Attmney Becket N 9.
`
`T33 PN—i}03/'001} S 3} 3€§(§3—2€}§ 5 (AKBM-321'7~'-i}
`
`?ATTENT
`
`EN
`
`UNTTEIB STATES PATENT ANT} T"RABTIMART{ GF T'<‘l?CTI
`
`in Re Patent ef:
`
`SAMPALIS, Fotini
`
`Confniiiatieii Ne;
`
`ii 897
`
`Control No:
`
`95./'00 1 , 774
`
`Group Art Unit:
`
`3991
`
`Filed:
`
`FOR:
`
`Oetehei i9fi 2011
`
`Exeniiner:
`
`CAMPELL Bruce R.
`
`TNTER PARTES REEXART 917 US. PATENT 8,030,348: NATURITTL MARINE
`SOURCTE T’E§0S§’Ti0T.fET’iE}§§ CGM§’RTSENG T’C’LYUNSATURATEE)
` F,i\'T'i”Y
`
`ACTBS AND THEIR AP ?T..TCATT{)NS
`
`Mai} Step Qeeieretien
`C()1'1’itIliSSi0Ii€1' fer Patents
`
`PO. Box M50
`
`Ai6X8.1ld,1'ia, VA 223 i 3-1450
`
`
`
`E, Bari L. White, declare as tbiiews:
`
`1.
`
`i am at
`
`Citizen.
`
`2.
`
`1 ant etmrentiy the President and CEO of MD); Biefxnaiytieai Labeietoiy,
`
`inc. in College
`
`S'tEt't'.i{_‘.iIi, TX, which offers, ahmitg other things, expert zttiztiytieai services for the identification
`
`of hiesuhstances.
`
`[N
`
`I have 61 PhD. in analytical eheinistry specializing in mass speetroiiietry from the Uiiiversity
`
`of Nerth Careiina. at Chapel i-iiii. Since i985, i have wei‘i<:ed prefessieneiiye in the area ef
`
`eiiaiytieai chemistry and mass speetmiiietry (amend 27 years).
`
`I was appointed aiici served
`
`as ,A£iju11£‘.i. Professor ef Ch,f:D'1iSi1'_‘y’,, Wake Forest University, Depertinent of Ci’i€i(}'tiiSt1”§/ and
`
`have published niere than 27
`
`reviewed jeurnai articles.
`
`I eurrentiy seive as 21 Peer
`
`Reviewer fer J. {7.i1mmaiog2i‘(1pi1ic Sciemre and J. C7i1r0nizar0gm<zpizy.
`
`I am a metnber (if the
`
`Aineriean Cheniicai Seciety (CN€I3S~Seetien Ciiairrnaii
`
`‘E33, ChainiiEeet/i’1regi'ain Chair “[92,
`
`«'eei'etary ‘9i and TI'€:’<!.§u1"t31‘
`
`‘$50), Mississippi Aeadteniy of Science, Society of Aiiaiytieai
`
`000001
`
`Petition for Inter Partes Review
`Of U.S. Patent 8,278,351
`Exhibit
`
`ENZYMOTEC - 1055
`
`000001
`
`

`
`U.S.S.N. 95./tllll ,7?‘
`Declaration of Dr. Earl l_.. White
`
`LI:
`
`6.
`
`Cheniists of Pittsburgh, Applied Spectiescopy Society, Phi Lambda Upsilon Honorary
`
`Chemical Society, America Society for M ass Spectrornetry, National Technical Association
`
`and Alpha Phi Alpha Fraternity, lne., Triangle Area Mass Spectronietry Discussion Group,
`
`National Organizatiori of Blacl: Chemists and Chemical Eirigirieers (N()l3»CliClE3), Bay Ai'ea
`
`l\/lass Spectrornetry Discussion group (BAl‘vlS) and the SF Bay Area Proteorne Society. My
`
`Curriculum Vitae is attached Appentlix A.
`
`l am consiclered an expert in the area of ideiititication of hiornolecules using, analytical
`
`techniques in general, and mass spectroine.try, specifically.
`
`l ant being cornpensated at my customary hourly rate fill‘ my time spent on developing,
`
`forrniiig, and expressing the facts and opinions in this cleclaration.
`
`l have no personal interest
`
`in the ultirnate outeonie of the reexaniination proeeediiigs involving US. patent 8,{}3ll,3r-l8
`
`(“the “"348 patent”).
`
`ln Ztlll, MDX Bioztinalytical Laboratory, lnc. was contracted. hy Neptune Tecliiiologies and
`
`Bioressources,
`
`lnc. of Quebec, Canada to analy;2:e certain phospholipid samples {the
`
`“Beaudoin Qil Fractions”) and report which fatty acid phospholipitls are present.
`
`Furthermore, l was asherl to opiiie on whether certain fatty acid phospliolipids were present
`
`or absent in the Beaudoin Gil Fractioiis, Within the levels of detection ofa conventional mass
`
`spectrometry experiment. The results of this analysis were suhiiiittetl in a Declaration <la.terl
`
`May 3l. 2(3ll in
`
`l(l.«"4-85,094 (now the ‘348 patent). There, l stated that “it my
`
`opinion that the Beaucloin Oil
`
`l9‘ractiohs received and testecl by me do not contain l’Ls
`
`[phospholipiclsj which have attachecl to them Dl~lA and DHA, EPA and EPA, l3‘l::lA and EPA,
`
`or EPA and DHA, at the detection limits d.esei‘il*>e(l ahove in paragraph 7 [outlining liquid
`
`chromatography/niass speetrorrietry (LC/l\/lS) and tandeni niass spectrornetry (l\/lS,/MS)
`
`techniques].” White Declaration ofivlay 3l, Zill l, fit l3.
`
`l have heen informed that Al{€:l' Biol\/larine filed a Request for Reexamination {U.S.S.N.
`
`95./{ltll ,774) which questions the accuracy of the data that l presented in the Declaration of
`
`May 3 l , 201 l. Al<:er also filed. a Corrected Request for Reexarnination, which I have read.
`
`I specifically note that Al<er’s Corrected. Request for Reexarriination states, at pages Zllwll
`
`(ernph asis add.eal.):
`
`OOQD02
`
`000002
`
`

