i:§©Cl£ll‘£i‘i‘.i0,’(l ofFoti1'ti Sarnpatlis, M.D., Pliti),
`U.S.S.N. 95/"G()l,774
`
`Attorney Deelxiet Ne. NEPN—%fi3./'fifiUS 3T3t)7€i3—2fiTS (A.T{BMm323T74}
`
`TATENT
`
`TN THE UNTTTETT STATES PATENT ANT} TRATltEl\rTARE{ (TFFTCE
`
`in Re Patent cf:
`
`SAMPALTS, Fotirii
`
`COI1fl1'1Tl’<tilGl1 Ne;
`
`i897
`
`Control No:
`
`95./tltll ,7?
`
`Group Art Unit:
`
`3991
`
`Filed:
`
`FOR:
`
`Gctober i9, 231 l
`
` Exsn'tiuer:
`
`CAM Pl?.LL, Bruce R
`
`ENTER Tt7’/TRTTES RETEXAIVT QT U.S. PATTENT 8,TE3il,3駫3: NATURAT It/T./f°s.RTNE
`SGURCE PHGSPHQLTTTDS C81‘:/TPRTSTNG TGLYUNSATURATED FATTY
`
`ACETTS ANT} 'T"l-TTETTT A??T.T{3A'TT {ENS
`
`Mail Step Declaration
`Cemruissionei' for Patents
`
`Pail Box M50
`
`Alexandi*iat, VA 223 l3 — l 45 G
`
`BECLARATTQN GT7 FQTTNT SAMPALTS it/T.D. PTLD. UNDER 37 C.F.R. R 1.1322
`
`
`
`
`1, Fotnti Sarnpalist declare as fellows:
`
`1.
`
`I am El Carisdiau citizen.
`
`2.
`
`I studied for my Bachelmi’s degree in Physiology in l‘»'i<:Gili University in Montreal, Canada.
`
`It have oltstairied a Doctor of t\/ledicine degree in iviay ef l988 from the University of Patras in
`
`Greece.
`
`Following this degree,
`
`1 uridierteok my residency in the Pediatric Sui*gei"y
`
`Departrnent ef the Pediatr‘ic Surgery Clinic 17’. and Aglaia E§y'i'iai<:eu Athens Pediatric Eiospitetl
`
`in Greece from Septenil:>er,, l992 to July;
`
`l99«-‘it.
`
`It else ceinpletetl a. seeonrl resideiicy from
`
`July, 1994 to» Qluly,
`
`ii}??? in General Surgery at the University General Pediatric Hospital in
`
`Greece.
`
`I subsequently obtained 8 Docterate in Surgery in Septe1iibei' of il9¥P7 from the
`
`University sf Atlieits in Greece. Finally, I also oloteiued at Pil.l:l‘. in Experirrntentalr Surgery in
`
`June of 2006 from l\/i”cGili University.
`
`3. To date T have ebtaiiied nurnerous special homers, awards, and recegnitioli.
`
`I have also had
`
`iiitniereus publications and p1”E.’.Sf3l1l§f.':(l many papers, all ef which are listed an my Currieulurri
`
`Vitae, enclosed lierewith (Appersdix A).
`
`1
`
`000001
`
`Petition for Inter Partes Review
`
`Of U.S. Patent 8,278,351
`
`ENZYMOTEC - 1057
`
`Exhibit
`
`000001
`
`

`
`lileclaratioo oflhtihi Sarnpalis, lVl.l3., Pill),
`U.S.S.N. 95/"0(ll,774
`
`l am the inventor ofnurnerous patents, iricluding a number in the area ofniarine extracts.
`
`l
`
`am the sole inventor ol‘ the present patent (US. l§,l}30,348}.
`
`1 am currently the Chief Scientific Officer of Neptune Technologies 84: Bioressources, Eric.
`
`(“Neptune”). Neptune is the sole assignee of the present patent. Further, l am the President
`
`of the iieptune subsidiary Acasti Pharrna inc.
`
`l have been asked to discuss the experirnents that were reported in the ‘B48 rpatent,
`
`Specifically, l have been asked to recount the extraction protocol used in the patent to ohtain
`
`a krill oil extract.
`
`To do so, I brietly recount rny initial involvernent in Neptune”s pursuit of a cornrnercial krill
`
`oil.
`
`1 joined Nepttrne in the late—l99l)s/early—2l)00s, when it was practically the only
`
`cornpany with significant cornrnercial interest in krill oil.
