UNITED STATES PATENT AND TRADEMARK OFFICE
`____________________
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`___________________
`
`Baxter Healthcare Corp., ApaTech, Inc., and ApaTech Limited,
`Petitioners
`
`v.
`
`Millenium Biologix, LLC,
`Patent Owner
`
`Patent No. RE41,251
`Issued: April 20, 2010
`Filed: January 30, 2008
`Inventors: Sydney M. Pugh, Timothy J. N. Smith,
`Michael Sayer, and Sarah D. Langstaff
`
`Title: SYNTHETIC BIOMATERIAL COMPOUND OF CALCIUM
`PHOSPHATE PHASES PARTICULARLY ADAPTED FOR SUPPORTING
`BONE CELL ACTIVITY
`
`Patent No. 6,585,992
`Issued: July 1, 2003
`Filed: October 4, 2001
`Inventors: Sydney M. Pugh, Timothy J. N. Smith,
`Michael Sayer, and Sarah Dorthea Langstaff
`
`Title: SYNTHETIC BIOMATERIAL COMPOUND OF CALCIUM
`PHOSPHATE PHASES PARTICULARLY ADAPTED FOR SUPPORTING
`BONE CELL ACTIVITY
`____________________
`
`Inter Partes Review Nos. 2013-00582 and 2013-00590
`
`Before SCOTT E. KAMHOLZ, MICHELLE R. OSINSKI, AND BRIAN P.
`MURPHY, Administrative Patent Judges
`__________________________________________________________________
`PETITIONERS' DEMONSTRATIVES
`
`
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, Cover
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`

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`1
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`U.S. Patent No. 6,585,992
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`IPR2013-00590
`
`U.S. Patent No. RE 41,251
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`IPR2013-00582
`
`Corp., ApaTech, Inc., and ApaTech, Limited
`Presentation of Petitioners Baxter Healthcare
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`p
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`p
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`p
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 1
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`

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`2
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`U.S. Patent No. 6,585,992 (‘992 patent)
`16-18, 20, 25-26, 36, 38, and 43-44 of
`PatentabilityofClaims124911
`Patentability of Claims 1, 2, 4, 9, 11,
`patent)
`13ofU.S.PatentNo.RE41,251(‘251
`13 of U.S. Patent No. RE 41,251 (251
`Patentability of Claims 1,6, and 8-
`
`II
`II.
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`I.
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`Corp., ApaTech, Inc., and ApaTech, Limited
`Presentation of Petitioners Baxter Healthcare
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`p
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`p
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`p
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 2
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`

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`3
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`Chaki(Ex1130)ispriorartunder§102(b)
`Chaki(Ex. 1130) is prior art under §102(b)
`
`
`
`••
`
`•Ohgushi(Ex. 1073) is prior art under §102(b)
`
`Lynch (Ex. 1026) is prior art under §102(b)
`
`Ichitsuka(Ex. 1024) is prior art under §102(b)
`
`Bioceramics 1993 (Ex. 1021) is prior art under §102(b)
`
`Davies(Ex1015)ispriorartunder§102(b)
`Davies (Ex. 1015) is prior art under §102(b)
`
`Ruys1993a(Ex. 1011) is prior art under §102(b)
`
`PrincipalPriorArtatIssue
`Principal Prior Art at Issue
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`•
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`••
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`•
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`•
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`•
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`IPR2013-00582, -00590
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 3
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`

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`4
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`4.Davies and Ichitsuka: Render claim 8 obvious.
`d813
`3Di
`3.Davies: Anticipates claims 1 and 8-13
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`2.Ruys1993aand Bioceramics 1993: Render claim
`1.Ruys1993a: Anticipates claims 1 and 8-13
`Grounds in This Trial
`
`6 obvious.
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`IPR2013-00582
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 4
`
`

`
`5
`
`IPR2013-00582, Paper No. 8 (Institution Decision) at 12.
`
`“MicroporousStructure”
`Ground 1: Ruys1993a
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`p
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 5
`
`