`
`U.S.S.N. 95./Gill ,7?‘
`Declaration of Dr. Earl L. White
`
`“Requestors further note that the analysis hy Dr. White was incomplete hecause Dr. Wliite
`apparently did not utilize any reference standards or positive controls in his analysis. This raises
`the questions of whether: 1) the conditions used by Dr. White were sufficient to detect the claimed
`phospholipid species; and 2) the assuniptions by Dr. White in the interpretation of the MS data
`were correct.
`dl:
`t
`'
`'
`‘"
`
`tndpoin
`tion 1 Chin ties. From an analytir
`Validate the det.
`_
`, iefere ce
`‘
`
`
`
`
`
`standarcts and ‘(iSlilV€
`controls to ‘verify’ that the analytical procedures are Worsuig and W ill
`perform their intended purpose.
`it
`is especially important
`to optimize mass specti'onietri(:
`
`paran
`is using re ference compounds. See the Declaration by Dr. Thoinas Gundersen in Support
`oflteogtiest for inter Parties Reexamination ofU.S. l’at.ent No. ?5.0'30,348.”
`
`9.
`
`I clarify herein that, as is standard in the industry, I eonteniporaneeusly ran adequate controls
`
`when l eondticted the experiments that were reported in the Declaration of May Bl , 201 1.
`
`10.1 suhniit herewith controls, which were analyzed at the sanie tiine the experiments were
`
`a.naly;3.ed, that were reported in the Deela.rati.on of May Ell,
`
`'20l l. Specifically, i ran the
`
`tellovvting eontrols that are St1TYlt.‘(12tl'i2‘.€Cl
`
`in detail helow:
`
`a.
`
`a series ofposirive controls in the form of a coniniereial phospholipid standard set
`
`which contains four pliospholipids of various weiglits; and
`
`h.
`
`a selvent—only rzegative control of 20% acetonitrile, which was run at the beginning of
`
`the experiinent and hetween each run that involved a species that differed frorn the
`
`previous.
`
`As discussed helow, such a contrel
`
`is crucial
`
`to correct
`
`for
`
`the
`
`eontaniination of data froin other samples (the somcalled “nieniory effect” or “carry~
`
`over effect”).
`
`ll. it is necessary to run positive centrcls to demonstrate expeiiinental sensitivity and validity of
`
`data generated.
`
`it is well known in the field that such controls inust he run, and therefore I,
`
`having over 25 years in the field, ran adequate positive controls in generating the data
`
`reported in my Declaration of May 3 l, Ztll i.
`
`12. Specitica.lly, I ran a series of positive controls in the forrn of a cornniercial pliesphoiipid
`
`standard.
`
`l?’igure l). This standard. set is cornrnereially available trorn Sigrna-Altlrich
`
`(Catalog No. P3Sl7-IVL). This standard set includes four different cornnion phospholipid
`
`species of dittereiit
`
`rnolecular masses,
`
`such
`
`as
`
` l_.~(i..—lysophosphatidylcholine,
`
`L-"fie
`
`phosphatidylcholine, L-onphospliatidylethanoiarnine, and L—d-pliosphatidylinositol sodium
`
`salt.
`
`13. llurther, a sound and experiinentally viahle mass speetroineti'y experiment i'equires solvent
`
`“hlanle” or “negative centrol”" sainples at the beginning of a series of runs and between
`
`OOQD03
`
`000003
`
`

`
`U,S.S.N. 95./Gt)? ,3774
`Declaration of Dr. Earl L. White
`
`different experiinentai runs, specifically when the chemical species to be studied are different
`
`between runs. Such standards correct for the ‘Tnernery effect,” ale, contarnination froin the
`
`cheniieal earryoVe.i* from prior sainpies. Blank controls in the form of 29% acetonitriie were
`
`run first thing each day, between every sarnpie set (which wonhi wash out carry over
`
`species}, and at the end at a day as a eohnnn-cleaning technique. A representative soiVent~
`
`eiiiy run is irieiuded as Figure 2. Note that the signal inteiisity is at least one order of
`
`magnitude lower than in the positive centre} {6.{)t’iX104 in Figure ii Versus 1.5x} G3 in Figure
`
`2}. The small peak at 22.22 minutes is a, eontarniiiant in the seivent hiank. The noise level is
`
`indicative of the iew ievei ef this contaminant. The haseiine rise at 26 minutes is due to high
`
`eeneentration of acetonitriie used to clean the column.
`
`It is weii known in the tieid that
`
`megtztive centreis tntist he run and therefoi'e I, having over 25 years in the field, ran adequate
`
`negative eentrels in generating the data reported in the Declaration of May 31,, 2011.
`
`14. A,CC01‘:‘.‘ii1lgify',
`
`5 eeiiternperaneousiy ran adequtate controls (lieu, positive and negatixze eeiitreis)
`
`when I conducted the experiments that were reported in the Deeiaration of May 31, 20} 1.
`
`[rest of page intemioiwdly left blank]
`
`OOOIDO4
`
`000004
`
`

`
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`
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`
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`
`

