(cid:19)(cid:19)(cid:19)(cid:19)(cid:19)(cid:20)
`
`Petition for Inter Partes Review
`Of U.S. Patent 8,278,351
`Exhibit
`ENZYMOTEC - 1057
`
`

`

`Eleclaration ofFotini Sarnpalis, Ml}, Phi).
`USSN. 95/00l,774
`
`l am the inventor of numerous patents, including a number in the area of marine extracts.
`
`l
`
`am the sole inventor of the present patent (US. 8,030,348}.
`
`1 am currently the Chief Scientific {)fticer of Neptune lechnologies 84: Bioressources, lnc.
`
`(“Neptune”). Neptune is the sole assignee of the present patent. Further, l am the President
`
`of the i'eptune subsidiary Acasti Pharrna inc.
`
`l have been asked to discuss the experiments that were reported in the ‘348 patent,
`
`Specifically, l have been asked to recount the extraction protocol used in the patent to ohtain
`
`a krill oil extract.
`
`To do so, l brieily recount my initial involvement in Neptune‘s pursuit of a commercial krill
`
`oil.
`
`i joined Neptune in the late—l990sl’early—2000s, when it was practically the only
`
`company with significant commercial interest in krill oil,
`
`1 was tasked with establishing
`
`whether krill oil had medical benefits and, made the initial discoveries that it has many,1 ln
`
`doing this, 1 improved the krill oil extraction process, and by deviating from prior processes
`
`(including those of Beaudoin),
`
`l discovered a krill oil extract
`
`that uniquely contained,
`
`substantial amounts of phospholipids bearing omega—3 fatty acids (such as EPA and DHA)
`
`and was suitable for human consumption
`
`l achieved this breakthrough, in part, by avoiding the use of heat during the extraction
`
`process l-leat was conventionally used in such processes to remove extraction solvents such
`
`as ethanol and acetone, which are not suitable for human consumption in significant
`
`amounts, Temperatures of at least 6004:? to 70%? were considered necessary for removal of
`
`these solvents, and temperatures of 1000C and above were often employed for their removal,
`
`as in Beaudoin (see Wt.) 00/234563, pages 7 and l0), However, these same temperatures lead
`
`to hydrolysis of the key phospholipids By avoiding substantial hydrolysis of phospholipids,
`
`: See, e. g Sampalis et (41., “Evaluation of the Et‘lects of Neptune Krill OilTM on the Management of Premenstrual
`Syndrome and Dysrnenon‘heal” Aliens Med Rev 8:
`l7l—9 (2003) (Appendix B); Bunca e: (12., “Evaluation of the
`Elleets of Neptune Krill Oil on the Clinical Course of Hyperlipidemia” Alter}? Med Rev 9(4): 42048 (2004)
`(Appendix C}.
`
`2
`
`000002
`
`000002
`
`

`

`Beclaration ofFotini Sarnpalia Mil, Phil).
`USSN. 95/’00l,774
`
`l discovered the recited composition and the superior efficacy of extracts containing
`
`significant levels ofthis phospholipidi
`
`9.
`
`The experiments in the “348 patent were conducted under my direction“ Our research made
`
`me particularly cognizant of the need to remove solvent? to make the extract suitable for
`
`human consurnption, while avoiding heating, to prevent hydrolysis of the hey phospholipids.
`
`Accordingly, I directed the extractions of the “348 patent to he conducted at temperatures no
`
`higher than 5°C. See the “348 Patent, Column l8, Lines 23—673 Particularlyn l avoided the
`
`use of heat to remove solvents, unlilre what was done in Beaudoin. See Beaudoin, WO
`
`00/213546 at pages ’7 and l0. Also? 1 ensured that despite not using heat, sufficient solvent
`
`was removed, unlilre what was taught by Beaudoih. See Beaudoin, Wt) 00/235546, ’l‘ahle l3
`
`(disclosing “volatile matter and moisture levels” of l0% and 6.8% respectively for fractions 1
`
`and ii) To ensure that we overcame these two limitations in the field, our solvent removal
`
`employed methods such as rotary evaporation and was conducted in the cold for extensi ’e
`
`periods of time,
`
`l0.
`
`Therefore 1
`
`instructed that the solvent evaporation experiments for the “348 patent he
`
`conducted using rotary evaporation at temperatures under 5°C. These involved long periods
`
`of time to rernove suffi cient solvent to render the extract suitable for human consumption
`
`However, as reported in the “348 patent, the resultant extracts contained only small amounts
`
`of extraction solvent residuefi below the lower tolerated level for chronic consumption. See
`
`“348 Patent, Table 6 (reporting “Solvent residuelj <25 ppm”).
`
`ll.
`
`Accordingly, among other major advances, the “348 patent encompasses the removal of
`
`extraction solvent at low temperatures and thus, unlike prior teachings of others, retains the
`
`structural integrity of the hey components of the extract and allows the extract to be suitable
`
`for human consumption.
`
`[Remainder of the page left intentionally blankj
`
`3
`
`000003
`
`000003
`
`