`
`6
`
`Ex. 1001 (‘251 Patent) at 33:59-63, cited in IPR2013-00582, Paper No. 8 (Institution Decision) at 4.
`
`Ex. 1001 (‘251 Patent) at 34:1-2, cited in IPR2013-00582, Paper No. 8 (Institution Decision) at 2, 30.
`
`Ex. 1001 (‘251 Patent) at 33:42-46, cited in IPR2013-00582, Paper No. 8 (Institution Decision) at 3-4.
`
`The ‘251 Patent, Claims 1, 6 and 8
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 6
`
`

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`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 7
`
`

`
`8
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 51.
`Ex. 1003 (MikosDecl.) at ¶ 750-51,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 8
`
`

`
`9
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 27.
`Ex. 1003 (MikosDecl.) at ¶ 727,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
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`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 9
`
`

`
`10
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 5-6.
`t78
`E1021(Bi
`Ex. 1021 (Bioceramics 1993) at 78,
`
`1993)
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`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
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`p
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`Ground 1: Ruys1993a
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 10
`
`

`
`11
`
`cited in Paper No. 1 (Petition) at 44; also cited in Paper No. 23 (Petitioners’ Reply) at 5.
`Ex. 1021 (Bioceramics 1993) at 129, cited in IPR2013-00582, Ex. 1003 at ¶ 70, cited in Ex. 1003 at ¶¶ 389, 391,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
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`Ground 1: Ruys1993a
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 11
`
`

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`12
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`Ex. 1134 at ¶ 147, cited in Paper No. 23 (Petitioner’s Reply) at 7.
`Ex. 1049 (Jianguo) at 2, cited in IPR2013-00582,
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 12
`
`

`
`13
`
`cited in IPR2013-00582, Paper No. 38 (Petitioners’ Response to Observations) at 15.
`Ex. 1133 (OngDep. Tr.) at 157:5-13,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
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`Ground 1: Ruys1993a
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 13
`
`

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`14
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`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 14
`
`

`
`15
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 6.
`Ex. 1133 (OngDep. Tr.) at 158:1-13,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 15
`
`

`
`16
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 7 n.1.
`Ex. 1011 (Ruys1993a) at 4, Fig. 2,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 16
`
`

`
`17
`
`23(Petitioners’Reply)at4-5;PaperNo1(Petition)at44
`23 (Petitioners Reply) at 4-5; Paper No. 1 (Petition) at 44.
`Ex. 1011 (Ruys1993a) at 4, cited in IPR2013-00582, Paper No.
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 17
`
`

`
`18
`
`Ex. 1003 at ¶ 424, cited in Ex. 1003 at ¶ 642, cited in Paper No. 1 (Petition) at 57.
`Ex. 1003 (MikosDecl.) at ¶ 373-74, cited in IPR2013-00582,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 18
`
`

`
`19
`
`cited in IPR2013-00582, Ex. 1003 at ¶ 642, cited in Paper No. 1 (Petition) at 57.
`Ex. 1003 (MikosDecl.) at ¶ 426,
`
`cited in IPR2013-00582, Ex. 1003 at ¶ 642, cited in Paper No. 1 (Petition) at 57.
`Ex. 1003 (MikosDecl.) at ¶ 424,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 19
`
`

`
`20
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 44; Paper No. 23 (Petitioners’ Reply) at 4.
`Ex. 1003 (MikosDecl.) at ¶ ¶ 388-91,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 20
`
`

`
`21
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 4.
`Ex. 1003 (MikosDecl.) at ¶ 631,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 21
`
`

`
`No. 1 (Petition) at 44; also cited in Paper No. 23 (Petitioners’ Reply) at 4-5.
`Ex. 1003 (MikosDecl.) at ¶ 70, cited in IPR2013-00582, Ex. 1003 at ¶¶ 389, 391, cited in Paper
`
`,
`
`,
`
`¶
`
`)
`
`(
`
`22
`
`p
`
`,
`
`,
`
`¶¶
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`p
`
`Ground 1: Ruys1993a
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 22
`
`

`
`23
`
`No. 1 (Petition) at 44; also cited in Paper No. 20 (PO Response) at 3.
`Ex. 1003 at ¶ 70, cited in Ex. 1003 at ¶¶ 389, 391, cited in Paper
`Ex. 1010 (Jarcho1976) at 5, cited in IPR2013-00582,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 23
`
`

