April 2012
`
`liver X receptor agonist in plasma using liquid chromatography-tandem mass
`spectrometry. J. Chromatogr. B. Analyt Technol Biomed. Life Sci. 878, 1885-1888 (2010).
`219. Hoshino J, Park E-J, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li
`Y, Cushman M. Selective synthesis and biological evaluation of sulfate-conjugated
`resveratrol metabolites. J. Med. Chem. 53, 5033-5043 (2010).
`220. Dahl JH, van Breemen RB. Rapid quantitative analysis of 8-iso-PGF2α using liquid
`chromatography-tandem mass spectrometry and comparison to an enzyme immunoassay
`method. Anal. Biochem. 404, 211-216 (2010).
`221. Bolca S, Li J, Nikolić D, Roche N, Blondeel P, Possemiers S, De Keukeleire D, Bracke
`M, Heyerick A, van Breemen RB, Depypere H. Disposition of hop prenylflavonoids in
`human breast tissue. Mol. Nutr. Food Res. 54, Suppl. 2, S284-94 (2010).
`222. Marler L, Conda-Sheridan M, Cinelli MA, Morrell AE, Cushman M, Chen L, Huang K,
`van Breemen R, Pezzuto JM. Cancer chemopreventive potential of aromathecins and
`phenazines, novel natural product derivatives. Anticancer Res. 30, 4873-4882 (2010).
`223. Dong L, Shion H, Davis RG, Terry-Penak B, Castro-Perez J, van Breemen RB. Collision
`cross-section determination and tandem mass spectrometric analysis of isomeric
`carotenoids using electrospray ion mobility time-of-flight mass spectrometry. Anal. Chem.
`82, 9014-9021 (2010).
`224. Wang Z, Chandrasena ER, Yuan Y, Peng KW, van Breemen RB, Thatcher GR, Bolton
`JB. Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-
`deoxyguanosine via reactive oxygen species differentiates equine and human estrogens.
`Chem. Res. Toxicol. 23, 1365-1373 (2010).
`225. Cao H, Yu R, Tao Y, Nikolic D, van Breemen RB. Measurement of cyclooxygenase
`inhibition using liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed.
`Anal. 54, 230-235 (2011). PMC2946453; NIHMS230195
`226. White AB, Galbiati F, Givogri MI, Lopez Rosas A, Qiu X, van Breemen R, Bongarzone
`ER. Persistence of psychosine in brain lipid rafts is a limiting factor in the therapeutic
`recovery of a mouse model for Krabbe disease. J. Neurosci. Res. 89, 352-364 (2011).
`227. Choi Y, Jermihov K, Nam S-J, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M,
`Chen S-N, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen
`RB. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration
`LC-MS. Anal. Chem. 83, 1048-1052 (2011). PMC3034444; NIHMS261572
`228. van Breemen RB, Tao Y, Li W. Cyclooxygenase-2 inhibitors in ginger (Zingiber
`officinale). Fitoterapia, 82, 38-43 (2011). NIHMS241578
`229. Chen SN, Friesen JB, Webster D, Nikolić D, van Breemen RB, Wang ZJ, Fong HH,
`Farnsworth NR, Pauli GF. Phytoconstituents from Vitex agnus-castus fruits. Fitoterapia,
`82, 528-533 (2011).
`230. Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy
`M, Huang R, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH,
`Chen YG, Zhang HJ. Bioactive compounds from the fern Lepisorus contortus. J. Nat.
`Prod. 74,129-136 (2011).
`
`
`
`
`
`
`19
`
`
`
`0000051
`
`

`
`April 2012
`
`231. Castelvetri LC, Givogri MI, Zhu H, Smith B, Lopez-Rosas A, Qiu X, van Breemen R,
`Bongarzone ER. Axonopathy is a compounding factor in the pathogenesis of Krabbe
`disease. Acta Neuropathol. 122, 35-48 (2011).
`232. Hu C, Eggler AL, Mesecar AD, van Breemen RB. Modification of Keap1 cysteine
`residues by sulforaphane. Chem. Res. Toxicol. 24, 515-21 (2011).
`233. van Breemen RB, Sharifi R, Viana M, Pajkovic N, Zhu D, Yuan L, Yang Y, Bowen PE,
`Stacewicz-Sapuntzakis M. Antioxidant effects of lycopene in African American men with
`prostate cancer or benign prostate hyperplasia: a randomized controlled trial. Cancer Prev.
`Res. (Phila.) 4, 711–718 (2011).
`234. Park EJ, Kondratyuk TP, Morrell A, Kiselev E, Conda-Sheridan M, Cushman M, Ahn S,
`Choi Y, White JJ, van Breemen RB, Pezzuto JM. Induction of retinoid X receptor activity
`and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.
`Cancer Prev. Res. (Phila.) 4, 592-607 (2011).
`235. Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB,
`Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM.
`Resveratrol derivatives as promising chemopreventive agents with improved potency and
`selectivity. Mol. Nutr. Food Res. 55, 1249-1265 (2011).
