`1968-197 CONFIDENTIAL RESUME OF AGIS KYDONIEUS
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`EDUCATION
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`University of Florida,
`BSChE Summa Cum Laude 1959
`Ph.D. Chem. Eng. 1964
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`17 Savage Road
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`Kendall Park, NJ 08824
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`Phone:732-4224600
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`e-mail: akydonieus@comcast.net
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`W O R K E X P E R I E N C E
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`SAMOS PHARMACEUTICALS, LLC
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`April 1998 - Present
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`President
`Consultant/Scientific Advisory Board Member/Executive for several
`companies in the fields of drug delivery, including oral(peptides),
`transdermal (passive and iontophoretic), implantable, injectable,
`buccal and vaginal delivery, DNA vaccine delivery, and biopolymers,
`resorbable and non-resorbable for medical devices and tissue
`engineering, including devices for orthopedics, adhesion prevention,
`ophthalmics, wound care, cardiovascular applications, as well as for
`cosmetics and skin care. Experience in preclinical as well as Phase I
`through III clinical development.
`
`Aids clients in Business Plan preparation and in venture financing,
`through venture groups and through strategic alliances and joint
`ventures.
`
`Bristol Myers—medical devices/2 year retainer; Convatec—skin issues;
`Kytogenics, Inc—peptide drug delivery, medical devices, polysaccharide
`biopolymers/10 year retainer; Indevus Pharmaceuticals—business
`development, implantable drug delivery, medical devices, biopolymers/10
`year retainer; Lavipharm Laboratories—transdermal delivery/3 year
`retainer; Agile Therapeutics—transdermal delivery/10 year retainer;
`Cedar Pharma—expert opinion on patents; Shire Pharmaceuticals—
`transdermal delivery; Transport Pharma—Iontophoretic delivery;
`Transave—liposomes; Howrey Law—expert opinion transdermals; MD 3—
`biopolymers/medical devices; Reckitt Benckiser—transdermal, injectable;
`JNJ—transdermals; TyRx Pharma—biopolymers, drug delivery; FMC
`Biopolymers—biopolymers, wound care, Quacker Bio—expert opinion,
`iontophoresis; Dechert, LLP—expert opinion dermatologicals; Collagenix—
`topical delivery; Edge Pharmaceutical—Implantable delivery;
`Polytherapeutics—topical delivery, business development; Kore Pharma—
`IUD delivery; KAT Transdermals—generic transdermals; InteguRx—topical
`gel delivery.
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`BRISTOL-MYERS SQUIBB CORPORATION June 1988 - April 1998
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`Vice President, Corporate R&D - ConvaTec
`
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`Responsible for polymer and process research, drug delivery, skin
`biology, analytical chemistry, clinical supply and preclinical
`testing groups. In charge of a group of 30 developing polymers,
`products, and processes for medical devices and pharmaceuticals.
`Development of devices for the wound care, ostomy and
`incontinence markets, and transdermal and buccal pharmaceutical
`systems for BMS support and diversification. Basic research in
`polymer and adhesive synthesis including urethane adhesives and
`thermoplastic hydrogels, polymer surface modification, and
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`biodegradable/bioabsorbable polymer modifications including PHB,
`caprolactone, chitosan, hyaluronic acid and collagen. Application
`of natural and synthetic polymers as templates for tissue
`engineering. Fundamental studies in skin adhesion, skin
`permeation, skin irritation and sensitization, antimicrobial skin
`lipids, and preparation of living skin equivalents. Responsible
`for identification, evaluation and project coordination of
`external industrial and academic programs.
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`HEALTH-CHEM CORP. June 1971 - August 1973/September 1974 - April 1988
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`President and Founder Hercon Laboratories Corporation
`
`
`Responsible for P & L for the company reporting directly to the
`President of Health-Chem. In charge of 110 employees in R & D,
`government regulations, quality control and production.
`Introduced to the marketplace a patch containing nitroglycerine
`and a novel wound dressing containing chlorhexidine. A clonidine
`patch for hypertension was submitted to FDA for approval and a
`dozen other products were in human clinical trials. The sales of
`the company had shown at least a 50% increase per year over the
`last four years.
`Made over 50 presentations to stock exchange groups,
`pharmaceutical analysts and institutional groups worldwide.
`Instrumental in obtaining a 20 million convertible debenture for
`Health Chem.