`
`l
`
`tasked with establishing
`
`whether krill oil had medical benefits and made the initial discoveries that it has l’}'l£il'l'3/,1
`
`in
`
`doing this, 1 improved the krill oil extraction process, and by deviating from prior processes
`
`(including those of Beaudoin),
`
`l
`
`tliseovered a krill oil extract
`
`that uniquely contained
`
`substantial amounts of phospholipids hearing ornega—3 fatty acids (such
`
`EPA and DlrlA)
`
`and was suitable. tor human consumption,
`
`l achieved this breakthrougli, in part, by avoiding the use of lieat during the extraction
`
`process.
`
`l-leat was conventionally used in such processes to remove 6Xl‘I'aCtlOl'l solvents such
`
`as ethanol and acetone, vvhieli are not suitable for hurnan consurnption in significant
`
`arnounts 'l'ernperatures of at least 6l)“'C to 70“'C were considered necessary for removal of
`
`these solvents, and temperatures of l()tl°C and above were often eniployecl for their removal,
`
`as in Beaudoih (see WO 00/23456, pages 7 and l0),
`
`,‘i*iowever, these same temperatures lead
`
`to hytlrolysis of the key phospholipids. By avoiding substantial hydrolysis of pliospholipids,
`
`: See, e. Sainpalis ea‘ 5.4., “Evaluation of the Effects of Neptune Krill Gill“ on the Management of Premenstrual
`Syndronie and D}/sine11or1‘lieal” Alierzz Med Rev 8: 171-9 (2003) (Agigsendix B); Bunea ex aZ., “‘l;'valuati0n of the
`Elleets of Neptune
`Oil on the Clinical Course of H}/pei‘lipiden1ia” Altern Med Rev 9(4): 420~28 (2004)
`(Appendix C}.
`
`2
`
`000002
`
`000002
`
`

`
`liteclaration ofl:7otini Sarnpalis, lVl.D., Pliil),
`U.S.S.N. 95./'{)()l,774
`
`l
`
`tliscovere.rl
`
`the recited composition and the superior efficacy of extracts containing
`
`significant levels ofthis phospliolipicl.
`
`9.
`
`The experiments in the ‘348 patent were conducted under my direction. Our research rnarle
`
`particularly cognizant of the need to remove solvent, to rnatlqe the extract suitable for
`
`hurrlan corisurription, while avoiding heating, to prevent hydrolysis of the key phospholipirls,
`
`Accordingly, l directed the extractions of the ‘348 patent to he conducted at temperatures no
`
`higher than 5°C. See the ‘348 Patent, Column l8, Lines 23-67. Particular'ly, l avoided the
`
`use of heat to renrove solvents, unlike what was done in Beancloin. See Beaucloin, W0
`
`00.53.3546 at pages 7 and ill. Also? l ensured thfitfi despite not using heat, sufficient solvent,
`
`was removed, unlilre what was taught by Beaudoih. See Beaudoin, ‘Wt? (ll)/'23546, Tahle l3
`
`(disclosing “volatile. matter and rnoistnre levels” of l0% and 6.8% respectively for fractions l
`
`and ll). To ensure that we overcarne these two lirnitations in the field, our solvent removal
`
`ernployecl rnetliocls such as rotary evaporation and was concluctecl in the cold for extensi *e
`
`periods of time,
`
`ll},
`
`Therefore,
`
`l
`
`instructed that the solvent evaporation experirnents for the ‘348 patent he
`
`conclucted, using rotary evaporation at teniperatures under 5°C. These involved long pr31‘lOClS
`
`of time to rernove S1ll"l,lC‘if3l'l'i solvent to render the extract suitable for hurnatn consumption.
`
`l-lowever, as reported in the ‘348 patent, the resultant extracts contained only small amounts
`
`of extraction solvent resirlue, below the lower tolera.te<l level for chronic consumption. See
`
`‘348 Patent, Table 6 (reporting “Solvent residue[:} <25 pprn”).
`
`ll.
`
`Accordingly, among other major advances, the ‘348 patent encompasses the removal of
`
`extraction solvent at low temperatures and thus, unlike prior teachings of others, retains the
`
`str'nctur'alt integrity of the key components ofthe extract and allows the extract to be suitable
`
`for human consumption.
`
`[Remainder -1/wfthe page left intentionally blankj
`
`3
`
`000003
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`000003
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`

`
`14
`
`G9:G2:é8
`
`(F-'36--2{¥‘:2
`
`4/4
`
`Deciaratian ef Fatizai Saznpahls, M.D°., Phi‘).
