WO 95/08306
`
`PCT/CI-I94/00184
`
`24
`
`18.
`
`Implantat nach Anspruch 17,
`
`dadurch gekennzeichnet, dass
`
`der Radius der einseitigen Abrundung (31) derart bemessen ist,
`
`dass
`
`a)
`
`die Differenz
`
`zwischen
`
`der
`
`grésseren
`
`Seite
`
`des
`
`rechteckigen Querschnittes
`
`und
`
`der
`
`Diagonalen fiber die
`
`abgerundete Kante kleiner als 3 mm,
`
`vorzugsweise 1
`
`— 2 mm be-
`
`tréqt:
`
`und
`
`b)
`
`die Kontaktfléche zum Knochen durch die Abrundung
`
`(31) um
`
`weniger als die Hélfte,
`
`vorzugsweise weniger als
`
`ein Drittel
`
`reduziert ist.
`
`19.
`
`Implantat
`
`nach
`
`einem der Ansprfiche
`
`1 bis
`
`18, dadurch
`
`gekennzeichnet,
`
`dass
`
`es
`
`einen rechteckigem Querschnitt mit
`
`einer doppelseitigen Abrundung (32) fiber die Diagonale aufweist.
`
`20.
`
`Implantat nach Anspruch 19,
`
`dadurch gekennzeichnet, dass
`
`die Radien der doppelseitigen Abrundungen (32)
`
`derart bemessen
`
`sind, dass
`
`a)
`
`die Differenz
`
`zwischen
`
`der
`
`grésseren
`
`Seite
`
`des
`
`Querschnittes und der Diagonalen fiber die
`
`abgerundeten Kanten
`
`kleiner als 3 mm, vorzugsweise
`
`0,5 - 1,0 mm betrégt und
`
`b)
`
`die kleinere Fléche
`
`des Implantates um weniger als
`
`die
`
`Hélfte, vorzugsweise weniger als ein Viertel reduziert ist.
`
`26
`
`

`
`W0 95l08306
`
`PCT/CI-I94/00184
`
`25
`
`21.
`
`Implantat nach Anspruch 19 oder 20, dadurch gekennzeichnet,
`
`dass
`
`es derart
`
`ausgebildet ist,
`
`dass bei paariger Anordnung
`
`solcher
`
`Implantate
`
`deren
`
`gerundete
`
`Kanten
`
`symmetrisch
`
`zueinander zu liegen kommen.
`
`22.
`
`Implantat nach einem der Ansprfiche
`
`19 bis
`
`21, dadurch
`
`gekennzeichnet, dass es einen rechteckigen Querschnitt aufweist,
`
`welcher derart beschaffen ist,
`
`dass nach der Rotation des
`
`Implantates in die Konkavitat
`
`der Deckplatten der angrenzenden
`
`Wirbelkérper
`
`eine Distraktion des Zwischenwirbelraumes (25)
`
`zwischen 1 und 4 mm,
`
`vorzugsweise zwischen 2 — 3 mm, verbleibt.
`
`23.
`
`Implantat nach
`
`einem der Ansprfiche
`
`19 bis
`
`21, dadurch
`
`gekennzeichnet, dass es einen Querschnitt aufweist, der zu einem
`
`Quadrat ~reduziert
`
`ist
`
`und
`
`dass
`
`nach der Rotation des
`
`Implantates in die Konkavitét
`
`der Endplatten der angrenzenden
`
`Wirbelkérper keine Distraktion des Zwischenwirbelraumes (25)
`
`verbleibt.
`
`24.
`
`Implantat nach
`
`einem der Ansprfiche
`
`19 bis
`
`22, dadurch
`
`gekennzeichnet,
`
`dass das posteriore Ende des
`
`Implantats (6)
`
`derart beschaffen ist, dass ein linkes und ein rechtes Implantat
`
`anterior derart mit einem Konnektor (34) verbindbar sind, dass
`
`(a)
`
`der Abstand zwischen dem linken und
`
`rechten Implantat
`
`(6)
`
`und
`
`deren Ausrichtung aufrechterhalten wird;
`
`(b) die Implantate (6) um ihre Langsachse (35) drehbar sind; und
`
`(C) die zwei Implantate (6) vor deren Implantation und/oder
`
`in
`
`situ mit dem Konnektor
`
`(34) koppelbar sind.
`
`27
`
`