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`Vice President
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`Responsible for R & D, government affairs, new product promotions
`and marketing, patent development and licensing for the newly
`formed Hercon Division. Introduced multimillion dollar products
`based on the Hercon controlled release technology, such as the S.
`C. Johnson Raid Roachtape and the Union Carbide Glad Air
`Freshener Scentstrips.
`Engaged company in transdermal delivery of pharmaceutical
`products and negotiated 45 agreements including those with Ortho
`Pharmaceutical, Lederle Labs, Smith Kline, Warner Lambert,
`Squibb, Schering Plough, Hoffman LaRoche, and others for the
`development of transdermal therapeutic systems.
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`Director R & D
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`Developed processes (Hercon) for controlling the release of
`chemicals such as drugs, insecticides, repellents and pheromones
`from polymer membranes. Over twenty U.S.A. patents have issued
`and many more in several foreign countries.
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`BAXTER LABORATORIES August 1973 - September 1974
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` Assistant Director of Corporate Biomedical Engineering
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`Responsible for the Corporate R & D for this half billion dollar
`medical device company. In change of 85 engineers and scientists
`in the departments of polymer development, container processing,
`packaging, humidification, special projects, and pilot plant
`facilities. Major emphasis was in the development of polymers
`and polymer processes for the manufacturing of new containers for
`intravenous solutions, blood bags, freezer bags, humidification
`containers and unit dose vials.
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`CHEMTECH, INC., BOSTON, MASSACHUSETTS May 1968 - June 1971
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`President and Co-founder
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`Responsible for financial and chemical engineering functions of
`the company. Supervised development work on urethane elastomers,
`moisture cured urethanes and two part system urethanes. Designed
`and installed pilot plant facilities and supervised the
`manufacture of several urethane products. Arranged financing for
`the company since its inception and negotiated the merger of
`Chemtech, Inc., with Ornsteen Chemical Co. (Seabrook, NH).
`Designed and installed the company's plant facilities for the
`production of urethane elastomers. Responsible for P & L until
`the company was acquired by Morton Thiokol (Chicago, IL).
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`COOPER UNION (POLYTECHNIC INSTITUTE), New York, NY May 1968 - January 1970
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`Assistant Professor of Chemical Engineering
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`Responsibilities involved teaching of graduate and undergraduate
`courses in chemical engineering. Taught courses in Mass Transfer
`Operations, Physical Chemistry, Plant Design, Chemical
`Engineering Economics and Air Pollution. Research interests were
`in the areas of minimization of intersolubilizing effects in
`solvent crystallization processes, and simulation of chemical
`plants by digital computer. Faculty adviser to student chapter
`of AIChE.
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`UNION CAMP CORPORATION December 1964 - May 1968
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`Process Scientist
`Responsibilities included project planning and coordination, and
`economic evaluation and profitability studies of chemical plants.
`Development studies on processes to separate fatty acids from
`rosin acids and monounsaturated acids from polyunsaturated fatty
`acids.
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`UNION CARBIDE CORPORATION
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`Chemical Engineer
`Responsibilities included the development of equipment for
`plastics processing; developed and designed pilot plant equipment
`used for the elimination of contamination from thermoplastic
`materials. U.S. Patent #3197533 was issued on the equipment and
`product obtained. Studied the pyrolysis of thermoplastic
`materials using pilot plant equipment; investigated the effect of
`branching and molecular weight distributions on the mechanical
`and rheological properties of polymers; above investigation
`allowed the tailor-making of products for specific uses such as
`blow molding, extrusion, injection molding, coating and wire and
`cable.