`U.S.S.N. 95./001,774
`
`12.. I fuamer dmsiatre that all steatemcms nude hczrein of my own knowiedge are: true, and that all
`I
`statements made on infom1at.i0:nV angi beiief aye beiieved to be me, and flxrthsr, that. éhcsc
`
`siatemems wera made: with the: knowledge that wiilfui false siatetnents arm the like so made
`are punis§?1:ai3}.«:~: by fine or :?m.prés.c:zm1ent, or both; under Sectinn 100}. of Title 38 :5? the Uniisd
`Stzmzs (ZTLu:E:.?,'an<i {hat such wiiiifui false stateinsamta 1"n.3,y jmpardéze the vaiidiiy of US. Patent
`,c»3<>,34&
`'
`0
`0
`
`GO
`
`
`
`Egtziaz S2..mpaE1s, ?.\/.L‘D., $331.32}.
`
`Dated: _,~\;’\_y_’§;g;._:1_r_¢_*§g___.‘g§, 203 2
`
`WW. V49/’;‘§4{;.£‘ ..-V, .;~,’{3§‘>§««.._\-N .. ....,.~...,,.‘..w. ..,..' ».v...,..~m»......w».».-_,.,.......,...w.,,.'... ...wM.»-.-,...-z..'.......w..;;..(..».w~A‘<-Alw*o¢r«-Au .-4.,w....,,,.,.w,m..,,a.-». ..,_.
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`\V-\A‘\IA—'€>\\WA\~V\—»’.‘l- _».,,.,..,.‘ .., ..-. ..,_.,..M ... .V..\.,.,,_....\.,.,....,.,,.,~. >4!/~\r
`
`..,....M. \Al¢A>—V
`
`000004
`
`000004
`
`

`
`U,S.S.N. 95./'00”? ,3774
`
`Declaration of Dr. Fotini Sampaiis
`
`A§§$EE§§X A
`
`Cumsuium Vfiae M313 Eating? Sampaiis
`
`000005
`
`000005
`
`

`
`F{}T1N E SAMPALES, M.B.,, Ph. D.
`
`Cwrricuium Vitae
`
`Last Revised: March 2012
`
`A. IDENTIFICATION
`
`e—meii:
`
`iir1a.sampaiis@,grnaii.c0rri
`
`5E‘.E}UCATi'ON'
`
`Year
`"i‘itie
`[De rrrtment
`'
`Universi
`
`
`as McGiii Ur1iye:rsi‘ry
`
`6'» University of Patras
`Greece
`
`6'»
`
`Peciiatric Surgery Clinic
`
`P. and A giaia Kyriakou
`
`Athens Pediatric Hospital
`Greece
`
`G Uiiiyersity General Eicspiiai
`Greece
`
`8 Uiiiyersity of Athens
`Greece
`
`Physiology
`
`Medicine
`
`09/} 980-05./1983
`
`MD.
`
`09/19 84---05./19
`
`Pediatric Surgery
`
`Residency
`
`09,/1992--07/’1994
`
`Pegiiatric Surgery
`
`Residency
`
`07,/1994--07/’i997
`
`Grariirate Stiidies
`
`Doctorate
`
`()9,I’19§P4-v09//’i997
`
`e McGiii Uriiversity
`
`Experimeritai Surgery i’i1.D.
`
`09,/1997 -- 06/2006
`
`C. SPECEAL HONURS, SCHOLARSHEPS
`
`Year
`
`Narne
`
`Amnunt
`
`University
`
`at
`
`at
`
`at
`
`as
`
`i980— i 985
`
`Heffirian LaRcche
`
`S i 80,000
`
`<3i‘3ftingeri, Germany
`
`Switzeriaiid
`
`Dusseidorf, Germany
`
`E 990
`
`Dani sh G ovemrn em
`
`33 i 0000
`
`M'arseiisbi‘;rg, Di3IlITl’c1l‘i(
`
`Medicai Sciiciarship
`
`i997—i998
`
`US. Surgical C0i°p0ra.ii0n
`
`$30,000
`
`Wefliii, Cariada
`
`199 8
`
`Heieri Hutciiisiioii
`
`i 5,000
`
`Mcfiiii, Caariaday
`
`D. AVVARDS
`
`9
`
`9
`
`June 2011
`
`Deka Innoyaiieii Award by The E-ieiienic Beard (if Trade of
`
`Metropeiitari Mentreai
`
`June 2011
`
`i1”1flOV3,ii0I’I Award (£2011, Genesis Gala held by Bi0Quei§ec
`
`Pace 1
`000006
`
`17/03/2012".
`
`000006
`
`

`
`E. TEACI-IING
`$1
`
`l985—liii Patras University Tutorial Services Tutor
`
`88
`
`S
`
`F.
`@-
`
`8!