`
`WO 95/08306
`
`PCT/CI-[94/00184
`
`25.
`
`Implantat
`
`nach
`
`einem der Ansprfiche
`
`19 bis
`
`22, dadurch
`
`gekennzeichnet,
`
`dass es derart beschaffen ist,
`
`dass
`
`es vor
`
`dessen Implantation oder
`
`in situ mit
`
`einem zweiten Implantat
`
`(6) verhakbar ist, wobei die Verbindung
`
`(a)
`
`den Abstand und
`
`den Winkel zwischen den
`
`Implantaten
`
`(6)
`
`J aufrecht erhalt; und
`
`(b)
`
`eine Rotation der Implantate (6) um ihre Léngsachse (35)
`
`in
`
`die Konkavitat der Deckplatten der
`
`angrenzenden Wirbelkorper
`
`(1,2) zulésst.
`
`26.
`
`Implantat nach einem der Ansprfiche
`
`19 bis
`
`22, dadurch
`
`gekennzeichnet,
`
`dass es derart beschaffen ist, dass es nach der
`
`Rotation
`
`um
`
`seine Léngsachse
`
`(35)
`
`in die Konkavitat der
`
`Deckplatten medial
`
`fiber ein weiteres Implantat winkelstabil
`
`verbindbar ist.’
`
`27.
`
`Implantat
`
`nach
`
`einem der Ansprfiche
`
`19 bis
`
`26, dadurch
`
`gekennzeichnet,
`
`dass
`
`es an seiner Oberflache beschichtet ist,
`
`vorzugsweise mit Hydroxylapatit oder Titanplasma.
`
`28.
`
`Implantat
`
`nach
`
`einem der Ansprfiche 13,
`
`14
`
`und einem der
`
`Ansprfiche 19
`
`—
`
`27, dadurch gekennzeichnet, dass es perforierte
`
`Wande
`
`aufweist, wobei
`
`die Perforationen (37)
`
`vorzugsweise
`
`lochartig sind und der Durchmesser der Lbcher derart konzipiert
`
`ist, dass
`
`(a)
`
`in die Léngsoffnung gepresste Spongiosa
`
`nicht seitlich
`
`austritt, und
`
`28
`
`

`
`WO 95108306
`
`PCT/CH94l00184
`
`(b)
`
`die
`
`in der
`
`Spongiosa
`
`enthaltene
`
`Flfissigkeit
`
`beim
`
`Stopfen der
`
`Implantate
`
`seitlich austreten
`
`und
`
`nach der
`
`Implantation wieder
`
`zurfickdiffundieren
`
`kann,
`
`um
`
`ein
`
`postoperatives Schwellen der
`
`Spongiosa zu bewirken;
`
`und
`
`(c)
`
`Knochen
`
`durch
`
`die
`
`Perforation
`
`in
`
`das
`
`Implahtat
`
`hineinwachsen kann.
`
`29.
`
`Implantat nach
`
`einem der Ansprfiche
`
`19
`
`-
`
`28,
`
`dadurch
`
`gekennzeichnet, dass die eine Kontaktflache zwischen Implantat
`
`und Knochen eine Rasterung in der Langsrichtung des Implantates
`
`aufweist.
`
`30.
`
`Implantat
`
`nach einem der Ansprfiche
`
`19
`
`-
`
`28,
`
`dadurch
`
`gekennzeichnet,
`
`dass beide Kontaktflachen zwischen Implantat
`
`und Knochen eine Rasterung in der Langsrichtung des Implantates
`
`aufweisen.
`
`31.
`
`Implantat nach
`
`einem der Ansprfiche
`
`29 oder
`
`30, dadurch
`
`gekennzeichnet,
`
`dass die Geometrie der Rasterung ein Rotieren
`
`des
`
`Implantates
`
`in eine Richtung zulasst und
`
`in die andere
`
`Richtung verhindert.
`
`32.
`
`Implantat
`
`nach
`
`einem der Ansprfiche
`
`19
`
`-
`
`28,
`
`dadurch
`
`gékennzeichnet,
`
`dass die
`
`eine Kontaktflache zwischen Implantat
`
`und Knochen eine Querrasterung aufweist.
`
`29
`
`