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`June 1960 - September 1962
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`HOBBIES AND OUTSIDE INTERESTS
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`Photography, Sports, Oil Painting
`American Men of Science
`Recognition Award by the Controlled Release Society, 1990
`BMS Outstanding Corporate Contribution Award, 1992
`Election to Fellow of the CRS, 2010
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`Adjunct Professor: Cooper Union 1970 - 1971
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` 1975 - 1976
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`Director to:
`Nex Med, Inc, Scientific Advisory Board, 2008-2009
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`Kytogenics Pharmaceuticals, Scient. Advis. Board 1998-2008
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`Transport Pharmaceuticals, Scientific Advis. Board 2007-
`2009
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`Valera Pharmaceuticals, Scientific Advisory Board,1998-2007
`New Jersey Center for Biomaterials & Medical Devices-Member
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`Industrial Advisory Board/1997
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`MIT Biomaterials Consortium-Member Industrial Advisory
`Board/1997
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`Health Chem Corp./1984
`Hercon Labs/1984-1988
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`Controlled Release Society, 1973 – Present
`Cofounder/President/Vice President/Board Member/Trustee
`Krikos, Inc./1973-1980
`Chemtech, Inc. (Chairman)/1968-1971
`Exicon Import-Export Co./1972-1981
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`BOOKS
`Kydonieus, A.F., Controlled Release Technologies: Methods, Theory, and
`Applications, Vol. I, CRC Press, Florida, 1979.
`
`Kydonieus, A.F., Controlled Release Technologies: Methods, Theory, and
`Applications, Vol. II, CRC Press, Florida, 1979.
`
`Kydonieus, A.F., and Beroza, M., Insect Suppression with Controlled Release
`Pheromone Systems, Vol. I, CRC Press, Florida, 1982.
`
`Kydonieus, A.F., and Beroza, M., Insect Suppression with Controlled Release
`Pheromone Systems, Vol. II, CRC Press, Florida, 1982.
`
`Kydonieus, A.F., and Langer, R., Controlled Release of Bioactive Materials,
`9th International Symposium Proceedings (Eds.), July 1982.
`
`Kydonieus, A.F., and Berner, B., Transdermal Delivery of Drugs, Vol. I, CRC
`Press, Florida, December 1986.
`
`Kydonieus, A.F., and Berner, B., Transdermal Delivery of Drugs, Vol. II, CRC
`Press, Florida, May 1987.
`
`Kydonieus, A.F., and Berner, B., Transdermal Delivery of Drugs, Vol. III,
`CRC Press, Florida, May 1987.
`
`Kydonieus, A.F., Treatise on Controlled Drug Delivery, Marcel Dekker, New
`York, September 1991.
`
`Kydonieus, A. F., and Wille, J., Biochemical Modulation of Skin Reactions:
`Transdermals, Topicals, Cosmetics; CRC Press, Florida, January 2000.
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`US PATENTS AND PATENT APPLICATIONS
`
`U.S. Patent #3,197,533; Gel and Fisheye Reduction in Thermoplastics (July
`1965).
`U.S. Patent #3,961,117; Antistatic Carpet and Method for Manufacturing
`Same (June 1976).
`U.S. Patent #4,102,991; Process for Controlling Cockroaches and Other
`Crawling Insects (July 1978).
`U.S. Patent #4,119,267; Blood and Intravenous Solution Bags (October
`1978).
`U.S. Patent #4,160,335; Dispensers for the Controlled Release of Pest
`Controlling Agents (July 1979).
`U.S. Patent #4,193,984; Method and Composition for Controlling Flying
`Insects (March 1980).
`U.S. Patent #4,198,782; Control of Agricultural Pests by Controlled
`Release Particles (April 1980).
`U.S. Patent #4,212,153; Time Color Indicator (July 1980).
`U.S. Patent #4,272,520; Compositions Comprising N-tetradecyl Formate and
`Their Use in Controlling Insects (June 1981).
`U.S. Patent #4,320,113; Process for Controlling Cockroaches (March 1982).
`EP-177329-A; Transdermal Delivery of Nitroglycerin, April 1986.
`U.S. Patent #4,639,393; Dispensers for the Controlled Release of Pest
`Controlling Agents (January 1987).
`U.S. Patent 4,666,767; Dispensers for the Controlled Release of Pest
`Controlling Agents and Method for Combating Pest Therewith (May 1987).
`U.S. Patent #4,792,450; Device for Controlled Release Drug Delivery
`(December 1988).
`U.S. Patent #4,764,382; Device for Controlled Release Drug Delivery;
`Gelled Systems (August 1988).
`U.S. Serial #06/875824; Device for Controlled Release Drug Delivery;
`System Methods.
`U.S. Patent #4,767,808; Article Useful for Administration of
`Pharmacologically Active Substances Transdermally, Orally, or by Means of
`an Implant (August 1988).
`U.S. Patent #5468501 Divisional of #17; Broad Polymer (November 1995).
`U.S. Patent #4,758,434; Divisional of #16; Specific Plasticizers (July
`1988).