`
`8
`
`l987—88 Patras University l')erinatology Clinic Tutor
`
`l995~97 Atliensljniversity Teaching Asisistant, Department of Surgery, Breast Clinic
`
`(}TI*IER ?R(IFESSI(INAIi ANI} SCIIENTIFIC CI)NTRII§I.l'fIONS
`
`Ilresident of Student Council, Uiiiversity of Patras, Greece, l98-4 ~ l988
`
`Rural Practice, Ancient Olynipia Medical Center, Greece, l99O i992
`
`President ot‘ATTll<;A Residence Association, Greece, l995—l 997 3
`
`lA'l”l{ll<,.O CE.N'l'ER Breast Clinic, Medical Center, Surgical Consultant, 1996--1997
`
`Educational Speakers Bureau in the Canadian Faculty of Medical Speakers for
`
`Miralunia, (Scintirnainniogranny) Breast Imaging, October l998
`
`Educational Speakers Bureau in the United States Faculty of Medical Speakers for
`
`Miralunia (Scintirnairinir_tgi‘aphy) Breast Imaging, October l999
`
`international Educational Spealrers Bureau in the United States Faculty of Medical
`
`Speakers for Miralunia (Scintirnairiniography) Breast lnmgiitg, Noveniljer l999
`
`Neptune Technologies & Bioressources, l999~ present
`0
`Chief Scientific Officer:
`
`is Lead the R&D department oi'7Neptune heing responsible for the developrnent
`
`and validation of marine sourced liioactive ingredients proven effective for the
`
`rnanagenient of dyslipidernia.
`
`5* During these years she has been in charge oftlie coinpaiijfs intellectual
`
`property, with issued patents in 30 countries, regulatory affairs and key
`
`strategic alliances.
`
`0
`
`President of Neptune’s two piiarrnaceutical sulisidiaries, Aeasti Pliarrna lric
`
`leading the development of two novel patented active pliarniaceutical ingredients
`
`targeting the prevention and treatment of mixed dyslipidemia and cardiornetaliolic
`
`disorders. In Acasti she is worlt:ing with world renowned KOLS like Dr. Steven
`
`Nissen, ‘Dr Jean Davignon, Dr lacqiies Genest, Dr Riith l‘vic‘Plierson, Dr William
`
`Harris and Dr. Magdy Abdel Malik.
`
`G.
`
`PUBLICATIONS
`
`'l'sa.nil>a.os D., Suing alis F., Berger H, Nikiferidis G; UV--radiation induced slrin cancer:
`
`Irllllbililflil by oral arotinoids. Gior. ltal. Chit. Derniatol. Oncol. 2:409 — 4l2, i987
`
`'l‘sainl:>aos D, Berger H, Sarnpalis
`
`Nilciforidis G;
`
`lst cine llernniung der
`
`Pliotol<arzinogenese dureii orales Arotinoid nioglicli? Ar;2:tiiclie lslosrnetologie, l9:
`136, i988
`
`l34 —
`
`Tsarnliaos D, Sanipalis l7., Berger l*I.: Generalized cutaneous liyperpigi'nentation in
`
`hairless IIIICEE, induced hy topical diinetliylbeiizaiithracene. Exp. Cell Biol, 57: 292 -- 299,
`l989
`
`Nil<:iforidis (3., 'l‘sainl:>aos D, Balas C, Sainpalis F; Meclianical Pi‘operties of liuinan hair
`
`in relation to its gross morphological and rnicrostructural features. Proceedings of the I
`
`5*’
`
`4.
`
`P 0° 2
`3650007
`
`000007
`
`

`
`Congress or‘
`
`the European Acatlerny of Dermatology and Venereology, Florence,
`
`Septernber 215 ~ 28, i989
`
`Ur
`
`Zeiya C., Sa.nipa.lis F., l<;iria.l<i ll, Gogas J ., Alevizou V; Tc Tetrofosrnin irnaging F. in
`
`breast turnours suspicious for rnalignancy. European Journal of Nuclear lvletlicine, i224;
`9.l996
`
`Marl<opoulos C, Sanipalis
`
`Givalos N}, Gogas ll: Association of breast cancer witli
`
`rneningionia. European Journal of Surgical Oncology Atig;24(4):332—4,l998
`
`l\/larkopoulos C., Sainpalis EL, Gogas ll, Kiria.l<oii V}: ‘Bilateral l3‘a.get,’s Disease, liuropean
`
`Journal of Gynecological Oncology l8((i):495—496, l 997
`
`lv’lai‘l<opoul0S
`
`Sanipalis
`
`Zerva. C., K.irial<i ll, Kitsou
`
`Gogas 3., Alevizou—'l'erzal<i
`
`V; 99n1TcTetrolosrnili
`
`imaging in breast tumors. European Journal of Gynecological
`
`Oncology l9(2):l63-l66,l998
`
`ll).
`
`ll.