`
`WO 95/08306
`
`PCT/Cl-I94/00184
`
`33.
`
`Implantat
`
`nach
`
`einem der Ansprfiche
`
`19
`
`—
`
`28, dadurch
`
`gekennzeichnet, dass beide Kontaktfléchen zwischen Implantat und
`
`Knochen eine Querrasterung aufweisen.
`
`34.
`
`Implantat
`
`nach
`
`einem der Ansprfiche
`
`32
`
`oder
`
`33, dadurch
`
`gekennzeichnet,
`
`dass
`
`die
`
`Geometrie
`
`der
`
`Rasterung ein
`
`Verschieben des Implantates
`
`in anteriorer Richtung verhindert.
`
`35.
`
`Implantat nach
`
`einem der Ansprfiche
`
`32 oder
`
`33, dadurch
`
`gekennzeichnet,
`
`dass
`
`die
`
`Geometrie
`
`der
`
`Rasterung ein
`
`Verschieben
`
`des
`
`Implantates
`
`in
`
`posteriorer
`
`Richtung
`
`verhindert.
`
`36.
`
`Implantat nach Anspruch
`
`32,
`
`dadurch gekennzeichnet, dass
`
`die Geometrie der
`
`Rasterung der beiden Kontaktfléchen zwischen
`
`Implantat
`
`und Knochen derart gestaltet
`
`ist,
`
`dass die eine
`
`Rasterung
`
`ein Verschieben des
`
`Implantates
`
`in anteriorer
`
`Richtung
`
`und die
`
`andere
`
`ein Verschieben in
`
`posteriorer
`
`Richtung verhindert.
`
`37.
`
`Implantat nach
`
`einem der Ansprfiche
`
`29
`
`oder
`
`32, dadurch
`
`gekennzeichnet,
`
`dass es eine Léngsrasterung der einen und
`
`eine
`
`Querrasterung der anderen Kontaktfléche aufweist.
`
`38.
`
`Implantat nach einem der Ansprfiche 32 — 35 oder 37, dadurch
`
`gekennzeichnet,
`
`dass
`
`die
`
`Querrasterung
`
`der
`
`einzelnen
`
`Kontaktfléchen derart
`
`ausgelegt ist,
`
`dass
`
`ein Verschieben in
`
`posteriorer und anteriorer Richtung verhindert wird.
`
`30
`
`

`
`WO 95/08306
`
`PCT/CH94/00184
`
`39.
`
`Implantat nach
`
`einem der Ansprflche
`
`13,14
`
`und
`
`einem der
`
`Ansprfiche 19-17
`
`und 29-38,
`
`dadurch gekennzeichnet,
`
`dass die
`
`Wénde (19) und (20) Querschlitze aufweisen.
`
`40. Implantat nach Anspruch 39, dadurch gekennzeichnet, dass die
`
`Hohlréume
`
`und
`
`Schlitze mit
`
`einem osteokonduktiven oder
`
`osteoinduktiven Material,
`
`vorzugsweise Hydroxylapatit, geffillt
`
`slnd,
`
`so dass der Knochen von den Deckplatten der angrenzenden
`
`Wirbelkérper und von der Seite her einwachsen kann.
`
`41. Implantat
`
`ffir den Zwischenwirbelraum (25) mit
`
`a)
`
`einer
`
`im wesentlichen quaderférmigen Gestalt mit
`
`den
`
`Kantenléngen a,b,c;
`
`b)
`
`einer vorderen axialen Endfléche
`
`(12) und einer hinteren
`
`axialen Endfléche
`
`(10),
`
`welche
`
`von der Léngsachse
`
`(35)
`
`durchstossen werden;
`
`c)
`
`zwei Seitenfléchen (14,15) welche Von einer Querachse (44)
`
`durchstossen werden7 und
`
`d)
`
`einer Oberflache (16) und einer Unterfléche (17)) welche von
`
`einer Querachse (45) durchstossen werden;
`
`dadurch gekennzeichnet,
`
`dass
`
`e)
`
`das Implantat (6)
`
`eine Vorrichtung (8) zur Ergreifung durch
`
`ein Werkzeug (9) aufweist; und
`
`f)
`
`die vordere axialen Endfléche
`
`(12)
`
`und/oder die hinteren
`
`axialen Endfléche
`
`(10) rechteckig ausgebildet sind.
`
`31
`
`

