PubMed
`Dec. 1, 2013 search for scientific articles by William Bonfield
`
`1: Enayati M, Stride E, Edirisinghe M, Bonfield W. Modification of the release characteristics of
`estradiol encapsulated in PLGA particles via surface coating.
`Ther Deliv. 2012 Feb;3(2):209-26.
`
`2: Munir G, Koller G, Di Silvio L, Edirisinghe MJ, Bonfield W, Huang J. The pathway to
`intelligent implants: osteoblast response to nano silicon-doped hydroxyapatite patterning. J R
`Soc Interface. 2011 May 6;8(58):678-88.
`
`3: Li X, Huang J, Edirisinghe M, Bonfield W. An electrically driven jetting technique for diverse
`high-resolution surface structures of nanometer hydroxyapatite crystals. Colloids Surf B
`Biointerfaces. 2011 Feb 1;82(2):562-70.
`
`4: Patel B, Inam F, Reece M, Edirisinghe M, Bonfield W, Huang J, Angadji A. A novel route for
`processing cobalt-chromium-molybdenum orthopaedic alloys. J R Soc Interface. 2010 Nov
`6;7(52):1641-5.
`
`5: Spence G, Patel N, Brooks R, Bonfield W, Rushton N. Osteoclastogenesis on hydroxyapatite
`ceramics: the effect of carbonate substitution. J Biomed Mater Res A. 2010 Mar 15;92(4):1292-
`300.
`
`6: Thian ES, Ahmad Z, Huang J, Edirisinghe MJ, Jayasinghe SN, Ireland DC, Brooks RA,
`Rushton N, Bonfield W, Best SM. The role of surface wettability and surface charge of
`electrosprayed nanoapatites on the behaviour of osteoblasts. Acta Biomater. 2010 Mar;6(3):750-
`5. A new deposition method is presented, based on electrospraying, that can build bioceramic structures
`with desirable surface properties. This technology allows nanoapatite crystals, including hydroxyapatite
`(nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on
`glass substrates. Human osteoblast cells cultured on nSiHA showed enhanced cell attachment,
`proliferation
`
`7: Harley BA, Lynn AK, Wissner-Gross Z, Bonfield W, Yannas IV, Gibson LJ. Design of a
`multiphase osteochondral scaffold. II. Fabrication of a mineralized collagen-glycosaminoglycan
`scaffold. J Biomed Mater Res A. 2010 Mar 1;92(3):1066-77.
`
`8: Lynn AK, Best SM, Cameron RE, Harley BA, Yannas IV, Gibson LJ, Bonfield W. Design of
`a multiphase osteochondral scaffold. I. Control of chemical composition. J Biomed Mater Res A.
`2010 Mar 1;92(3):1057-65.
`
`9: Harley BA, Lynn AK, Wissner-Gross Z, Bonfield W, Yannas IV, Gibson LJ. Design of a
`multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous
`interfaces. J Biomed Mater Res A. 2010 Mar 1;92(3):1078-93.
`
`10: Kirkpatrick CJ, Bonfield W. NanoBioInterface: a multidisciplinary challenge. J R Soc
`Interface. 2010 Feb 6;7 Suppl 1:S1-4.
`
`MILLENIUM EXHIBIT 2005
`Baxter Healthcare Corp. et. al. v. Millenium Biologix, LLC
`IPR2013-00582,-00583,-00590,-00591
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`11: Li X, Koller G, Huang J, Di Silvio L, Renton T, Esat M, Bonfield W, Edirisinghe M. A novel
`jet-based nano-hydroxyapatite patterning technique for osteoblast guidance. J R Soc Interface.
`2010 Jan 6;7(42):189-97.
`
`12: Huang J, Best SM, Bonfield W, Buckland T. Development and characterization of titanium-
`containing hydroxyapatite for medical applications. Acta Biomater. 2010 Jan;6(1):241-9.
`
`13: Liu P, Zhang YW, Yu H, Zhang X, Cheng QH, Lu C, Bonfield W. Spreading of an
`anchorage-dependent cell on a selectively ligand-coated substrate mediated by receptor-ligand
`binding. J Biomed Mater Res A. 2009 Dec;91(3):806-13.
`
`14: Huang J, Best SM, Brooks RA, Rushton N, Bonfield W. In vitro evaluation of nanosized
`carbonate-substituted hydroxyapatite and its polyhydroxyethylmethacrylate nanocomposite. J
`Biomed Mater Res A. 2008 Dec 1;87(3):598-607.
`
`15: Ahmad Z, Thian ES, Huang J, Edirisinghe MJ, Best SM, Jayasinghe SN, Bonfield W, Brooks
`RA, Rushton N. Deposition of nano-hydroxyapatite particles utilizing direct and transitional
`electrohydrodynamic processes. J Mater Sci Mater Med. 2008 Sep;19(9):3093-104.
`
`16: San Thian E, Ahmad Z, Huang J, Edirisinghe MJ, Jayasinghe SN, Ireland DC, Brooks RA,
`Rushton N, Bonfield W, Best SM. The role of electrosprayed apatite nanocrystals in guiding
`osteoblast behaviour. Biomaterials. 2008 Apr;29(12):1833-43. Osteoblasts were also cultured on
`apatite nanocrystals chemically modified with either carbonate or silicon ions.
