(12) United States Patent
`Nova et al.
`
`US006416714B1
`US 6,416,714 B1
`*Jul. 9, 2002
`
`(10) Patent N0.:
`(45) Date of Patent:
`
`(54) REMOTELY PROGRAMMABLE MATRICES
`WITH MEMORIES
`
`(75) Inventors: Michael P. Nova, Rancho Santa Fe;
`Andrew E. Senyei, San Juan
`Capistrano, both of CA (US)
`
`(73) Assignee: Discovery Partners International,
`Inc., San Diego, CA (US)
`
`( * ) Notice:
`
`Subject to any disclaimer, the term of this
`patent is extended or adjusted under 35
`USC 154(b) by 0 days.
`
`This patent is subject to a terminal dis
`claimer.
`
`(21) Appl. No.: 08/484,486
`(22) Filed:
`Jun. 7, 1995
`
`Related US. Application Data
`
`(63) Continuation-in-part of application No. 08/428,662, ?led on
`Apr. 25, 1995.
`
`(51) Int. Cl.7 ...................... .. G01N 15/06; G01N 33/53;
`C12Q 1/68; A61K 38/00
`(52) US. Cl. ........................ .. 422/68.1; 422/50; 422/57;
`422/58; 422/8205; 422/99; 422/102; 422/104;
`435/6; 435/5; 435/7.1; 435/7.2; 435/7.9;
`436/501; 436/518; 436/578; 436/523; 530/333;
`530/334; 530/388.1
`(58) Field of Search ........................ .. 435/6, 5, 7.1—7.9;
`436/501, 182, 183, 518, 578, 523, 524,
`525, 526,527,528; 340/572; 336/24.3—24.33;
`422/681, 50, 57, 58, 82.05, 99, 102, 104;
`530/334, 333, 335, 388.1; 364/496, 497,
`498, 499; 257/225, 390; 395/430; 438/131
`
`(56)
`
`References Cited
`
`U.S. PATENT DOCUMENTS
`
`3,704,952 A 12/1972 Bird .......................... .. 356/87
`
`(List continued on next page.)
`
`FOREIGN PATENT DOCUMENTS
`
`DE
`DE
`
`2344930
`9308204
`
`4/1974
`8/1993
`
`(List continued on next page.)
`
`OTHER PUBLICATIONS
`
`US 5,382,513, 01/1995, Lam et al. (Withdrawn)
`Jurisch, Identi?kation: kontaktlos via HochfrequenZ, Elek
`tronik 9, pp. 86—92 (1993) not in English.
`
`(List continued on next page.)
`
`Primary Examiner—W. Gary Jones
`(74) Attorney, Agent, or Firm—Kilpatrick Stockton LLP
`(57)
`ABSTRACT
`
`Combinations, called matrices With memories, of matrix
`materials With remotely addressable or remotely program
`mable recording devices that contain at least one data
`storage unit are provided. The matrix materials are those that
`are used in as supports in solid phase chemical and bio
`chemical syntheses, immunoassays and hybridization reac
`tions. The data storage units are preferably non-volatile
`antifuse memories. By virtue of this combination, molecules
`and biological particles, such as phage and viral particles
`and cells, that are in proximity or in physical contact With the
`matrix combination can be labeled by programming the
`memory With identifying information and can be identi?ed
`by retrieving the stored information. Combinations of matrix
`materials, memories, and linked molecules and biological
`materials are also provided. The combinations have a mul
`tiplicity of applications, including combinatorial chemistry,
`isolation and puri?cation of target macromolecules, capture
`and detection of macromolecules for analytical purposes,
`selective removal of contaminants, enzymatic catalysis,
`chemical modi?cation and other uses.
`
`3,119,099 A
`3,692,498 A
`
`1/1964 Biernat ..................... .. 365/151
`9/1972 Frank et al. ................ .. 23/292
`
`14 Claims, 7 Drawing Sheets
`
`202
`
`Luminex Ex. 1003
`Luminex/Irori - Page 1
`
`

`

`US 6,416,714 B1
`Page 2
`
`US. PATENT DOCUMENTS
`
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`2/1977 Olsen et a1~ "
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`
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`4,975,647 A 12/1990 Downer et a1~
`' 324/425
`4,990,756 A
`2/1991 Hoeman ................... .. 235/462
`g’ggé’gig 2
`g/ 1991 Butcher et a1‘ """""" " 209/33
`’
`’
`/ 1991 c‘impben et a1‘ '
`606/116
`5,004,606 A
`4/1991 Frincke et al. .