`
`24
`
`No. 1 (Petition) at 44; also cited in Paper No. 38 (Petitioners’ Response to Observations) at 11.
`Ex. 1039 (Denissen) at 9, cited in IPR2013-00582, Ex. 1003 at ¶ 70, cited in Ex. 1003 at ¶¶ 389, 391, cited in Paper
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 24
`
`

`
`25
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 5.
`Ex. 1124 (Witek) at 2,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 25
`
`

`
`26
`
`citedinIPR2013-00582PaperNo23(Petitioners’Reply)at5
`cited in IPR201300582, Paper No. 23 (Petitioners Reply) at 5.
`Ex. 1133 (OngDep. Tr.) at 116:4-7,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 26
`
`

`
`27
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 5.
`Ex. 1133 (OngDep. Tr.) at 111:3-13,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 27
`
`

`
`28
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 6.
`Ex. 1133 (OngDep. Tr.) at 161:2-10,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 28
`
`

`
`29
`
`,
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 5.
`Ex. 1134 (MikosReply Decl.) at ¶ 37-38,
`
`¶
`
`)
`
`py
`
`(
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`p
`
`Ground 1: Ruys1993a
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 29
`
`

`
`30
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 5.
`Ex. 1133 (OngDep. Tr.) at 300:14-301:11,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 30
`
`

`
`Ex. 1134 at ¶ 39, cited in Paper No. 23 (Petitioner’s Reply) at 6.
`Ex. 1010 (Jarcho1976) at 4, Table II, cited in IPR2013-00582,
`
`
`
`
`
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`
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`
`
`
`
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`
`
`E38Em.2:.5mwm.23FmE_m_o...§S__o_Em
`
`p
`
`Ground 1: Ruys1993a
`
`mmmmwm>:m_"F.3326
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 31
`
`

`
`32
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 5.
`Ex. 1133 (OngDep. Tr.) at 301:12-19,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 32
`
`

`
`33
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 5-6.
`Ex. 1133 (OngDep. Tr.) at 304:1-19,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 33
`
`

`
`34
`
`IPR2013-00582, Paper No. 20 (PO Response) at 56.
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 34
`
`

`
`35
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 7 n.1.
`Ex. 1133 (OngDep. Tr.) at 150:18-151:1,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 35
`
`

`
`36
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 7 n.1.
`Ex. 1134 (MikosReply Decl.) at ¶ 45,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 36
`
`

`
`37
`
`(Petitioners’ Response to Observations) at 14; also cited in Ex. 1003 at ¶ 195, cited in Paper No. 1 (Petition) at 13-14.
`Ex. 1001 (‘251 Patent) at 27:44-49, cited in IPR2013-00582, Paper No. 38
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 37
`
`

`
`38
`
`IPR2013-00582, Paper No. 20 (PO Response) at 42 n.9.
`
`IPR2013-00582, Paper No. 20 (PO Response) at 42.
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 38
`
`

`
`39
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 42-43.
`Ex. 1003 (MikosDecl.) at ¶ 624,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 39
`
`

`
`40
`
`at 5, 15, 55; also cited in Ex. 1003 at ¶ 624, cited in Paper No. 1 at 42-43.
`Ex. 1003 (MikosDecl.) at ¶¶ 219-222, cited in IPR2013-00582, Paper No. 1 (Petition)
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 40
`
`

`
`41
`
`5, 15, 55; also cited in Ex. 1003 at ¶ 624, cited in Paper No. 1 at 42-43.
`Ex. 1003 (MikosDecl.) at ¶¶ 225-226, cited in IPR2013-00582, Paper No. 1 (Petition) at
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 41
`
`

`
`42
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 43.
`Ex. 1003 (MikosDecl.) at ¶ 383,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 42
`
`

`
`43
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 42-43.
`Ex. 1003 (MikosDecl.) at Appendix D,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 43
`
`

`
`44
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 2.
`Ex. 1133 (OngDep. Tr.) at 144:4-11,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 44
`
`

`
`45
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 3-4.
`Ex. 1133 (OngDep. Tr.) at 194:5-13,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 45
`
`