`
`W0 95/013306
`
`PCT/CH94/00184
`
`32
`
`

`
`WO 95/08306
`
`PCTICH94/00184
`
`33
`
`

`
`WO 95/08306
`
`PCTICI-[94/00184
`
`34
`
`

`
`WO 95/08306
`
`PCT/CH94/00184
`
`35
`
`

`
`WO 95/08306
`
`4oo10NWWCP
`
`36
`
`

`
`WO 95/08306
`
`PCT/CI-I94/00184
`
`7
`
`67
`
`/
`
`25
`
`37
`
`

`
`WO 95/08306
`
`PCT/CH94/00184
`
`ERSATZBLATT
`
`38
`
`

`
`INTERNATIONAL SEARCH REPORT
`
`. CLASSIFICATION OF SUBJECT MATTER
`lPC 6
`A61F2/44
`A61F2/46
`
`According to International Patent Classification (IPC) or to bout national clamification and [PC
`B. FIELDS SEARCHED
`
`Minimum documentation searched (classification system followed by classification symbols)
`IPC 6
`A61F
`
`Inter.
`
`rial Application No
`
`PCT/CH 94/00184
`
`Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched
`
`Electronic data base consulted during the international search (name of data base and, where practical, mrch terms used)
`
`C. DOCUMENTS CONSIDERED TO BE RELEVANT
`Citation of document, with indication, where appropriate, ofthe relevant passages
`
`W0,A,90 00037 (MICHELSON) 11 January 1990
`
`see the whole document
`
`US,A,3 486 505 (MORRISON) 30 December
`1969
`
`see column 2,
`2-4
`
`line 21 - line 68; claims
`
`US,A,4 349 921 (KUNTZ) 21 September 1982
`see column 6,
`line 19 - line 24; figures
`2-4
`
`_/--
`
`R levant to claim No.
`
`1-3,8,9,
`12,13,
`17,41
`5,10
`4,28,40
`
`E Further documents are listed in the conti'nuau'on of box C.
`' Special categories of cited documents :
`
`‘A’ document defining the general state of the art which is not
`considered to be of particular relevance
`‘E’ earlier document but published on or alter the international
`filing date
`‘L’ document which may throw doubts on priority cIaim(s) or
`which is cited to establish the publication date of another
`citation or other special reason (as specified)
`'0' document referring to an oral disclosure, use. exhibition or
`other means
`‘P’ document published prior to the international filing date but
`later than the priority date claimed
`Date of the actual completion of the international search
`
`19 December
`
`1994
`
`Name and mailing address of the ISA
`European Patent Oflice. P.B. 5818 Patentlaan 2
`NL - 2280 HV Rijswijk
`Tel. (+ 3|-70) 3-to-2040, Tx. 31 65! epo nl,
`Fare (+ 31-70) 340-30l6
`
`Form PCT/ISA/210 (lemntl sheet) (July 1992)
`
`E Patent family members are listed in annex.
`
`"I" later docummt published after the international filing date
`or priority date and not in conilict with the
`liution but
`cited to understand the principle or theory un
`ying the
`invention
`‘X’ document of particular relevance; the claimed invention
`cannot be considered novel or cannot be considered to
`involve an inventive step when the document is taken alone
`'Y' document of particular relevance; t.he claimed invention
`cannot be considered to involve an inventive step when the
`document is combined with one or more other such docu-
`in
`e art.
`rrtegits. such comhination being obvious to a person slcillcd
`‘at’ document member of the same patent family
`Date of mailing of the international search report
`
`0 9. O1. 95
`
`Authorized ollicer
`
`Klein, C
`
`page 1 of 2
`
`39
`
`

`
`INTERNATIONAL SEARCH REPORT
`
`mm» M Ammo“ No
`PCT/CH 94/00184
`
`C.(Conu'nuation) DOCUMENTS CONSIDERED To BE RELEVANT
`
`Citation ofdocument. wlth indicauon, where appropriate. ofthe relevantpa.-sages
`
`Relevant to claim No.
`
`1—3,8,9,
`13,14,16
`28-33,
`35,40
`
`1~3,13
`
`4,15,28,
`40
`
`16,27,39
`
`EP,A,0 307 241 (BRANTIGAN) 15 March 1989
`
`see the who1e document
`
`W0,A,89 12431 (MICHELSON) 28 December
`1989
`
`see page 13,
`figures 4-5
`
`line 11 - page 16, 1ine 37;
`
`EP,A,0 260 044 (SHEPPERD) 16 March 1988
`see co1umn 7,
`line 28 - column 8, Iine 21;
`claim 15
`
`US,A,5 092 893 (SMITH) 3 March 1992
`see column 5, 1ine 7 - Iine 23; figures
`1,5
`
`W0,A,93 01771 (CALCITEK) 4 February 1993
`see abstract; figure 4
`
`WO,A,92 14423 (MADHAVAN) 3 September 1992
`see page 8, 1ine 11; figures 5,6
`
`EP,A,0 493 698 (HKRLE) 8 July 1992
`
`US,A,4 772 287 (RAY) 20 September 1988
`
`Form PCT/‘ISA/Illl (mnununinn of unmd slum) (July I992)
`
`page 2 of 2
`
`40
`
`