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`
`4,133,642 A 4,154,795 A 4,162,355 A
`
`
`
`
`
`1/1979 Nosaka et al' 7/1979 Tsibris ________ __ Thorne ______ n
`
`
`
`
`
`422/67 422/99 526/293
`
`
`
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`
`5,024,727 A 5,028,918 A 5,029,214 A
`
`
`
`
`
`6/1991 Cambpell et al. ......... .. 7/1991 Giles et al. .......... .. 7/1991 Hollander .................. .. 381/51
`
`4,171,412 A 10/1979 coupek et a1_
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`3/1982 McIntyre
`
`525/329
`536/57
`8/192
`536/59
`252/431
`585/644
`. . . .. 47/77
`428/407
`414/480
`
`3/1982 Ritter . . . . . . . .
`4,321,069 A
`6/1982 Beigel
`4,333,072 A
`9/1982 Sidman
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`1/1984 Roesner
`4,439,585 A
`3/1984 Gould et al.
`4,442,507 A
`4/1984 Roesner
`4,450,150 A
`5/1984 Sidman ..
`
`. . . . . . . .. 55/161
`. 340/825.54
`.. 128/260
`436/513
`365/105
`525/127
`365/100
`424/1.1
`
`. . . . .. 528/61
`260/112.5
`514/179
`424/78
`435/6
`
`4,485,227 A 11/1984 FOX . . . . . . . .
`4,507,230 A
`3/1985 Tam et al. .
`4,530,840 A
`7/1985 Tice et al. .
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`4,542,102 A
`9/1985 Dattagupta et al.
`4,562,157 A 12/1985
`4,569,981 A
`2/1986
`..
`4,588,880 A
`5/1986
`4,598,386 A
`7/1986 Roesner et al. ........... .. 365/105
`4,631,211 A * 12/1986 Houghten .................. .. 428/35
`4,646,266 A
`2/1987 OVshinsky et al.
`.. 365/105
`4,652,528 A
`3/1987 Domkowski ............... .. 436/56
`4,654,512 A
`3/1987 Gardosi .................... .. 235/376
`4,657,543 A
`4/1987 Langer et al.
`.. 604/891
`4,681,870 A
`7/1987 Balint, Jr. et al. ........ .. 502/403
`4,683,202 A
`7/1987 Mullis ....................... .. 435/91
`4,702,732 A 10/1987 Powers et al.
`604/20
`4,705,503 A 11/1987 Dorman et al. ............. .. 604/50
`4,745,072 A * 5/1988 Ekins et al. .............. .. 436/500
`4,762,881 A
`8/1988 Kauer
`.. 525/54.11
`4,777,019 A 10/1988 Dandekar .................. .. 422/68
`4,779,806 A 10/1988 Langer et al. ............... .. 241/1
`4,783,776 A 11/1988 lshigaki et al.
`369/109
`4,786,277 A 11/1988 Powers et al. .............. .. 604/20
`4,791,285 A 12/1988 Ohki ........................ .. 235/449
`4,796,074 A
`1/1989 Roesner
`357/51
`4,807,140 A
`2/1989 Saulnier ................... .. 364/468
`4,855,909 A
`8/1989 VinVent et al. ...... .. 364/413.01
`
`8/1989 Carroll . . . . . . . . . . . .
`. . . .. 340/572
`4,857,893 A
`9/1989 Limisimaque ............ .. 364/300
`4,870,574 A
`4,876,668 A 10/1989 Thakoor et al. .......... .. 365/163
`4,885,250 A * 12/1989 Eveleigh et al. .
`.. 435/181
`4,889,800 A 12/1989 Shinnick et al. ............. .. 435/7
`4,908,405 A
`3/1990 Bayer et al. ................ .. 525/61
`4,908,694 A
`3/1990 Hidaka et al.
`. 357/74
`4,908,813 A
`3/1990 Ojima et al. ................ .. 369/94
`4,927,879 A
`5/1990 Pidgeon ................... .. 525/54.1
`4,931,498 A
`6/1990 Pidgeon ..
