SAME3ALESF F
`
`I3+10.
`
`‘1}3:
`
`r
`11‘
`{10
`
`7311‘
`$331.83
`'i”i;
`
`3 N
`
`n
`.-.-’\ )2
`J..
`
`:3\
`1113116.
`
`‘
`
`3.-
`tL.
`
`V
`
`NR3
`
`3333945;
`
`r
`T
`‘1'}: .
`
`3K
`
`33a»
`
`a} '
`
`p.32.
`
`1.x.
`
`J1
`
`3
`E3333;
`
`
`
`‘E
`
`HQ}
`
`lililfifiifli
`
`”i
`
`sari
`
`BY
`
`2
`.71?.k
`
`3.
`
`3!»
`
`f\.
`
`vA
`
`RAKE
`
`L fifii‘C’LA
`
`'"X
`$1
`
`r
`
`up
`i.
`
`\I
`
`3335:
`
`...Y:1x.9.
`.(33.T,
`
`n).v.on3....3..
`
` +1.A.«8Rrx..8aX...«.3T.33..
`
`3..“z!anw.
`
` H».s.UG«n.E.3,.3a....Huinn
`
`.KE.
`..{v}3.,$3a03.,LuA_.,N.“new..
`
` +1.»Ui..vsfluasEJ....5
`.32.1.I.
`aw.1e,Ev.1“‘3:
`
`fr3‘
`
`(3,.
`
`‘1«i.2.,1.
`
`$3....“ann5,
`
`
`.(L.3,
`I“5.23.ia,xi{.33m.
`x}.xi.
`
`(5‘
`
`. 3'
`
`C“VVLi.J,0who,
`
`“7'
`_' «33.333333 3:333.
`
`«Lu
`an.
`
`A.
`
`EL
`
`uh“V...3I.
`.i.,L3...,
`.‘u
`
`
`
`18.23,a.
`
`39fl3.3.S3LPmin
`
`000001
`
`.3 m, a: 3333
`
`w.nluVeRsenaPretmr
`n.mu.”teP
`:nlv
`Of U.S. Patent 8,278,351
`
`ENZYMOTEC - 1052
`
`000001
`
`
`
`
`
`
`

