sieper J, Singer N, Van Riel PL, Weinblatt ME, Weisman MH, Winthrop K. Updated consensus
`statement on biological agents for the treatment of rheumatic diseases, 2009. Ann Rheum Dis. 2010 Jan;
`69 Suppl 1:i2-29.
`
`51. Desai SP, Gravallese EM, Shadick NA, Glass R, Cui J, Frits M, Chibnik LB, Maher N, Weinblatt ME,
`Solomon DH. Hand bone mineral density is associated with both total hip and lumbar spine bone mineral
`density in post-menopausal women with RA. Rheumatology (Oxford). 2010 Mar; 49(3):513-9.
`
`52. Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA,
`Chen R, Alfredsson L, Amos CI, Ardlie KG, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader
`KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga
`TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM,
`Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der
`Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, Altshuler D, Karlson EW, Toes
`RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge
`RM. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat
`Genet. 2009 Dec; 41(12):1313-8.
`
`53. Zella GC, Weinblatt ME, Winter HS. Drug-induced lupus associated with infliximab and adalimumab in
`an adolescent with Crohn disease. J Pediatr Gastroenterol Nutr. 2009 Sep; 49(3):355-8.
`
`54. Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM,
`McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, Eavey RD,
`Plenge RM, Shadick NA, Weinblatt ME, De Jager PL, Hafler DA, Breitbart RE, Seidman JG, Seidman CE. De
`novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet.
`2009 Aug; 41(8):931-5.
`
`55. Stoll ML, Solomon DH, Batra KL, Simard JF, Karlson EW, Dellaripa PF, Weinblatt ME, Glass R, Shadick
`NA. TNFalpha inhibitors may improve asthma symptoms: a case series of 12 patients with rheumatoid
`arthritis and asthma. J Clin Rheumatol. 2009 Jun; 15(4):198-200.
`
`56. Solomon DH, Finkelstein JS, Shadick N, LeBoff MS, Winalski CS, Stedman M, Glass R, Brookhart MA,
`Weinblatt ME, Gravallese EM. The relationship between focal erosions and generalized osteoporosis in
`postmenopausal women with rheumatoid arthritis. Arthritis Rheum. 2009 Jun; 60(6):1624-31.
`
`57. Weinblatt ME, Abbott GF, Koreishi AF. Case records of the Massachusetts General Hospital. Case 13-
`2009. A 54-year-old woman with respiratory failure and a cavitary lesion in the lung. N Engl J Med. 2009
`Apr 23; 360(17):1770-9.
`
`58. Cui J, Taylor KE, Destefano AL, Criswell LA, Izmailova ES, Parker A, Roubenoff R, Plenge RM,
`Weinblatt ME, Shadick NA, Karlson EW. Genome-wide association study of determinants of anti-cyclic
`citrullinated peptide antibody titer in adults with rheumatoid arthritis. Mol Med. 2009 May-Jun; 15(5-
`6):136-43.
`
`59. Behar SM, Shin DS, Maier A, Coblyn J, Helfgott S, Weinblatt ME. Use of the T-SPOT.TB assay to detect
`latent tuberculosis infection among rheumatic disease patients on immunosuppressive therapy. J
`Rheumatol. 2009 Mar; 36(3):546-51.
`
`60. Lee YC, Cui J, Costenbader KH, Shadick NA, Weinblatt ME, Karlson EW. Investigation of candidate
`polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Rheumatology
`(Oxford). 2009 Jun; 48(6):613-7.
`
`61. Furst DE, Keystone EC, Kirkham B, Kavanaugh A, Fleischmann R, Mease P, Breedveld FC, Smolen JS,
`Kalden JR, Burmester GR, Braun J, Emery P, Winthrop K, Bresnihan B, De Benedetti F, Dörner T, Gibofsky
`A, Schiff MH, Sieper J, Singer N, Van Riel PL, Weinblatt ME, Weisman MH. Updated consensus statement
`on biological agents for the treatment of rheumatic diseases, 2008. Ann Rheum Dis. 2008 Dec; 67 Suppl
`3:iii2-25.