`525/54.1
`4,933,285 A
`6/1990 Patton ...................... .. 435/181
`4,952,531 A
`8/1990 Cherukuri .................. .. 501/69
`4,952,928 A
`8/1990 Carroll et al.
`340/825.54
`4,954,444 A * 9/1990 Eveleigh et al. .......... .. 435/181
`4,958,452 A
`9/1990 Tate .......................... .. 40/301
`
`7/1991 Landt et al. .............. .. 235/375
`5,030,807 A
`7/1991 Grecksch et al. .
`.. 209/33
`5,033,623 A
`8/1991 Cherukuri ................. .. 428/432
`5,043,222 A
`9/1991 MunZ et al. .............. .. 271/223
`5,044,623 A
`9/1991 Cherukuri ....... ..
`.. 501/21
`5,047,371 A
`5,055,659 A 10/1991 Hendrick et al.
`. 235/439
`5,056,056 A 10/1991 Gustin ............ ..
`. 364/900
`5,063,417 A 11/1991 Hop?eld ..
`357/8
`5,064,767 A 11/1991 Le et al.
`436/89
`
`. 235/439
`5,073,703 A 12/1991 Wehrmacher
`128/899
`5,074,318 A 12/1991 Campbell et al. .
`5,087,570 A
`2/1992 Weissman et al. ..... .. 435/240.1
`5,089,391 A
`2/1992 Buechler et al. . . . . .
`. . . .. 435/7.1
`5,089,877 A
`2/1992 Queyssac et al. .
`.... .. 357/70
`5,092,992 A
`3/1992 Crane et al. .... ..
`.. . 210/198.2
`5,095,362 A
`3/1992 Roesner .... ..
`357/23.4
`5,099,226 A
`3/1992 Andrews .
`. 340/572
`
`422/100
`3/1992 Levin .... ..
`5,100,626 A
`340/825.54
`4/1992 Kip et al.
`5,105,190 A
`..... .. 424/422
`5/1992 Sabel et al.
`5,114,719 A
`. . . . .. 357/51
`6/1992 lshihara et al. . . . . . .
`5,119,163 A
`435/7.24
`6/1992 Schlossman et al.
`5,120,642 A
`436/530
`6/1992 Chan et al. ........ ..
`5,120,662 A
`128/631
`6/1992 DitZ et al.
`5,121,748 A
`250/214
`7/1992 Yerbury et al.
`5,134,277 A
`369/108
`8/1992 Bradley .......... ..
`5,136,572 A
`436/518
`9/1992 Pirrung et al.
`5,143,854 A
`357/45
`9/1992 Potash et al.
`5,148,256 A
`367/2
`9/1992 Hilferink et al. .
`5,148,404 A
`. 436/501
`5,171,695 A 12/1992 Ekins ............. ..
`204/403
`5,200,051 A
`4/1993 CoZZette et al. ..
`. 604/891.1
`5,201,728 A
`4/1993 Giampapa ....... ..
`5,211,165 A
`5/1993 Dumoulin et al. ..... .. 128/653.1
`5,212,050 A
`5/1993 Mier et al. ...... ..
`430/320
`5,212,315 A
`5/1993 Jones et al. .
`546/257
`5,214,409 A
`5/1993 Beigel ...... ..
`. 340/572
`5,215,899 A
`6/1993 Dattagupta
`435/6
`5,216,143 A
`6/1993 Hogan et al. ..
`. 536/24.32
`5,217,743 A
`6/1993 Farah .......... ..
`427/2
`5,217,870 A
`6/1993 Hession et al.
`435/7.24
`5,218,189 A
`6/1993 Hutchinson ............... .. 235/439
`5,218,343 A
`6/1993 Stobbe et al. ............. .. 340/572
`5,223,408 A
`6/1993 Goeddel et al. ..
`435/69.3
`5,223,409 A
`6/1993 Ladner et al. ........... .. 435/69.7
`5,228,001 A
`7/1993 Birge et al. ............... .. 365/215
`
`8/1993 Milliman et al. ............ .. 435/6
`5,232,831 A
`8/1993 Beigel et al. ........ .. 340/825.54
`5,235,326 A
`8/1993 BriZZolara et al. .......... .. 433/80
`5,236,355 A
`9/1993 Holmes et al.