`
`INTERNATIONAL SEARCH REPORT
`
`«n-'-1ApplicaII'°n N0
`lam
`PCT/CH.94/00184
`
`Patent document
`cited in search report
`
`Publication
`date
`
`Patent family
`member(s)
`
`W0-A-9000037
`
`11-01-90
`
`AU-A-
`EP-A-
`
`3965489
`0425542
`3505416
`
`EP-A-0307241
`
`15-03-89
`
`1292596
`3876909
`4878915
`614609
`3436389
`3503133
`8909035
`
`5015247
`3838789
`1332999
`0419564
`
`63145650
`4863476
`
`5306307
`0612230
`
`5171278
`1454192
`0571555
`6504704
`
`4101526
`0623323
`
`3871460
`0304305
`
`US-A-4772287
`
`20-09-88
`
`Publication
`date
`
`23-01-90
`08-05-91
`28-11-91
`
`30-05-89
`03-12-91
`04-02-93
`07-11-89
`05-09-91
`16-10-89
`18-07-91
`05-10-89
`
`14-05-91
`12-01-90
`15-11-94
`03-04-91
`
`17-06-88
`05-09-89
`
`26-04-94
`31-08-94
`
`15-12-92
`15-09-92
`01-12-93
`02-06-94
`
`02-07-92
`09-11-94
`
`02-07-92
`22-02-89
`
`Farm PCT/ISAIJID (pltml flnlily Innu) (July 1992)
`
`page 1 of 2
`
`41
`
`

`
`INTERNATIONAL SEARCH REPORT
`
`““‘*PP“““°“ N“
`mm‘
`PCT/CH 94/00184
`
`Patent. document
`cited in search report
`
`US-A-4772287
`
`4 Publication
`date
`
`Patent. family
`member(s)
`
`Publication
`date
`
`JP-A-
`US-A-
`
`1070041
`4904260
`
`15-03-89
`27-02-90
`
`Form PCT/[SA/110 (palsnt family Annex) (July 1992)
`
`page 2 of 2
`
`42
`
`