`

`514
`
`09:02:48 pm.
`
`Ganmmzmz
`
`4/4
`
`Daciamfiim 9f Emmi Szimpaiis, Mi), PhD.
`{£8.33}. 95/001,774
`
`12. I farm: decism: that all statements made herein 0'? my own knowiedge are true and ma all
`
`statements made on infommtion and beiief age beiisvsd to betme and Eunhsr that mass
`
`Siatemmts wera made: with the: knowledge that wiiiful false: simements am: the like so made
`are punishabie ”by fine 0r imprémzmmm or 130th; under Sectim 100}, of Title 38 if the: Unifisd
`
`Stags (1‘06%., and that such wififui false statementg may jeapardize the va‘ifiiiy 0‘U S Pawn:
`
`'
`
`.
`//.
`{Ohm Samm‘us, Ml) P}a E}.
`
`gated: March 16W2032
`
`8,0395%
`
`W wgggqxgyg‘MJQQWN NHVMWVMNWw‘vwxmvwmmmm” 4vwm
`
`. mw‘JMmea-h qwnw.‘ w _,-. "MRW ... “WM”MJWWH,‘
`
`000004
`
`000004
`
`

`

`USSN, 95/003 ,774
`
`Declaration of Dr. Fmini Sampaiis
`
`Ammmdix A
`
`Cumeuium Vims M Di: Fatim Sampaiis
`
`000005
`
`000005
`
`

`

`FQTINE SAMPALES, Md}? P11. Dc
`
`(Inrricuiuni Vitae
`
`Last Revised: March 2012
`
`A. EDENTIFICATEON
`
`e—rnaii:
`
`tinasanipaiis@gmai1.eorn
`
`B EBUCA’E‘E'ON
`
`Yer;r
`"i‘itie
`Be artment
`'
`Universi
`
`
`88 McGiii University
`
`a University of Patras
`Greece
`
`a
`
`Pediatric Surgery Ciinic
`
`P. and A giaia Kyriaketi
`
`Athens Pediatric Hospital
`Greece
`
`6» University General Hospitai
`Greece
`
`a University of Athens
`Greece
`
`Physiology
`
`Medicine
`
`MD.
`
`09/} 980—05/1983
`
`09/1984-05/1988
`
`Pediatric Surgery
`
`Residency
`
`09,1’19921-07/1994
`
`Pediatric Surgery
`
`Residency
`
`07/1994—07/1997
`
`Graduate Studies
`
`Doctorate
`
`09,1’1994-v09/1997
`
`a McGiii University
`
`Experimental Surgery P1111).
`
`09/1997 -- 06/2006
`
`C. SPECIAL HONORS? SCHOLARSHIPS
`
`Year
`
`Name
`
`Arnntint
`
`University
`
`a
`
`:9
`
`is
`
`a
`
`1 980—1985
`
`11efririan LaRoche
`Switzeriand
`
`$180,000
`
`Gi‘ittingen, Germany
`
`Dnsseidori Germany
`
`1 990
`
`Danish Government
`
`$10,000
`
`Marseiisborg, Denmark
`
`Medicai Scnoiarsnip
`
`1997—1998
`
`Ur :3. Surgical Corporatien
`
`$30,000
`
`MeGiii, Canada
`
`199 8
`
`Heien Hutcnishon
`
`S15,000
`
`McGiiL Caanada,
`
`D. AWARDS
`
`a
`
`a
`
`June 2011
`
`Deka Inneva‘rinn Award by The Hellenic Board of Trade of
`
`Metropolitan Montreai
`
`June 2011
`
`innovation Award at 201 1, Genesis Gala heid by BicQuebec
`
`Pace 1
`000006
`
`17/03/2012
`
`000006
`
`

