37th Annual Meeting & Exposition of the
`Controlled Release Society
`
`CRS 2010 Program
`
`J u l y 1 0 - 1 4 , 2 010 • Oregon Convention Center • Portland, Oregon, U.S.A.
`P e r s onalized Medicines and Products for the Next Generation
`
`Photo by Steve Terrill, courtesy of Travel Portland.
`
`

`
`3 M D R U G D E L I V E R Y S Y S T E M S
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`Explore our MTS capabilities
`at CRS (Booth 525-27) and
`get Post-It® Flags to highlight
`programs of interest in your
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`US: 1 800 643 8086
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`©3M 2010. All Rights Reserved. 3M is a trademark of 3M Company.
`
`E N A B L I N G Y O U R S U C C E S S .
`
`

`
`Dear Colleagues:
`As president of the Controlled Release Society (CRS), it is my pleasure to welcome you to the
`37th Annual Meeting & Exposition of the Controlled Release Society!
`This year, we convene in the beautiful Pacific Northwest city of Portland, where I know you’ll
`experience fresh air and I am sure that our conference will stimulate much fresh thinking. The
`CRS Annual Meeting & Exposition is a diverse and far-reaching experience attracting attendees
`from around the world. The Oregon Convention Center provides the perfect venue in which
`to see old friends, make new connections, strengthen important collaborations, and enhance
`professional development.
`The 2010 program promises to be one of discovery with many new programs and events:
`CRS Innovation Sunday, CRS Partnering, Women in Science Luncheon, Young Scientist
`Committee’s Networking Night at Bridgeport Brewing Company, and the After Party following
`the Closing Banquet. Yes, we have a lot of new and fun events for you to enjoy, and I hope that
`these enhance your experience at this our 37th Annual Meeting & Exposition. Make sure that
`you take advantage of these great networking opportunities! CRS Scientific Secretary Ijeoma
`Uchegbu and 2010 program chairs—David Putnam, Leila Zarif, Ick Chan Kwon, Christophe
`Barbe, James Oxley, and Mike Rathbone—have planned a terrific scientific program and
`I thank them for their efforts.
`I welcome you to the City of Roses, Portland, Oregon. I hope you have planned some free time
`before or after the meeting to enjoy all that Portland and the surrounding area has to offer
`visitors. Have a fabulous time at the 2010 CRS Annual Meeting & Exposition. Be sure to check
`out our scientific sessions, poster sessions, networking events, and do not miss the opportunity to
`connect with our wonderfully supportive exhibitors. Remember to let me know how you find the
`meeting by filling out our surveys!
`It’s been my honor and also my personal and professional pleasure to serve the CRS membership
`this past year. Best wishes for a successful annual meeting!
`Best regards,
`Diane J. Burgess, Ph.D.
`CRS President
`
`1
`
`