`
`INTERNATIONALER RECHERCHENBERICHT
`
`Inmna
`
`Ru: Akunnichen
`
`PCT/CH 94/00184
`
`. KLASSIFIZIERUNG DES ANMELDUNGSGEGENSTANDES
`‘ipx 5
`A61F2/44
`A61F2/46
`
`Nach der [nuermuonalen Patenfltlassifikafion (IPK) oder mch der naxionalcn Klassifikation und dcr IPK
`B. RECHERCHIERTE GEBIETE
`Rechercluerter Mindesqmlfswff (Klassifikafionssystem und Klamifikafionsymbole )
`IPK 6
`A61F
`
`Recherdaiene aber nicht zum Mindesupriifslofr gchiirende Veriitfentlichungen, sowcit dime unter die recherchiemn Gcbiete fallen
`
`Wihrcnd dcr xntemafionalen Recherche konsullierte elektronische Datznbank (Name der Datenhank und evtl. vmvcndcu Suchbcgriffe)
`
`C. ALS WESENTLICH ANGESEHENE UNTERLAGEN
`
`Bczeichnungder Veréffenuichung, sowdterfordu-lichunmr Angabc cmin BctrachtkommcndenTcile
`
`W0,A,90 00037 (MICHELSON) 11. Januar 1990
`
`siehe das ganze Dokument
`
`US,A,3 486 505 (MORRISON) 30. Dezember
`1969
`
`siehe Spa1te 2, Ze1'1e 21 - Ze1'1e 68;
`Ansprfiche 2-4
`
`US,A,4 349 921 (KUNTZ) 21. September 1982
`siehe Spa1te 6, Ze1'1e 19 - Ze1'1e 24;
`Abbildungen 2-4
`
`_/__
`
`IX] Siche Anhang Paranramme
`Weitcre verarrenuicnungen nd der Fonsemmg Von Feld c zu
`enmchmen
`'1" Spitcre Verbffendichtmg, die mach dem intn-nalionalen Anmeldcdatum
`' Buondere Katcgnrien von angegebenen Veréffenclichmgen
`:
`odcr dcm Pxioxivétsdaulm verfiffenflicht wordan ist und mil dnr
`..
`-
`-
`-
`-
`-
`.
`.
`.
`.
`.
`.
`.
`abcr nicht als besonders bcdcutsam anzusehen is:
`Anmddmg mu“ kdudiem gamma um zmvmfinms as def
`A Vcmffentlxchung. due den allgcmemen Stand der Tcchml: dcfimcrt,
`Erlind
`zugrundell
`nd: Pnnn
`dzr Ihr zugnmdeh send
`_
`_
`.
`1'h¢ofi‘:n§;.g¢5¢bgn 19:5:
`n
`P5 ad“
`e
`‘E’ iltcres Dokument, dgu Jedqch am am qdcr nach dcm mtcmanonnlcn
`‘X’ Verbtfentlichung von bcsonderer Bedeutnng; die hennspu-uchte Erfi
`A“m°“'°d3“’m "°'°m“m°h‘ ‘”°'d°“ ‘st
`kann allcin am“
`d diescr Vetéffmflichlmg nicht. 313 mu bder am“
`‘L’ Veréffamichtmg. die geeignet ist, eincn Priorititsanspruch zweifclhafl er-
`erfinderischer
`ifigkeit beruhcnd betrachut wcrdm
`schdnen zu lassen, oder dutch die das Venéifentlichungsdatum cine:
`3nd""' in‘ R°°h°”h‘“b°"°m 3°““““‘“ v“6“°"m°h'“n3 baa‘ “"5” ‘Y’ Vufiflcnuichung Von bcsondcrcr Bedeutung die beanspruchte Erfindun ;.
`9°“ °".F" 91° ‘"5 ““°'“ "'“"'°“ "°‘°“"“'“ 5”“ "'8‘8‘b°“ *5‘ (W
`kann nicht als auf erflndcnsdzer Tétigteil heruhend bctnchm
`.
`_
`_
`_
`.
`,
`wcndcn, wean die Vcréffcntlichung nut dner odcr mehnnn andcren
`'0 Veroffenfilchunz. size sch auf cine mlindllche Offcnbamnz.
`.
`veresrrenuicnungen dieser Kate
`‘e in Verbindun gcbracht wird und
`cine Benutzung, cmc Ausstellung oder andere Maflnahmen beacht
`digs: verbmdung [fir gum 1=,,._-fig-,1,-,.,., memmi1'5;
`"" fifififlgflhf}‘fgn§§g‘d‘fm“m‘““v:6“f§‘c;“m‘c“h“tW0”‘f.d°‘::""m“‘ ah“ “‘°" ‘a’ Veréffentlichung, die Mizyieu demclben Patmtfamilie in
`Datum des Abschlusses der mternatiomlen Recherche
`Abendcdauun des imzrnafiomlen Recherchenbericlm
`
`en
`-
`
`19. Dezember 1994
`Name und Poslanschrift dcr Internatiomle Recbcrchcnbehfirdz
`Eutopiisches Patentamt. P.B. 5818 Patentlnn 2
`NL - 2230 HV Rijswijk
`Tel. (+ 31-70) 3&0-2040, Tx. 3! 651 epo 111.
`Fax: (+ 3|-70) 34-0-3016
`
`For-mblm PCT/ISA/210 (mm 3) (Juli 1992)
`
`0 9- 01- 95
`
`Seite 1 von 2
`
`43
`
`

`
`INTERNATIONALER RECHERCHENBERICHT
`
`nalelltktenzeichen
`Inlnn
`PCT/CH 94/00184
`
`C.(F0flS¢E\.ll‘Ig) AL5 VVESENFLICH ANGESEHENE UNTERLACIEN
`
`Ben-. Anspruch Nr.
`1-3,8,9,
`13,14,16
`28-33,
`35,40
`
`1-3,13
`
`4,15,28,
`40
`
`16,27,39
`
`Bczeichnung dcr Veréffenuichung. soweit erfordcrlich unter Angabc der in Bclracht kommendcn Teilc
`EP,A,O 307 241 (BRANTIGAN) 15. Mfirz 1989
`
`siehe das ganze Dokument
`
`WD,A,89 12431 (MICHELSON) 28. Dezember
`1989
`siehe Seite 13, Zei1e 11 - Seite 16, Zeile
`37; Abbi1dungen 4-5
`
`EP,A,0 260 044 (SHEPPERD) 16. Mirz 1988
`siehe Spa1te 7, Zei1e 28 - Spa1te 8, Zei1e
`21; Anspruch 15
`
`US,A,5 092 893 (SMITH) 3. Mfirz 1992
`siehe Spa1te 5, Zei1e 7 - Zeile 23;
`Abbildungen 1,5
`
`W0,A,93 01771 (CALCITEK) 4. Februar 1993
`siehe Zusammenfassung; Abbi1dung 4
`
`N0,A,92 14423 (MADHAVAN) 3. September 1992
`siehe Seite 8, Zei1e 11; Abbildungen 5,6
`
`EP,A,0 493 698 (HKRLE) 8. Juli 1992
`
`US,A,4 772 287 (RAY) 20. September 1988
`
`Fonnblut PCT/ISA/Zlll (Fonmzun; van Bull 2) (Juli I991)
`
`Seite 2 Von 2
`
`44
`
`