`. 525/54.11
`5,242,974 A
`9/1993 Tung et al. ............... .. 437/195
`5,248,632 A
`5,250,459 A 10/1993 Lee ........................... .. 437/52
`5,250,944 A 10/1993 Urbas et al. .... ..
`.. 340/870.31
`5,251,635 A 10/1993 Dumoulin et al. ..... .. 126/653.1
`5,252,743 A 10/1993 Barrett et al. .......... .. 548/303.7
`5,252,962 A 10/1993 Urbas et al.
`.. 340/870.17
`5,253,198 A 10/1993 Birge et al. ............... .. 365/106
`5,255,680 A 10/1993 Darrow et al. ......... .. 128/653.1
`5,256,469 A 10/1993 Cherukuri et al.
`428/210
`5,257,011 A 10/1993 Beigel ...................... .. 340/572
`5,258,289 A 11/1993 Davis et al. ............. .. 435/69.6
`
`Luminex Ex. 1003
`Luminex/Irori - Page 2
`
`

`

`US 6,416,714 131
`Page 3
`
`5,260,203 A 11/1993 Ladner et a1. ......... .. 435/172.3
`5,262,772 A 11/1993 01666 6161. ..
`.. 340/825.54
`5,265,610 A 11/1993 Darrow 61 a1_
`__ 1253/6531
`5,266,926 A 11/1993 1361 61 ...................... .. 340/572
`5,268,371 A 12/1993 M6§616116 6161. ........ .. 514/185
`
`. 435/737 5,270,170 A 12/1993 SChatZ 6161. 5,270,251 A 12/1993 co11611 ................ .. 437/173
`
`
`5’271’400 A 12/1993 Dumoulin et a1‘
`Q8/6532
`5,272,666 A 12/1993 TSaIlg 6161. ................ .. 365/96
`2 131333 $213111?“ """"""""" " ‘Egg;
`
`7
`7
`5,282,158 A
`5,284,747 A
`5,285,514 A
`5,288,291 A
`5,288,476 A
`5,288,622 A
`5290734 A
`5,292,814 A
`5,292,874 A
`5,296,122 A
`5,296,722 A
`5,300,278 A
`5,300,456 A
`5,304,498 A
`5,306,466 A
`5,307,808 A
`5,308,967 A
`5,310,686 A
`5,311,039 A
`5,314,829 A
`5316922 A
`5316971 A
`5318354 A
`5,319,181 A
`5,322,812 A
`5,323,704 A
`5,324,324 A
`5,324,483 A
`5324591 A
`5,324,633 A
`5326449 A
`5326696 A
`5,328,603 A
`5,329,153 A
`5334640 A
`5334880 A
`5335219 A
`5,338,665 A
`5,342,772 A
`5,346,789 A
`5347263 A
`5,347,283 A
`5,348,705 A
`5,348,867 A
`5,349,173 A
`5,350,645 A
`5,351,052 A
`
`~~~~~~~~~~~~~~~~~~~~~~ "
`1/1994 L66 ........................... .. 365/96
`2/1994 Mllllman
`435/6
`2/1994 Ellman ........................ .. 427/2
`2/1994 Teoh ...~..~. ................... .. 604/60
`2/1994 Pasquallm ct a1~
`- 424/1-65
`2/1994 Gray 9191
`- ‘135/694
`3/1994 Boardman et a
`-- 437/195
`3/1994 B9794 91 a1
`-- 525/243
`3/1994 Mllllman
`-- 536/2“-32
`3/1994 Katsube et al.
`204/298.04
`3/1994 Potash e181.
`257/50
`4/1994 Pflsquallm ct a1~
`- 534/14
`4/1994 Tlgelaar ct a1~ -~
`-- 437/195
`4/1994 Ekms -~_ ~~~~~~~ --
`-- 436/501
`4/1994 Goldsml?h
`422/58
`5/1994 13119101111“ 51 a1~
`-- 128/653-2
`5/1994 Junsch . . . . . . . . . . . .
`. . . .. 235/492
`5/1994 séwyers 9191- -
`-- 436/518
`5/1994 Klmura ct a1~
`257/50
`5/1994 C0165 ......... ..