`
`General Meeting
`Information
`
`Program Modifications —All information is subject to change
`without notice. Please consult the program addendum for
`changes. All meetings and events take place at the Oregon
`Convention Center unless otherwise stated.
`Attendee Services Desk
`The Attendee Services Desk is located at the Oregon
`Convention Center, Pre-function C. The Attendee Services
`Desk will be open as follows:
`Saturday, July 10
`07:15-15:00
`Sunday, July 11
`07:30-19:00
`Monday, July 12
`07:00-18:00
`Tuesday, July 13
`07:00-17:30
`Wednesday, July 14
`07:45-13:30
`CRS Partnering
`Sponsored by Valeo Partners
`Making its annual meeting debut, CRS Partnering offers
`one-on-one partnering opportunities to help attendees
`connect with just the right contact for a project, product, or
`innovative collaboration. Already signed up with scheduled
`appointments? You’ll find the primary partnering location in
`the Exposition Hall. Pending availability, private rooms may
`be reserved at the CRS Partnering Concierge Desk. Not yet
`signed up? Go to the CRS Attendee Services Desk to register.
`Want to add more appointments? Just use your laptop or
`the Web Café in the Exposition/Poster Hall. Questions?
`You’ll find help at the CRS Partnering Concierge Desk in the
`Exposition/Poster Hall.
`CRS Partnering Registration Hours
`Sunday, July 11
`08:00-16:30
`Monday, July 12
`08:00-16:30
`Tuesday, July 13
`08:00-16:30
`Wednesday, July 14
`08:00-13:00
`Committee Meetings
`CRS committees are invited to schedule meetings. Use of the
`committee meeting room is by reservation only. Reservations
`can be made at the Attendee Services Desk. The room is
`available for use through the duration of the Annual Meeting
`& Exposition.
`Exposition Hours and Location
`The Exposition is located in Oregon Convention Center,
`Halls B/C. The scheduled Exposition activities are as follows:
`Saturday, July 10
`08:00-17:00
`Sunday, July 11
`08:00-14:00
`17:30-19:00
`
`Exhibit Set Up
`Grand Opening of the Exposition/Poster
`Hall and Welcome Reception
`
`Exhibit Set Up
`
`Table of Contents
`General Meeting Information ............................... 2
`Oregon Convention Center Floor Plan ................ 4
`Schedule-at-a-Glance
` Saturday–Sunday .............................................. 5
`Schedule-at-a-Glance
`Monday–Wednesday ........................................ 6
`Daily Schedule
` Saturday ............................................................ 8
` Sunday ............................................................ 10
` Sunday Releasing Technology Workshops ...... 14
` Sunday Soapbox Sessions ............................... 16
` Monday .......................................................... 18
` Tuesday ........................................................... 24
` Wednesday ...................................................... 33
`Posters ................................................................ 39
`Exposition .......................................................... 59
`Sponsors ............................................................. 71
`Acknowledgements ............................................ 78
`Author Index ...................................................... 81
`Keyword Index ................................................... 89
`Affiliation Index ................................................. 91
`
`Advertisers’ Index
`3M Drug Delivery Systems ...................... Cover II
` www.3m.com/dds
`Drug Delivery Technology ........... Expositions Tab
` www.drugdeliverytech.com
`Elan Drug Technologies ......................... Cover IV
` www.elandrugtechnologies.com
`Elsevier ............................................................... 17
` www.elsevier.com
`Eurand Pharmaceutical
` Technologies ................. Program Schedules Tab
` www.eurand.com
`NOF Corporation ............................... Posters Tab
` www.nof.co.jp/dds
`Texture Technologies Corp. ................. Indices Tab
` www.texturetechnologies.com
`
`2
`
`

`
`Monday, July 12
`09:00-17:00
`09:00-10:00
`
`12:00-14:00
`
`15:00-15:30
`
`Exposition/Poster Hall Open
`Networking Opportunity and Refreshment
`Break; coffee available for purchase
`Networking Opportunity; lunch available
`for purchase
`Networking Opportunity and Refreshment
`Break; coffee available for purchase
`
`Tuesday, July 13
`09:00-17:00
`09:00-10:00
`
`12:00-14:00
`
`12:00-13:30
`
`Exposition/Poster Hall Open
`Networking Opportunity and Refreshment
`Break; coffee available for purchase
`Networking Opportunity; lunch available
`for purchase
`Wednesday, July 14
`09:00-13:30
`Exposition/Poster Hall Open
`09:00-10:00
`Networking Opportunity and Refreshment
`Break; coffee available for purchase
`Networking Opportunity; lunch available
`for purchase
`Exhibit Take Down
`13:30-17:30
`Message Board
`For your convenience, a message board is located in
`Pre-function C.
`Abstract Printing Station
`Attendees may print abstracts at the Abstract Printing Station
`located in Pre-function C.
`Meeting and Future Event Literature
`Space for the display of promotional materials for future
`educational meetings is available in the Exposition/Poster Hall.
`Organizers of educational meetings and events may display
`their materials in this reserved location. Any literature that is
`left on tables other than this designated location and/or does
`not promote educational meetings will be discarded.
`Poster Sessions I, II, and III
`Co-sponsored by AstraZeneca
`The posters are located in the Exposition/Poster Halls B/C.
`Schedules for Poster Sessions I, II, and II are listed below. All
`posters must be removed at the times indicated or they will be
`removed and disposed of.
`Poster Session I
`Set Up
`Sunday, July 11
`Authors Present
`Monday, July 12
`Take Down
`Monday, July 12
`Poster Session II
`Set Up
`Monday, July 12
`Authors Present
`Tuesday, July 13
`Take Down
`Tuesday, July 13
`
`15:00-16:00
`
`13:00-14:00
`
`15:30-16:30
`
`16:30-17:30
`
`13:00-14:00
`
`15:30-16:30
`
`16:30-17:30
`
`12:30-13:30
`
`13:30-14:30
`
`Poster Session III
`Set Up
`Tuesday, July 13
`Authors Present
`Wednesday, July 14
`Take Down
`Wednesday, July 14
`CRS Career Center
`A103/104
`The CRS Career Center is your resource for professional
`development. Companies are invited to post available positions.
`The CRS Career Center will be open during these hours:
`Sunday, July 11
`09:00-17:00
`Monday, July 12
`09:00-17:00
`Speaker Preparation Room
`C120
`The Speaker Preparation Room is available for PowerPoint
`previewing and downloading presentation materials. Speakers
`are to upload presentations one day prior to their presentation
`date, i.e., if you speak on Monday, July 12, you will upload your
`presentation on Sunday, July 11. Presenters are not allowed to
`use their own laptops.
`The Speaker Preparation Room will be staffed and open as
`follows:
`Saturday, July 10
`
`Sunday, July 11
`
`Monday, July 12
`
`Tuesday, July 13
`
`Web Café
`The Web Café is located in the Exposition/Poster Hall and is
`available for all attendees to check and send e-mail. The Web
`Café will be open the following hours:
`Sunday, July 11
`17:30-19:00
`Monday, July 12
`09:00-17:00
`Tuesday, July 13
`09:00-17:00
`Wednesday, July 14 09:00-13:00
`Press Room
`C122
`Members of the press are welcome to use this room during
`these hours:
`09:00-17:00
`Sunday, July 11
`09:00-17:00
`Monday, July 12
`09:00-17:00
`Tuesday, July 13
`Wednesday, July 14 09:00-13:00
`
`10:00-14:00
`Sunday speakers upload presentations
`07:30-16:30
`Monday speakers upload presentations
`07:30-16:30
`Tuesday speakers upload presentations
`07:30-16:30
`Wednesday speakers upload presentations
`
`3
`
`