`
`62. Smolen JS, Weinblatt ME. When patients with rheumatoid arthritis fail tumour necrosis factor
`inhibitors: what is the next step? Ann Rheum Dis. 2008 Nov; 67(11):1497-8.
`
`63. Weinblatt ME, Kavanaugh A, Burgos-Vargas R, Dikranian AH, Medrano-Ramirez G, Morales-Torres JL,
`Murphy FT, Musser TK, Straniero N, Vicente-Gonzales AV, Grossbard E. Treatment of rheumatoid arthritis
`with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial. Arthritis Rheum. 2008
`Nov; 58(11):3309-18.
`
`64. Aletaha D, Landewe R, Karonitsch T, Bathon J, Boers M, Bombardier C, Bombardieri S, Choi H, Combe
`B, Dougados M, Emery P, Gomez-Reino J, Keystone E, Koch G, Kvien TK, Martin-Mola E, Matucci-Cerinic M,
`Michaud K, O'Dell J, Paulus H, Pincus T, Richards P, Simon L, Siegel J, Smolen JS, Sokka T, Strand V,
`Tugwell P, van der Heijde D, van Riel P, Vlad S, van Vollenhoven R, Ward M, Weinblatt M, Wells G, White
`B, Wolfe F, Zhang B, Zink A, Felson D. Reporting disease activity in clinical trials of patients with
`rheumatoid arthritis: EULAR/ACR collaborative recommendations. Arthritis Rheum. 2008 Oct 15;
`59(10):1371-7.
`
`65. Aletaha D, Landewe R, Karonitsch T, Bathon J, Boers M, Bombardier C, Bombardieri S, Choi H, Combe
`B, Dougados M, Emery P, Gomez-Reino J, Keystone E, Koch G, Kvien TK, Martin-Mola E, Matucci-Cerinic M,
`Michaud K, O'Dell J, Paulus H, Pincus T, Richards P, Simon L, Siegel J, Smolen JS, Sokka T, Strand V,
`Tugwell P, van der Heijde D, van Riel P, Vlad S, van Vollenhoven R, Ward M, Weinblatt M, Wells G, White
`B, Wolfe F, Zhang B, Zink A, Felson D. Reporting disease activity in clinical trials of patients with
`rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis. 2008 Oct;
`http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=3972
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`rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis. 2008 Oct;
`67(10):1360-4.
`
`66. Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD,
`Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM,
`Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin
`MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA,
`Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L,
`Gregersen PK, Daly MJ, Plenge RM. Common variants at CD40 and other loci confer risk of rheumatoid
`arthritis. Nat Genet. 2008 Oct; 40(10):1216-23.
`
`67. Weinblatt ME. Questions and answers in 2008 about biologics in rheumatoid arthritis. J Rheumatol.
`2008 Sep; 35(9):1878-81.
`
`68. Ting G, Schneeweiss S, Scranton R, Katz JN, Weinblatt ME, Young M, Avorn J, Solomon DH.
`Development of a health care utilisation data-based index for rheumatoid arthritis severity: a preliminary
`study. Arthritis Res Ther. 2008; 10(4):R95.
`
`69. Lutt JR, Pisculli ML, Weinblatt ME, Deodhar A, Winthrop KL. Severe nontuberculous mycobacterial
`infection in 2 patients receiving rituximab for refractory myositis. J Rheumatol. 2008 Aug; 35(8):1683-5.
`
`70. Agarwal SK, Glass RJ, Shadick NA, Coblyn JS, Anderson RJ, Maher NE, Weinblatt ME, Solomon DH.
`Predictors of discontinuation of tumor necrosis factor inhibitors in patients with rheumatoid arthritis. J
`Rheumatol. 2008 Sep; 35(9):1737-44.
`
`71. Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, Shadick N,
`Weinblatt M, Gonzalez A, Gregersen PK, Benoist C, Mathis D. A broad analysis of IL1 polymorphism and
`rheumatoid arthritis. Arthritis Rheum. 2008 Jul; 58(7):1947-57.
`
`72. Weinblatt ME, Schiff MH, Ruderman EM, Bingham CO, Li J, Louie J, Furst DE. Efficacy and safety of
`etanercept 50 mg twice a week in patients with rheumatoid arthritis who had a suboptimal response to
`etanercept 50 mg once a week: results of a multicenter, randomized, double-blind, active drug-controlled
`study. Arthritis Rheum. 2008 Jul; 58(7):1921-30.
