1
`
` LIFECOR-1017
` ZOLL Lifecor Corporation v. Koninklijke Philips Electronics N.V.
` IPR2013-00606, IPR2013-00607, IPR2013-00609, IPR2013-00612,
`IPR2013-00613, IPR2013-00615, IPR2013-00616, IPR2013-00618
`
`

`

`ADVE RTI EEM ENT
`
`Zoll Life-Vest data confirm its success.
`
`To date, 75,000 people have used the Lifth-st that, on
`average, '5 saving, one life aday. With 980 livessaved by
`Life‘v’est, the 1,000th is expected soon.
`
`"Were getting ready for a big celebration," said Marshal
`Lindcr, Zoll LifeVest president and chiefoperating officer.
`
`
`
`PG graphic Defibrillating vest
`{Click image «tartarger versronl
`
`when the heart's rhythm is so irregular the heart stops beating, a person must receive an
`electrical shock within five to 1 0 minutes to prevent death or brain damage. T hose whose
`experience one outside a hospital have less than a 1 O~purccnt chance of good sun-ire], with the
`rate generally related to how long it takes a paramedic or trained individual to arrive with a
`defibrillator and use it, said Norman C. Wang, the UPMC cardiac clertrophysiologist who's treating
`Mr. NeiLstm.
`
`Studies show that those who suffer a sudden cardiac arrest in airports, casinos or other crowded
`
`venues that have readily available automated external defibrillators have a survival rate of about
`50 percent, Dr. Wang said.
`
`But Zoll cites a 98-percent "first-treatment shodc Success rate" for resuscitating patients with the
`vest that doesn't require bystander intervention. When one is under way, the Lichcst not only
`issues a shock but transmits heitrtvt'ate details to the O'Hara facility that uses a secure online
`
`patient-management system to provide physicians with information or alerts whenever
`arrhythmia or a cardiac arrest occurs.
`
`Cardiac arrest caused by arrhythmia involves a din-option in the electrical impulses that came the
`heart to beat. it is different from a heart attack, which involves. disrupted blood flow to the heart.
`
`One person wearing a LiteVest, Mr. Linder said, collapsed from a cardiac arrest while (It a walk
`but a timely treatment shock restored consciousness, allowing the person to walk home. Another
`person wearing a Lifeth awoke one morning to discover bedclothes covered with the blue gel
`that the vest released to increase ornductivity for the electrical pads before the shodc mrcurs. The
`gel often serves as the only proof a patient hasthat he or she had received a life-saving stock.
`
`Invented in the 1986 by Stephen Hcilman, the Lifchst developed thrmgh his company, Lifecor,
`received approval in 2001 from the US. Food and Drug Administration followed in 2005 by
`Medicare’s approval for reimbursement. That led to soaring sales, Mr. Lieder said Zoll Medical
`put-diascd the company in 2006, with Zoll [ifeVest experiencing revenue growth of 60 percent a
`year with its O’Hara wtrkforce doubling over the past two years to more than 500 employees.
`The full rental price is $3,200 a month, which can be offset by insurance.
`
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`brought him back from the brink.
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`LEARN MORE
`
`On April 1.8, when Mr. Neilson began feeling ill, his wife took him to the Elk Regional Health
`Center in St. Marys, where he suffered a cardiac arrest, After his resuscitation, he was sent to
`UPMCPresbyterian on a medical helicopter.
`
`A patient of Dr. Wang, Mr. Neilson was anideal candidate for an implantable cardim-‘ertcr
`defibrillator, or 1CD, that‘s surgically implanted in the chest to monitor heart rhythms and provide
`electrical shocks to wrect serious arrhythmia or counter a cardiac arrest.
`
`2
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`

`

`But an active blood infection prevented Mr. Neilson from receiving an ICU at the time, So Dr.
`Wang prescribed a LifeVest, a temporary device that provides time to determine whether a
`patient's condition can be treated better with rnedicat‘nns or heart surgeryr or allow a patient to
`overcome other medical problems that prevent the surgery to implant an 1CD, as mirrored with
`Mr. Neilson.
`
`Returning, home, he wore the Lichest 24 hours a day for several weeks.
`
`On May 18, Mr. Neilson was resting in his recliner and watching the 5 p.1n,news when he fell
`unconscious seven minutes into the newscast. The electroenrdingraph the vest recorded tells the
`tale of what happened during the minute-[mg cardiac arrest
`
`Prim- to the attack, Mr. Neihon's heart was beating normall},r for him, about once per second. But
`then the rhythms turned erratic, soon deteriorating into full-scale arrhythmia signifying, a cardiac
`arrest. For the next 14 seconds, the LifeVest monitored chaotic arrhythmia before initiating a
`“treatment sequence." an- then high-level alerts were sounded, along with tactile alarms to
`provide a patient, if still oonscious, a chance to stop the painful electrical shock.
`
`But Mr. Neilson was unmnscims, his eyes rolling back into his head.
`
`The device released the blue gel 35 seconds after the arrhythmia began. Chaotic rhythms began
`dropping in amplitude, indicating that the heart was quivering rather than beating and not
`pumping blood. In the following secmds his heart rate on the ECG had reduced to a wiggly line,
`almost a flat line.
`
`Then it happened. Forty- five seconds into his cardiac arrest, the Life‘v‘est sent a tSOejoulcS shock.
`a pronounocd jolt, from the vest‘s front panel through his heart to two rmeiving paneh on his
`badti
`
`In another amazing sequence, the ECG showed that within two seconds,the shock reset Mr.
`Neihon's misfiring heartbeat. causing it return to a normal heartbeat, albeit one nowbeating twice
`rather than once a second. Save for a flutter or two, that trend continued until the LifeVest sensed
`a restored heart rhythm. prompting it to discontinue the emergency sequence. One minute after
`the event began, the LifeVest had completed the treatment successfully and returned to
`monitoring the heart rhythms. It was ready to repeat the emergency sequenm, if necessary.
`
`When Mr. Neilson awoke and recovered his senses, he heard his daughter Victoria calling 911. The
`blue gel smeared on his shirt made it clear to him he'd sulfered a cardiac arrest. 20]] soon alerted
`D1-.Wang with the details ofwhat had happened.
`An ambulance rushed Mr. Neilson to the Elk Regional Health Center and soon after he was flown
`once again to UPMC, where this time he was able to have the ICD imphntcd. He ham't had a
`cardiac arrest Since May 18.
`
`"He almost certainly would have died at home” without the LiteVest, Dr. Wang said
`
`Andthat's why Mr. Neilson was sitting with a broad smflc on a recent day inside the 2011 LifeVest
`building.
`
`"It's the greatest invention I‘ve ever come across, livr'ng in rural Pennsyh'ania." he said. "1‘ his is
`modern technology. If someone wears one after this interview and it saves a life, it‘s worth it ."
`
`"It definitely saved my life."
`
`David Templeton: g tent pk‘tongalg fit- gazette trim or 41 2-263-1578.
`
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