`
`U,S.S.N. 95./O03 ,7?‘
`Declaration of Dr. Earl L. White
`
`Phosphoiioid std
`Hlvlaw.
`L
`.
`.
`‘
`I
`
`Figure 1. Total ion Chiomatograms for phosphoiipid staiidard soiutioii. This standard was
`analyzed with fu}E~:9ca.o eiecti‘ospray ionization during the anaiysis of o‘L}'ier phosphoiipido
`samples.
`
`000906
`
`000006
`
`

`
`U,S.S.N. 95/06)”? ,3774
`Declaration of Dr. Earl L. White
`
`c
`
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`
`
`
`
`
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`
`
`Ffigméb 2. Totai ion chmmatcgram far 2: 26)‘?/is EiC13tO1'}iU.”i}6IH2O blank. Seivent biaiiks are ofierz
`so1Vent—pmgrammed at 21 faster 1':»1te fur the Sofie purpuse of sin/ing tinwe as is the case hrtreg
`
`93791 V1/EN
`
`OOODO7
`
`000007
`
`

`
`Suppltzrnentai Declaration of Dr. Earl L. ‘White
`
`U,S.S.N. 95./'00”? J74
`
`A§§$EE§§X A
`
`Cumcuium Vitas sf D1: Earl L. Whfis
`
`000008
`
`000008
`
`

`
`ATTACHMENT A
`
`EARL L Vs/’HE'E‘ E — Currieuium Vitae
`
`MDX Bifi./~XI‘iaiy”[iCai Laberatery, Erie.
`R0. Be); 236
`
`Weiibein, TX 77881
`
`Oftiee: (979) Sir-$7368
`Ceii:
`(520‘s981~629€i
`
`
`
`
`Etiiieatieii:
`
`University of North Carolina
`at Chapel Hill
`Chapel Hill, North Carolina
`Majer: Chemistry (Ariaiytiizai)
`Graduated: June £987
`
`University ef Pittsburgh
`iPisttsburgh, Penrisyivarii a
`M aj oi‘: Ciieinist1”y (Anaiyticaii)
`
`Degree: PhD.
`
`1983 1987
`
`Spectrometry
`
`1975 ~ 1 977
`
`1975
`
`1973 ~ 1 974 (pamtinie)
`
`Degree: MS.
`
`Jaeksen State University
`;Eaekseri, Mississippi
`Majer: Chemistry (Organie~Ari-aiytieai)
`Graduated: August 1975
`University ef Mississippi Fvtedieavi
`Center, Jaei<sen, Wississisppis
`
`Degree: BgSg
`
`1967-197}.
`
`Umlergrarluate Seheei:
`Jackson State Ceilege
`;Eaekseri, Mississippi
`Majer: Chemistry
`Graduated: December 73 971
`
`Prefessienal Experience:
`
`
`
`
`
`
`
`ii/G8—preserit President :3; CEQ
`Established MD); in 2008 and ineerperated in 2009, inanage business eenipenent and
`directs teehniseai ftirietiens. Maiiages but get, prepares quotes, prepesais, pi'eteceis and
`repeits for services peifermeci.
`
`lnterated Biemeleeuie Ceremtien Tues
`
`
`
`J "
`
`373:3
`
`Vice President, Anaiytieal & Fiiarmaeeiitieai Sciences
`G7/07m 11/GS
`Manage Advance Anaiytieai and Quality Ceritrei funsetiens at the Cer'pera,te ievei. Assist
`seiii0i'manageir1erit with the staff estimates and budgetary i‘equii'emerits.
`
`000009
`
`000009
`
`

`
`(CV Coritkl)
`
`l?.A.Rli lg. ‘Wlll'"l”l?.
`
`
`G9/02- 04,/l-,/2‘;ll{l7 Vice Presldeiit, Advanced Analytical Sciences & Blreettir, Quality
`Control
`
`to
`lunctiorls at the corporate level
`Manage Advance Analytical and Quality Control
`include QC operations in tilwensboro, KY and Gerniantown,
`ls/ll). Assist senior
`management with the staff estimates and budgetary requirements,
`research and
`development focuses.
`
`llllreetor, Advance Analytical Resources & Quality Control
`ll)/99439/’(l2
`Establislierl and directed tlie Advanced Analytical Resources Division including Assay
`Development Group. Directed Quality Control Group for production of pharmaceutical
`products under eGMP guidelines (proteins expressed in ]\7icorz‘a:zna beztzzizazmtzna plants)
`including Pliase l Clinical
`trials of at non—l*lodgl<in’s lymphoma vaccine. Release
`vaccines to Quality Assurance for patients use and maintained stability studies. Directed
`proteomics functions Within the Advance Analytical Resources Division.
`
`Large Scale Blolofi 7 Cor oration lformerl Blosouree Teelinolo ties lne. . Vaeaville CA
`
`l,€l,"98~lG/99
`
`Sr. Scientist
`
`included staffing with
`(Ilroup wliicli
`Developed Advance Analytical Resources
`approximately l0 scientist and purchasing of mass spectrometric equipment to include
`GC/'l\/lS, l‘vlALDl—TOF, LC/Q—TGF t‘vlS/l‘vlS and LCQwl\/lS/'l‘vl-S.
`
`Roll. Revnolds Tobacco Corn an ’ W/lll§‘i(3nv§?t3l£?EFl NC
`
`
`
`
`
`Sr. Staff R&l3 Clieniist, W ass Spectrometry Group lgeader
`l2/’88~(l9./98
`'l"eclinical responsibilities include; analytical methods
`development and analyses,
`operation and maintenance of gas clnoinatograplt/mass spectrometer/data systems, report
`writing and teclinical publication/presentations.
`Supervisory and managerial responsibilities included; learlersliip of mass specti‘onietr_v
`group, project management, budget proposal, capital equipment purchase, supervision of
`personnel, personnel evaluation and directed postdoctoral fellow research, etc.
`
`l2/85—l 2/88
`
`nan Clieiriist
`
`Responsibilities include; analytical methods development and analyses, operation and
`maintenance of gas cln‘omatograpl1/niass spectrometer/data systems, report writing and
`teclinical publication/presentations.
`
`Natlitnal lnstltute ofllinviromnental llealtli Sciences Nll?. llS‘ Research "lrlaiivle Purl»; NC
`
`
`Clieniist/Graduate Student Q-A}}§M}lEt’tiYl§3EHf
`(39/’83—l2,"85
`Graduate Student, Teacliing Assistant, Rt3S€E1l‘Cll Assistant, Chemist on "P Appointment”
`with NlEHS performing ion—molecule reaction studies using triple quadrupole mass
`spectrometry (M S/MS}.
`
`
`Clieniical lndustrv lnstitute e
`
`l98 l—l983
`Associate Scientist, Head, Analytical Services L-nit,
`Performed duties consistent with those of a department head to include budget and
`project management, proposal writing, equipment purcliasing, writing reports, and
`2
`0000010
`
`0000010
`
`