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`U.S. Patent #5310559; Copolymer Control Membranes (May 1994).
`U.S. Patent #5322695; Moisture Vapor Permeable Transdermal Dressing (June
`1994).
`U.S. Patent #5028431; Article for the Controlled Release and Delivery to
`Animal Tissue of a Pharmacologically Active Agent Which is a Causative
`Factor in the Occurrence of Non-Allergic or Allergic Contact Dermatitis
`Comprising an Anti-Dermatitic Substance, (July 1991).
`U.S. Patent #5580573; Temperature Activated Controlled Release
`Device,(December 1996).
`U.S. Patent #5591820; Polyurethane Hydrophilic Pressure Sensitive
`Adhesives, (January 1997).
`U.S. Patent #5843979; Transdermal Treatment with Mast Cell Degranulating
`Agents for Drug Induced Hypersensitivity (November 1998).
`U.S. Patent #5527271; Thermoplastic Hydrogel Impregnated Composite
`Material, (June 1996).
`U.S. Patent #6179818; Ostomy Bags and Vessels for Biological Materials,
`(January 2001).
`U. S. Patent #5686100; Prophylactic and Therapeutic Treatment of Allergic
`Contact Dermatitis, (November 1997).
`U. S. Patent #5618557; Prophylactic Treatment of Allergic Contact
`Dermatitis, (April 1997).
`U.S.Patent #5827525; Buccal Delivery System for Therapeutic
`Agents,(October 1998).
`U.S. Serial #0845244; Divisional; Contact Irritation Treatment (November
`1995).
`U.S. Patent #5912010; Prophylactic Treatment with Calcium Channel Blocking
`Agents for Drug Induced Hypersensitivity, (June 1999).
`U.S. Patent #5910536; Hydrophobic Urethane Adhesives (June 1999).
`U.S. Patent #5952422; Photopolymerizable Medical Pressure Sensitive
`Adhesives (September 1999).
`U.S. Patent #5714543; Water Soluble Polymer Additives for Polyurethane
`Based Pressure Sensitive Adhesives, (February 1998).
`W.O. #9816104; Skin Lipid Antibacterial Agents (April 1998).
`EP1210138A4; Controlled Release from Bisphosphonate Implants, (June 2003).
`U.S. Patent #6809085; Adherent N,O-carboxymethylchitosan drug delivery
`devices for mucosal tissue (October, 2004).
`EP1534261; Oral Delivery of Peptides and Proteins (June, 2002)
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`U.S. Patent Application; Implantable Delivery of Antihypertensive Drugs
`(2007)
`U.S. Patent Application; Transdermal Delivery of Cardiovascular Drugs
`(2007)
`U.S. Patent #7265097 Methods of Drug Delivery Using Chitinous Polymers
`(2007)
`U.S. Patent, US 7691830 B2. Methods and Compositions for Treatment of
`Mucosal Tissue Disorders (2010)
`U.S. Patent #8017595; N-Acylated Chitinous Polymers and Methods of use
`Thereof (Sept. 2011)
`U.S. Patent Application; Dermal Delivery Device with Ultrasonic Weld,
`WO2009/009651 A1 (2009)
`U.S. Patent 8246978 B2; Dermal Delivery Device with In Situ Seal, August
`2012
`U.S. Patent Application; Multi-day Delivery of Biologically Active
`Substances; WO2009002542A1 (January 2009).
`U.S. Patent Application; Intravesical Compositions with Valrubicin for the
`Treatment of Bladder Cancer, WO/2009/073517.
`U.S. Patent Application; WO/2010/111488 (PCT/US2009059826). Transdermal
`contraception regimen with drug free interval (October 2010)
`U.S. Patent Application; WO/2010/042612 (PCT/US2009059828). Monthly
`transdermal regimen for contraception (October 2010)
`U.S. Patent Application; WO/2010/042610 (PCT/US2009059823). Variable
`transdermal regimen for contraception (October 2010)
`U.S Provisional Patent Application; Enzyme Resistant Conjugates for the
`Multi-day Delivery of Biologically Active Substances (December 2010).
`U.S. Patent Application; US 2010/0178323 A; Dermal Delivery Device for
`Irritation and Adhesion (January 15, 2010).