`
`INTERNATIONALER RECHERCHENBERICHT
`
`[mm “mmmm
`PCT/CH 94/00184
`
`lm Recherchenbericht
`angeffihrnes Patentdokument
`
`Datum der
`Veréffentlichung
`
`Mitg1ied(er) dér
`Patentfamilie
`
`Datum der
`Veréffemlichung
`
`W0-A-9000037
`
`11-01-90
`
`AU-A-
`EP-A-
`
`3965489
`0425542
`3505416
`
`23-01-90
`08-05-91
`28-11-91
`
`EP-A-0307241
`
`15-03-89
`
`US-A-4772287
`
`20-09-88
`
`4834757
`1292596
`3876909
`4878915
`614609
`3436389
`3503133
`8909035
`
`5015247
`3838789
`1332999
`0419564
`
`30-05-89
`03-12-91
`04-02-93
`07-11-89
`05-09-91
`16-10-89
`18-07-91
`05-10-89
`
`14-05-91
`12-01-90
`15-11-94
`03-04-91
`
`63145650
`4863476
`
`17-06-88
`05-09-89
`
`5306307
`0612230
`
`5171278
`1454192
`0571555
`6504704
`
`4101526
`0623323
`
`3871460
`0304305
`
`26-04-94
`31-08-94
`
`15-12-92
`15-09-92
`01-12-93
`02-06-94
`
`02-07-92
`09-11-94
`
`02-07-92
`22-02-89
`
`Formblttt PCT/ISA/210 (Arman; PIuntflmilia)(.luli I992)
`
`Seite 1 von 2
`
`45
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`

`
`INTERNATIONALER RECHERCHENBERICHT
`
`Wm m‘“N"-m==i°hm
`PCT/CH 94/00184
`
`Im Recherchenbericht
`angefilhrtes Patentdokumenl
`
`Datum der
`Veréffentlichung
`
`Mitglied(er) der
`Palentfamilie
`
`Datum der
`Veréffentlichung
`
`US-A-4772287
`
`JP-A-
`US-A-
`
`1070041
`4904260
`
`15-03-89
`27-02-90
`
`Fm-mblm PCT/ISA/2l0 (Anhtng Pnunlhu-zilie)(Juli I992)
`
`Seite 2 von 2
`
`46
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`

`
`
`
`TRANSLATOR CERTIFICATION
`
`County of New York
`State of New York
`
`Date: June 3, 2013
`
`
`
`To whom it may concern:
`
`This is to certify that the attached translation from German into English is an accurate
`representation of the documents received by this office.
`
`The documents are designated as:
`x WO 95/08306 – “Implant for the intervertebral space”
`
`
`Roxanne Le, Project Manager in this company, certifies that Christian Scrogum, who translated
`these documents, is fluent in German and standard North American English and qualified to
`translate. Roxanne Le attests to the following:
`
`“To the best of my knowledge, the aforementioned documents are a true, full and accurate
`translation of the specified documents.”
`
`
`
`Signature of Roxanne Le
`
`
`
`47
`
`

`
`PCT
`WORLD ORGANIZATION FOR INTELLECTUAL PROPERTY
`International Bureau
`INTERNATIONAL APPLICATION PUBLISHED IN ACCORDANCE WITH THE PATENT COOPERATION TREATY (PCT)
`International patent classification6:
`International publication number: WO 95/08306
`(51)
`(11)
`A61F 2/44, 2/46
`
`A1
`
`(43)
`
`International
`publication date:
`
`30 March 1995 (03/30/1995)
`
`(21)
`
`International file number:
`
`PCT/CH94/00184
`
`(22)
`
`International application date:
`20 September 1994 (09/20/94)
`
`(81) Designated states: CA, JP, US, European patent (AT,
`BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC,
`NL, PT, SE).
`
`(30) Priority information:
`9300982
`21 September 1993 (09/21/93)
`
`BE
`
`Published
`With international search report.
`
`(71) Applicant (for all designated countries except US):
`SYNTHES AG, CHUR [CH/CH]; Grabenstrasse 15,
`CH-7002 Chur (CH).
`
`(72)
`(75)
`
`Inventor; and
`Inventor/applicant (only for US): BECKERS, Louis,
`François, Charles [BE/BE]; Peulisbaan 22, B-2820
`Rijmenam (BE). SCHLÄPFER, Johannes, Fridolin
`[CH/CH]; Leimen, CH-8750 Glarus (CH).
`
`(74) Attorney: LUSUARDI, Werther, G.; Dr. Lusuardi AG,
`Kreuzbühlstrasse 8, CH-8008 Zurich (CH).
`
`(54) Title: IMPLANT FOR INTERVERTEBRAL SPACE
`
`(57) Abstract
`
`The implant for the intervertebral space consists of an essentially cuboid body with a device for gripping by a tool.
`
`48
`
`

