`
`
`
`
`
` Paper No. ____
`
`
`
`Filed on behalf of: Junior Party FAN
`
`By: R. Danny Huntington, Esq.
`Sharon E. Crane, Ph.D., Esq.
`ROTHWELL, FIGG, ERNST & MANBECK, P.C.
`607 14th St., N.W., Suite 800
`Washington, DC 20005
`dhuntington@rfem.com
`scrane@rfem.com
`Main Telephone: (202) 783-6040
`Main Facsimile: (202) 783-6031
`
`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`_____________________
`
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`
`_____________________
`
`
`
`HEI-MUN CHRISTINA FAN and STEPHEN QUAKE
`Junior Party
`(Patent 8,195,415),
`
`v.
`
`YUK-MING DENNIS LO, ROSSA WAI KWUN CHIU, and KWAN CHEE CHAN
`Senior Party
`(Application 13/070,266),
`
`_____________________
`
`
`Patent Interference No. 105,922 (DK)
`(Technology Center 1600)
`
`____________________
`
`
`FAN PRIORITY STATEMENT
`
`
`
`
`
`
`
`
`Petitioner Sequenom - Ex. 1014, p. 1
`
`

`

`Interference No. 105,922
`
`1
`2
`3
`4
`5
`6
`
`7
`
`8
`
`9
`
`10
`
`11
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`12
`
`13
`
`14
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`15
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`16
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`17
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`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`26
`
`MAIL STOP INTERFERENCE
`United States Patent and Trademark Office
`Patent Trial and Appeal Board
`Madison Building East
`600 Dulany Street
`Alexandria, Virginia 22313
`
`
`
`
`
`Pursuant to Bd.R. 204(a)(1), Junior Party Fan (“Fan”) hereby sets forth the basis upon
`
`which Fan intends to establish its entitlement to judgment on priority.
`
`
`
`Date and Location of Fan’s Earliest Corroborated Conception
`
`
`
`Pursuant to Bd.R. 204(a)(2)(i), Fan intends to prove a date of earliest corroborated
`
`conception in the United States of on or about December 18, 2007. Exhibit A is a copy of the
`
`earliest document upon which Fan will rely to show conception.
`
`
`
`
`
`Date and Location of Earliest Corroborated Actual Reduction to Practice
`
`
`
`Pursuant to Bd.R. 204(a)(2)(ii), Fan intends to prove a date of corroborated actual
`
`reduction to practice in the United States of on or about March 24, 2008.
`
`
`
`Earliest Corroborated Date on Which Diligence Began
`
`
`
`Pursuant to Bd.R. 204(a)(2)(iii), Fan intends to prove diligence beginning on or about
`
`December 18, 2007.
`
`
`
`A Copy of the Earliest Document Relied Upon to Show Conception
`
`
`
`Pursuant to Bd.R. 204(a)(2)(iv), Fan hereby provides, as an attachment to this Priority
`
`Statement, a copy of the earliest document upon which Fan intends to rely to show conception.
`
`(Exhibit A).
`
`
`
`2
`
`Petitioner Sequenom - Ex. 1014, p. 2
`
`

`

`Interference No. 105,922
`
`
`
`1
`
`2
`3
`4
`5
`6
`7
`8
`9
`10
`
`11
`
`
`
`
`
`
`
`
`
`
`
`Respectfully submitted,
`
`
`
`By: /s/ R. Danny Huntington
`
`
`Date: July 31, 2013
`
` R. Danny Huntington, Reg. No. 27,903
`Sharon E. Crane, Ph.D., Reg. No. 36,113
`Rothwell, Figg, Ernst & Manbeck, P.C.
`607 14th St., N.W., Suite 800
`Washington, DC 20005
`
`Counsel for Junior Party Fan
`
`
`
`
`
`
`
`
`
`3
`
`Petitioner Sequenom - Ex. 1014, p. 3
`
`

`

`
`
`
`EXHIBIT A
`
`EXHIBIT A
`
`Petitioner Sequenom - Ex. 1014, p. 4
`
`Petitioner Sequenom - Ex. 1014, p. 4
`
`