`
`EARL L. VVHETE
`(CV Cont'ti)
`chronratograpli./'rnass
`operation
`and inaintenance of gas
`supervision,
`personnel
`speetromecter/'d.aita system, pnarniacoltinetics research, scientific writing presentations and
`publications.
`
`19774 981
`
`Senior Research Associate
`
`Performed toxicological research on environmental chemicals in small animal studies.
`Also, published the first peer—r‘eViewed niarruscript for CHT.
`
`‘Westing honse R&i1=, Pi3fiT§i)‘£1¥'§ii3 PA
`
`Sinnrner— l 977 Anaiytieai Chenii:-it
`Summer employment during gratlnate school.
`
`Universitv of Pittshnrgii. Pittsburgh: PA.
`()9/754 2/77
`Teaching/Research Assistant and firatinate Student
`'l'-aiight nritlergraduate clrernistry laboratory and performed r‘esearch.
`
`Mississi
`
`rm Crime Lahorator’/Universitv of Mississi :2 Medieai Center. Jaelisoii MS
`
`instrumentation Specialist/Section Chief, Toxieoiogy
`12/7r-l~8./'75
`Same as below with adtlitionali l,'8-S}30TlSli’)l,ill‘.y of mass spectrornete (l‘v’lS) purchase and
`Supervision of M S operator‘.
`
`Gl/73-12/'74 Toxicoltigist i/Section Chief, Toxieoiogy Section
`As Section Chief, Toxicology Section, coorclinated personnel, analysis of suspectecl drug
`overtlosage samples, operation and rnaintenance of
`eliromatographs/cliron’iatographic
`data
`systeni,
`€‘7V'£ll1.EEtl§l0Ii,
`specification writing,
`and
`purchasing
`of
`scientific
`instrumentation and performed hlootl alcohol analyses.
`
`G7/72~Gl/73 Toxieoioiiist i
`iPerformed anaiysiis of suspected drug overdosage biological sarnplest operation and
`maintenance of
`chrornatograplrs.
`
`Arniy Metiieai Hospital, Fort Qiaciésong South Caroiina
`G2/’72«-G6./'72 L/ai3or*atory'i"eehnieian
`
`ilriiversity of Mississippi Metiieal Center, Jackson, MS
`€36/’7l)~(P2.«"72
`LaboratoryTeehiiieian
`
`Appointments:
`Atljunct Professor of Chemistry, Wake Forest University, Dept. of Chernistry
`Liaison, R.lR_—Corpoi'ation Associate, American Cliernical Society
`Co—AdVisor, graclnate student program with North Carolina A&'l‘ State University
`Visiting Professor, National Urban League Black Executives Exchange Program (BEEP)
`Adjunct Visitirig Prtifessor, SeiWorl:<s ofWinston-Salem
`
`Anditionai iélxperieiieesz
`Proficient in the o aeration and maintenance of these Analvtical instruments:
`*7
`“.9
`ooobo11
`
`0000011
`
`