`
`4
`
`

`
`
`
`
`
`Schedule-at-a-Glance
`
`Saturday–Sunday
`
`
`Saturday
`
`
`
`Educational
`Workshops (running
`concurrently):
`
`
`
`08:00-17:15
`Characterization of
`Nanoparticles and
`Microparticles Using
`State-of-the-Art
`Techniques
`
`
`
`08:00-18:00
`Enhancing
`Bioavailability
`of Poorly Soluble Drugs
`via Melt Extrusion
`Technology:
`From Formulation
`to Commercialization
`
`
`
`09:00-17:30
`Nanomedicine: From
`Materials Design to
`Clinical Applications
`
`
`
`
`Time
`
`08:00
`
`
`
`09:00
`
`11:00
`
`
`
`12:00
`
`
`
`13:00
`
`
`
`14:00
`
`
`
`15:00
`
`
`
`16:00
`
`16:30
`
`17:00
`
`17:30
`18:00
`
`19:00
`
`
`
`
`
`
`
`
`
`
`
`Pearls of Wisdom Sessions:
`Bioactive Materials/Young Scientist
`Consumer & Diversified Products
`Veterinary
`Grand Opening Exposition and Welcome Reception
`
`
`State of the Industry Keynote
`
`
`
`
`
`
`
`5
`
`
`Young Scientist Workshop II:
`True Stories;
`Career Development
`
`
`
`
`
`Young Scientist
`Workshop I:
`Improving the
`Solubility of
`Poorly Soluble
`Drugs
`
`
`
`
`
`
`
`
`
`Sunday
`
`
`
`
`Roundtable
`Discussions
`and Focus
`Groups:
`
`Oral Drug
`Delivery
`
`Tablet and
`Capsule
`Manufacturing
`
`
`
`First Timers’
`Meeting and
`Volunteer
`Fair
`
`CRS Mentorship Program:
`Introduction
`Roundtable
`Discussion
`and Focus
`Group:
`Nano-
`medicines
`
`
`
`Roundtable
`Discussion:
`Young
`Scientist
`CRS Innovation Sunday
`Open Forum:
`From Bench to Market—The
`Route to Commercial Success
`
`
`
`
`
`
`
`
`
`
`
`
`Releasing
`Technology
`Workshops
`
`
`Soapbox
`Sessions
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`