`236. Yu R, Xiao L, Zhao G, Christman JW, van Breemen RB. Competitive enzymatic
`interactions determine the relative amounts of prostaglandins E2 and D2. J. Pharmacol.
`Exper. Ther. 339, 716-725 (2011).
`237. Gödecke T, Yao P, Napolitano JG, Nikolić D, Dietz BM, Bolton JL, van Breemen RB,
`Farnsworth NR, Chen S-N, Lankin DC, Pauli GF. Integrated standardization concept for
`Angelica botanicals using quantitative NMR. Fitoterapia 83, 18-32 (2012).
`238. Gaba RC, Baumgarten S, Omene BO, van Breemen RB, Garcia KD, Larson AC, Omary
`RA. Ethiodized oil uptake does not predict doxorubicin drug delivery after
`chemoembolization in VX2 liver tumors. J. Vasc. Interv. Radiol. 23, 265-73 (2012).
`239. Hu C, Nikolić D, Eggler AL, Mesecar AD, van Breemen RB. Screening for natural
`chemoprevention agents that modify Keap1. Anal. Biochem. 421, 108-114 (2012).
`240. van Breemen RB, Dong L, Pajkovic ND. Atmospheric pressure chemical ionization
`tandem mass spectrometry of carotenoids. Int. J. Mass Spectrom. 312, 163-172 (2012).
`241. Kondratyuk TP, Park E-J, Yu R, van Breemen RB, Asolkar RN, Murphy BT, Fenical W,
`Pezzuto JM. Novel marine phenazines as potential cancer chemopreventive and anti-
`inflammatory agents Mar. Drugs, 10, 451-464 (2012).
`242. Li J, Gödecke T, Chen SN, Imai A, Lankin DC, Farnsworth NR, Pauli GF, van Breemen
`RB, Nikolić D. In vitro metabolic interactions between black cohosh (Cimicifuga
`racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica.
`(2012) in press.
`243. Al-Alem U, Peter H. Gann PH, Dahl J, van Breemen RB, Mistry V, Lam PMW, Evans
`MD, Van Horn L, Wright ME. Associations between functional polymorphisms in
`antioxidant defense genes and urinary oxidative stress biomarkers in healthy,
`premenopausal women. Genes Nutr. (2012) in press.
`
`
`
`
`
`
`20
`
`
`
`0000052
`
`

`
`April 2012
`
`244. Nikolić D, Gödecke T, Chen S-N, White J, Lankin DC, Pauli GF, van Breemen RB. Mass
`spectrometric dereplication of nitrogen-containing constituents of black cohosh
`(Cimicifuga racemosa L.). Fitoterapia (2012) in press.
`245. Baumgarten S, Gaba RC, van Breemen RB. Confirmation of drug delivery after liver
`chemoembolization: Direct tissue doxorubicin measurement by UHPLC-MS-MS. Biomed.
`Chromatogr. (2012) in press.
`
`
`2. Chapters in Books
`
`246. van Breemen RB. Structural analysis of phosphatidylinositol from carrot cell membranes by
`fast atom bombardment and tandem mass spectrometry. In Mass Spectrometry in the
`Molecular Sciences: A Tutorial, pp. 443-451, ed. by Gross ML. Kluwer Academic
`Publishers, Dordrecht, 1992. Invited contribution.
`247. van Breemen RB. Mass spectrometry of textile dyes. In Advances in Colour Chemistry
`Series, pp. 96-116, ed. by Peters AT, and Freeman HS. Blackie Academic & Professional,
`Chapman and Hall, Glasgow, 1995. Invited contribution.
`248. van Breemen RB, Woodbury CP, Venton DL. Screening molecular diversity using mass
`spectrometry. In Mass Spectrometry of Biological Molecules, 2nd ed. Ed. by Larsen BS, and
`McEwen CN. Marcel Dekker, New York, pp 99-113, 1998.
`249. Fitzloff JF, Yat P, Lu LL, Awang, DVC, Arnason JT, van Breemen RB, Hall T,
`Blumenthal M, Fong HHS. Perspectives on the quality assurance of ginseng products in
`North America. In Advances in Ginseng Research – Proceedings of the 7th International
`Symposium on Ginseng. Ed. By Huh H, Choi KJ and Kim YC. The Korean Society of
`Ginseng, Seoul, Korea, September 22-25, 1998.
`250. Barua AB, Olson JA, Furr HC, and van Breemen RB. Vitamin A and carotenoids. In Modern
`Chromatographic Analysis of the Vitamins, 3rd ed. Ed. by De Leenheer A, Lambert WE, and
`Van Bocxlaer JF. Marcel Dekker, Inc., New York, pp 1-74, 2000.
`251. van Breemen RB. Mass Spectrometry of carotenoids. In Current Protocols in Food
`Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New York, pp F2.4.1-
`F2.4.13, 2001.