`
`EARL iii. is/iiii'"i”E
`{CV Coritki)
`Gas ehroinatograph/inass spectronieter/tlata systein, ultra—Violet Visible—, infrarecl—, atoinie
`ahsorption/'eniission
`spectrophcitonietei"s,
`pH meter,
`specti'oliuororneters,
`high
`perlcr'ii'iar1ce liquid clircrnatogra.ph,s, EMIT arialyzer system, liquid scintilliation counters,
`electi'ospray/'Al’Cl—MS, capillary electroplioi‘esis~MS aiitl l\/ES/"IVES.
`
`Gtiiersz
`
`Peer Reviewer:
`
`,lournal — J. Chroincztograpizic. Scz"enr:e
`Journal — J. Cizrrinzaiogmpizy
`Site Visitor/Grrant proposal reviei rer---NSF Grant l’roposal—lncarnate Worcl College (1994)
`
`Military:
`
`Lieutenant Colonel — Retired (April 30, 2009 w,/34.66 years of service)
`
`United States Army National Guard, December l 97 1 — l 977
`ll2lh l\«iP Battalion, H HID, Jacksoni, MS ~ Clerk Typist — 4 Years
`
`l07fl“ Field Artillery, HHC, l?’ittsl3urgli, l’A, Battery Aitlrnan ~ 2 years
`Discharge: Honorable
`
`United States Anny Reserve, August l98(l to Septernber i988
`80:3”; Ml’ Company (CS), Nuclear‘ Biological
`Clieiriical (i\‘=BC) i\lC() — Noveinber 1984
`Direct Coniniission as Chemical Officer, November l 984
`
`Tours ofDu ty (three weeks, each)
`Suhic Bay, PhlllI)1')il1€-S (l987)
`Suhic Bay, Philippines (3988)
`United States Army Reserve, Septeniber P988 to present
`Direct Coniinission, Chernical Corp, i984 (ZLT)
`Direct Cornrnissiion as Meclical, Service Officer, Septernber i988, Current Rani: (l,‘s/lager‘)
`Previotuslyz li\/EA, Defeiise intelligence Agency (DEA), Washington, D.C., AFl‘viiC, Ft.
`Derrick, Fredrick, MD, William Beaumont Army Medical Center, Ft. Bliss, TX
`Sr. Observer/Trainer, 91“ Division, lst Btlfi, C-SS—Tasl{ Force, Canip P§i1'l{S, Dublin, CA
`Currently: LTC, l\/ES; Envirorirnientali Science Ol’licer/’liistr1ictor — 2ND Medical Brigade./'
`
`WMD l-"liograin
`
`Membership:
`American Chemical Society (CNCS~Sectioii Cha,ir'inan "93, Cliair~ Elect/'Prograrn t'_3liair '92,
`Secretary ’9l and Treasurer '90), Mississippi Acadeniy of Science, Society of Aiialytical
`Chemists of l’ittsl>urgh, Applied Spectroscopy Society, Phi Lainbcla Upsilon Honorary
`Cheniical Society, America Society for Mass Spectrornetry, Natioiial Technical Association
`arid Alplia Phi Alpha Fraternity, inc, Triangle Area Mass Spectrornelry Discussion Group,
`National {)i'gani;:-ation of Black Clieniists and Chemical Engineers (i\l{)BChCE), Bay Area
`Mass Spectrometry Discussion group (BAMS) and the SF Bay Area Froteonie Society.
`
`Civic Activities:
`
`Visiting Pi'ofessor', Natioiial Uihan l..eag1.ie’s Black Execiitives Exchange Prograin (fl§iE3lEil’),
`(l 986- l 997).
`
`Sciworiss of ‘\Viiiston~Saleni ature Science Center), Adjunct Professor, (1993-1998).
`
`4
`0000012
`
`0000012
`
`

`
`{CV Coritki)
`Co~coor(:linator, '1‘utorial Prograin, Unitecl 1\/letropolitan Missionary Baptist Church, (11992-
`1998).
`
`EARL 1;. V1/H1‘"l"E
`
`lvtediation Services of Forsyth County, Member
`Boa.rd~of-Directors,
`President — (1994), Presitleiit and Chairman of the Boarrl (19954 998).
`Advisory Board Council, Forsyth Center for the Deaf and Hard of Hearing (111)113-1998)
`Paniicipant/Denionstrator, Local e1enientary, iniddie, high sehoo1s anti coileges.
`
`—
`
`(1993), Vice
`
`Certificates aru1Awari1s:
`48%
`
`lnterpietatioii ot‘li1l’rai'ed Spectra, Mississippi Section of The Arnerican Cheinicai Society,
`ACS Filrn Short Course, January 22,1971.
`
`Retention Data in Gas C1ii‘oniatogr‘aphy, Wasliiiigtoii University School of Continuing
`Education, October 16, 1973.
`
`CNTA Mei‘itorious Service Awarcl, 1982.
`E1ectecl Who’s—Who in the South and Southwest in 1983.
`
`Recipient of the NSF Fellovvsliip, 1984~85
`
`Gas Clironiatography Troub1eshooting course, Hevvlett—Pac1§ard, Atianta, GA, September 27,
`1987.
`
`lntrocluction to CALS Course, R.;1. Reynolds Toibacco Company, Winston—Salein, NC,
`February 14, 1986.
`
`Aquarius '1‘i‘aining Course, 1—iew1ett~1’ac1<ai'c1, New Orleans, 1.../~\, September‘ 11, 1987.
`
`RJR Manageinent Developnieznt Prograin Course, RJ. Reyno1t.1s Tobacco Cornpany,
`Winston~Sa1ern, NC, .1une 27, 1988.
`
`VG lnstruinents, 70s and 7OSE. Basic Operation, Savannah, GA, October, i198S.
`
`Vi} htstrurnents, Quantitative Trace Analysis, Sa.vannali,
`
`(SA, November, 1988.
`
`Beckinan 1’ea1<—1’ro for Experienced Users, V\"11’1StOl1-38.16111, NC, Novernher, 1988.
`
`Wl'1o's—Who in Scieriee and Erigirieer in 1992.
`
`National Urban League°'s Biack Executives Exchange Prograin (BEEP) 5 Year Service
`A.VVI>t1‘t1, 1995.
`
`RJR Project Leader '1‘raining Prograin, 1’ehi‘uai‘y, 1992.
`
`Central North Carolina. Section, ACS Presitlent"'s Avvarct, 1994.
`
`G. Robert 1)i1\/laico R&1) Team Award for Results '1'hrough Diversity Facilitatiori, 1995.
`
`Central North Carolina Section, ACS, Outstanding Service Avvarct, 1995.
`
`1\/lerliation Services of Foi‘syth County, Past~C1iair AWt?t1‘rf1, 1998
`
`Winston—Sa1ern Stacie University/RJR Partners Prograin Mentor—ol’—the—year Award, 1998.
`
`WQQQ
`
`& W
`
`
`
`fiflfififififitfivfifi
`
`Enstitutes, ‘wnrlrshops anti Corwentions Attended:
`8%
`
`Mississippi Section of The Anierican Chemical Society, 1971 ACS Filrn Short Course,
`llattiesburg, MS.
`
`Toxicology Worksliop, Houston TX, 1972
`
`Pittsburgh Corrference, Cleveland, 011, Atlantic City, NJ, 1973, 1977, 1979, 1981}.
`
`Gas Chroinatography Short Course, Wasliington University School of Continuing Etlucation,
`St. Louis, MO, 1973.
`
`1-lewlett~1’acl<ard Gas Chi'oinatography'1‘i'ouhleshooting course, Atlanta, (SA, 1974.
`
`Liquid Chroniatography Worlrsliop, Waters Associates, 1‘viti1foi"t1, MA, 1975.
`
`‘K
`
`0000013
`
`0000013
`
`