`U.S Provisional Patent Application; Transdermal Administration of
`Difficult to Deliver Therapeutics (January 11, 2011)
`U.S Patent 8039448; N-acetylated Chitinous Polymers (October 2011)
`U.S Patent Application 20120215186A1; Dermal Delivery Composition and
`Methods (August 2012)
`U.S Patent Application; Transdermal Delivery of Progestins (January 2013)
`U.S Patent Application; Transdermal Delivery of Selegiline; US 20130281542
`(October 2013).
`U.S. Patent Application; Transdermal delivery for Nausea and Vomiting; WO
`2014031958A1 (February, 2014)
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`61.
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`U.S. Patent Publication; Dermal Delivery Device with in Situ Seal; US
`2013/0018337 A1 (January 2013).
`US Patent Application 2013/0116222A1; Dermal Delivery Composition and
`Methods; (May 2013).
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`BOOK CHAPTER CONTRIBUTIONS
`Controlled Release of Pheromones Through Multilayered Polymeric
`Dispensers; ACS Symposium Series #33, pps. 283-294, April 1976.
`Application of a New Controlled Release Concept in Household Products; ACS
`Symposium Series #33, pps. 295-303, April 1976.
`The Effect of Some Variables on the Controlled Release of Chemicals From
`Polymeric Membranes; ACS Symposium Series #53, April 1977.
`Fundamental Concepts of Controlled Release; in book Controlled Release
`Technology, A.F. Kydonieus, ed., Vol. I, p. 1 (1979).
`Multilayered Laminated Structures; Ibid., p. 183 (1979).
`Other Controlled Release Technologies and Applications; Ibid., p. 235
`(1979).
`The Hercon Dispenser Formulation and Recent Test Results; in book
`Management of Insect Pests with Semiochemicals, E.R. Mitchell, ed., pps.
`445-454; Plenum Press, (1981).
`Pink Bollworm and Tobacco Budworm Mating Disruption Studies on Cotton;
`Ibid., pps. 367-284.
`Pheromones and Their Use; in book Insect Suppression with Controlled
`Release Pheromone Systems; A.F. Kydonieus and M. Beroza, Eds., Vol. I, p.
`3 (1982).
`Controlled Release Technologies; in book Insect Suppression with
`Controlled Release Pheromone Systems; A.F. Kydonieus and M. Beroza, Eds.,
`Vol. I, p. 131 (1982).
`Laminated Structure Dispensers; in book Insect Suppression with Controlled
`Release Pheromone Systems; A.F. Kydonieus and M. Beroza, Eds., Vol. I, p.
`213 (1982).
`Mating Disruption as a Method of Suppressing Pink Bollworm and Tobacco
`Budworm Populations in Cotton; in book Insect Suppression with Controlled
`Release Pheromone Systems; A.F. Kydonieus and M. Beroza, Eds., Vol. I, p.
`75 (1982).
`Marketing and Economics in Use of Pheromones for Suppression of Insect
`Populations; in book Insect Suppression with Controlled Release Pheromone
`Systems; A.F. Kydonieus and M. Beroza, Eds., Vol. II, p. 187 (1982).
`Formulations and Equipment for Large Volume Pheromone Application by Air;
`ACS Symposium Series #190, p. 175 (1982).
`Physical Methods of Controlled Release; in book Controlled Release
`Technology; G. Das, ed., pps. 61-120, John Wiley & Sons (1983).
`Controlled Release for Suppression of Rice Storage Pests; in book
`Controlled Release for Delivery Systems; T. Roseman and Z. Mansdorf, Eds.,
`pp. 301-313, Marcel Dekker (1983).
`
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`1.
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`2.
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`3.
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`4.
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`5.
`6.
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`7.
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`Plastic Laminate Dispensers; in book Insect Pheromones in Plant
`Protection; A. Jutsum and R. Gordon, Eds., pp. 149-171, J. Wiley & Sons
`Ltd. (1989).
`Transdermal Delivery From Solid Multilayered to Polymeric Reservoir
`Systems; in book Transdermal Delivery of Drugs; A.F. Kydonieus and B.
`Berner, Eds., pps. 145-156, CRC Press (December 1986).
`Fundamentals of Transdermal Drug Delivery; in book Transdermal Delivery of
`Drugs; A.F. Kydonieus and B. Berner, Eds., pps. 3-16, CRC Press (May
`1987).