`252. van Breemen RB. Mass spectrometry of chlorophylls. In Current Protocols in Food
`Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New York, pp F4.5.1-
`F4.5.9, 2001.
`253. van Breemen RB. Introduction to mass spectrometry for food chemistry. In Current
`Protocols in Food Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New
`York, Appendix 3A.1-3A.7, 2001.
`254. van Breemen RB. Mass spectrometry and drug discovery. In Burger’s Medicinal Chemistry
`and Drug Discovery. 6th Edition, Volume 1: Drug Discovery. Ed. By Abraham DJ. John
`Wiley & Sons, New York, 2003.
`255. Constantinou AI and van Breemen RB. Lycopene, a dietary cancer chemopreventive agent.
`In Cancer Chemoprevention, Volume 1: Promising Cancer Chemoprevention Agents. Ed. by
`Kelloff GJ, Hawk ET, and Sigman CC. Humana Press, Totowa, NJ, pp 525-535, 2004.
`
`
`
`
`
`
`21
`
`
`
`0000053
`
`

`
`April 2012
`
`256. Pajkovic N and van Breemen RB. Chapter 8: Analysis of carotenoids using atmospheric
`pressure chemical ionization mass spectrometry. In Modern Methods of Lipid Analysis. Ed.
`by Byrdwell WC. AOCS Press, Champaign, IL, pp 413-430, 2005.
`257. van Breemen RB. Chapter 4: Natural products from plants. In The Encyclopedia of Mass
`Spectrometry, Volume 3: Biological Applications, Part B: Carbohydrates, Nucleic Acids
`and other Biological Compounds. Ed. by Caprioli RM. Elsevier, Oxford, UK, pp 317-322,
`2006.
`258. Fong HHS, Pauli GF, Bolton JL, van Breemen RB, Banuvar S, Shulman L, Geller SE and
`Farnsworth NR. Chapter 2: Evidence-based herbal medicine: Challenges in efficacy and
`safety assessments. In Annals of Traditional Chinese Medicine – Vol. 2. Current Review of
`Chinese Medicine: Quality Control of Herbs and Herbal Medicine. Ed. by Leung PC, Fong
`H, Xue CC. World Scientific, New Jersey, pp 11-26, 2006.
`259. van Breemen RB. Chapter 5: Pharmaceutical Applications: On-line ultrafiltration mass
`spectrometry, principles and applications. In Encyclopedia of Mass Spectrometry Volume 8:
`Hyphenated Methods. Ed. by Niessen WM. Elsevier Science, Oxford, UK, pp 515-522,
`2006.
`260. van Breemen RB, Newsome AG, Dahl, JH. Mass spectrometry and drug discovery. In
`Burger’s Medicinal Chemistry, Drug Discovery and Development. 7th Edition, Volume 1:
`Drug Discovery. Ed. By Abraham DJ. John Wiley & Sons, New York, 2010.
`261. Koch D, Johnson L, Gehrke CW, Sandra P, van Breemen RB. Chapter 9. Chromatography -
`Advances in environmental and natural products, chemical analysis and synthesis. In
`Chromatography a Science of Discovery. Ed. By Wixom RL and Gehrke CW. John Wiley &
`Sons, Hoboken, New Jersey, pp 345-360, 2010.
`
`
`
`3. Patents
`
`US Patent No. US 5872015. “Molecular Diversity Screening Method.” Patent issued February 16,
`1999. Patent application filed May 10, 1996. Inventors: Venton, D. L., Woodbury, C. P., and van
`Breemen, R. B.
`
`US Patent No. US 6,995,022 B1. “Screening of Xenobiotics and Endogenous Compounds for
`Metabolic Transformation, Formation of Toxic Metabolites, and Bioavailability.” Patent issued
`February 7, 2006. Patent application filed December 23, 1999. Inventors: van Breemen, R. B., and
`Bolton, J. L.
`
`World Patent WO/2010/025209. “Jasmonic acid compounds in cocoa products.” Patent issued April
`3, 2010. Patent application filed August 27, 2009. Inventors: Hurst, W. J., Stuart, D. A., Calderon
`Justavino, A. I., van Breemen, R. B.
`
`4. Book Reviews
`van Breemen, R. B., Anal. Chem., 63, 235A (1991). Review of Biomedical Applications of Mass
`Spectrometry, Volume 34, C. H. Suelter and J. T. Watson, Eds., John Wiley & Sons, New York,
`1990.
`
`
`
`
`
`
`22
`
`
`
`0000054
`
`

`
`April 2012
`
`van Breemen, R. B., J. Am. Soc. Mass Spectrom., 3, 867 (1992). Review of Continuous-Flow Fast
`Atom Bombardment Mass Spectrometry, R. M. Caprioli, Ed., John Wiley & Sons, New York,
`1990.
`van Breemen, R. B., J. Med. Chem., 35, 4919-4920 (1992). Review of Mass Spectrometry in the
`Biological Sciences: A Tutorial, M. L. Gross, Ed., Kluwer Academic Publishers, Dordrecht, 1992.