`
`17: Thian ES, Huang J, Ahmad Z, Edirisinghe MJ, Jayasinghe SN, Ireland DC, Brooks RA,
`Rushton N, Best SM, Bonfield W. Influence of nanohydroxyapatite patterns deposited by
`electrohydrodynamic spraying on osteoblast response. J Biomed Mater Res A. 2008
`Apr;85(1):188-94.
`
`18: Juhasz JA, Best SM, Auffret AD, Bonfield W. Biological control of apatite growth in
`simulated body fluid and human blood serum. J Mater Sci Mater Med. 2008 Apr;19(4):1823-9.
`
`19: Huang J, Lin YW, Fu XW, Best SM, Brooks RA, Rushton N, Bonfield W. Development of
`nano-sized hydroxyapatite reinforced composites for tissue engineering scaffolds. J Mater Sci
`Mater Med. 2007 Nov;18(11):2151-7.
`
`20: Botelho CM, Brooks RA, Best SM, Lopes MA, Santos JD, Rushton N, Bonfield W. Human
`osteoblast response to silicon-substituted hydroxyapatite. J Biomed Mater Res A. 2006 Dec
`1;79(3):723-30.
`
`21: De Carlos A, Lusquiños F, Pou J, León B, Pérez-Amor M, Driessens FC, Hing K, Best S,
`Bonfield W. In vitro testing of Nd:YAG laser processed calcium phosphate coatings. J Mater Sci
`Mater Med. 2006 Nov;17(11):1153-60.
`
`22: Bonfield W. A tribute to Professor Larry Hench. J Mater Sci Mater Med. 2006
`Nov;17(11):965-6.
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`23: Botelho CM, Brooks RA, Spence G, McFarlane I, Lopes MA, Best SM, Santos JD, Rushton
`N, Bonfield W. Differentiation of mononuclear precursors into osteoclasts on the surface of Si-
`substituted hydroxyapatite. J Biomed Mater Res A. 2006 Sep 15;78(4):709-20.
`
`24: Vandiver J, Dean D, Patel N, Botelho C, Best S, Santos JD, Lopes MA, Bonfield W, Ortiz C.
`Silicon addition to hydroxyapatite increases nanoscale electrostatic, van der Waals, and adhesive
`interactions. J Biomed Mater Res A. 2006 Aug;78(2):352-63.
`
`25: Wu CY, Best SM, Bentham AC, Hancock BC, Bonfield W. Predicting the tensile strength of
`compacted multi-component mixtures of pharmaceutical powders. Pharm Res. 2006
`Aug;23(8):1898-905.
`
`26: Thian ES, Huang J, Best SM, Barber ZH, Bonfield W. Silicon-substituted hydroxyapatite
`thin films: effect of annealing temperature on coating stability and bioactivity. J Biomed Mater
`Res A. 2006 Jul;78(1):121-8.
`
`27: Porter AE, Buckland T, Hing K, Best SM, Bonfield W. The structure of the bond between
`bone and porous silicon-substituted hydroxyapatite bioceramic implants. J Biomed Mater Res A.
`2006 Jul;78(1):25-33.
`
`28: Thian ES, Huang J, Best SM, Barber ZH, Brooks RA, Rushton N, Bonfield W. The response
`of osteoblasts to nanocrystalline silicon-substituted hydroxyapatite thin films. Biomaterials. 2006
`May;27(13):2692-8.
`
`29: Thian ES, Huang J, Best SM, Barber ZH, Bonfield W. Novel silicon-doped hydroxyapatite
`(Si-HA) for biomedical coatings: an in vitro study using acellular simulated body fluid. J Biomed
`Mater Res B Appl Biomater. 2006 Feb;76(2):326-33.
`
`30: Bonfield W. Designing porous scaffolds for tissue engineering. Philos Trans A Math Phys
`Eng Sci. 2006 Jan 15;364(1838):227-32.
`
`31: Kelly A, Clyne B, Bonfield W, Willoughby A. Preface. Philos Trans A Math Phys Eng Sci.
`2006 Jan 15;364(1838):3-4.
`
`32: Zou S, Huang J, Best S, Bonfield W. Crystal imperfection studies of pure and silicon
`substituted hydroxyapatite using Raman and XRD. J Mater Sci Mater Med. 2005
`Dec;16(12):1143-8.
`
`33: Huang J, Jayasinghe SN, Best SM, Edirisinghe MJ, Brooks RA, Rushton N, Bonfield W.
`Novel deposition of nano-sized silicon substituted hydroxyapatite by electrostatic spraying. J
`Mater Sci Mater Med. 2005 Dec;16(12):1137-42.
`
`34: Porter A, Patel N, Brooks R, Best S, Rushton N, Bonfield W. Effect of carbonate substitution
`on the ultrastructural characteristics of hydroxyapatite implants. J Mater Sci Mater Med. 2005
`Oct;16(10):899-907.