`
`
`Tuesday
`
`
`Wednesday
`
`Get Up! Get Educated!
`
`
`
`Plenary Session
`Frank Szoka
`University of
`California-San
`Francisco, USA
`
`Networking
`Exposition
`Poster Viewing
`
`Mentor/Protégé
`Meet and Greet
`
`Plenary Session
`Mauro Ferrari
`University of Texas-Houston, USA
`
`
`
`Networking
`Exposition
`Poster Viewing
`
`Scientific Sessions/Mini-symposia:
`Encapsulation for Environmental
`Protection
`Medical Devices
`siRNA/Micro RNA
`Oral Delivery I
`PEGylated Technologies
`Vaccines
`
`
`Networking
`Exposition
`Poster Viewing
`
`(Lunch available
`for purchase)
`
`Poster Session II
`Authors Present
`13:00-14:00
`
`
`Highlights of
`Student Posters
`
`
`
`Members’ Meeting
`Awards Ceremony
`College of Fellows
`Induction
`
`Plenary Session
`Hiroshi Maeda
`Sojo University, Japan
`
`Break
`
`Awards Showcase
`
`Scientific Sessions/Mini-symposia:
`DNA Delivery
`Encapsulation of Cells & Microorganisms
`Intracellular Trafficking
`Liposomes
`Oral Delivery II
`Tumor Targeting
`
`
`Scientific Sessions/Mini-symposia:
`Environmentally Friendly and
`Biodegradable Controlled Release
`Systems
`Biomedical Photonics: In Vivo
`Diagnostics of Malignancy with
`Targeted Delivery Tools
`Sten Cells—Yes, We Can!!
`Nanomedicines I
`Hydrogels
`Networking
`Exposition
`Poster Viewing
`
`(Lunch available for purchase)
`
`Poster Session III
`Authors Present 12:30-13:30
`Plenary Session
`Nicholas Peppas
`University of Texas-Austin, USA
`
`Scientific Sessions/Mini-symposia:
`Biomaterials for Medicines
`Biomedical Imaging
`Vaginal Drug Delivery: Past, Present,
`and Future
`Nanomedicines II
`Tissue Engineering
`
`Meeting adjourned
`
`Schedule-at-a-Glance
`Monday–Wednesday
`
`
`Monday
`
`
`Young Scientist
`Workshop III:
`Team Working
`and Motivation
`
`
`
`Time
`
`07:00
`
`
`
`08:00 Plenary Session
`Raju Kucherlapati
`Harvard Medical
`School, USA
`
`
`09:00 Networking
`Exposition
`Poster Viewing
`
`
`
`Scientific Sessions/Mini-symposia:
`Theranostics: Diagnosis & Treatment in
`One Box
`New Chemistries for Drug Delivery
`Non-Parenteral Delivery of Biologics
`Novel Materials & Release Systems
`Opthalmic Medicines
`Prediction & Application of IVIVC for
`Veterinary Species
`Transdermal Drug Delivery
`Women in
`Networking
`Science Lunch
`Exposition
`(Tickets required)
`Poster Viewing
`
`
`(Lunch available
`for purchase)
`
`Poster Session I
`Authors Present
`13:00-14:00
`
`
`
`10:00
`
`
`
`12:00
`
`14:00
`
`14:30
`
`Plenary Session
`Ramin Najafi
`NovaBay Pharmaceuticals, USA
`
`15:00 Networking
`Exposition
`Poster Viewing
`
`15:30 Scientific Sessions/Mini-symposia:
`Biomarkers: The Needle in the
`Haystack
`Nanoparticles & Fibers for Controlled
`Release Systems
`Peptide & Protein Medicines
`Polymer Therapeutics
`Pulmonary Drug Delivery
`Translational Medicine
`
`Vet Get
`Together
`
`17:30
`
`
`Networking Night
`at BridgePort
`Brewing Co.
`(Ticket required)
`
`Closing Banquet and After Party
`Portland Art Musuem
`(Ticket required)
`
`18:30
`
`
`
`6
`
`

`
`Program Schedules
`
`37th Annual Meeting & Exposition of the
`Controlled Release Society
`
`Program Schedules
`
`Oregon Convention Center
`
`
`
`

`
`F01 Eurand CRS 2010 outlines.indd 1
`
`6/4/10 3:17 PM
`
`

`
`Enhance your professional
`development with CRS!
`
`Vaccine Development—CRS-IPTS Educational
`Workshop
`To be held immediately prior to the 15th International Pharmaceutical
`Technology Symposium
`September 11-12, 2010
`Kervansaray Lara Hotel, Antalya, Turkey
`
`Novel Methods for Developing Clinically Relevant
`Product Specifications
`Workshop co-sponsored by the American Association of
`Pharmaceutical Scientists and the Controlled Release Society.
`To be held immediately prior to the FIP Pharmaceutical Sciences
`World Congress 2010 in association with the AAPS Annual Meeting
`Saturday, November 13, 2010
`Morial Convention Center, New Orleans, Louisiana, U.S.A.
`
`CRS Product Development Forum – Poorly
`Soluble Drugs
`January 27–28, 2011
`Doral Golf Resort and Spa, Miami, Florida, U.S.A.
`
`38th Annual Meeting & Exposition of the
`Controlled Release Society
`July 30–August 3, 2011
`Gaylord National Resort and Convention Center
`National Harbor, Maryland, U.S.A.
`
`39th Annual Meeting & Exposition of the
`Controlled Release Society
`July 14–18, 2012
`Centre des Congrès de Québec
`Québec City, Canada
`
`