`van Breemen, R. B., Anal. Chem., 65, 795A (1993). Review of Liquid Chromatography-Mass
`Spectrometry, W. Niessen and J. van der Graaf, Marcel Dekker, Inc., New York, 1992.
`van Breemen, R. B., J. Am. Chem. Soc., 121, 8413-8414 (1999). Review of Integration of
`Pharmaceutical Discovery and Development: Case Histories. Volume 11. Pharmaceutical
`Biotechnology. Edited by R. T. Borchardt, R. M. Freidinger, T. K. Sawyer and P. L. Smith. Plenum
`Press, New York. 1998.
`van Breemen , R. B. J. Am. Chem. Soc., 123, 8646-8647 (2001). Review of Combinatorial
`Chemistry. A Practical Approach, Willi Bannwarth and Eduard Felder, Eds. Wiley-VCH:
`Weinheim. 2000.
`
`COURSES TAUGHT
`CH527 Mass Spectrometry, created and taught new course Fall 1986, 1988, 1990, 1992
`CH525 Physical Methods in Organic Chemistry, Spring 1987-1993
`CH220 Introductory Organic Chemistry, Fall 1987
`CH315 Quantitative Analysis, Spring 1988
`CH221 Organic Chemistry I, Spring 1989, Fall 1993
`CH223 Organic Chemistry II, Fall 1989, Fall 1991
`BPS385 Special Topics: Survey of Research in Pharmaceutical Sciences, Fall 2006
`BPS471 Clinical Pharmacology II, Spring 2005, Spring 2006 (lecturer)
`MDCH 561 Principles of Medicinal Chemistry, Fall 1996-1997 (lecturer), 1998 (coordinator),
`1999-2006 (lecturer)
`MDCH 562 Spectroscopy in Medicinal Chemistry, Fall 1994-1995 (coordinator), 1996-2000
`(lecturer), 2001 (coordinator), 2002 (lecturer), 2004-2012 (coordinator)
`MDCH 565 Laboratory Methods in Medicinal Chemistry, Summer 1995-2001 (lecturer)
`MDCH 592 Research Topics in Medicinal Chemistry 2002-2008 (lecturer)
`MDCH 594 LC-MS Techniques 2007-2008 (coordinator)
`MDCH 595/PMPG 595 Seminars in Medicinal Chemistry/Pharmacognosy 1999, 2002, 2006,
`2007(coordinator); 2001, 2003, 2005 (lecturer)
`PHAR 333 Review of Spectroscopy, Fall 1998-1999 (lecturer), 2000 (co-coordinator), 2001-
`2011 (lecturer)
`PHAR 403 Principles of Drug Action and Therapeutics VI: Medicinal Chemistry of Antiviral
`Agents, Spring 2008-2011 (lecturer)
`
`
`
`
`
`
`23
`
`
`
`0000055
`
`

`
`April 2012
`
`PHAR 406 Principles of Drug Action and Therapeutics VI: Chemistry of Antivirals, Fall 1999-
`2007 (lecturer)
`PMMP 323 Bioanalytical Chemistry, Fall 1994-1995, 1997 (lecturer), 1996 (coordinator)
`PMMP 623 Bioanalytical Chemistry, Spring 1995-2000 (coordinator)
`PMPG 480 Methods of Evaluating Biologically Active Natural Product Drugs, Spring 1998-
`2006; Fall 2009 (lecturer)
`PMPG 507 Drug Discovery, Design and Development, Fall 2005-2011 (lecturer)
`PMPG 510 Research Techniques in Pharmacognosy, Fall 1997-2011 (lecturer)
`PMPG 515 Structure Elucidation of Natural Products, Spring 1998, 2000 (lecturer)
`PMPG 495 Introduction to Pharmaceutical Biotechnology, Spring 1999 (lecturer)
`PMPG 511 Advanced Pharmacognosy II, Spring 2006-2012 (lecturer)
`International Training Program in New Crops: Aromatic and Medicinal Plants – 2000. Taught
`laboratory practicum on, “Medicinal plant analysis using HPLC and LC-MS.” University of
`Illinois at Chicago and Purdue University. Chicago, IL. June 19-30, 2000.
`
`RESEARCH STUDENTS AND POST-DOCTORAL FELLOWS SUPERVISED
`Graduate Students
`1. LeRoy B. Martin, III, Ph.D. Chemistry, 1990
`"Mass Spectrometry of Organometallics and Several Platinated Oligonucleotides"
`Current position: Mass spectrometry applications scientist with Micromass, Division of Waters,
`Danvers, MA
`2. David R. Goodlett, Ph.D. Biochemistry, 1991
`"Studies on the Active Site of Juvenile Hormone Esterase"
`Current position: Professor of Medicinal Chemistry, University of Washington, College of
`Pharmacy, Seattle, WA
`3. Chien-Hua Huang, Ph.D. Chemistry, 1991
`"Synthesis of Poly-3,3,3-trifluoro-1-phenylpropyne and Poly-1-phenylpropyne and
`Characterization by Chromatography and Mass Spectrometry"
`Current position: Chemist in Taiwan
`4. Roderick G. Davis, M.S. Chemistry, 1991
`"Rates of Proteolysis of Bioactive Peptides Determined Using HPLC and Mass Spectrometry"
`Current position: Mass spectrometry specialist, Research Resources Center, University of
`Illinois at Chicago, Chicago, IL
`5. Catherine Ann Culver, Ph.D. Food Science, 1991
`“Application of Immobilized Digestive Enzyme Assay Fluidized-bed Reactors and
`Characterization of Their Digests.”
