`From: Troy Norred
`
`Dear Dr. Flaker;
`
`I have
`This is a letter in follow-up to our conversation regarding my percutaneous aortic valve.
`since been in touch with a Medtronic representative and a Guidant representative. We are initiating
`meetings to discuss their interest and participation with the forthcoming project. Depending upon the
`results ofthe said meetings I will forward to you a protocol and time table for the project.
`I anticipate the
`need for 4 to 6 mo dedicated time to accomplish my initial goals.
`
`The goals I have set forth to reasonably pursue this technology includes but is not limited to the
`following statements. First, I would like to establish the feasibility of delivering a valve and having it
`anchored in the ascending aorta in an animal model. Secondly, I would like to explore different designs
`upon this central theme to assess which device Would be most generalizably effective. Thirdly. I would
`like to explore the different materials available and assess in these models their thrombogenicity and
`durability at different stress levels. Fourthly, I would like to finalize ancillary techniques to aortic
`debulking and assess the feasibility, generalizability , thrombogenicity and emolization ofthese techniques.
`Finally,
`I would like to package the results in an ambitious effort to design Phase I trials to look at the
`device in the most dire of patients with inoperable AS. Thus, this is an ambitious undertaking, but I have
`the desire and have shown the motivation and creativity to move this project to a successful completion.
`
`1 am collaborating with several well repected professors here and will continue to look for
`constructive collaboration with our staff. Your encouragement, guidance and mentoring has been
`invaluable and for this I am indebted to you.
`
`incel'e Y CDZUJ’“, 2
`
`8'
`
`1
`
`Troy N orred
`
`.
`
`.__
`
`_
`
`cores.» X
`
`NORRED EXHIBIT 2035 - Page 1
`Medtronic, Inc., Medtronic Vascular, Inc.,
`& Medtronic Corevalve, LLC
`
`v. Troy R. Norred, M.D.
`Case |PR2014-00110
`
`