`
`Daily Schedule
`
`Saturday, July 10
`
`07:15-15:00
`08:00-17:00
`08:00-17:15
`
`
`08:00-18:00
`
`
`
`08:30-16:45
`09:00-17:30
`
`10:00-14:00
`12:00-13:30
`
`Attendee Services Desk Open
`Exhibit Set Up
`Educational Workshop: Characterization of Nanoparticles and
`Microparticles Using State-of-the-Art Techniques*
`Co-sponsored by Celanese EVA Performance Polymers
`Educational Workshop: Enhancing Bioavailability of Poorly Soluble
`Drugs via Melt Extrusion Technology: From Formulation to
`Commercialization*
`Co-sponsored by BASF and PolyMedex Discovery Group–Delivery Science
`Young Scientist Workshop I: Improving the Solubility of Poorly Soluble Drugs
`Educational Workshop: Nanomedicine: From Materials Design to
`Clinical Applications*
`Speaker Preparation Room Open
`Lunch for Educational Workshops (ticket required)
`
`Pre-function C
`Halls B/C
`A105
`
`A106
`
`C123
`C124
`
`C120
`B113/116
`
`Saturday
`
`*Additional registration required.
`
`Saturday Program Highlights
`
`Educational Workshop: Nanomedicine: From
`Materials Design to Clinical Applications
`Additional registration required.
`Chairs: Hamid Ghandehari, University of Utah, U.S.A., and
`Claus-Michael Lehr, Saarland University, Germany
`During this workshop the attendees will learn and engage in
`the discussion of concepts related to the design and synthesis/
`fabrication of nanomaterials, their interaction with cells and
`biological systems, and their translation to clinic.
`Educational Workshop: Characterization of
`Nanoparticles and Microparticles Using
`State-of-the-Art Techniques
`Additional registration required.
`Co-sponsored by Celanese EVA Performance Polymers
`Chairs: Zhibing Zhang, University of Birmingham, U.K., and
`Nicole Papen-Botterhuis, TNO Science & Industry, The
`Netherlands
`This workshop will provide knowledge on the possibilities of
`many state-of-the-art techniques to characterize encapsulates
`for various controlled release applications, such as (cryo)electron
`microscopy (SEM/TEM), dynamic light scattering (DLS),
`zeta potential measurements, dissolution testing (DSP), atomic
`force microscopy and micromanipulation, thermogravimetric
`analysis (TGA), differential scanning calorimetry (DSC),
`dynamic in vitro gastrointestinal models (TIM), confocal
`laser scanning microscopy (CLSM), in vivo toxicology studies
`of nanoparticles, permeation measurements for determining
`barrier properties, etc. After this workshop, you will be able to
`decide which characterization tool gives you the best answer to
`your problem.
`
`8
`
`Educational Workshop: Enhancing Bioavailability of
`Poorly Soluble Drugs via Melt Extrusion Technology:
`From Formulation to Commercialization
`Additional registration required.
`Co-sponsored by BASF and PolyMedex Discovery Group-Delivery
`Science
`Chairs: Nigel Langley, BASF, U.S.A., and Michael Repka,
`University of Mississippi, U.S.A.
`The workshop’s primary goal is to provide updates of existing
`knowledge for hot-melt extrusion (HME) such that attendees
`will increase their expertise with respect to this rapidly
`emerging processing technique. The workshop will also present
`an overview to those who are new to the technology such that
`these scientists may examine the opportunities available via
`HME. Attendees will also hear about the outlook regarding
`further perspectives for this technology.
`Young Scientist Workshop I: Improving the
`Solubility of Poorly Soluble Drugs
`Chairs: Raid Alany, University of Auckland, New Zealand, and
`Ron Ortiz, Upsher-Smith Labs, U.S.A.
`Technological advances in drug discovery have revolutionized
`the efficiency of lead identification. However, the promise of
`New Chemical Entities (NCEs) as suitable drug treatments
`can only be fulfilled if they can be successfully formulated
`and administered in vivo. One of the major barriers to
`the development of many NCEs is their poor solubility in
`aqueous media. This complimentary young scientist workshop
`will introduce the audience to the science underpinning the
`technologies for improving drug aqueous solubility. The secrets
`to successfully formulating a poorly soluble drug using a
`number of formulation strategies will be discussed. Examples of
`commercialized delivery technologies will be presented.
`
`