`Current position: Principal scientist, Pepsi-Cola Co., Valhalla, NY
`6. Yinhsien Tsou, Ph.D. Chemistry, 1993
`"Degradation of Xenobiotic Compounds by Immobilized Enzymes and Cells"
`Current position: Killed in automobile accident
`
`
`
`
`
`
`24
`
`
`
`0000056
`
`

`
`April 2012
`
`7. Kevin Blackburn, M.S. Chemistry, 1993
`"Degradation of Lysobactin by Digestive Proteases"
`Current position: Analytical chemist, Glaxo SmithKline Pharmaceuticals, Research Triangle
`Park, NC
`8. Dejan Nikolic, Ph.D. Medicinal Chemistry, 1999
`“Screening of Combinatorial Chemistry Libraries Using Pulsed Ultrafiltration-Mass
`Spectrometry” Current position: Mass spectrometry lab manager and Research Assistant
`Professor, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois
`College of Pharmacy, Chicago, IL
`9. Lixin Shen, M.S. Medicinal Chemistry, 1999
`“Analysis of DNA Oxidation Products using Liquid Chromatography-Mass Spectrometry”
`Current position: Mass spectrometrist, Roche Pharmaceuticals, Nutley, NJ
`10. Yecheng Tan, Graduate Student, 1995-2000
`“Liquid Chromatography-Mass Spectrometry of Oligonucleotides”
`Current position: Mass spectrometrist at Decode, Lemont, IL
`11. Xiaoying Xu, Ph.D. Pharmacognosy, 2000
`“Antiproliferative Effect of Lycopene on Prostate Cancer Cells”
`Current position: Group Leader Analytical and PMPK, Novartis, Shanghai, China
`12. Yan Wang, Ph.D. Medicinal Chemistry, 2001
`“Prevention of Prostate Cancer by Lycopene”
`Current position: Director of Proteomics, College of Chemical and Life Sciences, University of
`Maryland, College Park, MD
`13. Chongwoo Yu, Ph.D. Chemistry, 2002
`“Investigation of Resveratrol Metabolism using Liquid Chromatography-Mass Spectrometry”
`Current position: Office of Clinical Pharmacology, U. S. Food and Drug Administration, Silver
`Spring, MD
`14. Yanan Yang, Ph.D. Medicinal Chemistry, 2003
`“Quantitative Determination of DNA Oxidation and DNA Methylation by Using LC-UV-MS-
`MS” Current position: Mass spectrometrist, Agilent Technologies, Palo Alto, CA
`15. Benjamin M. Johnson, Ph.D. Medicinal Chemistry, 2003
`“Mass Spectrometric Assays for Electrophilic Metabolites of Natural Product Mixtures”
`Current position: Senior scientist, Bristol Myers Squibb, Wallingford, CT
`16. Spiros Garbis, Ph.D. Pharmacognosy, 2003
`“Bioavailability Studies of Folate in Humans”
`Current position: Staff research scientist, Academy of Athens, Foundation for Biomedical
`Research, Athens, Greece
`17. Yongmei Li, Ph.D. Pharmacognosy, 2004
`“Caco-2 cell permeation studies and metabolism of botanical natural products”
`Current position: Senior Scientist in Drug Metabolism and Pharmacokinetics. Boehringer
`Ingelheim, Ridgeland, CT
`18. Natasa Pajkovic, Ph.D. Medicinal Chemistry, 2005
`“Prevention of Prostate Cancer by Lycopene”
`Current position: Senior Scientist in Drug Metabolism. Merck, West Point, PA
`
`
`
`
`
`
`25
`
`
`
`0000057
`
`

`
`April 2012
`
`19. Wenzhong Liang, Ph.D. Pharmacognosy, 2005
`“Pharmacokinetics and metabolism studies of active compounds in botanical dietary supplements
`for womens’ health”
`Current position: Senior Scientist at Pharmaceutical Product Development, Inc. Madison, WI
`20. Xun Cheng, Ph.D. Medicinal Chemistry, 2005
`“Ultrafiltration Mass Spectrometric Screening for Inhibitors of Macromolecular Aggregation”
`Current position: Senior Scientist at Affymax, Palo Alto, CA
`21. Yongkai Sun, Ph.D. Medicinal Chemistry, 2005
`“Characterization of estrogens using ultrafiltration mass spectrometry”
`Current position: Scientist at Celgene, Summit, NJ
`22. Xiaofeng Yang, Ph.D. Medicinal Chemistry, 2005
`“Studies of protein covalent modifications using mass spectrometry”
`Current position: Scientist I at Millennium Pharmaceuticals, Cambridge, MA