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`35: Lynn AK, Nakamura T, Patel N, Porter AE, Renouf AC, Laity PR, Best SM, Cameron RE,
`Shimizu Y, Bonfield W. Composition-controlled nanocomposites of apatite and collagen
`incorporating silicon as an osseopromotive agent. J Biomed Mater Res A. 2005 Sep 1;74(3):447-
`53.
`
`36: Mayhew PM, Thomas CD, Clement JG, Loveridge N, Beck TJ, Bonfield W, Burgoyne CJ,
`Reeve J. Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet.
`2005 Jul 9-15;366(9480):129-35.
`
`37: Aizawa M, Porter AE, Best SM, Bonfield W. Ultrastructural observation of single-crystal
`apatite fibres. Biomaterials. 2005 Jun;26(17):3427-33.
`
`38: Thian ES, Huang J, Best SM, Barber ZH, Bonfield W. Magnetron co-sputtered silicon-
`containing hydroxyapatite thin films--an in vitro study. Biomaterials. 2005 Jun;26(16):2947-56.
`
`39: Wu CY, Best SM, Bentham AC, Hancock BC, Bonfield W. A simple predictive model for
`the tensile strength of binary tablets. Eur J Pharm Sci. 2005 Jun;25(2-3):331-6.
`
`40: Patel N, Brooks RA, Clarke MT, Lee PM, Rushton N, Gibson IR, Best SM, Bonfield W. In
`vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an
`ovine defect model. J Mater Sci Mater Med. 2005 May;16(5):429-40.
`
`41: Thian ES, Huang J, Best SM, Barber ZH, Bonfield W. A new way of incorporating silicon in
`hydroxyapatite (Si-HA) as thin films. J Mater Sci Mater Med. 2005 May;16(5):411-5.
`
`42: Lynn AK, Bonfield W. A novel method for the simultaneous, titrant-free control of pH and
`calcium phosphate mass yield. Acc Chem Res. 2005 Mar;38(3):202-7.
`
`43: Vandiver J, Dean D, Patel N, Bonfield W, Ortiz C. Nanoscale variation in surface charge of
`synthetic hydroxyapatite detected by chemically and spatially specific high-resolution force
`spectroscopy. Biomaterials. 2005 Jan;26(3):271-83.
`
`44: Lynn AK, Yannas IV, Bonfield W. Antigenicity and immunogenicity of collagen. J Biomed
`Mater Res B Appl Biomater. 2004 Nov 15;71(2):343-54. Review.
`
`45: Lynn AK, Brooks RA, Bonfield W, Rushton N. Repair of defects in articular joints.
`Prospects for material-based solutions in tissue engineering. J Bone Joint Surg Br. 2004
`Nov;86(8):1093-9.
`
`46: Rea SM, Best SM, Bonfield W. Bioactivity of ceramic-polymer composites with varied
`composition and surface topography. J Mater Sci Mater Med. 2004 Sep;15(9):997-1005.
`Abstract. HAPEX trade mark (40 vol % hydroxyapatite in a high-density polyethylene matrix)
`and AWPEX (40 vol % glass-ceramic apatite-wollastonite in a high-density polyethylene matrix)
`
`47: Rea SM, Brooks RA, Schneider A, Best SM, Bonfield W. Osteoblast-like cell response to
`bioactive composites-surface-topography and composition effects. J Biomed Mater Res B Appl
`Biomater. 2004 Aug 15;70(2):250-61. Abstract.(cid:3)Two bioactive composites, containing 40 vol %
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`filler in high-density polyethylene (HDPE), were investigated to examine the effects of different
`filler compositions and different surface patterning. The first composite, known as HAPEX,
`consists of hydroxyapatite within HDPE, and the second composite, known as AWPEX, consists
`of glass-ceramic apatite-wollastonite in HDPE(cid:3).(cid:3).(cid:3).(cid:3)
`
`48: Rea SM, Brooks RA, Best SM, Kokubo T, Bonfield W. Proliferation and differentiation of
`osteoblast-like cells on apatite-wollastonite/polyethylene composites. Biomaterials. 2004
`Aug;25(18):4503-12.
`
`49: Porter AE, Patel N, Skepper JN, Best SM, Bonfield W. Effect of sintered silicate-substituted
`hydroxyapatite on remodelling processes at the bone-implant interface. Biomaterials. 2004
`Jul;25(16):3303-14.
`
`50: Porter AE, Botelho CM, Lopes MA, Santos JD, Best SM, Bonfield W. Ultrastructural
`comparison of dissolution and apatite precipitation on hydroxyapatite and silicon-substituted
`hydroxyapatite in vitro and in vivo. J Biomed Mater Res A. 2004 Jun 15;69(4):670-9.
`
`51: Best SM, Patel N, Porter AE, Bonfield W. A "healthy apatite" for bone repair. Med J
`Malaysia. 2004 May;59 Suppl B:129-30.
`
`52: Bonfield W. From concept to patient--biomaterials solutions to medical problems. Med J
`Malaysia. 2004 May;59 Suppl B:1.
`
`53: Huang J, Best SM, Bonfield W, Brooks RA, Rushton N, Jayasinghe SN, Edirisinghe MJ. In
`vitro assessment of the biological response to nano-sized hydroxyapatite. J Mater Sci Mater
`Med. 2004 Apr;15(4):441-5.