`

`file:///C:/Documents%20and%20Settings/Yann/My%20Documents ...
`
`* 1 2 3 4 5 6 ? 8
`A
`:H ~
`B
`c ;x
`D
`B
`F ;x
`G ;x
`H :X
`
`.......
`
`9 11 0 11121
`
`w~ o rakt( we({ f
`o-tJ"e {lo(- 1\J\~o( 11.\ Ov\~c.;;)]
`
`1-<
`
`1-<
`
`1-<
`
`User: Shared
`Data File:C:\ Documents and Settings\ Yann\ My Documents\ Down Syndrome
`Diagnostics\ Real-Time PCR\ 20071218_P27 -P37.tad
`Active Dye: (HEX)
`C(T) Threshold: 0.002010
`Threshold has been set manually.
`&oo Mi. pla.Sff1 et ~ SO.Mi Bvf\ifAt
`( exmlf.ll.d I <it/ ! T/ 2--"'-o7)
`o2..SM..€ ~plate ChofV!S~f{J.J rsfr) )
`
`Quantitation Graph
`
`H~f-
`
`{ Gfl.fprL fl.)
`
`•
`
`'
`
`~<I>
`v--- - ~ 3 0
`c. u
`
`<..>
`
`Q
`
`u..
`
`Note
`
`25
`!cycle I
`
`5
`
`0
`
`1
`
`2
`3
`!Log Quantity I
`
`4
`
`Set
`NTC
`P27
`P28
`P30
`P31
`P32
`P35
`P36
`P37
`std 1
`std 2
`std 3
`std 4
`std 5
`
`Dye
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`
`Efficiency C(t)
`N/A
`N/A
`68.82
`30.43
`68.44
`31.00
`31 07
`64.42
`65.54
`30.46
`31. 72
`68.30
`69.37
`31.00
`73.84
`31.11
`30.50
`77.50
`83.83
`21.83
`76.12
`25.07
`28. 13
`60.36
`47.07
`31.92
`92.3 1
`36.47
`
`copies
`N/A
`45.18
`31.44
`30 .12
`44.13
`19.92
`31.5
`29.24
`43.18
`1.364e+004
`1364
`136
`13.6
`1.36
`
`Avg C(t) MaxC(t)
`49.49
`49.49
`30.42
`30.55
`31.06
`31.32
`31.10
`31 .30
`30.55
`30.47
`31.75
`32.21
`31.61
`31.05
`31 .13
`31 .34
`30.50
`30.50
`21.83
`21.83
`25 06
`25.40
`28. 10
`28.28
`32.00
`32 .52
`36.47
`36.47
`
`MinC(t)
`49.49
`30.29
`30.65
`30.97
`30.43
`31 .38
`30.50
`30.79
`30.50
`21.83
`24.72
`27.90
`31 .56
`36.47
`
`( & n ~ I 4
`sf<?( I q U.tr\j\"h ~ Q c( cu
`18 ·~ !!) ,"2.
`fd ;, o~3 ;:
`c.or~ w- ::.
`I o --(br d t:Jt,'rvrt>on ~ -(?s .
`
`( ('J M 0 o{f' r )
`11ofle >
`I ~ C 51,
`
`C(t) SD Avg copies Max copies Min copies copies SD
`0.00
`0.0002592 0.0002592 0.0002592
`0
`0 .13
`45.49
`49.17
`41.81
`3.68
`0.30
`30.78
`39.28
`25.62
`6.054
`0.14
`29.57
`31 .97
`25.92
`2.621
`-44
`0.05
`45.06
`41.93
`1.463
`0.35
`19.98
`24.7
`14.59
`4.158
`0.45
`43.26
`3U9
`21.41
`8.956
`0.24
`29.37
`35.89
`25.33
`4.656
`0.00
`.-43.18
`43.18
`43. 18
`0
`0.00
`1.364e+004 1.364e+004 1.364e+004
`0
`0.28
`1364
`1364
`1364
`0
`0.16
`136
`0
`136
`136
`0 .39
`13.6
`13.6
`13.6
`0
`0.00
`1.36
`1.36
`1.36
`0
`£.itt>rYla Dr.Jt:. CQil- :
`II 3T Cof"e5 / ('()l f (aSt.., ~
`PQ7:
`1£ q. 5 copies I !Yl' f ICH tYI~
`f&8 :
`t3q eop;e,stl'fl' p laJI}f~
`P~:
`! l OO cofl'tl's/ 111 / f /tHrYt o......
`? 3 1:
`500 c.op; eslrv1 / f Jcl>Mo.....
`r ?~:
`7 q 5 wple.r 1 tVJI pia>~ tL
`f t, 5 :
`::; 3 q- copies 1 (VI [ f i?~S"" A
`P-36
`lo BO GOfi()J/fYI I rlasfvl t}.,
`P?:>i
`
`1 of I
`
`OUTSIDE ATTORNEYS' EYES ONLY
`
`1/1 5/2008 3:36PM
`
`VRNT A00002004
`
`Petitioner Sequenom - Ex. 1014, p. 5
`
`