`

`TEACHING
`
`BEES—till Patras University Tutorial Services Tutor
`
`l987—88 l’atras University Dermatology Clinic Tutor
`
`l995~97 AthensUniversity Teaching Assistant, Department of Surgery, Breast Clinic
`
`OTHER FRQFESSIQNAL ANB SCEENTIFIC CGNTRIBUTIONS
`
`President of Student Council, University of Patras, Greece, l984 ~ 1988
`
`Rural Practice, Ancient Olympia Medical Center, Greece, l99ll
`
`l992
`
`President t’it‘ATTlKA Residence Association, Greece, l995—l 997 3
`
`E.
`at
`
`$ &
`
`E Q 8
`
`! 8
`
`lA’l‘RlléO CENl'ER Breast Clinic, Medical Center, Surgical Consultant, l99r’i-l997
`
`Educational Speakers Bureau in the Canadian Faculty of Medical Speakers for
`
`Miralunia (Scintirnainniograpny) Breast imaging, October 1998
`
`Educational Speakers Bureau in the United States Faculty of Medical Speakers for
`
`Miraluma (Scintimainmograpliy) Breast imaging, October l999
`
`international Educational Spealters Bureau in the United States Faculty of Medical
`
`Speakers for Miraluma (Scintimainmograpliy) Breast lrnaging, November l999
`
`Neptune Technologies & Bioressources, l999~ present
`0
`Chief Scientific Officer:
`
`“I Lead the R&D department ot‘r‘leptune heing responsible for the development
`
`and validation of marine sourced hioactive ingredients proven effective for the
`
`management of dyslipidernia.
`
`5* During these years she has been in charge ofthe company’s intel ectual
`
`property, with issued patents in 30 countries, regulatory affairs and key
`
`strategic alliances.
`
`0
`
`President of Neptune’s two pharmaceutical subsidiaries, Aeasti Pharrna lnc
`
`leading the development of two novel patented active pharmaceutical ingredients
`
`targeting the prevention and treatment of mixed dyslipidemia and cardiometaholic
`
`disorders. in Acasti she is working with world renowned KQLS like Dr. Steven
`
`Nissen, Dr Jean Davignon, Dr Jacques Genest, Dr Ruth McPherson, Dr William
`
`Harris and Br. Magdy Abdel Malik.
`
`G.
`
`PUBLICATIGNS
`
`'l'sarnhaos D, Sump. alis E, Berger H, Nikiforidis (3.: UV-radiation induced skin cancer:
`
`inhibition by oral arotinoids. Gior. ltal. Chit. Dermatol. Oncol. 2:409 — 4l2, 198.7
`
`'l‘sarnhaos D, Berger ll, Sarnpalis E, Nikiforidis
`
`(3.:
`
`lst eine Hernniung der
`
`Photokarzinogenese durch orales Arotinoid moglich? Arztliclre Kosrnetologie, l9:
`136, l988
`
`l34l —
`
`Tsarnhaos 0., Sarnpalis E, Berger ll: Generalized cutaneous liyperpigrnentation in
`
`hairless inice, induced by topical diinetliylhenzanthracene. Exp. Cell Biol, 57: 292 -- 299,
`l989
`
`Nikiforidis (3., 'l‘sarnhaos l1, Balas C, Sainpalis E: Mechanical Properties of human hair
`
`in relation to its gross morphological and rnicrostructural features. Proceedings of the l
`
`to
`
`4.
`
`r a» 2
`h60007
`
`U)
`l7.l) ,I'ZO if:
`
`000007
`
`