`
`54: Juhasz JA, Best SM, Brooks R, Kawashita M, Miyata N, Kokubo T, Nakamura T, Bonfield
`W. Mechanical properties of glass-ceramic A-W-polyethylene composites: effect of filler content
`and particle size. Biomaterials. 2004 Mar;25(6):949-55.
`
`55: Hing KA, Best SM, Tanner KE, Bonfield W, Revell PA. Mediation of bone ingrowth in
`porous hydroxyapatite bone graft substitutes. J Biomed Mater Res A. 2004 Jan 1;68(1):187-200.
`
`56: Porter AE, Best SM, Bonfield W. Ultrastructural comparison of hydroxyapatite and silicon-
`substituted hydroxyapatite for biomedical applications. J Biomed Mater Res A. 2004 Jan
`1;68(1):133-41.
`
`57: Juhasz JA, Best SM, Kawashita M, Miyata N, Kokubo T, Nakamura T, Bonfield W. Bonding
`strength of the apatite layer formed on glass-ceramic apatite-wollastonite-polyethylene
`composites. J Biomed Mater Res A. 2003 Dec 1;67(3):952-9.
`
`58: Porter AE, Patel N, Skepper JN, Best SM, Bonfield W. Comparison of in vivo dissolution
`processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics. Biomaterials.
`2003 Nov;24(25):4609-20.
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`59: Dalby MJ, Bonfield W, Di Silvio L. Enhanced HAPEX topography: comparison of
`osteoblast response to established cement. J Mater Sci Mater Med. 2003 Aug;14(8):693-7.
`
`60: Stokes DJ, Rea SM, Best SM, Bonfield W. Electron microscopy of mammalian cells in the
`absence of fixing, freezing, dehydration, or specimen coating. Scanning. 2003 Jul-
`Aug;25(4):181-4.
`
`61: Juhasz JA, Best SM, Bonfield W, Kawashita M, Miyata N, Kokubo T, Nakamura T. Apatite-
`forming ability of glass-ceramic apatite-wollastonite – polyethylene composites: effect of filler
`content. J Mater Sci Mater Med. 2003 Jun;14(6):489-95.
`
`62: Lusquiños F, De Carlos A, Pou J, Arias JL, Boutinguiza M, León B, Pérez-Amor M,
`Driessens FC, Hing K, Gibson I, Best S, Bonfield W. Calcium phosphate coatings obtained by
`Nd:YAG laser cladding: physicochemical and biologic properties. J Biomed Mater Res A. 2003
`Mar 15;64(4):630-7.
`
`63: Opara TN, Dalby MJ, Harper EJ, Di Silvio L, Bonfield W. The effect of varying percentage
`hydroxyapatite in poly(ethylmethacrylate) bone cement on human osteoblast-like cells. J Mater
`Sci Mater Med. 2003 Mar;14(3):277-82.
`
`64: Vashishth D, Tanner KE, Bonfield W. Experimental validation of a microcracking-based
`toughening mechanism for cortical bone. J Biomech. 2003 Jan;36(1):121-4.
`
`65: Patel N, Best SM, Bonfield W, Gibson IR, Hing KA, Damien E, Revell PA. A comparative
`study on the in vivo behavior of hydroxyapatite and silicon substituted hydroxyapatite granules. J
`Mater Sci Mater Med. 2002 Dec;13(12):1199-206.
`
`66: Gibson IR, Bonfield W. Preparation and characterization of magnesium/carbonate co-
`substituted hydroxyapatites. J Mater Sci Mater Med. 2002 Jul;13(7):685-93.
`
`67: Dalby MJ, Di Silvio L, Gurav N, Annaz B, Kayser MV, Bonfield W. Optimizing HAPEX
`topography influences osteoblast response. Tissue Eng. 2002 Jul;8(3):453-67. Abstract. HAPEX
`(hydroxyapatite-reinforced polyethylene composite)
`is a second-generation orthopedic
`biomaterial designed as a bone analog material, which has found clinical success.
`
`68: Wang M, Chandrasekaran M, Bonfield W. Friction and wear of hydroxyapatite reinforced
`high density polyethylene against the stainless steel counterface. J Mater Sci Mater Med. 2002
`Jun;13(6):607-11.
`
`69: Barralet J, Knowles JC, Best S, Bonfield W. Thermal decomposition of synthesised
`carbonate hydroxyapatite. J Mater Sci Mater Med. 2002 Jun;13(6):529-33.
`
`70: Gibson IR, Bonfield W. Novel synthesis and characterization of an AB-type carbonate-
`substituted hydroxyapatite. J Biomed Mater Res. 2002 Mar 15;59(4):697-708.
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`71: Dalby MJ, Di Silvio L, Harper EJ, Bonfield W. In vitro adhesion and biocompatability of
`osteoblast-like cells to poly(methylmethacrylate) and poly(ethylmethacrylate) bone cements. J
`Mater Sci Mater Med. 2002 Mar;13(3):311-4.
`
`72: Dalby MJ, Kayser MV, Bonfield W, Di Silvio L. Initial attachment of osteoblasts to an
`optimised HAPEX topography. Biomaterials. 2002 Feb;23(3):681-90.