`
`46
`
`(Petition) at 5; also cited in Paper No. 37 (Petitioners’ Opposition to Motion to Exclude) at 7-8.
`Ex1003(MikosDecl)at¶233citedinIPR201300582PaperNo1
`Ex. 1003 (MikosDecl.) at ¶ 233, cited in IPR2013-00582, Paper No. 1
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 46
`
`

`
`47
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 2.
`Ex. 2026 (OngDecl.) at ¶ 49
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 47
`
`

`
`48
`
`Paper No. 1 (Petition) at 4; also cited in Ex. 1134 at ¶ 11, cited in Paper 23 at 2.
`Ex. 1001 (‘251 Patent) at 17:34-61, cited in IPR2013-00582,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 48
`
`

`
`49
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 2-3.
`Ex. 1001 (‘251 Patent) at 11:45-12:11,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 49
`
`

`
`50
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 2-3.
`Ex. 1133 (OngDep. Tr.) at 127:18-128:9
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 50
`
`

`
`51
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 2-3.
`Ex. 1133 (OngDep. Tr.) at 129:7-130:2,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 51
`
`

`
`52
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 2.
`Ex. 1134 (MikosReply Decl.) at ¶ 10,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 52
`
`

`
`53
`
`,
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 2.
`Ex. 1134 (MikosReply Decl.) at ¶ 11-12,
`
`¶
`
`)
`
`py
`
`(
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`p
`
`Ground 1: Ruys1993a
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 53
`
`

`
`54
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 3.
`Ex. 1134 (MikosReply Decl.) at ¶ 14,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 54
`
`

`
`55
`
`Paper No. 23 (Petitioners’ Reply) at 2-3; Paper No. 20 (PO Response) at 14.
`Ex. 2026 (OngDecl.) at ¶ 50, cited in IPR2013-00582,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 55
`
`

`
`56
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 3.
`Ex. 1001 (‘251 Patent) at 28:42-29:5,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 56
`
`

`
`57
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 3.
`Ex. 1133 (OngDep. Tr.) at 134:13-135:13,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 57
`
`

`
`58
`
`IPR2013-00582, Paper No. 7 (PO Prelim. Resp.) at 9.
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 58
`
`

`
`59
`
`(Petitioners’ Reply) at 3; also cited in Ex. 1134 at ¶ 20, cited in Paper No. 23 at 3.
`Ex. 1017 (Pugh) at 8:5-15, cited in IPR2013-00582, Paper No. 23
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 59
`
`

`
`60
`
`(Petitioners’ Reply) at 3; also cited in Ex. 1134 at ¶ 20, cited in Paper No. 23 at 3.
`Ex. 1017 (Pugh) at 14:20-15:10, cited in IPR2013-00582, Paper No. 23
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 60
`
`

`
`61
`
`(Petitioners’ Reply) at 3; also cited in Ex. 1134 at ¶ 20, cited in Paper No. 23 at 3.
`Ex. 1017 (Pugh) at 34:14-35:4, cited in IPR2013-00582, Paper No. 23
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 61
`
`

`
`62
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 3.
`t¶21
`E1134(Mik
`Ex. 1134 (MikosReply Decl.) at ¶ 21,
`
`RlDl)
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 62
`
`

`
`63
`
`Response) at 2; Paper No. 23 (Petitioners’ Reply) at 3.
`Ex.. 2026 (OngDecl.) at ¶ 42, cited in IPR2013-00582, Paper 20 (PO
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 63
`
`

`
`64
`
`cited in IPR2013-00582, Paper No. 38 (Petitioners’ Response to Observations) at 7-8.
`Ex. 1133 (OngDep. Tr.) at 136:20-137:4,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 64
`
`

`
`65
`
`cited in IPR2013-00582, Paper No. 38 (Petitioners’ Response to Observations) at 8.
`Ex. 1133 (OngDep. Tr.) at 285:20-286:5,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 65
`
`

`
`66
`
`(Petitioners’ Reply) at 3; also cited in Ex. 1134 at ¶ 23, cited in Paper No. 23 at 3.
`Ex. 1001 (‘251 Patent) at 30:40-51, cited in IPR2013-00582, Paper No. 23
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 66
`
`

`
`67
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 3.
`Ex. 1133 (OngDep. Tr.) at 144:18-145:7,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 67
`
`