`

`--
`
`file :///C:/Documents%20and%20Settings/Yann/My%20Documents ...
`
`7
`
`9 11 ol1112l
`
`!-"
`
`User: Shared
`Data File:C:\ Documents and Setting s\ Yanni My Documents\ Down Syndrome
`Diagnostics\ Real-Time PCR\ 20071 218_P27-P37.tad
`Active Dye: (FAM)
`C(T) Threshold: 0.007589
`Threshold has been set manually.
`
`X
`
`* l 2 3 4 s 6 7 8
`A H :H ><
`13
`c
`D
`E
`F
`G
`H
`
`'-'
`
`Quantitation Graph
`
`Note
`
`25
`lc:ycle I
`
`s
`
`Set Dye Efficiency C(t)
`N/A
`N/A
`NTC FAM
`N/A
`N/A
`P27 FAM
`59.17
`31 .88
`P28 FAM
`46.33
`P30 FAM
`6.19
`31 .87
`28.35
`P31 FAM
`N/A
`N/A
`P32 FAM
`N/A
`N/A
`P35 FAM
`N/A
`N/A
`P36 FAM
`7.27
`36. 33
`P37 FAM
`73.01
`18.90
`std 1 FAM
`22.45
`71.63
`std 2 FAM
`71.31
`26.00
`std 3 FAM
`29.46
`std 4 FAM
`64.53
`33.47
`std 5 FAM
`84.78
`
`copies Avg C(t) MaxC(t) MinC(t) C(t)SD Avg copies
`NIA
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`31.91
`32 .24
`31 .63
`0.25
`N/A
`N/A
`38.65
`38.65
`38.65
`0.00
`N/A
`NIA
`31 .91
`32.26
`31.42
`0.36
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`36.33
`36. 33
`36.33
`0.00
`N/A
`N/A
`18. 90
`18.90
`18.90
`0.00
`N/A
`0.07
`N/A
`N/A
`22.45
`22.5 1
`22.34
`26.1 5
`N/A
`26.02
`25.86
`0.12
`N/A
`29. 11
`0.23
`N/A
`N/A
`29.44
`29.62
`N/A
`33.47
`33.47
`33.47
`0. 00
`N/A
`
`Max copies Min copies copies SD
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`
`a)) -/v-lp 1 ,' C~:k£' howe. f. t5tw w tfi tft' aJ
`rrttM.t fefus : p .29 1r31 1
`
`I of I
`
`OUTSIDE ATTORNEYS' EYES ONLY
`
`1115/2008 3:37 PM
`
`VRNTA00002005
`
`Petitioner Sequenom - Ex. 1014, p. 6
`
`