`
`73: Di Silvio L, Dalby MJ, Bonfield W. Osteoblast behaviour on HA/PE composite surfaces with
`different HA volumes. Biomaterials. 2002 Jan;23(1):101-7.
`
`74: Dalby MJ, Di Silvio L, Harper EJ, Bonfield W. Increasing hydroxyapatite incorporation into
`poly(methylmethacrylate) cement increases osteoblast adhesion and response. Biomaterials.
`2002 Jan;23(2):569-76.
`
`75: Vázquez B, Deb S, Bonfield W, Román JS. Characterization of new acrylic bone cements
`prepared with oleic acid derivatives. J Biomed Mater Res. 2002;63(2):88-97.
`
`76: Bonfield W. Materials science: materials in medicine. J Mater Sci Mater Med. 2002
`Jan;13(1):iii.
`
`77: Dalby MJ, Di Silvio L, Harper EJ, Bonfield W. Initial interaction of osteoblasts with the
`surface
`of
`a
`hydroxyapatite-poly(methylmethacrylate)
`cement. Biomaterials.
`2001
`Jul;22(13):1739-47.
`
`78: Wang M, Bonfield W. Chemically coupled hydroxyapatite-polyethylene composites:
`structure and properties. Biomaterials. 2001 Jun;22(11):1311-20.
`
`79: Vashishth D, Tanner KE, Bonfield W. Fatigue of cortical bone under combined axial-
`torsional loading. J Orthop Res. 2001 May;19(3):414-20.
`
`80: Patel N, Gibson IR, Ke S, Best SM, Bonfield W. Calcining influence on the powder
`properties of hydroxyapatite. J Mater Sci Mater Med. 2001 Feb;12(2):181-8.
`
`81: Gibson IR, Ke S, Best SM, Bonfield W. Effect of powder characteristics on the sinterability
`of hydroxyapatite powders. J Mater Sci Mater Med. 2001 Feb;12(2):163-71.
`
`82: Nazhat SN, Kellomäki M, Törmälä P, Tanner KE, Bonfield W. Dynamic mechanical
`characterization of biodegradable composites of hydroxyapatite and polylactides. J Biomed
`Mater Res. 2001;58(4):335-43.
`
`83: Dalby MJ, Di Silvio L, Davies GW, Bonfield W. Surface topography and HA filler volume
`effect on primary human osteoblasts in vitro. J Mater Sci Mater Med. 2000 Dec;11(12):805-10.
`
`84: Gibson IR, Rehman I, Best SM, Bonfield W. Characterization of the transformation from
`calcium-deficient apatite to beta-tricalcium phosphate. J Mater Sci Mater Med. 2000
`Dec;11(12):799-804.
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`85: Barralet JE, Best SM, Bonfield W. Effect of sintering parameters on the density and
`microstructure of carbonate hydroxyapatite. J Mater Sci Mater Med. 2000 Nov;11(11):719-24.
`
`86: De Santis R, Anderson P, Tanner KE, Ambrosio L, Nicolais L, Bonfield W, Davis GR. Bone
`fracture analysis on the short rod chevron-notch specimens using the X-ray computer micro-
`tomography. J Mater Sci Mater Med. 2000 Oct;11(10):629-36.
`
`87: Nazhat SN, Joseph R, Wang M, Smith R, Tanner KE, Bonfield W. Dynamic mechanical
`characterization of hydroxyapatite reinforced polyethylene: effect of particle size. J Mater Sci
`Mater Med. 2000 Oct;11(10):621-8.
`
`88: Ton That PT, Tanner KE, Bonfield W. Fatigue characterization of a hydroxyapatite-
`reinforced polyethylene composite. II. Biaxial fatigue. J Biomed Mater Res. 2000 Sep
`5;51(3):461-8.
`
`89: That PT, Tanner KE, Bonfield W. Fatigue characterization of a hydroxyapatite-reinforced
`polyethylene composite. I. Uniaxial fatigue. J Biomed Mater Res. 2000 Sep 5;51(3):453-60.
`
`90: Vashishth D, Tanner KE, Bonfield W. Contribution, development and morphology of
`microcracking in cortical bone during crack propagation. J Biomech. 2000 Sep;33(9):1169-74.
`
`91: Harper EJ, Bonfield W. Tensile characteristics of ten commercial acrylic bone cements. J
`Biomed Mater Res. 2000 Sep;53(5):605-16. Erratum in: J Biomed Mater Res 2001;58(2):216.
`
`92: Gibson IR, Rehman I, Best SM, Bonfield W. Characterization of the transformation from
`calcium-deficient apatite to beta-tricalcium phosphate. J Mater Sci Mater Med. 2000
`Sep;11(9):533-9.
`
`93: Harper EJ, Braden M, Bonfield W. Mechanical properties of hydroxyapatite reinforced
`poly(ethylmethacrylate) bone cement after immersion in a physiological solution: influence of a
`silane coupling agent. J Mater Sci Mater Med. 2000 Aug;11(8):491-7.
`
`94: Yoneyama T, Doi H, Kobayashi E, Hamanaka H, Tanabe Y, Bonfield W. Stress transmission
`through Ti-Ni alloy, titanium and stainless steel in impact compression test. J Mater Sci Mater
`Med. 2000 Jun;11(6):333-6.