`
`{CV Corit'd)
`48%
`
`EARL L. VVTTCTTTE
`
`Southern Association o1’17orensic Scientist Meeting, Aiburn, AL, 1975
`
`Mississippi AcaC1err1j~,IofScieiice Convention, ,1ac1t:son, MS, 1975
`
`Mass Spectrai 1111'f31‘p1’f3t’<11'10:11 Course (Fred 1\/1cLafferty), Raieigir, NC, 1978.
`
`North Carolina Academy of Science, Greensboro, NC, 1979.
`
`Arnerican Society for Mass Spectronietry, 1\/1inneapo1is, MN, Hono1u1u, H1, San Antonio,
`TX, San Diego, CA, Cincinnati, 011, Denver, CC’, San Francisco, CA, 1\’1i£t1'1’11 Beaxcii, 17L,
`Tucson, AZ, Washington, DC, Atlanta, GA; 1981, 1982, 19S4, 1985, 1986, 1987, 1988,
`1989, 1990, 1992, 1995.
`
`Nationai Teciinicat Association Nationai Convention, 1<.issirninee, 171..., C1eve1a.nd, 011, 1983,
`1984.
`
`Tntroduction to CALS Course, R1. Reynoids Tobacco Coinpany, W111S'1,G11-S’<1.1f.’.111, NC, 1986.
`
`1<,epnei‘—'1‘i‘egoe Ratioriai
`Winston—Sa1ern, NC, 1986.
`
`Processing
`
`course, R1. Reynoids Tobacco Company,
`
`1'1evv1ett—Pac1<ard Aquarius Training Course, Nevv Qrieans, LA, 1987.
`
`VG instruments 70S Basic Operation Training Course, Savannah, GA, 1988.
`
`Vi} Tnstrnrn ents Quantitative Ariaiysis Course, Savannah, GA, 1988.
`
`internationai Wor1<shop on Hybrid Mass Spectrornetry, Lake Louise, Canada, 1988.
`
`Arnericari C1ien'iica1 Society 1\1ation,a,1 Meeting, Washington,, DC, New Yor'1<, NY, Denver,
`CO, Chicago, 11..., San Diego, CA, San Francisco, CA, Oriaiitio, FL, Las Vegas, NV, Daiias,
`T'X, San Francisco, CA; 1990, 1991, 1992, 1993, 1994, 1995, 1996, 1997, 1998 and 1999.
`
`Sever-a1 Statistics Courses (1989, 90} and severai others.
`
`United States Army Reserve Annual Training, Medicai Service Corp, Oft1cer’s Basic and
`Advance Courses, Ft Sam Houston, TX, 1989 and 2003.
`
`United States Army Reserve Annuai Training, Medicai Service Corp, Wiiiiani Beaumont
`Arrny 1‘v1edica1 Center (Chief, Chemistry Lab Training), E1 Paso, TX, 1990, 1991, 1992, 1993
`and 1994.
`
`United States Army Reserve Annuai Training, ivietiicai Service Corp, Arnied Forces Medicai
`inte11igence Center (Anaiyst, NBC), Ft. Detrick, MD) 1995 & 1996.
`
`United States Army Reserve Annu-a1 Tmiriing, Meiiicai Service Corp, Detenise 1rite11igence
`Agency (fD1A} (Sr. Anaiyst, NBC),
`iiioiiing AF1E3, Washington, DC, 1997, 1998, 1999 &
`20110.
`
`innovation Week Training, R.1R.11RDepartnierit, Wi,nstori~Sa1eni, , (1993).
`
`Creative Leadership Trairiing, Center for Creative Leadersiiip, Greensboro, “NC, (1993).
`
`United States ,Arniy Reserve Anriuai Training, Medicai, Service Corp, Armed Forces 1‘v1ei1ica1
`inteiiigence Center (Senior Anaiyst Training}, 1’t. Detrick, MD, 1995 and 1996.
`
`United States Anny Reserve Annuai Training, Defeiise 1nte11igence Agency, DTA (Senior
`,Ana1yst Training}, Wasiiirigtori, DC. 1997.
`
`Tobacco Chemist Research Conference, Greensboro, NC, Winston—Sa.1ein, NC, (19911, 1997).
`
`fifififi
`
`Q Q
`
`éfifififi
`
`Q
`
`6
`0000014
`
`0000014
`
`