`

`”.3ca...1..A5
`.3...
`2.5.
`«Ar.A.mwmx...
`mu.m..u2.2A,.0.an-_
`.>\5A.r,5.,
`.N.3.a.xA.00.,a.a4..5G,_.
`wx.A.
`..
`....l.....
`.3c..21fl...:5.F...7“,...”M2.5x20“:.T»2:.32f
`.9:.2.A...3I.22...”.F..3...33US:
`.50...A...r...ni.0“aC.K...A.15...4.
`m_80C.A...z.Va.CA».W.Bm...SGx»...e
`JV.a.»...V.Vivvi0...55.5..fix.a.A....2"Q.2H...
`
`
`EL22.X.1v2...2..o.x...”“V...T.33.12LV}.....
`uon”.(L..3a.$1.3a.4......
`3:1..
`A...A.Ax0....5g5.,.0,.0xx...c
`
`
`
`
`
`..«lweMy.“39mi... ”5!“.I«N.1\9w.Kx..(A.Su:CT.n1.5.\....i,xI.....<$225.as..3A2...d.«Aa..5+1,.45.3.12...3.a...x.T.2:‘4..3an»in!.ii“MuSm3...0.0...MN3Q2.”.:3..W...«U:..\.\WU.ex...x...Q.5H“A1z“5...2.3..5in.55.5....2..x\>AMTh..13.xxx34..mi
`
`..2:r.
`
`x...fei.CaaNV.v...”5.fi.w...2....V.3»«Kv.1s....xIe42.2.1.K.i21\e..
`.35.
`
`32.x.>x...1..no.i.9KC3....+5....2:.GM3.m2.“«xin1mm.“8”.3.mmmm.mmMM5a\.\mma...GMRH...flu
`
`.2i
`
`v.2.“..axKrLCit2...25...1n...at:\.:8.152..NW.aB12o..5u.rmnW...bn.a.
`«3._.Saw..v.u..2..05..x.62...3u\....
`{Ax..."xwu.05na2.aw,.nu...nn...
`..25....”1...TA...3.E:0..“nu.”K.<\x:nu?
`
`
`6iG(x3.3i...t...ELcE..0A...en\x,A...(.3.:5.1.a.Fx5..01;(xx..25K.»V...1...v2.4...1;
`....1.25..a.:xw.5:1x.....2.x...y.A.Txa}.2.Y2...
`.2...
`5....mm6...rv.m2.0“x22.R30..,K.N.at.wfl.AU*2}.i
`
`2.......KW.n.umF.KS.3.!.HV.5Wuw....55“..52.Q...fl.
`51..xxu.2.BP.20.23a»3...S3:.\«LA....5;W2:
`1.525$P.uA..{a1312....5.x..1C5.2.5.4.
`
`asSA:3:..BC3..5Au,..5.t...n»0..Aa».55...C3.;5»C.a...3ax.iCA;
`..ts...._5,0.x...5daEh.5..m.A...
`mu.5.mu2R.3A...xY2b.iw:Ew....53.n
`
`
`9.b.3..a.asa...n3.aGn.....5..,3...ne3....L.a2.ifSg.4...mm.C._..f,mACxxA...K5..9...x“{HE......«x»x..z
`
`
`
`152...T;x....55..111......r6.\Xx...:w-m.5....AA...5.5,.A,Ai.
`
`
`IAr5xfli..5K»:Ts.2..fA.x.Yc+125..1M1
`45...‘f+5.xav:.x:S22..xv:\
`x\..X)L\1
`c»1..ha”V:f.00+2..“2C.AUA...x3..6.3
`...§..m;L...mm.
`x2w.....u\d.5£3“.1..5.mu3.a...1..
`1.....52x..bx.V...A...5A....2..s....)KG.
`in.
`.
`.5
`.5.
`.1....i.
`.
`..
`w.32..P9....4:.»r....25.51.3.1...V“A“,AA.
`..xi\5hnEak.5.1.5a.
`..
`fl..\.3“..
`a.s...mu9Am.V...2.,.
`k3..\..6r;21i3.x...QA...3.n.H
`.fl.52.{rEx..._.\<..0.32..x:u...Au
`x.r..FA?SQ
`,QM.rmns..9.111x1.
`.xx."1..J....2mx..v2...:G3.
`..2....5..2.C21.
`...«ixu.«in.
`,«x.tx...)
`.21
`xxx...Q‘5.S.\yno.5..Nu1x...