`
`68
`
`(Petitioners’ Reply) at 3; also cited in Ex. 1134 at ¶ 25, cited in Paper No. 23 at 3.
`Ex. 1017 (Pugh) at 34:3-11, cited in IPR2013-00582, Paper No. 23
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 68
`
`

`
`69
`
`(Petitioners’ Reply) at 3; also cited in Ex. 1134 at ¶ 25, cited in Paper No. 23 at 3.
`Ex. 1017 (Pugh) at 24:5-25, cited in IPR2013-00582, Paper No. 23
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 69
`
`

`
`70
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 3.
`Ex. 1134 (MikosReply Decl.) at ¶ 28,
`
`anticipates claims 1 and 8-13 of the ‘251 patent
`
`p
`
`Ground 1: Ruys1993a
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 70
`
`

`
`71
`
`cited in IPR2013-00582, Paper No. 8 (Institution Decision) at 4.
`Ex. 1001 (‘251 patent) at 33:59-63,
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 71
`
`

`
`72
`
`Ex. 1021 (Bioceramics 1993) at 108, cited in IPR2013-00582, Paper No. 1 (Petition) at 46-47.
`
`Ex. 1021 (Bioceramics 1993) at 116-17, cited in IPR2013-00582, Paper No. 1 (Petition) at 46.
`
`Ex1021(Bioceramics1993)at110citedinIPR2013-00582PaperNo1(Petition)at47
`Ex. 1021 (Bioceramics 1993) at 110, cited in IPR2013-00582, Paper No. 1 (Petition) at 47.
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 72
`
`

`
`73
`
`Ex. 1021 (Bioceramics 1993) at 111, Fig. 4, cited in IPR2013-00582, Paper No. 1 (Petition) at 47.
`
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`
`Ex. 1021 (Bioceramics 1993) at 109, Fig. 2, cited in IPR2013-00582, Paper No. 1 (Petition) at 47.
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 73
`
`

`
`74
`
`IPR2013-00582, Paper No. 1 (Petition) at 48.
`
`IPR2013-00582, Paper No. 1 (Petition) at 51.
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 74
`
`

`
`75
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 51.
`Ex. 1003 (MikosDecl.) at ¶ 144,
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 51.
`Ex. 1003 (MikosDecl.) at ¶ 142,
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 75
`
`

`
`76
`
`cited in IPR2013-00582, Paper No. 1 (Petition) at 48.
`Ex. 1003 (MikosDecl.) at ¶ 160,
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 76
`
`

`
`77
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 9.
`Ex. 1133 (OngDep. Tr.) at 154:5-10,
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 77
`
`

`
`78
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 9.
`Ex. 1133 (OngDep. Tr.) at 159:16-160:3,
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 78
`
`

`
`79
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 9.
`Ex. 1133 (OngDep. Tr.) at 36:22-37:16,
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 79
`
`

`
`80
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 9.
`Ex. 1133 (OngDep. Tr.) at 38:4-7,
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 80
`
`

`
`81
`
`(Petition) at 46; also cited in Paper 20 (PO Response) at 34.
`Ex. 1011 (Ruys1993a) at 3, cited in IPR2013-00582, Paper No. 1
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 81
`
`

`
`82
`
`cited in Ex. 1134 (MikosReply Decl.) at ¶ 23, cited in Paper 23 at 3.
`IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 3; also
`Ex. 1001 (‘251 Patent) at 30:54-31:19, cited in
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 82
`
`

`
`83
`
`cited in IPR2013-00582, Paper No. 23 (Petitioners’ Reply) at 9-10.
`Ex. 1133 (OngDep. Tr.) at 232:11-233:1,
`
`Ground 2: Ruys1993aand Bioceramics 1993
`
`render claim 6 of the ‘251 patent obvious
`
`p
`
`Baxter Healthcare Corp., et al. v. Millenium Biologix, IPR2013-00590, Exhibit 1179, p. 83
`
`

`
`84
`
`citedinIPR2013-00582PaperNo23(Petitioners’Reply)at9-10
`cited in IPR201300582, Paper No. 23 (Petitioners Reply) at 910.
`Ex. 1133 (OngDep. Tr.) at 2