`23. Guowen Liu, Ph.D. Medicinal Chemistry, 2005
`“Screening for potential chemopreventive agents targeting human Keap1 and human RARγ
`using mass spectrometry”
`Current position: Scientist at Bristol Myers Squibb, New Brunswick, NJ
`24. Dongwei Zhu, Ph.D. Medicinal Chemistry, 2006
`“β-Carotene bioefficacy and prevention of lipid peroxidation by lycopene”
`Current position: Research Scientist at Xenobiotics Laboratory, Plainsboro, NJ
`25. Yan Pang, Ph.D. Medicinal Chemistry, 2006
`“In vitro studies of intestinal absorption, blood brain barrier permeability and metabolism of
`natural products using mass spectrometry”
`Current position: Senior Scientist in Drug Metabolism at Abbott Laboratories, Abbott Park, IL
`26. Aarti Sawant, Ph.D. Medicinal Chemistry, 2006
`“In vitro and in vitro identification and evaluation of electrophilic precursors in natural products”
`Current position: Senior Scientist at Pfizer, Groton, CT
`27. Yi Tao, Ph.D. Medicinal Chemistry, 2007
`“Characterization of cyclooxygenase-2 inhibitors from ginger dietary supplements and in vitro
`metabolism studies of gingerol-related compounds”
`Current position: Director of DMPK, GlaxoSmithKline Research and Development, Shanghai,
`China
`28. Yan Luo, Graduate Student, Ph.D. Medicinal Chemistry, 2008
`“Application of proteomics mass spectrometry to the Keap1/Nrf2 chemoprevention pathway”
`Current position: Mass spectrometrist, at Dow Chemical, Shanghai, China
`29. Long Yuan, Ph.D. Medicinal Chemistry, 2008
`“Identification and quantitative analysis of DNA damage products using LC-MS-MS”
`Current position: Senior Investigator at Bristol-Myers Squibb, New Brunswick, NJ.
`30. Jian Guo, Ph.D. Medicinal Chemistry, 2008
`“Metabolism of active compounds in botanical dietary supplements”
`Current position: Senior Investigator at Astrazeneca, Wilmington, DE.
`31. Dongting Liu, Ph.D. Medicinal Chemistry, 2008
`
`
`
`
`
`
`26
`
`
`
`0000058
`
`

`
`April 2012
`
`“Screening natural products for cancer chemopreventive agents based on binding to RXRα and
`alkylation of Keap1”
`Current position: Senior Scientist at Dow Chemical, Indianapolis, IN
`32. Ang Liu, Ph.D. Medicinal Chemistry, 2008
`“Mechanisms of prostate cancer prevention by lycopene”
`Current position: Principal Investigator, Matrix Bioanalytical Laboratories, New Haven, CT
`33. Hongmei Cao, Ph.D. Medicinal Chemistry, 2009
`“Role of cyclooxygenases in inflammation and chemoprevention”
`Current position: Senior Scientist at Shire Pharmaceuticals, Lexington, MA
`34. Jeffrey H. Dahl, Ph.D. Medicinal Chemistry, 2010
`“Antioxidant effects and metabolism of lycopene”
`Current position: Scientist at Shimadzu Instruments, Columbia, MD
`35. Jinghu Carl Li, Ph.D. Medicinal Chemistry, 2010
`“Studies of metabolism and disposition of natural products using mass spectrometry”
`Current position: Senior Research Scientist at AMRI, Albany, NY
`36. Chenqi Hu, Ph.D. Medicinal Chemistry, 2011
`“Analysis of Nrf2-Keap1 chemoprevention signaling using mass spectrometry”
`Current position: Scientist at Amgen, Cambridge, MA
`37. Zhiyuan Sun, M.S. Medicinal Chemistry, 2011
`“Mass Spectrometric studies of Keap1-Nrf2 binding interactions.”
`Current position: Staff Scientist in University of Pittsburgh Proteomics Center, Pittsburgh, PA
`38. Soyoun Ahn, Ph.D. Pharmacognosy, 2011
`“In vitro studies of intestinal absorption and blood-brain barrier penetration of pharmacologically
`active compounds using cell monlayer models combined with HPLC-mass spectrometry”
`Current position: Postdoctoral fellow at Oregon State University, Corvallis, OR
`39. Yang Song, Ph.D. Pharmacognosy, 2011 “ADMEt Evaluation of Anti-tuberculosis
`Compounds and New Methodologies Development.”