`(Kc.0.
`.5..33u...may.1AKAinE»80..36MAAxum.4.5;
`...‘5.aa2...x;1.T.«A1...52.\..25x.5.(a
`1.2213:.22
`.....
`...
`..
`.52...x.
`..1.2..8.,a(2...«<2....x.A....xa».aP.2..
`..2.2.....u.5..5.a6.2..ad.3.55..3aC
`SAan.mI...
`,.r..
`..IV2...2m4....i.f....
`ripT.{A2LR...in...3.‘5.3.5C(xx.3.as.«H».KKn
`
`v.2...5,E....2mm.n«u.a1...22...,G...K.2..Riii.vs.5W2..KWm.K.fl.0..3«a.a...Q.2...ma
`fl85Q
`«Mu3.3M5.Hoam8RatA....5...xx.
`«2...KM..2....arwPM.5PM.7...5.xi..
`.w..2.2.
`at.7.5‘1
`..\.nut....xx?6...An”.E..6.
`
`...Q.1.53.
`,x.....u...T..3.31.a.5C3xx”
`.3F..2...
`.5.x.».2..:1.l.S.“5.3.2x.x5...3
`..R.1..Kn...3......u.MH.:0.0..2.
`.52.2..it..2.
`mm.21rs...wt.A.»umif.n50.Add.5x
`.Kul\2tkw....,5.85...
`3}a“?..
`m5“.«.0..4wmtramamAx.m.WV.n...A...fix..5.U)3.:2.f.
`
`4L.tT}...Ru.1..,.Txn+20.1T...M....‘hu.(4w.iiA...»:55.
`
`
`
`.r..3...:A»B...5......dz....F.a.H5..A...“C.2.x_.2..22.MW1.GS.uw..H.8n...V...5.3.n....5...an..i.2..
`
`x.C«x.\...vi.12f...\21.x.m«1“3S.
`
`re...an“;ana»;5n...“a....n.SfluM3.an...C63in.».mz.:n...
`
`
`1AK.30A:Cn59}.shJ.J..5..my...0fl.20.t5w...H3.,.H.A.a5.m...5.3.a
`
`
`
`may“J{A.0h.«AAHi«AM.......sC.H...mmis.“0.7.a.Ah.....1x.a$2....u,.1..32..a...«aCS.._3002.to.“.2.P...3.3...x.3dh....C....2x.52r..2...2.«flu.nA3A"xv...aMA03..52.x.4”).Qn9..
`
`2I...“h“..5.
`O.83Gr.."i”.5a).x.E.ab2:.
`5.2.A}..va.2...
`L2.5..(2.n...
`km«h.(F.Hwit..."My.
`.xI.:53.{2.
`C52.ab.511..MFA....2...\Q...K...x
`.99WV..oxm
`
`
`.92.r.23RdE."1mm..Hmm.H...4.2.»;5..was$15.3....\«A.\.a“..x).(D
`
`
`3v.x
`s1xv...._......0L..2..3...(n.35‘.(2
`x...f...:31<Tc
`.LTA8
`.v12.3L“ano......3...x...2..
`a...“.VJ.«awn.NM..“5...15¢.WU..52.$29up5K5.
`
`.2.n...3,i1.L.i“A.a»mmW....8
`aA...
`I.32.
`.(a..33...\..i.(AA..:wu2....
`,aNx...nVm.a.fl.1a...3f2.0.D.c.
`...m.h.4...
`..3ux.L.3..,..5.Q2.x...
`.51.0Eaa.0.nu.5...
`.x...,n»..
`.2.u.\a.
`*A...,2(a.2.~x..1x:..n...:K.
`
`.5).2...
`22.
`5.i,.......
`fx.5...
`a3AK...“H..NMx...3....“.5.M\Wx)S?.a....2.Cw...
`
`2a.0En.S,nCCv....2.C.3.p»n
`.2.x3...5“.
`11..an..31s....2.....2.
`v.).n2...
`.
`.
`..5.......A...x....
`.L1.2...2.
`nA...“.
`5<
`
`..«
`.n...
`.5a»:...
`..i.
`x25.2.5.4m...8..1.2.mv)..NK.as
`.a
`.q
`...
`.a2y.1...
`1;.txxL...»M:st2.“H.:wumLP“
`
`.1.a
`n.
`
`xx...\{L“’25....2.
`,(i...0
`
`000002
`
`000002
`
`
`
`