`
`Saturday
`
`9
`
`CRS Headquarters & Staff
`
`3340 Pilot Knob Road
`St. Paul, MN 55121 U.S.A.
`Telephone: +1.651.454.7250
`Facsimile: +1.651.454.0766
`www.controlledreleasesociety.org
`Steven C. Nelson, Executive Vice President
`+1.651.994.3832 • snelson@scisoc.org
`Amy Hope, Vice President of Operations
`+1.651.994.3827 • ahope@scisoc.org
`Barbara Mock, Vice President of Finance
`+1.651.994.3829 • bmock@scisoc.org
`Jody Grider, Director of CRS Operations
`+1.651.994.3862 • jgrider@scisoc.org
`
`Lisa Anderson, Administrative Coordinator
`+1.651.994.3809 • landerson@scisoc.org
`Jordana Anker, Technical Editor
`+1.651.994.3866 • janker@scisoc.org
`Leah Barna, Meeting Manager
`+1.612.813.0363 • lbarna@scisoc.org
`Susan Casey, Meeting Coordinator
`+1.651.994.3846 • scasey@scisoc.org
`Linda Schmitt, Program Supervisor
`+1.651.994.3828 • lschmitt@scisoc.org
`Cheryl Sundquist, Member Relations Specialist
`+1.651.994.3801 • csundquist@scisoc.org
`Debby Woodard, Exhibits, Sponsorship and
`Advertising Sales & Foundation
`+1.651.994.3817 • dwoodard@scisoc.org
`
`08:30-12:00
`08:30-08:45
`08:45-09:15
`
`09:15-10:00
`
`10:00-10:30
`10:30-11:15
`
`11:15-12:00
`
`12:00-13:00
`13:00-16:45
`13:00-13:45
`
`13:45-14:30
`
`14:30-15:15
`
`15:15-15:30
`15:30-16:15
`
`16:15-16:45
`
`Session 1: Advances in Technology
`Welcome and Workshop Objectives
`Introduction to Poorly Soluble Drugs, Ali
`Rajabi-Siahboomi, Colorcon, U.S.A.
`Technologies for Delivering Poorly Soluble
`Compounds, Dan Smithey, Agere
`Pharmaceuticals, U.S.A.
`Break
`Solid State Modification to Improve Drug
`Solubility, Paolo Gatti, Eurand, Italy
`Optimization and Development of a
`Cyclodextrin-based IV Formulation of a Poorly
`Water Soluble Compound, Sid Patil, Millenium
`Pharmaceuticals, U.S.A.
`Lunch Break
`Session 2: Administration Challenges
`Recent Advances on Nano-suspensions, Rajeev
`Gokhale, Abott Laboratories, U.S.A.
`Formulating Poorly Soluble Drugs Using
`Liposomes, Tom Redelmeier, Northern
`Lipids Inc., Canada
`Advances in Formulations of Poorly Soluble
`Drugs Using Self-Microemulsifying Drug
`Delivery Systems (SMEDDS), Anja Graf,
`University of Auckland, New Zealand
`Break
`Spray-Dried Dispersions (SDDs) for
`Solubilization: Immediate and Controlled
`Release Applications, Brett Caldwell, Bend
`Research, U.S.A.
`Panel Discussion
`
`

`
`Sunday, July 11 – CRS Innovation Sunday
`
`Speaker Preparation Room Open
`Attendee Services Desk Open
`Young Scientist Workshop II: True Stories; Career Development
`Exhibit Set Up
`CRS Partnering: See Page 2 for Details
`Sponsored by Valeo Partners
`Career Center Open
`Exhibitor Welcome and Orientation
`Releasing Technology Workshop: Elan Drug Technologies
`Releasing Technology Workshop: Analytical Solutions
`Tablet and Capsule Manufacturing Roundtable
`Oral Drug Delivery Roundtable
`Co-sponsored by Colorcon, Inc.
`Releasing Technology Workshop: ChemImage
`Releasing Technology Workshop: Pii
`Releasing Technology Workshop: Sotax
`Tablet and Capsule Manufacturing Focus Group
`Oral Drug Delivery Focus Group
`Co-sponsored by Colorcon, Inc.
`Releasing Technology Workshop: Eurand Pharmaceutical Technologies
`First Timers’ Meeting/Volunteer Fair
`Soapbox Sessions
`Co-sponsored by Molecular Profiles Ltd.
`Releasing Technology Workshop: OctoPlus NV
`Young Scientist Roundtable and Overview to the CRS
`Mentorship Program
`Nanomedicines Roundtable
`Releasing Technology Workshop: Lubrizol
`CRS Innovation Sunday – Open Forum
`From Bench to Market—The Route to Commercial Success
`Co-sponsored by Pfizer
`Nanomedicines Focus Group
`Poster Session I Set Up
`Pearls of Wisdom: Bioactive Materials/Young Scientist
`Co-sponsored by DSM Biomedical
`Pearls of Wisdom: Consumer & Diversified Products
`Pearls of Wisdom: Veterinary
`Co-sponsored by Merial
`State of the Industry Keynote
`Co-sponsored by Pfizer
`Grand Opening of the Exposition/Poster Hall and Welcome Reception
`(ticket required)
`
`C120
`Pre-function C
`C123
`Halls B/C
`
`A103/104
`A105/106
`B110/111
`B113/115
`A107/109
`C124
`
`B117/119
`B113/115
`B110/111
`A107/109
`
`C124
`B117/119
`A105/106
`B113/116
`
`B110/111
`
`C123
`C124
`B117/119
`A107/109
`
`C124
`Halls B/C
`C124
`
`B110/111
`B117/119
`
`A107/109
`
`Halls B/C
`
`07:30-16:30
`07:30-19:00
`08:00-12:00
`08:00-14:00
`08:00-16:30
`
`09:00-17:00
`08:30-09:15
`09:00-10:00
`09:00-10:00
`09:00-11:00
`09:00-11:00
`
`10:00-11:00
`10:30-11:30
`11:00-12:00
`11:00-11:30
`11:00-11:30
`
`11:30-13:00
`11:30-13:30
`12:00-14:55
`
`12:30-14:30
`12:30-15:00
`
`13:00-15:00
`13:30-14:30
`14:00-16:30
`
`
`15:00-15:30
`15:00-16:00
`16:30-17:30
`
`16:30-17:30
`16:30-17:30
`
`16:45-17:30
`
`17:30-19:00
`
`
`10
`
`Sunday
`
`