`436/165
`5/1994 BIQWH ct a1~ -
`“35/69-7
`5/1994 Chung 9191-
`437/170
`6/1994 Tyler ------------------ -- 303/3
`6/1994 shellhammer et al-
`235/462
`6/1994 DIX“ ct a1~ ---- --
`437/60
`6/1994 Fraclek
`101/375
`6/1994 Vachon et al-
`607/120
`6/1994 Cody 9191
`422/131
`6/1994 Georger ct a1~
`428/552
`6/1994 Fodot ct a1~ --
`435/6
`7/1994 Cunmngham -
`204/403
`7/1994 Chang ----------- --
`435/7-24
`7/1994 V0l8nder et 81.
`210/1982
`7/1994 Dlxlket 81
`257/530
`8/1994 D6591 ct a1~ --
`524/56
`8/1994 Abadéer et a1- -
`307/219
`8/1994 ovshmsky 9t 91-
`369/288
`8/1994 Schatl ct a1~ - - - -
`- - - -- 435/6
`8/1994 Are/“Zen et al-
`435/181
`9/1994 LeWlS ct a1~ -
`430/19
`9/1994 (3890118181 ------------ ~~ 340/572
`9/1994 KnZek et a1. ............. .. 342/201
`9/1994 Koreyfisu 9t 91
`422/67
`9/1994 Georglou ct a1~ -------- -- ‘135/697
`9/1994 Scheckel et a1. .......... .. 235/492
`9/1994 Lake 51 a1
`~~ 429/124
`9/1994 D’_H_<>I1t ct a1~ -------------- -- 342/42
`
`
`
`
`
`5,352,579 A 10/1994 MllllIIlaIl ..................... .. 5,353,795 A 10/1994 SouZa et a1. .. 128/653.2
`
`5,359,115 A 10/1994 Campbell et a1. ......... .. 558/110
`5,359,250 A 10/1994 TOda ........................ .. 310/313
`5,361,385 A 11/1994 13611616611
`395/124
`5,362,899 A 11/1994 (36111116611 ................. .. 558/108
`5,364,797 A 11/1994 Olson 6161. .............. .. 436/501
`5,366,733 A 11/1994 1311ZZo1616 6161.
`.. 424/426
`5,374,718 A 12/1994 H6111111o1111 6161. .... .. 536/24.32
`5,377,678 A
`1/1995 Dumoulin 6161. ..... .. 128/653.1
`5,381,035 A
`1/1995 (311611 6161.
`257/530
`5,383,873 A
`1/1995 Hoey 6161. ............ .. 604/891.1
`5,384,028 A
`1/1995 11o ........................... .. 204/403
`
`DE
`DE
`DE
`DE
`DE
`EP
`EP
`EP
`EP
`
`5,384,261 A * 1/1995 Wrinkler et a1. .......... .. 436/518
`5,384,481 A
`1/1995 HolZWorth 6161. ....... .. 257/530
`2,386,024 A * 1/1992 izfacian et all.
`........... .. 536/2554
`389,449 A
`2/199
`eV911 at a- ------------ -- 428/ 23
`53896534 A
`2/1995 Von Gemlkow eta1~
`435/180
`
`2632612: A 7 1
`
`
`5,395,587 A
`273327338 2
`5,399,339 A
`
`51332 ffmllashitalet a1~ ~~~~~~~~ ~~ 1% ere a' ~~~~~~~~~~~~~~ ~
`
`3/1995 Br~lgham—Burke et a1. . 422/68.1
`Z1332 ggiggnetefla'l """""""" "332/54;
`3/1995 1366611161111 61 61.
`424/153
`
`356/301
`3/1995 vo-D11111 ......... ..
`5,400,136 A
`2O4/418
`3/1995 King etaL
`5,401,378 A
`. 435/235.1
`4/1995 L61111616161.
`5,403,484 A
`436/531
`4/1995 Braatz et a1'
`5,403,750 A
`436/518
`4/1995 Pirrung et aL _
`5,405,783 A
`530/308
`4/1995 81111111 6161. ....... ..
`5,408,037 A
`250/364
`4/1995 Thompson 6161. ..
`5,410,155 A
`606/117
`5/1995 (361111111611 6161.
`RE34,936 E
`365/96
`5/1995 M6g616161.
`5,412,593 A
`. 530/334
`5/1995 D6661 .......... ..
`5,416,193 A
`342/42
`5/1995 Koert et a1'
`5,416,486 A
`558/11O
`5/1995 Campbell
`5,420,328 A
`.. 340/870.31
`5/1995 011166 6161.