`Current position: Senior Scientis at Chemocentryx, San Francisco, CA
`40. Linlin Dong, Graduate Student, 2007-present
`“Carotenoid bioavailability and chemoprevention mechanisms”
`41. Rui Yu, Graduate Student, 2007-present
`“Prostaglandins and asthma”
`42. Ke Huang, Graduate Student, 2007-present
`“Metabolism of chemoprevention agents”
`43. Lian Chen, Graduate Student, 2008-present
`“Discovery of chemoprevention agents targeting RXRα”
`44. Yang Yuan, Graduate Student, 2008-present
`“Microfluidics LC-MS-MS analysis of DNA alkylation products in human tissue”
`45. Jerry White, Graduate Student, 2008-present
`“Determination of sites of binding of selective HDAC inhibitors”
`46. Kevin Krock, Graduate Student, 2008-present
`“Mass spectrometry-based discovery of β-amyloid aggregation inhibitors”
`
`
`
`
`
`
`27
`
`
`
`0000059
`
`

`
`April 2012
`
`47. Brian Wright, Graduate Student, 2008-present
`“Pharmacokinetics of cocoa antioxidants”
`48. Yongchao Li, Graduate Student, 2009-present
`“Mechanisms of lycopene uptake by prostate cells”
`49. Andrew Newsome, Graduate Student, 2009-present
`“Discovery of food pigments and chemoprevention agents from extremophiles”
`50. Caleb Nienow, Graduate Student, 2010-present
`“Mass spectrometry investigation of binding modes of selective HDAC inhibitors”
`
`Undergraduates and High School Students
`Michael G. Bartlett, B.A. 1990. North Carolina State University, Raleigh, NC.
`Senior undergraduate research project in chemistry."Degradation of Bioactive Peptides by
`Immobilized Proteases."
`Subsequent position: Ph.D. program, Dept. of Chemistry, Indiana University, Bloomington, IN.
`Current position: Professor of Medicinal Chemistry, College of Pharmacy, University of
`Georgia, Athens, GA.
`Jack Thornquest, B.A. 1992. North Carolina State University, Raleigh, NC. Senior
`undergraduate research project in chemistry. "Interaction of Phage mRNA with a Regulatory
`Protein." Subsequent position: Ph.D. program, Dept of Chemistry, Univ. of North Carolina at
`Chapel Hill.
`Jacob Lai, B.S. 2000. Northwestern University, Evanston, IL. Summer research 1996-1999.
`Subsequent position, Ph.D. program, Dept. of Chemistry, Stanford University, Palo Alto, CA.
`Current position, Senior Chemist, Alza (Johnson & Johnson), Mountain View, CA.
`Jacob Lai and Donald Park. 1994-1995. Illinois Mathematics and Science Academy, Aurora, IL.
`High school science project supervisor/mentor. “C18 reversed phase high-performance liquid
`chromatography and mass spectrometry of oligonucleotides.”
`Priscilla A. Bernikowicz. 1995-1996. Lincoln Park High School, Chicago, IL. High school
`science project supervisor/mentor. “Nicotine analysis and ETS exposure.” Named Semifinalist in
`the national Westinghouse 55th Annual Science Talent Search. Attended Northwestern
`Univeristy.
`Helen Feinstein, Jennifer Mack and Donald Park. 1995-1996. Illinois Mathematics and Science
`Academy, Aurora, IL. High school science project supervisor/mentor. “Affinity LC-MS of
`antisense oligonucleotides.”
`Bradley Jellerichs and Angela Janis. 1996-1997. Illinois Mathematics and Science Academy,
`Aurora, IL. High school science project supervisor/mentor. “Synthesis of oxidized
`deoxynucleosides.”
`Adam Rojan. 1997-1998. Illinois Mathematics and Science Academy, Aurora, IL. High school
`science project supervisor/mentor. “Pulsed ultrafiltration affinity constant measurements.”
`Marissa Fierz. 1998-1999. Illinois Mathematics and Science Academy, Aurora, IL. High school
`science project supervisor/mentor. “Degradation products of lycopene and their linkage to
`prostate cancer.”
`
`
`
`
`
`
`28
`
`
`
`0000060
`
`

`
`April 2012
`
`Eric Bunnelle and Stephen Trevick, 2000-2001. Illinois Mathematics and Science Academy,
`Aurora, IL. High school science project supervisor/mentor. “Pulsed ultrafiltration measurement
`of receptor-ligand interactions.” Eric Bunnelle attended the University of Illinois at Champaign-
`Urbana as a chemical engineering major.
`Kevin Yang and Sri P. Vagvala, 2001-2002. Illinois Mathematics and Science Academy, Aurora,
`IL. High school science project supervisor/mentor. “Chamber miniaturization to shorten assay
`time and minimize ligand and receptor consumption during pulsed ultrafiltration.”
`Alex Viana, B.S. 2007. University of Wisconsin, Madison, WI. Summer research 2001-2003.
`“Evaluation of the safety and efficacy of botanical dietary supplements as alternatives to
`hormone replacement therapy.” Current position: M.S. program in astronomy, the Johns
`Hopkins University, Baltimore, MD.