`

`3«a.
`
`1.“..:._S
`
`...u.a}\1...ia}
`a;3..mm,8x,6C,
`.“7x
`.1Y.1.xr...(K8.1,\v41.T‘2:.
`:1.gk,0a,Eti,3h1:.Au.v.av
`
`+13..81a;.1.0.$1gQa;,La3
`x1ad3C(a.na.1/.«.1a1.3.,1»
`R.G6m\15xx3,Nuf.a.aq1
`8Wn3...3,1,1an.X1G35a,s.“IC
`Vat.at.1;,a)“."n.as.11\JW5:4tion.\,WM7“on.,
`
`
`
`gambm.daaaa00‘sa.a.m$1V}.au1...1.1xunu1.,a.i.1CH.B5SS1.6,é,0.x.0fu,Eifl.1S:0..1.1.aS.“a...0an.31....xi1.x...‘a.i{A,8...rx.,i
`(i.11
`.7,xxwk.
`,4:,fi8:.A
`
`.n.»(i
`.12i
`u.3...
`,3.«23a,1K3.)11t}.«L13...
`
`
`
`vg8..r3.E.S.0.«flu,..)3£4,“aY.£03...1yvfi.N.W..ISla(n.ma...»itach,P...«C«C..1\2,C.,8u,3..1a,Q,V..11.>1..11x.vL.Mu.i,31sTx....Lash.p.31.0.3Ann3,31KQSX“of
`i.3“X0<{:5av.
`15it.
`.3,.:..AUn:.:.
`{mm\‘M3.CQ,1.1Q;So:We1S
`“HM“.{ki.i.Hfir“u3,K1,,fr.3$3.,an1;WuMU:
`.S4m.a.z,.w...0\{a.,3Ps,E.1S
`
`
`7.3.‘(L(at(L,.‘Tvfir...
`,f‘i.)3.i.1.w!1<391..aEm»Cn5)»8.m),.«3.1..V5.I:d.1,A13}
`
`
`
`
`
`
`
`
`
`1.x.38‘.1w“..8.1Can,Lu.v.)in4.f,1...1x,.37»Q.1.LnumC.3.ia4t,9‘Nwuit«a113;SP..0.Sw.”.3,r},(xwas,«.52x.P....3is,3h.nV.,N.aw“«i,1»32,.i+1.,Y..1Wu.m»;n.0«u,xa,.u..,.1no,3.3,.Vnufl..5,I.r.i.<a.H2m5.r1,5‘212¢.,is.1(runnowAn11m1.1Ran.M5,.3.Ur.4:13:.,.\.1.19WA,uxe»..MC(x1maL15as‘.1a«iuh,f.“1flu
`.+1c.”.Mu,\1{\‘31SR
`AvxxCu,.\xMl
`.a...W1.ax\
`
`\m,.51..,
`31.3{3‘“a,”p11..
`5..3..{V,1:
`
`(s.,aLu.,1...C1...x.at}.an1C.3:.,u.5.uS.11+1,:1.Cm:an.3.3..
`.34,tT:1,.._T.\.31..
`IE.mt..
`1.“
`famm,1.4hR._UQmuTu..9.:3.1.1.E\i,:n
`w,1;f,S1:3:AB.1..a
`1.u1aEh8+,W.fi..fi.31;D1..5X.I
`
`
`
`
`anmi1...1S,1u.1.1i.1iAa.,...+1.8.1!QLi.v2.3Q»3..f1:vQ,m.dun{.E.TA21:1.u,1.£1.11“AvQV1...Smmk1m.“n.SV1,,1h1an\...£3a».C
`31..VJ4».t.“a,«s.a«a3mi,(6..a...a“.i.<5
`>.itx..J.«S.n.1,4it0;.«i
`
`c,.Hu.5.,fix‘1I..
`rWth.“.8.,2T..11n,a.h.aR
`.1CL5.ut.l.o1...35,.a3%..0.2V.g.11.i33.C
`
`A3....1$1,1I:S,aup?i<5..,
`1.4uaH...3.r.“,3PM.:1an,aM)...1,.,0
`.1a.1fl.3xa}l,...up.H.:3.w“ri
`.11%+2...A:
`is,.I1..,...,.._,CE.A)”
`
`.
`an:.is.
`.1
`3
`i.Y.H1x..,,‘.U,
`.K.3,..a.
`r....4:,.L,~.1»1.»3
`l.«x.so:3x.00x.\
`