`
`73. Setoguchi S, Schneeweiss S, Avorn J, Katz JN, Weinblatt ME, Levin R, Solomon DH. Tumor necrosis
`factor-alpha antagonist use and heart failure in elderly patients with rheumatoid arthritis. Am Heart J.
`2008 Aug; 156(2):336-41.
`
`74. Todd DJ, Weinblatt ME. Oral versus parenteral administration of methotrexate for the treatment of
`active RA. Nat Clin Pract Rheumatol. 2008 Jul; 4(7):342-3.
`
`75. Roubenoff R, Beckman E, Weinblatt M, Shadick N, Gregersen PK. Biological significance of anti-cyclic
`citrullinated peptide antibody in rheumatoid arthritis. Ann Intern Med. 2008 Mar 4; 148(5):403; author
`reply 403-4.
`
`76. Furst DE, Halbert RJ, Bingham CO, Fukudome S, Anderson L, Bonafede P, Bray V, Cohen SB, Sherrer
`YR, St Clair EW, Tesser JR, Weinblatt M, Dubois RW. Evaluating the adequacy of disease control in
`patients with rheumatoid arthritis: a RAND appropriateness panel. Rheumatology (Oxford). 2008 Feb;
`47(2):194-9.
`
`77. Royle L, Campbell MP, Radcliffe CM, White DM, Harvey DJ, Abrahams JL, Kim YG, Henry GW, Shadick
`NA, Weinblatt ME, Lee DM, Rudd PM, Dwek RA. HPLC-based analysis of serum N-glycans on a 96-well
`plate platform with dedicated database software. Anal Biochem. 2008 May 1; 376(1):1-12.
`
`78. Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B,
`DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R,
`Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov
`L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA,
`Daly MJ, Altshuler D. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat
`Genet. 2007 Dec; 39(12):1477-82.
`
`79. Furst DE, Breedveld FC, Kalden JR, Smolen JS, Burmester GR, Sieper J, Emery P, Keystone EC, Schiff
`MH, Mease P, van Riel PL, Fleischmann R, Weisman MH, Weinblatt ME. Updated consensus statement on
`biological agents for the treatment of rheumatic diseases, 2007. Ann Rheum Dis. 2007 Nov; 66 Suppl
`3:iii2-22.
`
`80. Bijlsma JW, Weinblatt ME. Optimal use of methotrexate: the advantages of tight control. Ann Rheum
`Dis. 2007 Nov; 66(11):1409-10.
`
`81. Schmajuk G, Schneeweiss S, Katz JN, Weinblatt ME, Setoguchi S, Avorn J, Levin R, Solomon DH.
`Treatment of older adult patients diagnosed with rheumatoid arthritis: improved but not optimal. Arthritis
`Rheum. 2007 Aug 15; 57(6):928-34.
`
`82. Parker A, Izmailova ES, Narang J, Badola S, Le T, Roubenoff R, Ginsburg GS, Maier A, Coblyn JS,
`Shadick NA, Weinblatt ME. Peripheral blood expression of nuclear factor-kappab-regulated genes is
`associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis
`factor-alpha versus methotrexate. J Rheumatol. 2007 Sep; 34(9):1817-22.
`
`83. Karlson EW, Chibnik LB, Cui J, Plenge RM, Glass RJ, Maher NE, Parker A, Roubenoff R, Izmailova E,
`Coblyn JS, Weinblatt ME, Shadick NA. Associations between human leukocyte antigen, PTPN22, CTLA4
`genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a
`large cohort study. Ann Rheum Dis. 2008 Mar; 67(3):358-63.
`
`84. Schneeweiss S, Setoguchi S, Weinblatt ME, Katz JN, Avorn J, Sax PE, Levin R, Solomon DH. Anti-
`tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with
`rheumatoid arthritis. Arthritis Rheum. 2007 Jun; 56(6):1754-64.
`
`85. Shadick NA, Heller JE, Weinblatt ME, Maher NE, Cui J, Ginsburg G, Coblyn J, Anderson R, Solomon DH,
`Roubenoff R, Parker A. Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on
`disease activity and certain disease phenotypes in rheumatoid arthritis. Ann Rheum Dis. 2007 Nov;
`66(11):1497-502.