`
`Markopoulos (3., Sarnpalis F., Gogas J-l., Kiriakou V .: Cavernous liernangionia of the
`
`breast. European Journal of Gynecological Oncology. l.9(3):‘.24lv6—8,l99f§
`
`Tailleler R, Sarnpalis JS. Sanipalis FS., Laufer .l., Veireult J ., Durnont M: Reduction in
`
`Unnecessary Breast Biopsies
`
`and lvlissetl Breast, Cancer Using 99nt'l'c—Sesta.nii‘oi
`
`Scintiniannnograpliy. J. Nucl. Med. 1999; 40 (stipplenient), 249?
`
`Sanrpalis F-S, Denis R, Picartl D, Fleiszer D, Martin G, Nassif
`
`Sarnpalis JJS.
`
`lnternational prospective
`
`evaluation of
`
`scintiniarrnnograpliy with
`
`99rntecnnetiurn
`
`sestanribi: interirn results. Anierican Journal of Surgery 200i; l8L2(/-'l):344—403.
`
`.Sanipalis
`
`Denis R, Picarcl D, Fleiszer D, Martin G, Nassif E, Sarnpalis
`
`International
`
`prospective
`
`evaluation of
`
`scintirnarnnftogr'apny' with 99nrteclnnetiurn
`
`sestaniibi. American Journal of Sui'gery 2003; l8S:54l4—49.
`
`.l..il:ternian M,
`
`iianipalis
`
`l3, Miilrler US, Sarnpalis
`
`JS. Breast cancer diagnosis of
`
`scintiniannnograpliy: a nieta~analysis and review oftlie literature. Breast Cancer Research
`
`and "l‘reat,nient 2003; 80( l):l l5—26.
`
`l4.
`
`Sarnpalis F. Bunea R. Pelland Ml-7. liowalski 0. Duguet N. Dupuis S. Evaluation of the
`
`effects of Neptune Krill Oil on the nianagernent of prernenstrual
`
`synclronie and
`
`tlysrnenorrhea. {Clinical Trial. Journal Article. Rantlornizeti Controlled Trial] Alternative
`
`lvletlicine Review. , 2003; 8(;):l7l--9.
`
`. Sarnpalis T. Benelices pour la sante liurnaine de l'utilisation dc l‘eXtrait lipielique tlu Krill,
`
`NAEAS, Zlltlll ; 2(l
`
`l6.
`
`l7.
`
`Sanipalis T. S-llO'ult1l We Attri‘o’ute Potential Pro—arrliytnniic Properties to Ornega~3 Fatty
`
`Acids or Only to Fish Oil? Arnerican Naturopathic Mecliciiie Association, 2095; 9(3)
`
`Sarnpalis T. The J-lealing Power of Nepturie Krill Gil, Rebus LLC. New York, 2005
`
`Sarnpalis JS, Lilaerrnan M, Davis L, Angelopoulos J, Longo
`
`loch ls/l, Santpalis F,
`
`Nikolis A, Lavoie A, Denis R,
`
`lvlultler DS. Functional status and quality of life in
`
`survivors of injury treated at tertiary traurna centers: what are we neglecting? Journal of
`
`Trauma 2006; 6€}(4,):8(l6—l 3.
`
`000008
`
`

`
`i8.
`
`19.
`
`Bissonnette S, Habit) R, Sainpaiis F, Bouiras S, Sainnaiis JS and the Ezetroi Acid~Oii
`
`Investigators, Efficacy and toierahiiity of Ezetirnibe ithng/riay eowariniinistereti with
`
`statins in patients with prirnary hyperciioiesteroietnia not achieving target LDL—C whiie
`
`on statin inonotherapy: A Canadian. muh‘,i~r:enter, prospective study. The Ezetroi Ariri—On
`
`Sitiéiiy. Can .3 Cardioi. 2006 Oct;22(ji2):i035-44.
`
` E.i'i'atuin in: Can J Cartiioi. 2007 Feb;
`
`23(2):i59.
`
`Sainnahs IS, Sanipaiis F, Christen N. Iinnact of Bariatric Surgery on Cardiovascular‘ and
`
`Museuioskeietai Morbitiity. Surgery for Obesity and Reiated Disorders Siirg Ohes Reiat
`
`Dis. 2006 Nev—Dec;2(6):5t§7—9i. Epub 2006 Sep 22.
`
`H.
`
`SE L{E°CTED PATENTS / PATENT APPLECATHFNS INVENTOR
`
`1. Concentrated Therapeiitic Phosphoiipid Compositions (US. Patent Pub. No.
`
`2011016016?)