`1.3.,fi,a...+13,.3.7.Q“M:1rx.r».,S..3.c.b
`fE.(aWait3.1u,u,8.J.
`,1Vx\.H2i
`:1\.,hm.“i\....,vk.a}‘t.»of}.
`O...1L1mm3.68S.51km1x...A,HEK
`
`.13,.T:3,,\Ifr...1».L:3.33..iA:L
`1..>3..4._3’1I(pQ:fix8f«A
`..,3N,,.31..‘,
`
`honi.ag€,0.1‘1n51.x,1...,\l.y....
`
`
`.1,1s..1a.fi,.L+1..I3..Y....3,r»K.3P.\c,1
`
`Enn.8....:2VicT.S35n}.K3..C
`LSh".88..1N.vb,,LE.5.2.IE
`91T.a.5ckfluin:Lat_.‘18.x\.x!«Aat,
`.a».3:1i:
`.1.r...‘uéxi.M.,+3ZI
`..42l.4..1
`
`I.....a!w.a.
`
`.....1
`t1»rmS.L3...,TE.138»r:+1,\,.1w:
`,.,1g
`mg.1xam.16,0o.1,10g1.
`
`61.8.031::xx1;i3<1,9R.V21Mi,{S1.r.kf,s;821..fl1‘.1.\,1$13p1S,
`AhlT.,.<Rw.v.W)i«ia5.11;,a\wV
`
`
`
`
`
`
`(E,.p.auC..iDG.,Et:5a..(Y;,3.11,.3.«A8wW..$8.1.1+83Hr,z.,.«a,n).W“.1,H.vin3..w.1WuRn,.1”WPBi..1w;,1a,,.3113.ftS.\.1PMJ..".vw},a.naau.1n,nfa.s3,»,,i8,a:23.E
`atk:E.Tv313.3.$1.1.\..5.L...fix.:.1x,,.
`E.Ih.»~,,,..v.,».3.pl,“«.1a.fi.Wx..Wu
`1..3“x..at;x.....:1.\
`,
`.,3
`
`...,.t11«I!...1C8.mm0,}.13.1..3WuC1:“.et3...Y......t3
`
`
`
`
`1.“,.r.VA....MwmSUM.C09..S:aSch.(Xit.NE
`#1.1‘1.11...
`.
`.x.,1,.3
`L,.Ih.3.+1.”r“W.1...IL3.._is,.a.»\..(x
`.G1"ireL,4.!1.6Q..Ru.ckC:e,si,,.1
`.1is.+1.Hh..3.3“v.«1.1T52...22.G
`
`f.,3x....‘1:1.AVit...a“:.41u\x4?.»
`.0}..a}.1«x.332..E1,5..1..1“.a...
`F..if.n:iS0,ga:GS31.1p:
`1V}«au.nu.....iwe,\:my3E\Jv
`a.IOV:itx...".rs‘\{\x,vs)2,Li
`.n,«rV.,0...anmu;,3..\1,2.m1K...(v
`.1.,31
`.x,
`1+11“31..{.51‘81(v31.>1i
`.V
`.0,8“2+1..3,,wan,13x;«C1:..r\nu...w?”(on
`.U,4.0...LSC«:1ma:3.x:«R.1V.”is.3...a4
`AC1
`s.x,Gi,13V1...
`8r3am“ux211W«2if3J1.MM:5,in;‘
`ct:.21?«aR.R9i.but‘3U»a..Rn\
`
`E...11C5.1,3,anis,an.S.‘5....A3.Ln.rw:
`3:“a,“i,1.5,1vXx‘C3‘a
`
`.1,m.S.xx..3.1T.>NE.1.fl1xx.VJ.hm.,0»mum.1flrWmSa:1.8mu3Q
`C.®a.«1a«uH.3.L135+1mm\.30np
`1.1Su...E;.Ua,“IE,..KC
`
`,\,..iv.3,x.n,3xiR.J,k,.,a
`
`P.,$.11;,3mm“3iitit)0“...t.1.“
`
`1?;«\w.,J.“a;
`‘1Du(«A
`Ip11....
`‘11.2,cs‘.3:
`.....6w
`18...v.,f»v.“
`8..{I
`
`~
`
`:1V.Sxi4
`
`‘2
`
`f
`
`i .
`
`\“.45..“
`i
`
`i
`
`1.."
`
`\‘
`
`,
`
`13
`
`000003
`
`000003
`
`
`