`Controlled Release Technologies for Pest Management; in book Delivery of
`Crop- Protection Agents; R. M. Wilkins, Ed., pp. 43-58 (1990).
`Transdermal Delivery; in book Treatise in Controlled Drug Delivery; A.F.
`Kydonieus, ed., pps. 341-421, Marcel Dekker (September 1991).
`Novel Drug Delivery Systems in the book The Drug Development Process:
`Increasing Efficiency and Cost Effectiveness; P. G. Welling,Ed., pps 169-
`201, Marcel Dekker, (July 1996).
`Dermal and Transdermal Delivery of Drugs; in book Biochemical Modulation
`of Skin Reactions in Dermal and Transdermal Delivery of Drugs; A. F.
`Kydonieus and J. Wille, Eds., pps 1-15, CRC Press, (January 2000).
`Modulation of Skin Irritation and Sensitization Reactions: A General
`Overview; in book Biochemical Modulation of Skin Reactions in Dermal and
`Transdermal Delivery of Drugs; A. F. Kydonieus and J. Wille, Eds., pps
`205-223, CRC Press (January 2000)
`Ion Channel Modulation of Contact Irritant and Contact Allergic
`Dermatitis; in book Biochemical Modulation of Skin Reactions in Dermal and
`Transdermal Delivery of Drugs; A. F. Kydonieus and J. Wille, Eds., pps
`233-245, CRC Press (January 2000).
`Mast Cell Degranulating Agents in Contact Allergic Dermatitis; in book
`Biochemical Modulation of Skin Reactions in Dermal and Transdermal
`Delivery of Drugs; A. F. Kydonieus and J. Wille, Eds., pps 245-261, CRC
`Press (January 2000).
`Novel Topical Agents for Prevention and Treatment of Allergic and Irritant
`Contact Dermatitis; in book Advances in Toxicology; H. Maibach, ed.,pp
`235-262 Tailor & Francis, Philadelphia (May 2001).
`Transdermal Delivery Device Development: A Patent Review; in book Skin
`Delivery Systems; J. Wille, ed., pps 297-308, Blackwell Publishing (June
`2006)
`Abrogation Of Skin Reaction: Agents and Methods; in book Skin Delivery
`Systems; J. Wille, ed.,pps 43-68, Blackwell Publishing (June 2006)
`Fundamental Mechanisms of Skin Reactivity; in book Skin Delivery Systems;
`J. Wille, ed., pps 3-23, Blackwell Publishing (June 2006)
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`
`PUBLICATIONS & PRESENTATIONS
`A Multi-State Aerosol Sampler for Extended Sampling Intervals; American
`Industrial Hygiene Association Journal 31, November 1970.
`A Polymeric Delivery System for the Controlled Release of Pesticides; 45th
`Annual Meeting, Eastern Branch of the Entomological Society of America,
`New York, N.Y., November 1, 1973.
`HERCON* ROACH-TAPE; Proceedings - 1975 International Controlled Release
`Pesticides Symposium, pps. 60-75, September 1975.
`Field Studies on the Control of the German Cockroach using HERCON* ROACH-
`TAPE and Standard Sprays; Proceedings - 1975 International Controlled
`Release Pesticides Symposium, pps. 247-257, September 1975.
`Marketing and Economic Considerations for HERCON* Consumer and Industrial
`Controlled Release Products; Part I, UNIT p.10 - July/August 1976.
`Ibid, Part II, UNIT p. 6 - September 1976.
`HERCON* LURE 'N KILL* FLYTAPE: A Non-Fumigant Insecticidal Strip
`Containing Attractants; Proceedings - 1976 International Controlled
`Release Pesticides Symposium, pps. 3.40-3.51, September 1976.
`HERCON* Granules and Powders for Agricultural Applications; Proceedings -
`1976 International Controlled Release Pesticides Symposium, pps. 4.23-
`4.35, September 1976.
`HERCON* INSECTAPE: The PCO's New Weapon for the Ancient War on Roaches;
`Pest Control Magazine, October 1976.
`INSECTAPE is Working; Pest Control Technology, February 1977.
`Advantages of Using Controlled Release Formulations for Insect Control in
`Commercial Food-Handling Establishments, Proceedings - 1977 International
`Controlled Release Pesticide Symposium, pps. 216-225, August 1977.