`
`95: Rehman I, Karsh M, Hench LL, Bonfield W. Analysis of apatite layers on glass-ceramic
`particulate using FTIR and FT-Raman spectroscopy. J Biomed Mater Res. 2000 May;50(2):97-
`100.
`
`96: Dalby MJ, Di Silvio L, Harper EJ, Bonfield W. In vitro evaluation of a new
`polymethylmethacrylate cement reinforced with hydroxyapatite. J Mater Sci Mater Med. 1999
`Dec;10(12):793-6.
`
`97: Hing KA, Best SM, Tanner KE, Bonfield W, Revell PA. Quantification of bone ingrowth
`within bone-derived porous hydroxyapatite implants of varying density. J Mater Sci Mater Med.
`1999 Oct-Nov;10(10/11):663-70.
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`98: Di Silvio L, Bonfield W. Biodegradable drug delivery system for the treatment of bone
`infection and repair. J Mater Sci Mater Med. 1999 Oct-Nov;10(10/11):653-8.
`
`99: Gibson IR, Best SM, Bonfield W. Chemical characterization of silicon-substituted
`hydroxyapatite. J Biomed Mater Res. 1999 Mar 15;44(4):422-8.
`
`100: Hing KA, Best SM, Bonfield W. Characterization of porous hydroxyapatite. J Mater Sci
`Mater Med. 1999 Mar;10(3):135-45.
`
`101: Wang M, Hench LL, Bonfield W. Bioglass/high density polyethylene composite for soft
`tissue applications: preparation and evaluation. J Biomed Mater Res. 1998 Dec 15;42(4):577-86.
`
`102: Wang M, Joseph R, Bonfield W. Hydroxyapatite-polyethylene composites for bone
`substitution: effects of ceramic particle size and morphology. Biomaterials. 1998
`Dec;19(24):2357-66.
`
`103: Di Silvio L, Dalby M, Bonfield W. In vitro response of osteoblasts to hydroxyapatite-
`reinforced polyethylene composites. J Mater Sci Mater Med. 1998 Dec;9(12):845-8.
`
`104: Borzacchiello A, Ambrosio L, Nicolais L, Harper EJ, Tanner KE, Bonfield W. Comparison
`between the polymerization behavior of a new bone cement and a commercial one: modeling and
`in vitro analysis. J Mater Sci Mater Med. 1998 Dec;9(12):835-8.
`
`105: Fernandez E, Planell JA, Best SM, Bonfield W. Synthesis of dahllite through a cement
`setting reaction. J Mater Sci Mater Med. 1998 Dec;9(12):789-92. Abstract: Dahllite is a
`synthetic carbonated hydroxyapatite with a carbonate ion content similar to bone mineral.
`
`106: Merry JC, Gibson IR, Best SM, Bonfield W. Synthesis and characterization of carbonate
`hydroxyapatite. J Mater Sci Mater Med. 1998 Dec;9(12):779-83.
`
`107: Kobayashi E, Doi H, Yoneyama T, Hamanaka H, Gibson IR, Best SM, Shelton JC,
`Bonfield W. Influence of aging heat treatment on mechanical properties of biomedical Ti-Zr
`based ternary alloys containing niobium. J Mater Sci Mater Med. 1998 Nov;9(11):625-30.
`
`108: Wang M, Berry C, Braden M, Bonfield W. Young's and shear moduli of ceramic particle
`filled polyethylene. J Mater Sci Mater Med. 1998 Nov;9(11):621-4. Abstract: Tensile and shear
`properties were determined for hydroxyapatite reinforced poly-ethylene composites (HAPEX) for
`medical applications.
`
`109: Guild FJ, Bonfield W. Predictive modelling of the mechanical properties and failure
`processes in hydroxyapatite- polyethylene (Hapex) composite. J Mater Sci Mater Med. 1998
`Sep;9(9):497-502.
`
`110: Rehman I, Knowles JC, Bonfield W. Analysis of in vitro reaction layers formed on Bioglass
`using thin-film X-ray diffraction and ATR-FTIR microspectroscopy. J Biomed Mater Res. 1998
`Jul;41(1):162-6.
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`111: Barralet J, Best S, Bonfield W. Carbonate substitution in precipitated hydroxyapatite: an
`investigation into the effects of reaction temperature and bicarbonate ion concentration. J
`Biomed Mater Res. 1998 Jul;41(1):79-86.
`
`112: Vazquez B, San Roman J, Deb S, Bonfield W. Application of long chain amine activator in
`conventional acrylic bone cement. J Biomed Mater Res. 1998 Summer;43(2):131-9.
`
`113: Borzacchiello A, Ambrosio L, Nicolais L, Harper EJ, Tanner KE, Bonfield W. Isothermal
`and non-isothermal polymerization of a new bone cement. J Mater Sci Mater Med. 1998
`Jun;9(6):317-24.
`
`114: García F, Arias JL, Mayor B, Pou J, Rehman I, Knowles J, Best S, León B, Pérez-Amor M,
`Bonfield W. Effect of heat treatment on pulsed laser deposited amorphous calcium phosphate
`coatings. J Biomed Mater Res. 1998 Spring;43(1):69-76.