`
`{CV Cotitki)
`Piiiilicatinns:
`
`EARL L. ‘WH l’"l"E
`
`l.
`
`5»:
`
`DJ
`
`L, Development of Gas Chroinatograpliic Techniques for the Analysis of
`‘White,
`Toxapltene, Cltloroforni and HGXa.Cl1iG1‘0Gll1€tflC".
`l\/l.S. Thesis, (i975).
`IRCS
`Hume, A. 8., Douglas, B. H. and White, E. L, Placental transfer of ethyl alcohol.
`El/Zed. Sci: Drug ll/feiczb. and Taxical. Phi:irrm:zc0i., P!zysioi.,‘ Repi“0::z’., Biostretic rims’ Gym, 4:
`203 (l 976).
`M. and Plaiultey, F. W. Flarne
`‘White,
`L, Zielinslii, C. A., Former‘, R,l‘°~/'l., lleitliinar,
`emission studies of several metal ehloritles with vapor phase sampling.
`/lztzai. Cizim. /lam,
`ltll: 89-97, (l 978’).
`White, E. L, Bus, 3. S. and l‘l€t3l{,
`
`l-E.
`
`ii'A.
`
`Simultaneous rleterinination of n~l—lexane,
`
`tissues by gas
`in biological
`antl 2,5—lieXanecti0ne
`2—hexanone
`speetroinetry. Biomed. M52155 Specz‘re;>i:rz., 6:
`il69-l72, (E979).
`Bus, J. S., (White,
`L, Tyl, R. W. and Barrow, C. S. Perinatal toxicity and metabolism of
`n—liexane in Fiseliei‘—3=-‘V-i rats after inhalation C){pOSlll‘C during gestation.
`Toxicroi.
`/lppi.
`P.izarmac0f., 51: 295-302, G979).
`
`eliromatograpliy—niass
`
`Gillies, P. J, Norton, R. lvl, ‘White, E. L. and Bus, 1. S. Studies on the inhibition of
`
`sterologensis in it6X3.CEtt“i)Gl'1—lti(.ltlC§3(l distal axoriopa,tliy in sciatic nerve of the rat. Togricoi.
`/lppi. _P!zarn'za(:0i., 54: 2l7~22'2, (l 980).
`irons, R. D9,, Gross,
`A. and ‘White, E. L. Atlliillti-.2 Eyidertee for an euterogastrie cycle in
`the rat. Food C0.s'1m2z. Toxi(:(ii., iii: 393~39'7, (l.98(l‘).
`Bus, 3. S,, White,
`L, Gillies, P. J. and Barrow, C.
`
`Tissue distribution ot‘i1—liexane,
`
`nietliyl n—butyE l<etone and 2,5~liexanedione in rats after single or repeated inhalation
`exposure to n—hexane. Dmg Metczi). Z3lisp0s., $3‘: 3S6~38'7, (l98l).
`l-leek, l-E. d‘A., ‘White, E. It... and Selirnitz, M. C. Determination olfornialcleliyde in biological
`5
`tissue by
`ehi'oi'natography~mass speetronietry. Birzined.
`1‘/2F’ic2,s'.s‘ Specz‘r0m.,
`$3‘: 347-353
`(1982).
`An
`.lr., T.
`L, Cheplen, J. M., Sherrill, J. M. and Hanan,
`‘White,
`Raynor, T.
`evaluation of a water puritieation systein for use in animal facilities. La:zl70rat0.ry Am'mais.,
`18: 4561, (l9Sr-i).
`
`10.
`
`ll.
`
`l2,
`
`Cheplen, J. M, Barrow, C. S. and ‘White, E. L, Deteiniination of airborne tree elilorine in
`the presence of aniinonia by capillary gas ehr‘oniat0gra,plty. Anai’. Chem., ‘S6:
`il9/l—ll96,
`(l,984‘).
`ll»/l., Reaction of aninionia with
`l3ursey, M,
`liass, J, R. amt
`.l~t'_3.,
`‘White, E. in, Tabet,
`accelerated benzoyl ions using triple qi.iaclri.ipole mass speeti‘onietry. Org. M'ass S[.?E3(T'i7’()i?’l.
`22, l32—l39 (il987).
`ions:
`.White, E. L, "Reaction of arnnionia with g-as~pliase plienyl benzo-ate and benzoyl
`lon—moleeule reaction study using triple quadrupole niass speetroinetiy". Phi}. tlissertation,
`G987).
`
`l4.
`
`7
`
`l7., Chung, H. l.,., Coletrtaii, W. M., ill, Elder, J. F., Giles, J.
`(Bordon, M., Boigerding, l\/l.
`A., l‘~/loore, D.
`Rix, C.
`Uhrig, M.
`anti ‘White,
`E... Analysis of tlue—eurecl tobacco
`essential oil by l'1§/1‘)l,18l'1?ll(;‘(i analytical teeliniques, J. Chrmnc:z.i. Sci, 25, (1988).
`,‘White,
`E... and l3ursey, M.
`l\/l.,
`Distinguisliirig positional
`isomers of l'lf3X?lClll0l‘ll’la.l,§3d.
`hiplienyls by ion—moleeule reactions in a trig:tle~o,uacli'upoEe instrument. Bioazed. Erzvirrm.
`11/;!’a5:.s‘ Specfrmn.
`ltl, 4l 3-415, (l 989).
`
`P1
`I
`0000015
`
`0000015
`
`