`Insect Control with the Multilayered Luretape* Dispenser, Proceedings -
`1977 International Controlled Release Pesticides Symposium, pps. 78-89,
`August 1977.
`A Novel Way to Dispense Fragrances and Room Deodorizers; Soap Cosmetics
`and Chemical Specialties, p. 53, May 1978.
`Use of Laminated Controlled Release Contact-Action Insecticidal Strips for
`Cluster Fly Control; Entomological Society of America, 1978 National
`Meeting Presentation, Houston, Texas, November 26, 1978.
`Controlled Release Air Fresheners; Maintenance Supplies, July 1978.
`Controlled Release Modes and Methods; International Controlled Release of
`Bioactive Materials Symposium, p. 2.56, August 1978.
`Hercon Luretape Disparture Dispensers for Mating Suppression of Gypsy
`Moth; Eastern Branch Entomological Society of America, New York,
`September 27, 1978.
`
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`Use of Multilayered Pheromone Dispensers for Control of Cotton Insects;
`Biologically Active Chemicals in Air Symposium of ACS, (Hawaii) April 1,
`1978.
`Hercon Commercial Pheromone Products - 7th International Controlled
`Release Symposium Proceedings, p. 27, July 1980.
`Cotton Insects: Dispenser Development and Disruption of Mating Trials;
`6th International Controlled Release of Bioactive Materials Proceedings,
`p. IV-13, July 1979.
`Diffusion through Laminated Polymeric Films: Theoretical Considerations
`and Applications to Agriculture. American Institute of Chemical
`Engineers; National Meeting, Philadelphia, June 10, 1980.
`Recent Progress with Gossyplure for Pink Bollworm Mating Disruption; 8th
`Desert Cotton Insect Symposium, March 12, 1980.
`Mating Disruption and Mass Trapping of Insects with Hercon Flake;
`Colloquium on Management of Insects with Semiochemicals, Gainesville,
`Florida, March 24, 1980.
`Convention Agrichemical Controlled Release Formulations for Agriculture,
`Forestry, and Food Protection; 8th International Controlled Release of
`Bioactive Materials Symposium Proceedings, p. 66, July 26, 1981.
`Controlled Release Insecticide Formulations for Long-Term Fire Ant Control
`in Nursery and Sod Industry; Imported Fire Ant Workshop, Biloxi, Miss.,
`March 24, 1981.
`Gossyplure in Laminated Plastic Formulations for Mating Disruption and
`Pink Bollworm Control; Journal of Economic Entomology, p. 376, August
`1981.
`Lawn and Garden Insect Suppression with Pheromone Baited Traps; 9th
`International Controlled Release of Bioactive Materials Symposium
`Proceedings, p. 76, July 25, 1982.
`Potential of Periplanone B: Enhancement of Cockroach Control Treatments;
`Pest Control Magazine; in press.
`Transdermal Delivery of Medication Through Polymeric Laminated Structures;
`9th International Controlled Release Symposium of Bioactive Materials
`Proceedings, p. 128, July 25, 1982.
`Development of the Hercon Plastic Laminate System for Control of the
`Artichoke Plume Moth, Joint Meeting ESA-ESC; Toronto, Canada, November 29,
`1982.
`Controlled Release Formulations of Periplanone B Sex Pheromone for
`American Cockroach Control; 10th International Symposium on Controlled
`Release of Bioactive Materials Proceedings, pps. 223-230, July 1983.
`Attraction of American Cockroaches to Traps Containing Periplaone B:
`Journal of Economic Entomology, Vol. 3, No. , p. 448, 1984.
`
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`26.
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`27.
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`32.
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`Page 13 of 19
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`

`

`Transdermal Delivery of Nitroglycerin from a Laminated Reservoir System;
`11th International Symposium of Controlled Release of Bioactive Materials
`Proceedings, p. 2, July 1984.
`Controlled Release Technology and its Applications to Pharmaceuticals and
`Agriculture, Presentation to the North Jersey Section of the American
`Institute of Chemical Engineers; February 26, 1985.
`Pink Bollworm Management Program Using a Heat Unit-Based Model and
`Controlled Release Pheromone Systems; 12th International Symposium on
`Controlled Release of Bioactive Materials Proceedings, p. 62, 1985.