`
`’\
`
`4. Natural Marine Source Phosphoiipids Comprising Polyunsaturated Fatty Acids and
`
`Their .A‘ippiica.tions (US. Patent 8,(i3(),348)
`
`'7W
`
`Krill extracts for treatment OfC{:ll‘diOV’§:lSC11i9ll‘£;iiS€8.S€S
`
`(US. Patent 8,057,825
`
`4. Breast Cancer Lesion Detection and Localisation Device (CA) (Pub. # CA2324756)
`
`I.
`
`i.
`
`Saifnpaiis EL,
`
`'i"saniba.os D; The effect of careinogenes on rneianocytes of the skin, The
`
`Greek Dermatology Association Congress, Thessaloniki, January 25, £986.
`
`2.
`
`Sarnpalis EL, Tsarnbaos ii: The effect of arotinoie ethyiester in sebaceous gianiis in
`
`vivo. The Greek Dei'inato1ogy Association Congress, Thessaloniki, January 25, 1986.
`
`3..
`
`Sarnpaiis F., Tsanfliaos D; Mutationai pro erties of synthetic retinoids:
`
`in Vitro
`
`experinientai studies. The Greeir Derrnatoiogy‘ Association Congress, Athens, Aprii
`
`19, 1986.
`
`4. Tsarnbaos
`
`1)., Sarhpaiis F3 Pi'opiiyiactic
`
`effect of retinoids
`
`in experiinentai
`
`carcinogenesis of the skin. National Greek Medical Conference, Athens, May if-1 — £7’,
`
`E986 (First award for best oral presentation).
`
`5. K.atsaVocnristos PX, Sarnpaiis 13,, Tsanii.iaos 13.: Tire effect of hyperoxidants on
`
`epitheiiai “tissue. The Greek Derrnatoiegy Association Congress, Athens, June 28,
`1986.
`
`6.
`
`Sarnpaiis 17., Tsarnhaos D; Stirnniation of cutaneous rneiariocytes by D.M.B.A.
`
`Congressns Qtiaittis Derinatoiogiae Bnigaricae, Verna, October 3-5, 1986
`
`7. Tsarnbaos D, Sarnpaiis F.: Effects of orai arotinoid Re 15 — 0778 on the sebaceous
`
`glands. Congressus Quarttis Derinatoiogiae Bnigaricae, Verna, October 3-5, 1986
`
`P 0° 4
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`Tsanihaos D., Sarnpalis F., Berger‘ l-l., Sarnpalis .3}: UV radiation — inclueetl sls:in cancer:
`
`lnliibition by oral arotinoitls. International Syrnposium on Aging and Skin Cancer,
`
`Rome, February l5 — l9, i987
`
`Skoiitelis A., Sarnpalis F., Tsarnhaos D; Morphological study of triehotlriotiystrophy.
`
`The Gl‘€t3lt' Dermatology Association Corigr‘ess, Athens, _/»ipr'ii 25, i987.
`
`Tsa.n“il3a,os ll, Sa.rnpa.lis
`
`Berger ll, Sa,rnpa.lis .3}: Prevention of skin carcinogenesis.
`
`International Congress ofNutrition, Growth antl Caneer, Athens, April 20
`
`26, i987.
`
`Mantagos
`
`'l'sarnl3a.os
`
`i')., Sainpalis
`
`l5'.: Sebosupressive activity of a new
`
`noriteratogenie retirioid. Annual Meeting of the Society of Cutaneous Ulti'astruetur'ai
`
`Research, Erlinhiirgh, July 8 — l l, i987
`
`Sanipalis E, Tsanihaos D; Recognition of the epiclerniai arnirioaeids eatrsetl by
`
`systemic retirioids. The Greek lilerinatology Association Congress, Tril<ala, October l,
`l988.
`
`.
`
`'i'sa.nil3a.os 1),, Nil<iforitlis G., Sa.rnpa.lis F: Mechanical properties of huinan hair in
`
`aging. Vi World Congress of Dermatology, Rio ale Janeiro, April 29 - May 3, W89
`
`Nll(ifOE“l(liS G.,
`
`'l'sainbaos ll, Sainpalis EL, Bezerianos
`
`‘Salas C; COtTGpu’t€)1”lZ€c'.i
`
`system for quarititative determination of the viscoelastic pararneters oflinrnari hair. Vi
`
`Worltl Congress of l)erinatology, Rio tle .laneiro, April 219 — May 3, 1989
`
`. Nikiforidis (3., Tsarnbaos 1)., Balas C, Bezerianos A., Sampaiis F;
`
`l‘:/lechariical
`
`properties of hiirnan hair in relation to its gross nioi'plftological anal rniei'ostructural
`in
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`t}fl:l€ET1‘i2i"tt}l0C{
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`
`Florence, September 25 ~28, i989
`
`l6.