`

`U;
`
`00
`
`10.
`
`ll.
`
`Congress of the European Academy of Dermatology and Venereology, Florence,
`
`September 215 ~ 28, 1989
`
`Zeiva (3., Sampalis F, liiriaki l1, Gogas J ., Alevizou V; Tc Tetrofosmin imaging F. in
`
`breast tumours suspicious for n'ralignancy. European Journal of Nuclear Medicine, 1224;
`9.1996
`
`lvlarl'x'opoulos C, Sarnpalis F., Givalos N, Gogas ll: Association of breast cancer with
`
`rneningionta. European Journal of Surgical Oncology Aug;24(4):332—4,l998
`
`Markopoulos C., Sampalis F, Gogas ll, Kiriakou V.: Bilateral Fagetls Disease. Furopean
`
`Journal of Gynecological Oncology 18(6):£l95—496, l 997
`
`lvlarl'x'opoulos C Sampalis F Zeiva C, Kiriaki 1)., Kitsou F Gogas 3., Alevizou—'l"erzal<i
`
`V; 99ancTetrol’osmin imaging in breast tumors. European Journal of Gynecological
`
`Oncology 19(2):163—l66,1998
`
`Markopoulos (3., Sampalis 17., (logas ll, Kiriakou V: Cavernous liemangionia of the
`
`breast. European Journal of Gynecological Oncology, l9(3):2£l6—8,1998
`
`Tailleler R., Sarnpalis JS. Sanipalis FS., Laui‘er .l., Veireult J ., Dumont M: Reduction in
`
`Unnecessary Breast Biopsies
`
`and Missed Breast, Cancer Using 99m'l'e—Sestaniibi
`
`Scintinianirnograpliy. J. Nucl. Med. 1999; 40 (supplement), 249?
`
`Sampalis FS, Denis R,
`
`l’icard l3, Fleiszer T), Martin G, Nassif F, Sampalis JS.
`
`lnternational prospective
`
`evaluation of
`
`scintiniammograpliy with 99rntecnnetium
`
`sestaniibi: interim results. American Journal of Surgery 200l; l82(/—l):344—403.
`
`.Sanipalis‘ FS Denis R, Pieard D, Fleis‘zer D, Martin G, Nassif 13, Sampalis .lS
`
`international prospective
`
`evaluation of
`
`scintirnarnmograpny with 99nitecnnetium
`
`sestaniibi. American Journal of Surgery 2003; $554449.
`
`.l..il)ernian M, Sampalis F,
`
`llvlulder US, Sampalis
`
`JS. Breast cancer diagnosis of
`
`scintinianimograpliy: a nieta~analysis and review oftlie literature. Breast Cancer Research
`
`and "l‘reatnient 21003; 80( l):l lS—Zo.
`
`14.
`
`Sarnpalis F. Buriea R. Felland MF. liowalski 0. Duguet N. Dupuis S. Evaluation of the
`
`effects of Neptune Krill Oil on the management of premenstrual
`
`syndrome and
`
`dystnenorrhea. {Clinical Trial. Journal Article. Randomized Controlled Trial] Alternative
`
`Medicine Review. , 2003; 8(2):l7l--9.
`
`. Sarnpalis T. Benefices pour la santé liurnaine de l'utilisation de l‘extrait lipidique du Krill,
`
`NAFAS, zoos. ; 2o
`
`16.
`
`17.
`
`Sanipalis T. Should We Attribute Potential Pro—arrhythmic Properties to Ornega~3 Fatty
`
`Acids or Only to Fish Oil? American Naturopathic Medicine Association, 2005; 9(3)
`
`Sarnpalis T. The Healing Power of Neptune Krill Gil, Rebus LLC. New York, 2005
`
`Sampalis JS, Liberman M, Davis L, Angelopoulos J, Longo N,
`
`.locn M, Sampalis F,
`
`Nikolis A, Lavoie A, Denis R, Mulder DS. Functional status and quality of life in
`
`survivors of injury treated at tertiary trauma centers: what are we neglecting? Journal of
`
`Trauma 2006; 60(4llz806—l 3.
`
`50008
`
`U)
`17.0 .120 1?.
`
`000008
`
`