`
`Sunday
`
`CRS Innovation Sunday Program Highlights
`
`CRS Innovation Sunday
`Science • Partnering • Commercialization
`Co-sponsored by Pfizer
`Build your networks for success during CRS Innovation
`Sunday! Partnering, technology, innovation, big pharma,
`entrepreneurs, research, commercialization. You will find all
`of these elements in the fast-paced programming focused
`on taking innovative science into the commercial sector.
`By attending, you will network with developers from
`entrepreneurial start-ups, venture capital firms, mid-sized and
`major pharmaceutical companies, and academia.
`CRS Partnering
`08:00 – 17:00
`Making its annual meeting debut, CRS Partnering offers one-
`on-one partnering opportunities to help attendees connect
`with just the right contact for a project, product, or innovative
`collaboration.
`See page 2 for details.
`
`Releasing Technology Workshops
`This series of complimentary one- and two-hour workshops
`are scheduled throughout the day and are open to all registered
`attendees. These informative sessions focus on in-depth facets
`of controlled release technology and are hosted by the following
`companies:
`B110/111
`09:00-10:00 Elan Drug Technologies
`B113/115
`09:00-10:00 Analytical Solutions
`B117/119
`10:00-11:00 ChemImage
`B113/115
`10:30-11:30 Pii
`B110/111
`11:00-12:00 Sotax
`11:30-13:00 Eurand Pharmaceutical Technologies B117/119
`12:30-14:30 OctoPlus
`B110/111
`13:30-14:30 Lubrizol
`B117/119
`See pages 14-15 for descriptions.
`Soapbox Sessions
`Co-sponsored by Molecular Profiles Ltd.
`Chair: Eyal S. Ron, MADASH LLC, U.S.A.
`Identify new ideas and potential collaborations in these fast-
`paced presentations where technology-driven, emerging, and
`established businesses present their products, services, and
`technology.
`See page 16 for descriptions.
`
`CRS Innovation Sunday Open Forum: From Bench
`to Market—The Route to Commercial Success
`Co-sponsored by Pfizer
`CRS Innovation Sunday is delighted to have the inside story
`from entrepreneurs and large pharma in two sessions with open
`forum discussions.
`14:00-15:00 • Session I
`Converting Innovation into Commercial Success
`Moderator: Julia Rashba-Step, Pfizer BioTherapeutics R&D,
`U.S.A.
`Speakers: Debra Bingham, Valeo Partners, U.S.A.;
`Lisbeth Illum, IDentity, U.K.; Art Tipton, SurModics
`Pharmaceuticals, U.S.A., and a venture capitalist will
`complete the panel.
`Hear from and discuss with entrepreneurs as they give their
`practical insight on how to take innovation and build it into a
`commercial venture.
`15:00-16:30 • Session II
`Current Industry Needs in Drug Delivery Partnerships
`Moderator: Debra Bingham, Valeo Partners,U.S.A.
`Speakers: Henry Havel, Eli Lilly, U.S.A.; Julia Rashba-Step,
`Pfizer BioTherapeutics R&D, U.S.A.; and Barbara Lueckel,
`F. Hoffmann-La Roche, Switzerland
`Big pharma panelists share their strategic plans for current and
`future drug delivery. It is the opportunity to directly ask what
`they are looking for in an alliance or partnership.
`State of the Industry Keynote
`Co-sponsored by Pfizer
`Returning by popular demand, Sarah Terry, vice president of
`Life Science Analytics, Inc., will present the latest statistics,
`trends, and drivers of the industry along with the projected
`future of drug delivery.
`Grand Opening of the Exposition and
`Welcome Reception
`CRS Innovation Sunday culminates in the Exposition Hall
`with the Grand Opening of the Exposition and Welcome
`Reception. Join 100+ exhibiting companies and more than
`1,000 of your colleagues in the exposition/poster hall where
`thousands of products, services, and innovations still-to-be-
`developed can be discussed one-on-one.
`
`continued on page 12
`11
`
`

