`
`
`
`
`
`
`PHIGENIX
`PHIGENIX
`Exhibit 1001
`Exhibit 1 00 1
`
`
`
`(12) Unlted States Patent
`(10) Patent No.:
`US 8,337,856 B2
`
`Bliittler et al.
`(45) Date of Patent:
`*Dec. 25, 2012
`
`USOO8337856B2
`
`.................. 536/235
`................ 424/1811
`
`................... 530/326
`
`............ 424/1301
`. 424/1431
`. 530/3873
`. 424/1381
`424/93,7
`.....
`.............. 435/691
`
`
`
`............. 424/1951
`
`................. 435/696
`
`............... 424/1431
`
`
`
`5,183,884 A
`5,208,020 A *
`5,217,713 A
`5,395,924 A
`5,416,064 A
`5,480,968 A
`5,514,554 A
`5,639,641 A
`5,648,237 A
`5,677,171 A
`5,679,648 A
`5,705,157 A
`5,725,856 A
`5,747,261 A
`5,772,997 A
`5,783,186 A
`5,821,337 A
`5,824,311 A
`5,837,234 A
`5,840,525 A
`5,877,305 A
`5,919,815 A
`5,968,517 A
`6,022,541 A
`6,054,297 A *
`6,333,410 B1
`6,436,931 B1
`6,441,163 B1
`6,531,131 B1
`6,627,196 B1
`233% E?
`,
`,
`6,914,130 B2
`6,949,245 B1*
`7,030,231 B1
`7,041,292 B1
`7,097,840 132
`7,122,636 B1
`7,214,776 132
`7,276,497 B2
`7 288 249 B2
`7,303,749 B1
`7:375:078 B2
`7,435,416 B2
`
`2/ 993 Kraus et a1.
`5/ 993 Chari et al.
`6/ 993 Iwasa et al.
`3/ 995 Blattleretal.
`5/ 995 Chariet al.
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`5/ 996 1330115
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`12/2001 Chari et a1.
`8/2002 Charietal.
`8/2002 Chan et 31'
`3/2003 Gu etal.
`9/2003 Bqughman et al.
`1%882 $145011:th
`1.
`evaux e a.
`7/2005 Gao et a1.
`9/2005 Sliwkowski
`4/2006 Craik et al.
`5/2006 Sliwkowski
`8/2006 Erickson et 31.
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`10/2008 Devaux et a1.
`(Continued)
`
`(54) METHODS OF TREATMENT USING
`ANTI-ERBB ANTIBODY-MAYTANSINOID
`
`CONJUGATES
`
`(75)
`
`Inventors: Walter Blattler, Brookline, MA (US);
`RaviV. J. Chari, Newton, MA (US)
`
`.
`~
`(73) ASSlgnee Immunogen9 Inc" Waltham, MA (Us)
`.
`*
`.
`.
`.
`.
`) Not1ce:
`Subject to any d1scla1mer, the term of this
`patent is extended or adjusted under 35
`U.S.C. 15403) by 839 days.
`
`(
`
`This patent is subject to a terminal dis-
`claimer.
`
`.
`(21) APPLNO" 110493351
`.
`Flled:
`
`DeC- 3, 2007
`
`(22)
`
`(65)
`
`Prior Publication Data
`
`US 2008/0226659 A1
`
`Sep. 18, 2008
`
`Related U.S.Application Data
`
`(60) Division of application No. 11/488,545, filed on Jul.
`17, 2006, now Pat. No. 7,575,748, which is a
`.
`.
`.
`.
`cont1nuation of application No. 09/811,123, filed on
`Man 16, 2001,110W Pat N0~ 7,097,840
`.
`.
`.
`.
`Prov1s1onal application No. 60/238,327, filed on Oct.
`5, 2000, prov1s1onal application No. 60/189,844, filed
`011 Mar.
`16, 2000, provisional application No.
`60/327,563, filed on Jun. 23, 2000.
`
`(60)
`
`(51)
`
`Int“ Cl“
`(200601)
`A61K 39/00
`(52) US. Cl.
`.................................. 424/181.1; 530/387.1
`(58) Field of Classification Search ........................ None
`See application file for complete search history.
`
`FOREIGN PATENT DOCUMENTS
`
`(56)
`
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`It d
`IDS fil d] 1 6 2010 *
`Cl e on
`e
`u '
`’
`'
`
`-
`(commued)
`
`Primary Examiner 7 Laura B Goddard
`-
`- 7
`~
`.
`ASS’SmmExammer Mega Natarajan
`(74) After/16y, Agent, or Firm * Sthrue M1011, PLLC
`
`ABSTRACT
`(57)
`The application concerns methods of treatment using anti-
`ErbB receptor antibody-maytansinoid conjugates,
`and
`articles of manufacture suitable for use in such methods. In
`particular,
`the 1nventlon concerns ErbB receptor-d1rected
`cancer therapies, using anri-ErbB receptor antibody-may-
`tansinoid conjugates.
`
`8 Claims, 46 Drawing Sheets
`
`PHIGENIX
`
`Exhibit 1001-01
`
`
`
`US 8,337,856 B2
`
`Page 2
`
`US. PATENT DOCUMENTS
`
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`
`
`
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`
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