PHIGENIX
`PHIGENIX
`Exhibit 1026
`Exhibit 1026
`
`

`
`IN THE UNITED STATES PATENT" AND TRADEMARK OFFICE
`
`PATENT A_PPLICATlON
`
`111 re Application of:
`
`Attomey Docket No: ‘£10421
`
`Walter BLALTTLER
`
`Confirmation No.2 4593
`
`Appln. No: 11/949,351
`
`Group ArtUnit: 1543
`
`Filed: Deceniher 3, 2007
`
`Examiner: Nat-arajzm, Meera
`
`For:
`
`huMab4D5—8 ANTI~ErbR2 V
`ANTIBODY-MAYTANSINOID CONJUGATES
`
`DECLARATIION UNDER 37 CJIR. § 1.132
`
`MAIL STOP AMENDMEN'I‘
`Commissioner for Patents
`i R0. Box 14-50
`
`Alexandria, VA 223134450
`
`Sit‘:-_¢
`
`state:
`
`We, Walter A. Bliittler and Ravi V. J. Chari, the undersigned, hereby declare and
`
`Z
`
`That we are the joint inventors of the subject mat-‘:e.r claimed in the
`
`above—identified applicatiozi, wliiczh includes an imniunoeonjugate comprising the anti-
`
`ErbB2 antibody, huMab4D5-8, conjugated to a maytansinoid, e.g., DM1, wherein the
`
`antibody is conjugated to 3 to 5 niaytansinoid molecules per antibody moiecule, and
`
`wherein the antibody and maytansinoid are chemically linked by a disulfide or thioether
`
`group, and wherein the antibody and maytansinoid are conjugated by a chemical ‘sinker,
`
`e.g., N-succinimidyl~3—«(2- pyridyldithio)propionate, N=sueciuimidyl-4~(2-
`
`pyridyltbio)pe11tano ate or sueoinimidyl-4-{N-maleimidomethyl)cyciohexane1~
`
`earboxylate, and a composition comprising the immunoconjugate and 2. ph.armaceuti.eally
`
`acceptable carrier;
`
`Tiiat this subject matter is not claimed in the U.S. Patents and Publications listed
`
`in the attached chat’: (Appendix A), and that to the extent that this subject matter is
`
`PHIGENIX
`
`Exhibit 1026-01
`
`

`
`
`
`Ii1a(:;1ur;xI{gxt1’1,:<3:~‘z’I;U_N1)»E1¥:37 cma. § 1.132
`U__}-
`‘._A;_;;pl[i‘:caf’i’un:'-Nii; v13—1l9i~‘¥‘9,351
`(_Atm1:~.ne‘.:.'r I)o::ij:é—t N_‘o._ 2'1-Vg;jx_."_a_ai21)
`
`-d-i=s<:I:c:s1etI In Pa:e:m§.--iand.}?1:‘d!'i%:z1;im3sVQinsr-me »at‘tachedP.~<:1u%ai?1%::'(fA;pp¢z;dix.;.A’},
`ti;c=$iI'¥23j¢:‘«:t mzittet aexaivved‘ @111 .115‘,
`
`We jc?.¢i>.laf_c..fi1-1?l11¢r .ti1'a't‘=_iz:,l’}:::smt:m1ent$ .;tzi;".«‘id'<*« .¥1.j¢fi=;i.x ‘ nus?-='uwn ?k1:dwi‘ec5;gjc:=-a_:~e.i;_r,-he
`a111“t:itlfx’a_’t‘ba_i1 staigxpetzts n1adé_x)“n_. in7£'éi;?n1a=ti.().i2;::_sm;i 5{.>_ejl_.ii<::f,":1r:;:= b’t:1-I§i'x:x-<<*:i_cf1“‘£(i;_-béftl
`mad fiariiiaer
`111.’;-xjt 'tIJ¢s§s_:'_ s_r;:'te.m_ezxt‘s*K-%.*:::i1“1;;L1'::=*u'zic3i“e ‘\r«‘it11».ti1£::?.l¥:_t1n3v£_\?_}:t:aLi;=,I1“:_{hat wi'1If§;1£.fi1Ise:.st::1emt::1ts agzugi me.
`;§Zz:15.!1i$lv'Iz'1‘-bié ‘by: =1j*m_'.: _‘o1=‘i1_11p;:iAs_c;nmrenf,- gar‘ I13:i::';t111',uu_x‘1,t‘ffe.rjS;5:;tic;n=
`
`_. fill o’-5'1’-i.t:1.r.:
`Sfiites CT<zde,s.;i:1”<I fiia;l gzvuczii-._w.i:ll_;_t ‘rii_ faiI‘5€:'si:%i§;*§1:ie;iis
`n,";1§,§_'i::‘¢pzi:t?t§5i2¢..il1e
`ji8" .qf.t¥1e
`yaiiégity‘ of the ap}}1f‘(,:ati.()i1;d;*;;iuy’jp&£i:nt‘i'ss:L;3i11g1 {I-‘L-i‘E>£r‘()-I1fp::
`
`
`
`PHIGENIX
`
`Exhibit 1026-02
`
`