`

`l8.
`
`l9.
`
`Bissonnette S,
`
`l-labib R, Sampalis F, Boulras S, Sampalis TS and the Ezetrol Add~0n
`
`Investigators, Efficacy and tolerability of Ezetirnibe Wing/(lay cowatlniinisteretl with
`
`statihs in patients with primary hypereholesterolernia not achieving target LDL—C while
`
`on statin inonotlterapy: A Canadian, molti~centen prospective study, The Ezetrol Add—On
`
`Stutly. Can J Cardiol. 2006 Oct;22(l2):l035—£ltl. Erratum in: Can J Cartliol. 2007 Feb;
`
`23(2):l59,
`
`Sampalis JS, Sarnpalis F, Christou N. impact of Bariatric Surgery on Cardiovascular and
`
`Musculoskeletal Morbidity, Surgery for Obesity and Related Disorders Snrg Obes Relat
`
`Dis. 2006 Nov—Dec;2(6):5l§7~9l, Epuh 2006 Sep 22.
`
`H.
`
`
`SELECTED PATENTS / PATENT APPLICATTGNS INVENTOR
`
`l. Concentrated "Therapeutic Phospholipid Compositions (US. Patent Pub. No.
`
`lel lOlofllol)
`
`’\
`
`a. Natural Marine Source Pbospholipids Comprising Polyunsaturated Fatty Acids and
`
`Their Applications (US. Patent 8,639,348)
`
`3 Krill extracts for treatment of cardiovascular diseases (US. Patent 8,057,825
`
`4. Breast Cancer Lesion Detection and Localisation Device (CA) (Pub. tt CA2324756)
`
`l.
`
`PRESENTATTQN of PAPERS:
`
`l,
`
`Sainpalis E, 'l'sambaos l): The effect of carcinogenes on rnelanocytes of the skin, The
`
`Greek Dermatology Association Congress, Thessaloniki, January 25, l986,
`
`2.
`
`Sarnpalis E, 'l'sarnbaos ll: The effect of arotinoic ethylester in sebaceous glands in
`
`yiyo. The Greek Dermatology Association Congress, Thessaloniki, January 25, l98ti.
`
`3.,
`
`Sarnpalis E, "l‘sanihaos l1: Mutational pro erties of synthetic retinoids:
`
`ln yitro
`
`experimental studies. The Greet: Dermatology Association Congress, Athens, April
`
`l9, l986.
`
`4. Tsarnhaos
`
`1)., Sarnpalis E: Prophylactic eilect of retinoids
`
`in experimental
`
`carcinogenesis of the skin, National Greek, h'lerlical Conference, Athens, May l4 — l7,
`
`L986 (First awarrl for best oral presentation).
`
`3/: Katsayochristos R, Sarnpalis l3, "l‘sanihaos ll: The effect of byperoxidants on
`epithelial
`tissue, The Greelt Dermatology Association Congress, Athens, June 28,
`1986.
`
`6,
`
`Sarnpalis E, Tsarnbaos D: Stimulation of cutaneous rnelanocytes by DMBA.
`
`Congressus Quartus Derrnatologiae Bulgaricae, Varna, October 3-5, l986
`
`7. Tsarnbaos D, Sanipalis E: Effects of oral arotinoiol Ro l5 — 0778 on the sebaceous
`
`glands. Congressus Quartus Dermatologiae Bulgaricae, Verna, October 3-5, 1986
`
`P 0° 4
`lfiooog
`
`l7. 0
`
`U)
`
`/'Z() if:
`
`000009
`
`

`

`C7)
`
`9.
`
`10.
`
`ll.
`
`lsamhaos 3., Sarnpalis F, Berger l1, Sarnpalis .3}: UV radiation — intlucetl slrin cancer:
`
`Inhibition by oral arotinoitls. International Symposium on Aging anrl Skin Cancer,
`
`Rome, February l5 — 19, 1987
`
`Skouteiis A, Sarnpaiis 17., Tsarn‘oaos D: Morphological study of trichothiotiystrophy.
`
`The Greelt Dermatology Association Congress, Athens, April 25, l987.
`
`'l'sambaos 1)., Sampalis F, Berger 1%., Sampalis 3}: Prevention of skin carcinogenesis.
`
`International Congress ol‘Nutrition, Growth and Cancer, Athens, April 20
`
`26, l987.
`
`Mantagos 8.,
`
`'l'sambaos
`
`ll, Sampalis F'.: Sebosupressive activity of a new
`
`nonteratogenic retinoid. Annual Meeting of the Society of Cutaneous Ultrastructural
`
`Research, Edinburgh, July 8 — l l, 1987
`
`Sampalis F, Tsamhaos D: Recognition of the epidermal arninoaeids causetl by
`
`systemic retinoirls. The Greek Dermatology Association Congress, "l‘ril<ala, October 1,
`1988.
`
`.
`
`'l'sambaos 1)., Nihiforitlis (1., Sampalis F: Mechanical properties of human hair in
`
`aging. Vl World Congress of Dermatology, Rio tie laneiro, April 29 — May 3, 1989
`
`Nikiforitiis G, 'l‘sambaos 1)., Sampalis 19., Bezerianos A Balas C.: Computerized
`
`system for quantitative determination of the viscoelastic parameters of human hair. Vi
`
`World Congress of Dermatology, Rio rle .l’aneiro, April 219 — May 3, 1989
`
`. Nikiloridis (3., Tsarnbaos 1)., Balas C, Bezerianos A., Sampalis F.: Mechanical
`
`properties of human hair in relation to its gross morphological and microstiuctural
`ha
`I?
`:3
`features. 1. Con ”tress Of the Euro ean Academ of Dermatolog
`and Venereolog ',
`
`Florence, September 25 ~28, 1989
`
`16.
`
`Sampalis 17., Balas K, Niltil‘orirlis (3., Tsambaos 13.: Viscous and elastic parameters of
`
`hair with trichothiodystrophy. 16th National Greek Medical Congress, May S — 121,
`1990.
`
`.
`
`'l'sambaos l), Nikiforitiis G. Sampalis F'., Balas C.: Mechanical parame ,ers of human
`
`hair in androgenetie alopeeia. 9th Regional Conference of Dermatology (Asian —
`
`Australasian), Kuala Lumpur, lune l9 .. 24, 1990
`
`lsamhaos 13., Kalotoutis A., Sampalis F., Koulocheri
`
`1-3.: Oral acitretin induces
`
`alterations in mouse liver phospholipitl composition. 9th Regional Conference of
`
`Flermatology (Asian — Australasian), Kuala Lumpur, June l9 — 24, 1990
`
`19.
`
`Marliopoulos C, Sampalis 13., Gogas ll, liarirlalris 13., Papacln‘istodoulou A, Gogas
`
`3.: Axillary lymph norle metastasis in infiltrating breast tumors with greatest diameter
`
`of l cm or less Annual Congress of the Greek Mastology Association, Patras, March
`
`3l —April 2, 1995.
`
`Liapis C., Misiakos B, Sampalis 13., lioutsogiorgas 1)., Gougoulakis A, Dousaitou M.,
`
`Berilrolros (I, Seehas M.: The treatment of a ceiiac artery aneurysm in the presence of
`
`a petaloid kidney. lst Hellenic---ltalian Congress of Angiology antl Vascular Surgery
`
`with international participation, Ancient Olympia. May 211 — 25, 1995.
`
`17/03/2012
`
`0000010
`
`