`
`CRS Innovation Sunday Program Highlights (continued)
`
`Young Scientist Workshop II: True Stories; Career
`Development
`Chair: Jeffrey James, Molecular Profiles Ltd., U.K., and
`Jonathon Zhao, Cordis Johnson & Johnson U.S.A.
`The career landscape for the young scientist in controlled
`release and delivery is more varied and challenging. While
`post-graduate programs continue to provide the platform for
`professional growth, how does the young scientist make use
`of such growth for achievement and career development? The
`True Stories workshop will provide young scientists with the
`information to “fast-track” their career decisions, from both an
`academic and industrial perspective. The workshop will feature
`stories from speakers who have “been there and done that,”
`from putting their CV together all the way through to starting
`their own successful company! Informally, the True Stories
`workshop offers you, the young scientist, a feel for the types
`of issues, technical and non-technical, that may occur during
`career development. This workshop aims to uncover issues
`experienced by those in the industry, with an emphasis on the
`important information that you cannot get from a textbook!
`08:00-08:10
`Welcome and Introduction
`08:10-08:50
`The Choice Between Industry and Academia,
`Sarah Eccleston, Encap Drug Delivery,
`U.K., and Teresa Virgallito, Microtek
`Laboratories, U.S.A.
`University Funding; Is Release Too
`Controlled?,Thomas Rades, University
`of Otago, New Zealand, and Vladimir
`Torchilin, Northeastern University, U.S.A.
`Starting a Controlled-Release Company, Andy
`Lewis, Critical Pharmaceuticals, U.K.,
`and Ronald J. Versic, Ronald T. Dodge
`Company, U.S.A.
`Break
`Leaving the Lab Coat Behind: Non-Technical
`Roles in Controlled Release, Claire Madden
`Smith, Molecular Profiles, U.K., and Kurt
`Fegely, Colorcon, U.S.A.
`Do’s and Don’ts: Applying for Positions in the
`CR Arena, Vinay Chattre, Northern Lipids,
`Canada, and Andrew Parker, Molecular
`Profiles, U.K.
`First Timers’ Meeting/Volunteer Fair
`If this is your first CRS Annual Meeting & Exposition or
`perhaps you’re a seasoned veteran, learn how to get the most
`out of an annual meeting program by attending this welcome
`and question-and-answer session presented by the CRS Board
`of Directors. New this year! CRS Committee Chairs will be
`hosting a “Volunteer Fair” showcasing the many ways members
`can get involved with CRS committees.
`
`11:05-11:45
`
`12
`
`08:50-09:30
`
`09:30-10:10
`
`10:10-10:25
`10:25-11:05
`
`Roundtables and Focus Groups
`Tablet and Capsule Manufacturing Roundtable
`Future Trends in Tablet and Capsule Manufacturing
`Moderators: Gino Martini, GlaxoSmithKline, U.K. and
`Claudia Leopold, University of Hamburg, Germany
`Keynote: Stephen W. Hoag, School of Pharmacy, University of
`Baltimore, U.S.A.
`Presentations:
`Is There a Role for Compaction Simulators in Tablet
`Manufacturing?, Micael Guillot, Eurand, U.S.A.
`Oral Drug Delivery Using Technology Platforms, Pat Crowley,
`Callum Consulting, U.S.A.
`OSDrC®, a One-step Dry Coating Technology, Joseph Fix,
`Pharma-Fix Consulting, U.S.A.
`Novel Developments in Hard and Soft Capsules, Sven
`Stegemann, Capsugel, Belgium
`Panel discussion follows with all speakers.
`The Tablet and Capsule Manufacturing Focus Group will
`immediately follow the Tablet and Capsule Manufacturing
`Roundtable in the same meeting