`
`115: Suwanprateeb J, Tanner KE, Turner S, Bonfield W. Influence of sterilization by gamma
`irradiation and of thermal annealing on creep of hydroxyapatite-reinforced polyethylene
`composites. J Biomed Mater Res. 1998 Jan;39(1):16-22.
`
`116: Hing KA, Best SM, Tanner KE, Revell PA, Bonfield W. Histomorphological and
`biomechanical characterization of calcium phosphates in the osseous environment. Proc Inst
`Mech Eng H. 1998;212(6):437-51.
`
`117: Deb S, Vazquez B, Bonfield W. Effect of crosslinking agents on acrylic bone cements
`based on poly(methylmethacrylate). J Biomed Mater Res. 1997 Dec 15;37(4):465-73.
`
`118: Harper EJ, Braden M, Bonfield W, Dingeldein E, Wahlig H. Influence of sterilization upon
`a range of properties of experimental bone cements. J Mater Sci Mater Med. 1997
`Dec;8(12):849-53.
`
`119: Deb S, Braden M, Bonfield W. Effect of crosslinking agents on poly(ethylmethacrylate)
`bone cements. J Mater Sci Mater Med. 1997 Dec;8(12):829-33.
`
`120: Huang J, Di Silvio L, Wang M, Rehman I, Ohtsuki C, Bonfield W. Evaluation of in vitro
`bioactivity and biocompatibility of Bioglass-reinforced polyethylene composite. J Mater Sci
`Mater Med. 1997 Dec;8(12):809-13.
`
`121: Huang J, Di Silvio L, Wang M, Tanner KE, Bonfield W. In vitro mechanical and biological
`assessment of hydroxyapatite-reinforced polyethylene composite. J Mater Sci Mater Med. 1997
`Dec;8(12):775-9.
`
`122: Hing KA, Best SM, Tanner KE, Bonfield W, Revell PA. Biomechanical assessment of bone
`ingrowth in porous hydroxyapatite. J Mater Sci Mater Med. 1997 Dec;8(12):731-6.
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`123: Kobayashi A, Freeman MA, Bonfield W, Kadoya Y, Yamac T, Al-Saffar N, Scott G, Revell
`PA. Number of polyethylene particles and osteolysis in total joint replacements. A quantitative
`study using a tissue-digestion method. J Bone Joint Surg Br. 1997 Sep;79(5):844-8.
`
`124: Vashishth D, Behiri JC, Bonfield W. Crack growth resistance in cortical bone: concept of
`microcrack toughening. J Biomech. 1997 Aug;30(8):763-9.
`
`125: Suwanprateeb J, Tanner KE, Turner S, Bonfield W. Influence of Ringer's solution on creep
`resistance of hydroxyapatite reinforced polyethylene composites. J Mater Sci Mater Med. 1997
`Aug;8(8):469-72.
`
`126: Vazquez B, Deb S, Bonfield W. Optimization of benzoyl peroxide concentration in an
`experimental bone cement based on poly(methyl methacrylate). J Mater Sci Mater Med. 1997
`Jul;8(7):455-60.
`
`127: Luklinska ZB, Bonfield W. Morphology and ultrastructure of the interface between
`hydroxyapatite-polyhydroxybutyrate composite implant and bone. J Mater Sci Mater Med. 1997
`Jun;8(6):379-83.
`
`128: Jha LJ, Best SM, Knowles JC, Rehman I, Santos JD, Bonfield W. Preparation and
`characterization of fluoride-substituted apatites. J Mater Sci Mater Med. 1997 Apr;8(4):185-91.
`
`129: Rehman I, Bonfield W. Characterization of hydroxyapatite and carbonated apatite by photo
`acoustic FTIR spectroscopy. J Mater Sci Mater Med. 1997 Jan;8(1):1-4.
`
`130: Kobayashi A, Bonfield W, Kadoya Y, Yamac T, Freeman MA, Scott G, Revell PA. The
`size and shape of particulate polyethylene wear debris in total joint replacements. Proc Inst Mech
`Eng H. 1997;211(1):11-5.
`
`131: Rehman I, Harper EJ, Bonfield W. In situ analysis of the degree of polymerization of bone
`cement by using FT-Raman spectroscopy. Biomaterials. 1996 Aug;17(16):1615-9.
`
`132: Knowles JC, Gross K, Berndt CC, Bonfield W. Structural changes of thermally sprayed
`hydroxyapatite investigated by Rietveld analysis. Biomaterials. 1996 Mar;17(6):639-45.
`
`133: Barralet JE, Best SM, Bonfield W. Carbonate hydroxyapatite gel monolith formation and
`drying. Biomed Mater Eng. 1996;6(2):101-12.
`
`134: Rehman I, Smith R, Hench LL, Bonfield W. Structural evaluation of human and sheep bone
`and comparison with synthetic hydroxyapatite by FT-Raman spectroscopy. J Biomed Mater Res.
`1995 Oct;29(10):1287-94.
`
`135: Deb S, Braden M, Bonfield W. Water absorption characteristics of modified hydroxyapatite
`bone cements. Biomaterials. 1995 Sep;16(14):1095-100.