`
`Sanipalis F., Balas K, Niltiforidis (3., Tsarnbaos D.: Viscous and elastic parameters of
`
`hair with triehotltiotiystropliy.
`W90.
`
`loth National Greek Merlioal Congress, May 8 — ‘:21,
`
`Tsa.n“il3a.os 1)., Nikiforitiis G., Sarripalis l9'., Balas C.: lVleelia,nical pai'arnetei's of human
`
`hair in ancirogenetie aiopeeia. 9th Regional Conference of Dermatology (Asian -
`
`Anstralasiaii), Kuala Lnrnptir, lune l9 - 24-, l990
`
`Tsanihaos B9,, Kalofoutis A., Sampaiis F., Kouloelieri
`
`l-3.: Oral acitretin induces
`
`alterations in mouse liver phospholipitl composition. 9th Regional Conference of
`
`Dermatology (Asian — Australasian), Koala i..nrnpi.ir, June l9 — 24, i990
`
`l9.
`
`Markopoulos C, Sarnpalis F., Gogas
`
`l§ai'idal<is 8., i’apa.christodorilou A., Gogas
`
`3.: Axillary lymph node metastasis in infiltrating breast minors with greatest tliarneter
`
`of 1 cm or
`
`Annual Congress of the Greels: Mastology Association, Patras, March
`
`3l —April 2, W95.
`
`Liapis C., lvlisiakos
`
`Sanipalis F., lioutsogiorgas l’., Gotigoulakis A., Dousaitou M},
`
`Berilrolcos C., Seclias M; The treatment of a celiac artery ariet.irysrn in the presence of
`
`a petaloid l<is;lney. lst Hellenic---ltalian Congress of Angiology antl Vascular Surgery
`
`with lnterna.tionai participation, Ancient Olympia, May 211 — ‘.25, i995.
`
`i7/03/Z012".
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`i\/1.ar'i<opo’u1os C., Gogas H., Sarnpaiis F., Aievras P., Kontzogiou K., Gogas 1.: Breast
`
`cancer in the ehieriy. OEC1 Conference, Cancer in The Elderly, Athens, Greece, May
`
`1(1~ 12, 1996 (Poster)
`
`.7
`
`23.
`
`Zerva C., Sarnpaiis Fa, Kiriaki 1)., Kitson 13., Gogas 1., Aievi;2:ou ‘v’.: TeTetrofosrnin
`
`irnaging in breast tnrriors suspicious for rnaiignancy. Eznropeart Association ofNticiear'
`
`Medicine Congress, 14 - 18 Septeniher 1996, Copenhagen, Dehinari-<
`
`Marhopotiios C., Koufopouios K., Sarnpaiis
`
`13., Karidakis 13.,
`
`iélontzogiotr K,
`
`Tzottzotis 13., Flores 1),: The surgical treatinent of non—paip,ab1e breast tumors. XX
`
`National Greeis: Surgical Congress, Athens, Novernber 3
`
`7, 1996.
`
`'
`
`. Karidahis 1%,, Markoponios
`
`Sarnpaiis F., Tseieni
`
`Gogas 1.: Weihdifferentiated
`
`thyroid cancer
`
`Staging and prognostic factors. XX National Gr'ee1<.' Surgicai
`
`Congress, Athens, November 3 — 7, 1996.
`
`7?‘?
`
`Sanipaiis
`
`Markopotiios C., Zerx/a C., Kir'iai<i D., iiitsou
`
`Gogas .E., Alex/izou~
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`Terzaki
`
`Scintiniarnntography in the diagnosis of breast tumors, XX National Greek
`
`Surgical Congress, Athens, Novernber 3
`
`7, 1996.
`
`. Kittas C., Koirtronrnpi E., Marhoponios C, S’<l1’1'.tp3.iiS R, Kiriakoti
`
`Spa.na1<i
`
`tliorgouiis 13., Gogas 1.: A study of the oncogene p16 in breast cancer. Nationai
`
`Congress of the Greek Mastoiogy Association combined with the internationai
`
`Congress of the Greek Association of Breast Cancer Research. Aiexaridronpoiis —
`
`'i‘hrace, June 12.
`
`16, 1997
`
`. 1<.ontseiini E, Sanipaiis 17., Maricopouios C., Csogas H, Aiexoponion 1)., Kandarairis
`
`C, Gogas 1.: irnninnocytocheniical study of oncoprotein hci--2 in inriitrating breast
`
`carcinoma cei1s. National Congress of the Greek Mastoiogy Association combined
`
`with the international Congress of the Greek Association of Breast Cancer Research.
`
`Aiexandronpoiis — Thrace, .1D.1'l§3 i2 — 16, 1997 (First award of the “iaso” institute for
`
`best scierititic paper).
`
`28.
`
`29.