`

`. h/larkopoulos C, Gogas H, Sampalis F, Alevras P., Kontzoglon K., Gogas l: Breast
`
`cancer in the elderly. OECl Conference, Cancer in The Elderly, Athens, Greece, May
`
`10 ~ l2, 1996 (Poster)
`
`r? .7,
`
`23.
`
`Zerva C., Sarnpalis l1, Kiriaki D, Kitsou l3, Gogas l., Alevizou V; TcTetrofosrnin
`
`imaging in breast tumors suspicious for malignancy. European Association of Nuclear
`
`Medicine Congress, 14 — l8 September l996, Copenhagen, Denmark
`
`Markoponlos C., Koutopoulos K Sarnpalis E, Kariclakis 3.,
`
`liontzoglou K,
`
`'l‘zortzotis ll, Floros l): The surgical treatment of non—palpable breast turnors. XX
`
`National Greek Surgical Congress, Athens, November 3
`
`7, 1996.
`
`'
`
`. Karidakis B, Markopoulos C Sainpalis F., Tseleni 8., Gogas 3.: Weil~differentiated
`
`thyroid cancer
`
`Staging and prognostic factors. XX National Greek Surgical
`
`Congress, Athens, November 3 — 7, l996.
`
`7‘2
`
`Sarnpalis F, Markopoulos C., Zen/a C., Kiriaki D., liitsou E, Gogas .E., Alevizou~
`
`Terzaki l3: Scintiniainntography in the diagnosis of breast tumors. XX National Greek
`
`Surgical Congress, Athens, November 3
`
`7, 1996.
`
`. Kittas C., Koutrournpi B, Markopoulos C., Santpalis R, Kiriakou B. Spanaki N.,
`
`Gorgoulis 8., (logas l: A study of the oncogene tile in breast cancer. National
`
`Congress of the Greek Mastology Association combined with the international
`
`Congress of the Greek Association of Breast Cancer Research. Alexandroupolis —
`
`'l‘hrace, June 12.
`
`l6, l997
`
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`carcinoma cells. National Congress of the Greek Mastology Association cornbinetl
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`with the international Congress of the Greek Association of Breast Cancer Research.
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`Alexandroupolis — Thrace, lune l2 — lo, l997 (First award of the “laso” institute for
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`breast cancer. National Congress of the Greek Mastology Association combined with
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`Alexandroupolis — Thrace, lune l2 — l6, l997 (Second award for best scientific paper)
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`Research. Alexandroupolis — Thrace, lune l2 — lo, l997
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`Sanipalis E,
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`67th Annual Meeting, September 2447', l998, Toronto, Ontario, Canada.
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`1998, 'I'oronto, Ontario, Canada.
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`Canadian Nuclear Medicine Society Ai’inual Scientific Meeting, Mareli 29 — April 2,
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`Thailand, July l5,2(l(l(), Royal CliffBeacli Resort Pattaya, Thailand.
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