`

`I 5
`
`3
`
`‘:w«.41:;2.,,2
`
`4'
`
`'EE21'1123? $112,121: N111.
`
`.1E'EE'\I~E'}EEEJ72ES 3861‘}
`
`2.1 {A} M; 1-1.-1,1:
`fl?"”2‘,2.$35you: 7 (2‘3 1
`
`22113-2211 111.113
`
`w
`S1112}:2'11111.1'E2'11??'Es11111112: 12111111'211-1111113-2112E"- . . 20:11:11 1112218 11:1 15:11:: the
`1
`I
`0311111111221 12.11113613‘a: E'mm'911111" 3111211331. E31H112 1:111:11
`
`EE'E'EEK?- EOE’EEE E'EE' .-- .. {132€313,139 EEEEEE'EES WEEKS
`
`
` -::221E 0f 2 day as :111312111»CE21.11'111'1g 3.1.1:}:1:11'13112.
`
`21-13511 E23 E1221332211 2372131- 321113331:
`
`51-11: {31-2122 3221.213 wash 1311 c2113: .22:
`
`£1 1231123223211: SG'E‘JE‘EE-
`
`211E3- 11.111 is 11123 111211 2.5 $121111?” NQE1E2$1191:
`1
`.
`.4.
`1112g11EEud-2E111121'1LE1211'111EE12 1111's 21111.22 {1-8111 (1" 111 E'E413212 E 3:21:12 ESEE ‘1'?"
`
`{313.- Sig112E EE'Eiensii'y '12 21: 2221‘ 111113 111212.: 111"
`
`1211. F321
`
`3} E111;‘21112EE 11.2222 2‘: ’3’322 11111111122815. 1'1«11221111111111: 1111213 :11E‘1-‘1'5113' E22111. "“1 11222211112212
`
`2121221322 111':E12 E11312 E2)2? 13.11.13 21'111211
`1
`(2011191212312111 13E? {icetsnitriifi 31813111? "E651“: EEze 1103.1.11'1'11'1.
`
`12211:.TE121'12111E1'1 EE‘ES :113EE'21E111'13122E2 {31.112111 ”11.11
`
`.E' E11 3192.E ELSE-KNEE?E11 EE‘E'S .1136 EE 53E.
`\
`
`11232121112 21111111113 11123112211111 2:11? 13121"11111121, having 13112" 2;? 32112. E11 1312$212 1111‘. 1122321112
`
`tv
`‘
`-
`1:121:21221111111112111211; 1111111113111 22112121111111.1211: E12} {3111:31‘1'211111111EM23 3E, ECEE
`
`1..“
`EEA;1101'11111313.
`
`‘1
`2211121 '13:~11)1111211211111. 2621322113 22111211.3 {11.2. 11113111112 «1% 12111212 1:13:11: 11
`1
`i1.) 2.; \y/ M M
`”2,; w2;» ,1 «m 3,2 ‘u-AS ._,
`La.-
`1111311111311 E'E1'12211211111"1'.1:- :21. 171111-31 111213d123E12LE31'1E1111 1‘1
`
`371-":11‘1.1
`
`{1325: 11):: 31-2g2 ’11112112132315): E2171 11.531111}
`
`r-.
`
`1,...
`000004
`
`000004
`
`

`

`333333333333' B333333:3 N33. NB;
`
`,... £13
`
`E ‘53::333 3:3 (33.3.3333:thett3313 \323333330333133333315 333333323 {3'3 33333 333333 333033;@3393 33.333333. 33.33333 3hat
`
`;t.";3§ 33:33?333033533333313: 3:333 333.3333'333331'3333'3 333331. 1333'3333333 3.333%;33.3.:333‘;
`
`3.33 53333'3333.6. 333; 35; 333333323‘. 333333 333.
`
`3:333:3333333133‘3- 33333333: 33333333: with thee k330wi333§3.33433 3.3333; 333333333 33.33%3: 333333333333333333333 the 3.13:3“: 33:: 333333333
`
`33333.3333333:33323§3333 3'33’33333:33333333.:;33333‘3§:.;:. :33 33333'33, 333331333 Sachem;{3333 (33‘f3338 33.3’3.i'3§: Umitmt
`
`3533333333:
`
`{33.35.33,
`
`3333?; 33:3:
`
`3333-0133 3333-33;
`
`{:33 33:: 33333323330335? 33:3 33303333333323”.
`
`83.333333333333333 333333333333333:33:33sungt‘n'33:333.
`
`.s‘
`
` .33 a
`
`000005
`
`000005
`
`

`

`Phosphoiiuid std
`HMa‘».
`i
`.
`.
`‘
`
`l
`
`"fatal i911 Chi‘OmathramS fer pimsphoiipid standard seiii‘iian. This standard was
`Figure 1“
`analyzed with ihii~30an electi'gspmy ionization during the ai'iaiysis 0f 0:116.” pimspiisiipid
`samples.
`
`000906
`
`000006
`
`

`

`
`
`{EYE
`H”16:
`
`2
`
`0 blank.
`
`Salvent bianks are Often
`
`saving films. as
`
`is the case hem
`
`hgm‘ij 2. Tami i011 chmmamgram far a 20 Via aceton
`72.:
`hr
`star rate if
`at a 1‘80Event—pmgranmled »'
`
`the sole purpese 01’
`
`93791 VUBN
`
`0001307
`
`000007
`
`