`
`39.
`
`Markoponlos C, Sanipaiis F, Zerva C, Kiriakis 13., Kitson E, Gogas 1., AieVizon—
`
`Terzairi B: The roie of 99rn Te Tetrofosrnin Sciritiniarnrnography in the diagnosis of
`
`breast cancer. Natioriai Congress of the Greek Mastoiogy Association combined with
`
`the internationat Congress of the Greek Association of Breast Cancer‘ Reearch.
`
`Aiexandronpoiis — Thrace, June 12 — 16, 1997 (Second award for best scientific paper)
`
`Kontseiini
`
`13.,
`
`iviarhoposnios C, Sarnpaiis
`
`Gogas
`
`H, Alexoponiou
`
`13.,
`
`I..tanipropou1orr 8., Gogas .1 .; Th? expression of protein nniI?13 on ce11n1ar prints of
`
`invasive breast carcinornas. Natioriai Congress of the Greek Mastoiogy Association
`
`combined with the internationai Congress of the Greek Association of Breast Cancer
`
`Research. Aiexandroupoiis — Thrace, June 12 — 16, i997’
`
`Sa.rnpa.1is F., Mariroponios C., Zerva C, Kiriahi D., Kontzogion K», Gogas (3.,
`
`AieVizou—Ter;:ai<i V., Gogas 1.: Tc Tetrot"osniin irnaging in breast tumors suspicions
`
`for niaiignancy. internationai Strrgicai ‘Week 1997, Atrgust 24 -- 3t), 1997, Acaptrico,
`Mexico
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`
`triultlceritricity of breast cancer. lnternatiorial Surgical Weelr l997, August 24 ~ 39,
`
`I997, Acapulco, Mexico.
`
`. Sarnpalis F, Fleiszter D., Sainpalis J.: Evaluation of the Arlvaneerl Breast Biopsy
`
`lnstrurnentation Systein. Royal College of Physicians antl Surgeons of Canada l998,
`
`67th Annual Meeting, Septeniher Elli-‘.27’, i998, Toronto, Ontario, Canada.
`
`. Sanipalis l3.,
`
`l\/l.arl<opoulos (3., Zerva C, Fleiszer D, Sanipalis 3.:
`
`livaluation of the
`
`99l”ll-TC 'l'etrofosmin Imaging in the Assessment of Breast Tuinors. Royal College of
`
`Physicians and Surgeons of Canacla i998, 67th Annual Meeting, September 24-27,
`
`l998. 'l"oronto, Ontario, Canada.
`
`Sanipalis F; The Clinical Usefulness and Cost-liffectiveness of Scintirnainniograpihy
`
`wltli "l‘c~99ni-Sestaniihi. “Guest Speal<er” l999 Canadian Nuclear Medicine Society
`
`Annual Scieiititic M eeting, March 27-3 l, l999, l:§antl’, Alberta, Canada.
`
`‘. Sampalis F; Seintiinannriography Wllll
`
`'l'c-99ni—Sestaniihi
`
`in our Clnical Practice,
`
`“Guest Speaker” W99 Annual Meeting of Obstetricians anal Gynecologists, May 2l,
`
`1999, Ottawa, Ontario, Canacla.
`
`. Sainpalis
`
`Denis R; Localization of non-palpable breast lesions detected only by
`
`scintirnainniogr'a.pliy with 99in--Teclinetiuin Sestarnihi.
`
`“Guest Spealrer”
`
`2t)(3(}
`
`Canadian Nuclear Medicine Society Annual Scientific Meeting, March 29 — April 2,
`
`Ztltltl, Mont 'l‘rernt*rlant, Quebec, Canada.
`
`. Sainpalis F, Sainpalis .l: Seintiinarnrnograpliy. Tlie New Frontier For Breast Cancer
`
`Detection. “Guest Speaker” 25th Annual Meeting Of Royal College Of Surgeons Of
`
`Thailanrl, July l5,2(l(l0, Royal CliffBeacli Resort Pattaya, Tliailantl.
`
`38.
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`Prospective
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`Evaluation
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`
`Seintirnainrnograpliy With 99rn—teclinetiurn Sestarnihi. Interim Results. Zntl Annual
`
`Meeting ot‘The American Society of Breast Surgeons, May 3-6, 2001, l-lilton La .lolla
`
`Torrey Pines, La lolla, California.
`
`Sarnpalis T.
`
`lniproves;l Bioavailaliility antl Effectiveness of Polyunsatnratetl fatty
`
`Acids. lnternatlonal Foruni Life Science 2905, lfieyern Innovative GniBll and City of
`
`Biotechnology, Laval, Quebec, Canada, Municli, Germany, Deceinlier l2, 2004
`
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