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`11 of 14
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`136: Tanner KE, Yettram AL, Loeffler M, Goodier WD, Freeman MA, Bonfield W. Is stem
`length important in uncemented endoprostheses? Med Eng Phys. 1995 Jun;17(4):291-6. Erratum
`in: Med Eng Phys 1995 Sep;17(6):478.
`
`137: Rehman I, Hench LL, Bonfield W, Smith R. Analysis of surface layers on bioactive glasses.
`Biomaterials. 1994 Aug;15(10):865-70.
`138: Knowles JC, Bonfield W. Development of a glass reinforced hydroxyapatite with enhanced
`mechanical properties. The effect of glass composition on mechanical properties and its
`relationship to phase changes. J Biomed Mater Res. 1993 Dec;27(12):1591-8.
`
`139: Netti PA, Shelton JC, Revell PA, Pirie C, Smith S, Ambrosio L, Nicolais L, Bonfield W.
`Hydrogels as an interface between bone and an implant. Biomaterials. 1993 Nov;14(14):1098-
`104.
`
`140: Guild FJ, Bonfield W. Predictive modelling of hydroxyapatite-polyethylene composite.
`Biomaterials. 1993 Oct;14(13):985-93.
`
`141: Bhatia D, Tanner KE, Bonfield W, Citron ND. Factors affecting the strength of flexor
`tendon repair. J Hand Surg Br. 1992 Oct;17(5):550-2. NR
`
`142: Evans GP, Behiri JC, Vaughan LC, Bonfield W. The response of equine cortical bone to
`loading at strain rates experienced in vivo by the galloping horse. Equine Vet J. 1992
`Mar;24(2):125-8.
`
`143: Doyle C, Tanner ET, Bonfield W. In vitro and in vivo evaluation of polyhydroxybutyrate
`and of polyhydroxybutyrate reinforced with hydroxyapatite. Biomaterials. 1991 Nov;12(9):841-
`7.
`
`144: Langton CM, Ali AV, Riggs CM, Evans GP, Bonfield W. A contact method for the
`assessment of ultrasonic velocity and broadband attenuation in cortical and cancellous bone. Clin
`Phys Physiol Meas. 1990 Aug;11(3):243-9.
`
`145: Sharp DJ, Tanner KE, Bonfield W. Measurement of the density of trabecular bone. J
`Biomech. 1990;23(8):853-7.
`
`146: Lakes RS, Nakamura S, Behiri JC, Bonfield W. Fracture mechanics of bone with short
`cracks. J Biomech. 1990;23(10):967-75.
`
`147: Bonfield WC. Techniques for integrating functions of hospital administration and medical
`staff. Med Staff Couns. 1990 Winter;4(1):31-5. NR
`
`148: Nunn D, Freeman MA, Tanner KE, Bonfield W. Torsional stability of the femoral
`component of hip arthroplasty. Response to an anteriorly applied load. J Bone Joint Surg Br.
`1989 May;71(3):452-5.
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`
`149: Behiri JC, Bonfield W. Orientation dependence of the fracture mechanics of cortical bone. J
`Biomech. 1989;22(8-9):863-72.
`
`150: Bonfield W. Composites for bone replacement. J Biomed Eng. 1988 Nov;10(6):522-6.
`Abstract: The application of synthetic materials for bone replacement is now well established,
`but it is recognized that mechanical compatibility, as well as biocompatibility, of the tissue and
`implant is required if stress shielding and consequent bone resorption is to be avoided at areas
`of fixation. The development of materials analogous to the natural tissue for longer term
`implantation is discussed, with particular reference to hydroxyapatite reinforced polymers.
`151: Tanner KE, Bonfield W, Nunn D, Freeman MA. Rotational movement of femoral
`components of total hip replacements in response to an anteriorly applied load. Eng Med. 1988
`Jul;17(3):127-9.
`
`152: Behiri JC, Bonfield W. Composites for bone replacement. Biomed Tech (Berl). 1988
`May;33(5):109-12.
`
`153: Tanner KE, Reed PE, Bonfield W, Rasmussen GL, Freeman MA. A system for modelling
`forces on the hip joint in one-legged stance. J Biomed Eng. 1988 May;10(3):289-90.
`
`154: Bonfield W, Lacefield W, Clark T, Kelly BS, Kelman D, Lee R, Page D, Renz E, Soltész U,
`Tolbert J, et al. Biomechanical stability and design. Strength. Ann N Y Acad Sci. 1988;523:287-
`91.
`
`155: Bonfield W. Hydroxyapatite-reinforced polyethylene as an analogous material for bone
`replacement. Ann N Y Acad Sci. 1988;523:173-7.
`
`156: Bonfield W. Advances in the fracture mechanics of cortical bone. J Biomech. 1987;20(11-
`12):1071-81.
`
`157: Behiri JC, Bonfield W. Fracture mechanics of bone--the effects of density, specimen
`thickness and crack velocity on longitudinal fracture. J Biomech.1984;17(1):25-34.
`
`158: Bonfield W, Grynpas MD. Spiral fracture of cortical bone. J Biomech.1982;15(8):555-9.
`