`
`..f‘3‘«;..‘m..«mw.m«
`
`DECLARATION UNDER 37 C.F.R. § 1.132
`U.S. Application No. 11/949,351
`(Attorney Docket No. AI0421)
`
`APPENDIX A
`
`.............“.___.._.... M0,“.
`1,
`Inv.e10.’t0r§V ‘
`I
`‘.
`3‘
`-- sf.
`.._..........;......,......mm.0..............,....,..,.“....“....0......
`V‘
`3
`‘
`5:
`" HSEI '-“ ai
`
`
`
`
`
`L’1
`
`;%fi;0ma“:‘7s427s9 1
`1
`1100121 ah
`...‘..‘..«,"...............................2....“.w....\,..,,,.....
`....._,M__._..._.....W 3
`.?_§HsE1eta1.
`inns. 1>éét0n1N0. 0147030
`.
`_
`
`
`
`
`
`
`
`
`1.I~.S.~0%€:0:Es>;.§§2_:iZ351....
`
`;s A"2i1011mz3';'721'3'5‘21‘i’é3“’
`
`
`
`
`
`7
`._..
`§:“Li.k..Tfé:-r‘-[.‘.i€-‘-:1.‘-:{-'-L§------~»--—----
`\~--~--k~--u»»u~~».~--.Q;. 1 ....................
`.,._.,,,,.,,.,,_«,,.,,,,.,,.,....,,.....~................4,.. .....................0-...«..-._.,..7_»,..«..........m.....““.\-1..“-“wM“.““.‘ ‘
`A
`:1 B¢‘{1‘G'}.§§l.{‘ N ,.g_
`""""""""
`
`
`
`
`%TI‘S'
`N0. 5
`1 US. Patent No. ,0_0f271._
`......................;.»...v.......»...,. _.,_
`;::.‘i—T~\S““‘fl;’V;21<'=;111t.'1§.1'o. 70_41292"“
`_.~_}_fatcnt
`
`
`
`.....;........s. .....................
` I U.S.
`.1?at?nt.1i“E2§.i°ati°fl Ti.*’9- 200$°299 1?-.9.......§ A
`. .. .
`U.S. Patent Pfibiication No. 201 10110352
`
`.
`I
`;. 0U.s..0Pace:{t_1>i;b110a0;mNo. 20100003252
`:1.
`
`
`. ...».._-..».».._;-.».r..........._......_...._..3.....,v...,.........._...
`“us. Patent 13001100000 Np. 20030000924"
`_s,;_L._11z.(_1<,'_._F<33y.s,___1;<1\__A
`-------—~-----—--—---~.-. -~»---
`-h--n --’-v-s------»--------.-3.2---7,--.—.3§
`US. Patent Publication No. 20040013667
`"I<iiif.7si§:Y‘e;‘a1I"
`_{‘UIS;"Pkif0iit"PfibIiA0é1i0h'N0. 2AGG6G2'I6285?‘x"“’§§ ’é't_‘_
`Patent ‘Publication 1010.. 2'O0.'l0.18.4G5:‘;’_
`.1. SLIWKOW BKI
`U.’S,,,Pat¢r1t 00011000100 N0. 20070209429-’;__ E KELSEY ‘et“a.1;‘
`«s-w,....»...-.»,._,».~».-._-.~x,...-.
`.
`.
`A-*9.
`. .--—-—-......».—-.»~——-—;—-
`U.S. PatentVPub1ication No; 2_(_)1 101294642
`V§JR\\‘IRAR§Ah§I&<AAAP>~
`j 001. Patefii P1ib1i0afi0ii1Nf0.. 21020601033073
`Pa1e 900s743‘2*
`
`
`
`
`
`_'\ U.3.
`
`; _1j_§1_§§nt Publication No. 290890503 73 ‘
`
`
`
`
`.
`
`2
`
`
`5
`
`
`
`' Cited in In.f0rmat5.on Disclosure Statement filed July 16, 2012
`2 Cited in Information Disclosure Statement filed January 5, 2012
`
`-3-
`
`PHIGENIX
`
`Exhibit 1026-03