`Transdermal Delivery of ISDN from Hercon Patches Containing Azone; 12th
`International Symposium on Controlled Release of Bioactive Materials
`Proceedings, p. 322, 1985.
`Applications of Controlled Release to Pharmaceuticals; Presentation at the
`Annual Technical Conference of the Society of Plastics Engineers, April
`1985.
`Transdermal Delivery of a Prostaglandin from Hercon Polymer Matrix System;
`13th International Symposium on Controlled Release of Bioactive Materials,
`p. 09, 1986.
`Luretape with Grandlure; 13th International Symposium on Controlled
`Release of Bioactive Materials, p. 162, 1986.
`Drug Delivery Systems, 2nd Annual Drug and Health Care Seminar; Plaza
`Hotel, New York City, October 28, 1986.
`New Sex Weapon for American Cockroach Control; Pest Control Magazine; p.
`40, November 1986.
`Hercon Technology for Transdermal Delivery of Drugs; Journal of
`Biomaterials Applications, Vol. 1, p. 239, October 1986.
`Controlled Release of Propoxur from the Hercon Flea and Tick Collar; 14th
`International Symposium on Controlled Release of Bioactive Materials, p.
`48, 1987.
`Effect of Bait Color and Placement on Boll Weevil Trap Capture;
`Entomological Society of America Annual Meeting; Boston, December 1987.
`Hercon Transdermal Technologies; Presented at Biomedical Business
`International Conference; Philadelphia, Pa; November 1987.
`Transdermal Delivery of Prostaglandin R022; AAPS Meeting, Orlando, FL,
`p. S-128, June 1988.
`Development and Optimization of a Clonidine Transdermal Patch; 15th
`International Symposium on Controlled Release of Bioactive Materials, p.
`114, 1988.
`Novel Transdermal Drug Delivery System; 15th International Symposium on
`Controlled Release of Bioactive Materials, p. 87, 1988.
`
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`Page 14 of 19
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`

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`Patent Watch-Transdermal Update, in Controlled Research Newsletter, T.
`Roseman, Ed. - 7 (Issue 2):5 (1989).
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 7 (Issue 3):8 (1989).
`Hydrophilic Polyurethane Adhesives and Elastomers for Bioapplications;
`Bristol-Myers Squibb Product Development Seminar, Hyatt Regency Hotel,
`Buffalo, NY, July 16, 1990.
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 8 (Issue 1):11 (1990).
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 8 (Issue 2):10 (1990).
`Bioadhesive Mechanisms: FTIR Studies on Hydration Induced Hydrocolloid/
`Rubber Phase Reversal; 18th International Symposium of Controlled Release
`of Bioactive Materials, p. 113, 1991.
`Temperature Activated Controlled Release; 18th International Symposium of
`Controlled Release of Bioactive Materials, p. 417, 1991.
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 9 (Issue 1):16 (1992).
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 9 (Issue 2):18 (1992).
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 9 (Issue 3):16 (1992).
`Chemical Stability of Polyurethane Foam Covered Breast Implants; The
`Toxicologist, Vol. 12, No. 1, p. 133 (1992).
`Thermoplastic Adhesive Hydrogels; BMS Product Development Seminar,
`Princeton, NJ; 5/27/92.
`Development of Mucoadhesives: Physicochemical Studies; BMS Product
`Development Seminar, Princeton, NJ; 5/27/92.
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 10 (Issue 2):12 (1993).
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 10 (Issue 3):16 (1993).
`Analysis of the Extractive and Hydrolytic Behavior of Micro thane poly
`(ester-urethane) Foam by High Pressure Liquid Chromatography; J. of
`Biomedical Materials Research, Vol. 27, 655 (1993).
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 11 (Issue 1 ):20 (1994).
`Patent Watch-Transdermal Update, in Controlled Release Newsletter, T.
`Roseman, Ed. - 11 (Issue 2):16 (1994).
`
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`Skin Compatible Polyurethane Pressure Sensitive Adhesives for Ostomy,
`Wound and Skin Care Applications; BMS Product Development Seminar, New
`Brunswick, NJ; June 9, 1994.
`Sensitization of Mice to Topically Applied Drugs: Albuterol,
`Chlorpheniramine, Clonidine, and Nadolol; J. Investigative Dermatology,
`104, No. 4, P. 680 (April 1995).
`Abrogation of Cont