`

`file: ///C:/Documents%20and%20Settings/Yann/My%20Documents ...
`
`* l 2 3
`A )<
`B
`)<
`c )<
`D
`ll )<
`F )<
`G
`
`H )< -
`
`4 s 6 7 8 9 10 11 11 21
`
`)< )
`
`"- ~.0
`
`e \J~o I'~ weer.s
`r/l.re. 1\ot-tne-Lltd.Q&
`t'l1. Oo.A~S;":s.
`User: Shared
`Data File:C :\ Documents and Settings\ Yann\ My Documents\ Down Syndrome
`Diagnostics\ Real-Time PCR\ 20080 114_P34P38-P45.tad
`Active Dye: (HEX)
`C(T) Threshold : 0.003976
`Threshold has been set manually.
`~o-oP fiO.SMCl -7 S o-«e 'St(fe.r AE
`( e )C"f.r-a r.:tuf ~ o I I f 4 I 2-oo?)
`( ~ St¥V! pt;,s 'r s1zJ )
`[), "S ,(£ kmp lt?lte
`
`<I>
`
`<.; = <I>
`'-'
`~
`
`0 -u.. •..
`
`<:·
`...J
`
`25
`lcytle l
`
`s
`
`0
`
`l
`
`2
`
`ILQg O"alrtily I
`
`3
`
`Note
`
`Set
`
`Dye
`
`Efficiency C(t)
`
`molecules
`
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`HEX
`
`N/A
`N/A
`59.72 32.56
`73.37 32.60
`73.69 32.60
`72.25 32.88
`33.52
`83.63
`60.43 33.02
`5902
`31 .92
`70.48 31.99
`57 .14 33.30
`
`N/A
`21.56
`21.05
`20.93
`17.31
`11.06
`15.63
`33.7
`32
`12.96
`
`Max
`Avg
`Avg Max Min C(t)
`Min
`C(t)
`C(t)
`C(t)
`SD molecules molecules molecules
`N/A
`N/A
`N/A N/A
`N/A
`N/A
`N/A
`32.61 33. 14 31.89 0.53
`22.42
`34.44
`14.4
`32.59 32.76 32.42 0.17
`2"1.36
`23.87
`18.84
`32.65 33.07 32.39 0.30
`24 .27
`15.19
`20.75
`32.93 33.42 32.48 0.39
`17.29
`22.79
`11.86
`33.52 33.64 33.35 0.13
`n.12 ~
`12.51
`10.19
`3303 33.13 32.92 0.09
`l5.64
`16.81
`14.53
`31.92 31 .96 31.85 0.05
`33.65
`35.25
`32.82
`32. 00 32.44 31.73 0.31
`32.58
`38.48
`23.5
`1'3.'29
`33.30 33.65 32. 95 0.35
`16.44
`10.14
`
`NTC
`P34
`P38
`P39
`P40
`P41
`P42
`P43
`P44
`P45
`female
`control
`male
`dilution 1
`male
`dilution 2
`male
`dilution 3
`male
`dilution 4
`male
`dilution 5
`w.aLt.-dilvrho~ 1 1jAM-hr;'w ar
`
`HEX
`
`70.66 23.44
`
`1.209e+004
`
`23.45 23.70 23.25 0.19 1.213e+004 1.387e+004 1.011 e+004
`
`HEX
`
`68.60 22.99
`
`1.644e+004
`
`22.99 23. 03 22.95 0.04 1.644e+004 1.644e+004 1.644e+004
`
`HEX
`
`60.83 26.37
`
`1644
`
`26.37 26.45 26.33 0.05
`
`HEX
`
`65.58 29.52
`
`164
`
`29.51 29.76 29.09 0.30
`
`HEX
`
`48.40 33.13
`
`16.4
`
`33.13 33.40 32.93 0.20
`
`HEX
`
`39 .70 36.19
`
`1.64
`
`3625 36.79 35.71 0.54
`
`1644
`
`1644
`
`1644
`
`164
`
`16.4
`
`1.64
`
`164
`
`16.4
`
`1.64
`
`164
`
`16.4
`
`1.64
`
`r:X!. 7-flej !»f.
`( f'lrMocJ.;op)
`iO p~ .# = @ ·1X~ ·S'») _ 1 b
`4-3 ~
`6 · b XI 0 -3
`
`-
`
`Pla.SM t.l l>tJA
`C~>"p'e.s r p0~~
`
`w{l(i.
`
`56o.'5
`'63 lf
`s tq
`49~
`2 "7-8
`3q J
`84 1
`St s
`33.9.
`
`4
`
`molecules
`SD
`N/A
`8.654
`2.514
`3.975
`4.462
`1.001
`0.9314
`1.132
`6.514
`3.151
`
`1547
`
`0
`
`0
`
`0
`- -
`0
`
`0
`
`t 0 tolo( JIIC4-h0tl 51lA·e r
`
`I of l
`
`OUTSIDE ATTORNEYS' EYES ONLY
`
`1115/2008 3:36PM
`
`VRNTA00002006
`
`Petitioner Sequenom - Ex. 1014, p. 7
`
`