`Brent Terry-Penak, 2009. St. Ignatius College Prep, Chicago, IL. High school summer research
`internship. “Ion mobility mass spectrometry of lycopene.”
`Summer 2010 and 2011. California Institute of Technology, Pasdena, CA. “Ion mobility mass
`spectrometry of lycopene.”
`
`Postdoctoral Fellows
`1. Chien-Hua Huang, Post-doctoral fellow 1991-1993
`"Liquid Chromatography-Mass Spectrometry of Serum Carotenoids"
`Current position: Chemist in Taiwan
`2. Chao-Ran Huang, Post-doctoral fellow 1994-1996
`"Liquid Chromatography-Mass Spectrometry of Carotenoids"
`Current position: Senior scientist at Biogen Idec, Cambridge, MA
`3. Henry Xiong, Postdoctoral Fellow, 1997-1998
`“Prevention of DNA Oxidation by Carotenoids”
`Current position: Mass spectrometry applications specialist at Micromass, Waters Inc., Danvers,
`MA
`4. Samuel B. Wainhaus, Postdoctoral Fellow, 1998-1999
`“LC-MS-MS Quantitation of DNA Oxidation Products”
`Current position: Senior scientist, Schering-Plough Pharmaceuticals, Kennilworth, NJ
`5. Dejan Nikolic, Post-doctoral fellow, 1999-2001
`Current Position: Research assistant professor, mass spectrometry laboratory manager, UIC/NIH
`Center for Botanical Dietary Supplements Research, University of Illinois at Chicago
`6. Yousheng Hua, Postdoctoral Fellow, 1999-2000
`“LC-MS-MS Quantitation of DNA Oxidation Products”
`Current position: Senior Scientist at Baxter, Technology Resources/Physics & Chemistry
`Department. Round Lake, IL.
`7. Young-Guen Shin, Postdoctoral Fellow, 1999-2001
`“Natural Inhibitors of Carcinogenesis, LC-MS-MS Applications”
`Current position: Senior scientist, Genentech, South San Francisco, CA
`8. Chuck Gu, Postdoctoral Fellow,1999-2001
`“NCI LC-MS-MS Core for Cancer Research”
`Current position: Senior Scientist at Astrazeneca, Wilmington, DE
`
`
`
`
`
`
`29
`
`
`
`0000061
`
`

`
`April 2012
`
`9. Liqiong Fang, Postdoctoral Fellow, 1999-2002
`“Prevention of Prostate Cancer by Lycopene”
`Current Position: Senior Scientist at Baxter Healthcare, Round Lake, IL
`10. Wenkui Li, Postdoctoral Fellow, 2001-2003
`“Standardization of Botanical Dietary Supplements”
`Current Position: Senior Scientist at Novartis, East Hanover, NJ
`11. Huaping Wu, Postdoctoral Fellow, 2001-2004
`“Mass Spectrometry-based Proteomics”
`Current position: Research scientist, Illinois Institute of Technology, Chicago IL
`12. Sool Yeon Cho, Postdoctoral Fellow, 2002-2004
`“Lycopene Degradation Products and Cancer Chemoprevention”
`Current position: Postdoctoral Fellow, New York University School of Medicine, New York,
`NY
`13. Zorica Vujic, Postdoctoral Fellow, 2003-2004
`“Mechanism of Prostate Cancer Prevention by Lycopene”
`Current Position: Lecturer in Medicinal Chemistry, School of Pharmacy, Belgrade University,
`Belgrade, Serbia
`14. Christopher Pennington, Postdoctoral Fellow, 2006-2007
`“Mass spectrometry-based discovery of natural product chemoprevention agents”
`Current Position: Senior Scientist, Abbott Laboratories, North Chicago, IL
`15. Angela Calderon, Postdoctoral Fellow, 2006-2008
`“Mass spectrometry-based assays of antioxidants in chocolate”
`Current Position: Assistant Professor of Medicinal Chemistry, Harrison School of Pharmacy,
`Auburn University, Auburn, AL
`16. Yongsoo Choi, Postdoctoral Fellow, 2006-2010
`“Mass spectrometry-based screening for estrogenic natural products”
`Current Position: Scientist at U.S. Food and Drug Administration, Silver Spring, MD
`17. Sigrid Baumgarten, Postdoctoral Fellow, 2009-2011
`“Mass spectrometry-based chemoprevention agent discovery and development”
`18. Shunyan Mo, Postdoctoral Fellow, 2009-present
`“Cyclooxygenase inhibitors in cocoa”
`
`Visiting Scholars
`Florentina Catana, 1998
`State Institute for Drug Control and Pharmaceutical Research, Bucharest, Romania
`Mine Bilsel, 2000
`Tübitak Marmara Materials and Chemical Technologies Research Institute, Tübitak, Turkey
`Genying Xu, 2001
`Shongshan Hospital, Fudan University. Shanghai, Peoples Republic of China
`Sara Madelene Johannson, 2002
`Swedish University of Agricultural Sciences, Uppsala, Sweden.
`Zeying