`5,420,579 A
`.. 340/825.54
`6/1995 011166 6161.
`5,422,636 A
`........ .. 435/6
`5,424,186 A * 6/1995 Eodo16161.
`........ .. 435/5
`5,432,018 A
`7/1995 Dower 6161. ..
`5,435,937 A
`7/1995 136116161. ............ .. 252/301.18
`5,437,277 A
`8/1995 Dumoulin et a1' _____ u 128/653_1
`5,438,439 A
`8/1995 Mok 6161. .................. .. 359/10
`5,440,511 A
`8/1995 Y61116111o1o 6161.
`365/189.05
`5,442,212 A
`8/1995 Eimori ~~~~~ n
`_ 257/303
`5,442,584 A
`8/1995 Jeong 6161.
`365/149
`5,442,940 A
`8/1995 8661161 6161.
`128/670
`5,443,066 A
`8/1995 Dumoulin 6161. ..... .. 128/653.1
`5,443,816 A
`8/1995 Z6111o16 6161.
`424/1.69
`5,443,953 A * 8/1995 116116611 6161.
`424/1.49
`5,445,150 A
`8/1995 Dumoulin 6161. ..... .. 128/653.1
`5,447,533 A
`9/1995 v6611o11 6161. ..... ..
`607/120
`5,449,941 A
`9/1995 YaIIlaZaki 6161. ........ .. 257/411
`5,451,683 A * 9/1995 136116116161. .......... .. 548/3027
`5,451,896 A
`9/1995 Mo11 .............. ..
`327/543
`5,452,251 A
`9/1995 Akaogi 61 61. ............ .. 365/200
`5,452,311 A
`9/1995 W6116 6161. ............. .. 371/51.1
`5,453,633 A
`9/1995 Yun
`_ 257506
`5,457,184 A 10/1995 L61111 6161. ................. .. 534/15
`5,463,564 A 10/1995 Ag16?o116 6161. ........ .. 364/496
`5,482,867 A
`1/1996 136116116161.
`436/518
`5,489,678 A
`2/1996 Fodor 6161. ............. .. 536/221
`5,491,074 A
`2/1996 Aldwin 6161. ........... .. 435/69.7
`5,498,530 A
`3/1996 SChatZ 6161.
`435/69.1
`5,503,805 A
`4/1996 sug61111611 6161. ........ .. 422/131
`5,527,681 A
`6/1996 Ho111166 ....................... .. 435/6
`5,541,061 A
`7/1996 Fodor et a1_
`435/6
`5,545,531 A
`8/1996 R6v6 6161. .................. .. 435/6
`5,547,839 A
`8/1996 Dower 6161. ................ .. 435/6
`5549974 A
`8/1996 Holmes _______ __
`428/403
`5,556,762 A
`9/1996 P1111116 6161. .......... .. 4351/7.21
`5,572,410 A 11/1996 G1161616o11 ................. .. 361/807
`
`5,641,634 A
`
`6/1997 Mandecki ________________ u
`
`FOREIGN PATENT DOCUMENTS
`
`4310169
`4213065
`4313807
`4306563
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`9/1993
`10/1993
`11/1993
`9/1994
`12/1994
`10/1986
`7/1990
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`EP
`EP
`EP
`EP
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`EP
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`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
`WO
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`2/1993
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`2/1993
`0526173 A3
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`* 4/1993
`0541340
`5/1993
`0554955
`8/1993
`0569215
`11/1993
`0637750
`2/1995
`0640826
`3/1995
`2110030
`5/1972
`2526169
`4/1983
`2555744
`5/1985
`2306484
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`8603840
`7/1986
`8801302
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`8901157
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`8908264
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`9015070
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`9201268
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`9207093
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`9209300
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`9210092
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`9306121
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`9308472
`* 4/1993
`9413402
`* 1/1994
`9402634
`2/1994
`9405394
`3/1994
`9408051
`4/1994
`9411388
`5/1994
`9413623
`6/1994
`9414980
`* 7/1994
`9417208
`8/1994
`9422889
`10/1994
`9426413
`11/1994
`9428424
`12/1994
`9500530
`* 1/1995
`9502566
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`9624061
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`9720073
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`9720074
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`.......... .. C12Q/1/68
`
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