`

`file:/ I /C :/Documents%20and%20Settings/Y ann/M y%20 Documents ...
`
`71
`
`-
`
`* 11 2 3 4 5
`A
`B
`c
`~
`E r-
`F
`G
`H X
`
`6 7 8 9 101 11 2 1
`
`- ~.0
`
`User: Shared
`Data File:C :\ Documents and Settings\ Yann\ My Documents\ Down Syndrome
`Diagnostics\ Real-Time PCR\ 2008011 4_P34P38-P45.tad
`Active Dye: (FAM)
`C(T) Threshold: 0.01 2365
`Threshold has been set manually.
`
`Qua ntitation Graph
`r-=~----------------------------------.
`<I>
`v ,..
`a;
`~ ....
`-u..
`Q -2. 5
`
`<.)
`
`C(T) Control Graph y = 1; rA2 = 0
`
`25
`!c.y·i:le l
`
`5
`
`Note
`
`Set
`
`Dye
`
`Efficiency C(t)
`
`molecules
`
`FAM
`FAM
`FAM
`FAM
`FAM
`FAM
`FAM
`FAM
`FAM
`FAM
`
`19.45 40.16
`35.80 35.59
`20.26
`2.95
`N/A
`N/A
`57.58
`32.95
`N/A
`N/A
`46.88 34.14
`N/A
`N/A
`13.34 43.64
`33.98 31.86
`
`FAM
`
`N/A
`
`N/A
`
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`
`N/A
`
`NTC
`P34
`P38
`P39
`P40
`P41
`P42
`P43
`P44
`P45
`female
`control
`male
`dilution 1
`male
`dilution 2
`male
`dilution 3
`male
`dilution 4
`male
`dilution 5
`
`Avg
`C(t)
`37 .62
`35 .73
`N/A
`N/A
`32 .97
`N/A
`34. 19
`46.45
`41.65
`31.80
`
`Max Min
`C(t)
`C(t)
`37.62 37 .62
`37.52 34.26
`N/A
`N/A
`N/A
`N/A
`33.52 32.65
`N/A
`N/A
`34.59 33.78
`46.45 46.45
`42.84 40.46
`32.35 31 .25
`
`C(t)
`Max
`Avg
`Min
`SD molecules molecules molecules
`N/A
`N/A
`N/A
`0.00
`1.35
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`0.39
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`0.33
`N/A
`N/A
`N/A
`0.00
`N/A
`N/A
`N/A
`1.19
`N/A
`N/A
`N/A
`0.55
`N/A
`N/A
`N/A
`
`molecules
`SD
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`FAM
`
`59.34
`
`19.85
`
`N/A
`
`19.84
`
`19.98 19.70
`
`0.14
`
`FAM
`
`59. 19 23.46
`
`N/A
`
`23.43
`
`23 .82 22.72
`
`0.50
`
`N/A
`
`N/A
`
`FAM
`
`5506 26.59
`
`N/A
`
`26.55
`
`26.93 2607
`
`0.36
`
`N/A
`
`FAM
`
`59.00 29.81
`
`N/A
`
`29.82
`
`29.97 29.64
`
`0.13
`
`FAM
`
`60.57
`
`33.48
`
`N/A
`
`33.48
`
`33.57 33.40
`
`0.08
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
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`N/A
`
`N/A
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`N/A
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`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`N/A
`
`1 of 1
`
`OUTSIDE ATTORNEYS' EYES ONLY
`
`1115/2008 3:36PM
`
`VRNT A00002007
`
`Petitioner Sequenom - Ex. 1014, p. 8
`
`

`

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`OUTSIDE ATTORNEYS' EYES ONLY
`
`VRNTA00002008
`
`Petitioner Sequenom - Ex. 1014, p. 9
`
`

`

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`OUTSIDE ATTORNEYS' EYES ONLY
`
`VRNT A00002009
`
`Petitioner Sequenom - Ex. 1014, p. 10
`
`