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`Michael Elliott Weinblatt - Department of Medicine
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`86. Weinblatt ME, Kuritzky L. RAPID: rheumatoid arthritis. J Fam Pract. 2007 Apr; 56(4 Suppl):S1-7;
`quiz S8.
`
`87. Solomon DH, Stedman M, Licari A, Weinblatt ME, Maher N, Shadick N. Agreement between patient
`report and medical record review for medications used for rheumatoid arthritis: the accuracy of self-
`reported medication information in patient registries. Arthritis Rheum. 2007 Mar 15; 57(2):234-9.
`
`88. Todd DJ, Costenbader KH, Weinblatt ME. Abatacept in the treatment of rheumatoid arthritis. Int J Clin
`Pract. 2007 Mar; 61(3):494-500.
`
`89. Solomon DH, Avorn J, Katz JN, Weinblatt ME, Setoguchi S, Levin R, Schneeweiss S.
`Immunosuppressive medications and hospitalization for cardiovascular events in patients with
`rheumatoid arthritis. Arthritis Rheum. 2006 Dec; 54(12):3790-8.
`
`90. Cannon CP, Curtis SP, FitzGerald GA, Krum H, Kaur A, Bolognese JA, Reicin AS, Bombardier C,
`Weinblatt ME, van der Heijde D, Erdmann E, Laine L. Cardiovascular outcomes with etoricoxib and
`diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and
`Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Lancet. 2006 Nov 18;
`368(9549):1771-81.
`
`91. Furst DE, Breedveld FC, Kalden JR, Smolen JS, Burmester GR, Emery P, Keystone EC, Schiff MH, van
`Riel PL, Weinblatt ME, Weisman MH. Updated consensus statement on biological agents for the treatment
`of rheumatic diseases, 2006. Ann Rheum Dis. 2006 Nov; 65 Suppl 3:iii2-15.
`
`92. Weinblatt ME, van Riel PL. Targeted therapies: summary clinical trials working group. Ann Rheum Dis.
`2006 Nov; 65 Suppl 3:iii89.
`
`93. Weinblatt M, Combe B, Covucci A, Aranda R, Becker JC, Keystone E. Safety of the selective
`costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and
`nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study.
`Arthritis Rheum. 2006 Sep; 54(9):2807-16.
`
`94. Setoguchi S, Solomon DH, Weinblatt ME, Katz JN, Avorn J, Glynn RJ, Cook EF, Carney G, Schneeweiss
`S. Tumor necrosis factor alpha antagonist use and cancer in patients with rheumatoid arthritis. Arthritis
`Rheum. 2006 Sep; 54(9):2757-64.
`
`95. Weinblatt M, Schiff M, Goldman A, Kremer J, Luggen M, Li T, Chen D, Becker JC. Selective
`costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving
`etanercept: a randomised clinical trial. Ann Rheum Dis. 2007 Feb; 66(2):228-34.
`
`96. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis
`corrects for stratification in genome-wide association studies. Nat Genet. 2006 Aug; 38(8):904-9.
`
`97. Benito-Garcia E, Heller JE, Chibnik LB, Maher NE, Matthews HM, Bilics JA, Weinblatt ME, Shadick NA.
`Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritis. J
`Rheumatol. 2006 Jul; 33(7):1275-81.
`
`98. Solomon DH, Goodson NJ, Katz JN, Weinblatt ME, Avorn J, Setoguchi S, Canning C, Schneeweiss S.
`Patterns of cardiovascular risk in rheumatoid arthritis. Ann Rheum Dis. 2006 Dec; 65(12):1608-12.
`
`99. Moreland LW, Weinblatt ME, Keystone EC, Kremer JM, Martin RW, Schiff MH, Whitmore JB, White BW.
`Etanercept treatment in adults with established rheumatoid arthritis: 7 years of clinical experience. J
`Rheumatol. 2006 May; 33(5):854-61.
`
`100. Noss EH, Hausner-Sypek DL, Weinblatt ME. Rituximab as therapy for refractory polymyositis and
`dermatom