`
`EARL L. Vi/'H1‘"1"E
`
`{CV Ceritki)
`16.
`Robertson, .111, 13., ‘White, 13. E1. and Bus, .1. S. Effects of niethyi etnyi ketone on hepatic
`niixed-tiinction oxidase activity and on in viva inetaboiisni of I’l~i16X£tI’l6. Xz2I2()i)i(3lic:'a,. 19,
`721-729, (19891).
`. ‘White,
`14., Unrig, M. S., Johnson, '1'. 1., Gordon, B. M., Hicks, R. D, Borgerding, M. 1?},
`Coleman, 111, W. M. and Elder, Jr., .1. F. Quantitative determination 01’ seieeteti eninpnnnds
`in a K,eritueky iR4F cigarette S)”,1’10i,{€ by inultidiniensional
`ehrornategrapiiy and selected
`ion rnnnit0ring—mass speetrnrnetry.
`.1. Clzronzaragzi‘. S<::i., 28, 393-399, (1990).
`Chu, 1., Bndnar, .1. A., Bownian, R. N. and ‘White,
`L. Deter'n'iin21tieri 01’ vincristine and
`
`17
`
`18.
`
`19.
`
`vinbiastine in C::zihz;n"c2nl‘izu.<: rosem plants by high perforrnance iiquid cnrornatography/i
`eieetrospray ionization mass spectri'>n'1etry.
`.1’. Liz}. (.71r()n'zair)gr. (ii: Rel. Teeiznoi. Et1{8) 1 1:39-
`1174 (1997).
`Cnu, 1., Botinar, .1. A, Bowman, R. N, aiid‘«1/Elite, E. L. Quantification ofyineristine and
`yinbiastine in C'z:zt.h»;:zraz'zzi2us roseus plants by capillary zonal eieetrepheresis. J. of
`Cfiroznafogz". A. 755 281-288 (1996).
`. Che, 1-H. and ’W1ii§‘.e, E. L, On—1ine Focusing CE~1‘v'1-S Deterinina.tinn of vinbiastine and
`\7111,C1‘iSEi11f3, 1n preparation, (1 998).
`.Chu, 1~i*1., Munze, .1.
`and ‘wiiite, E. 1...,
`
`A capillary eieetropnmesis/niass speetrernetry
`niethed for the deterrnination of tobacco specific nitiesaniines with eieetrespray ionization
`detection, 1n preparation, (1998).
`. VVBHQ, E. L and Brooks, C. 0., Development of an on-eoinrnn cryogenic trapping method
`for the d.eterniina.tion of Vinyl chloride in fresh niainstreain Vapor phase cigarette smoke, 111
`pr'eparation , ( 1998).
`.. 1-1aniey, K., Nguyen, E_.., Khan, 13., Pegue, (3., Vojdaiii, 13., Panda, 5)., Pinot, E9}, Oriedo, V.,
`Rasecinwa, 1..., Siibraniaiiian, S., Miiier, B. and ‘WS’iite., 131. 1... Development of a piant Vi1”Eii-
`Vect0r—based gene
`expression assay for
`the
`screening of yeast cyteehrenie P450
`inonenxygenases. Assay amt? Drug deveiopznent Tecr’2r20i0g‘ies.
`1(1—;?;) 147~1€S€)
`(20031).
`Du, 11., Cameron, '1‘. L, Garger,
`1., Pegne, G. 1)., Hannn, 1;. A., ‘White,
`Haniey, K M.
`and Grab0ws1<i, G. A., Woinian disease/eheiesteryi ester stnrage disease: effieaey o1’p1ant—
`produced hunian iyseseniai acid lipase. in mice. J. Lipid Res. 49, 16464657 (2008).
`i\) ‘J:
`.. MeCer'n’iici<., A. A., Rei‘id;v',S., Rein}, S. 1., Cameron, D. 1., C;e:ervvinks1~;i, D. K, Vejdani,
`Haniey, K 1i/1., Garger, S. 1., ‘White,
`1..., Nevak, 1,, Barrett, 1,, Holtz, R. 8., Tuse', D. and
`Levy, R. Plain.’-producer} idiotype Vaccines for the treatnient of i'1on~1*1or1gE<in’s iympi'}01’l'}.?t2
`Safetyt and ininninogenicity in a phase 1 clinical st1.idy.
`’]‘v’/£5 ‘£1111-(29) 101 3}»-111136 (20118).
`Zoi.ii<:nri, D., Rawe, 1., Singh, EVE}, Kubiin, C., Dawson, K., 1-1-addori, W. 17., ‘White, E. 11.,
`Haniey, K M., Tuse, D, Maiyj, W. and Papas, A. Discovery of Putative Salivary Bieinarkers
`for S_i'dgi'en’s Syndronie Using High Resointien Mass Speetrenietry and Bioinforrnaties,
`Subniitted, (21109).
`. Pogne, G.1’., Voj dani, F, Painier, i{.i§i., Hiatt, 131., Hume, S., Phelps, 1., Long, 1_.oi'i, Bohoroya,
`N, Kim, D0,, Pauly, M., Veiasco,
`.31., Wnaiey, K, Zeitiin, 1..., Garger, S.
`.31., ‘White,
`14).,
`Hayden, H. and Bratcher, 3., Protinction of Piiarinacentieai—grat’ie reconibinant apretinin and
`a monoclonal antibedy preduet using piant—based transient expressien systems.
`Pirmt
`BiozecknozioggryJournal. 8, 1-17, (2010).
`
`26.
`
`8
`0000016
`
`0000016
`
`

`
`{CV Coritkl)
`Abstracts aiitl./or l‘*“resentations:
`
`EA.RL 1;. ‘WHITE
`
`l.
`
`is
`
`'u.)
`
`L, 1’articipating Lecturer, Pre-suninrer lnstitute on lnstrurnental Methods,
`‘White,
`Jackson State College, Jaclrson, MS (May 1975).
`Plftllliffy, F. W. and ‘Willie, E. L, A niicroconiputer controlled atoniic ernission systein.
`l?.asterri Anal. Syri'ipos., (1977).
`Bus, .1. S., ‘White,
`14., 1%lecl<, ll. d’A. and Gibsori, .1. 13., The distribution and ri'ieta‘oolisni
`
`ot"n-liexane in pregnant Fiselier~344 rats. Temz't)i0gj.r, 17:42/X, (1978).
`Bus, ,1. 8., VVlllill.€:,
`1.. and Barrow, C.
`Disposition of n,-liexane in rats after single and
`repeated inlnaiaticon exposure. Taxicoi. Aflo