`
`Codes for the identification of PCT designated states in the headers of documents in which international applications are
`published in accordance with PCT.
`
`FOR INFORMATION ONLY
`
`Austria
`AT
`Australia
`AU
`Barbados
`BB
`Belgium
`BE
`Burkina Faso
`BF
`Bulgaria
`BG
`Benin
`BJ
`Brazil
`BR
`Belarus
`BY
`Canada
`CA
`Central African Republic
`CF
`Congo
`CG
`Switzerland
`CH
`Côte d’Ivoire
`CI
`CM Cameroon
`CN
`China
`CS
`Czechoslovakia
`CZ
`Czech Republic
`DE
`Germany
`DK
`Denmark
`ES
`Spain
`FI
`Finland
`FR
`France
`
`Gabon
`GA
`United Kingdom
`GB
`Georgia
`GE
`Guinea
`GN
`Greece
`GR
`Hungary
`HU
`Ireland
`IE
`Italy
`IT
`Japan
`JP
`Kenya
`KE
`Kyrgyzstan
`KG
`Democratic People’s Republic of Korea
`KP
`Republic of Korea
`KR
`Kazakhstan
`KZ
`Liechtenstein
`LI
`Sri Lanka
`LK
`Luxembourg
`LU
`Latvia
`LV
`MC Monaco
`MD Republic of Moldova
`MG Madagascar
`ML Mali
`MN Mongolia
`
`MR Mauritania
`MW Malawi
`NE
`Niger
`NL
`Netherlands
`NO
`Norway
`NZ
`New Zealand
`PL
`Poland
`PT
`Portugal
`RO
`Romania
`RU
`Russian Federation
`SD
`Sudan
`SE
`Sweden
`SI
`Slovenia1
`SK
`Slovakia
`SN
`Senegal
`TD
`Chad
`TG
`Togo
`TJ
`Tajikistan
`TT
`Trinidad and Tobago
`UA
`Ukraine
`US
`United States of America
`UZ
`Uzbekistan
`VN
`Viet Nam
`
`49
`
`

`
`WO 95/08306
`
`1
`
`PCT/CH94/00184
`
`Implant for intervertebral space
`
`The invention concerns an implant for the intervertebral space according to the preamble of
`
`patent claim 1. Such implants are principally intended to promote bone bridges on vertebral
`
`bodies and are put in place following resection of disks or intervertebral disks between the
`
`vertebral body and the spinal column.
`
`It is known that if an intervertebral disk is damaged, it can be removed and the space thereby
`
`produced can be filled with cortico-spongiose bone.
`
`With this method, the vertebral bodies are first spread as far apart from each other as possible
`
`using a spreader. One special technique consists of placing wedge-shaped pieces – so-called
`
`dilators – between the two vertebral bodies, to spread them in stepped fashion apart from each
`
`other. In turn, dilators with diameters that increase in each case by 1 mm are alternately inserted
`
`from the left and right from the posterior. After the greatest possible spreading has been
`
`achieved, the dilators are replaced by the above-mentioned cortico-spongiose bone.
`
`This known technique has the disadvantage that the bone is difficult to manipulate and bring into
`
`the correct position, with corrections being nearly impossible. An additional disadvantage of this
`
`technique is that, in the intervertebral space, a rectangular or cylinder-shaped recess must be cut
`
`away or milled out in order to insert the bone implants between the initially concave sides of the
`
`adjoining vertebral bodies, which is complicated and also causes damage to the vertebral body.
`
`It is the intention of invention to provide a remedy for this. The object of the invention is to
`
`provide an implant for the intervertebral space which, due to its specific shape and the method of
`
`50
`
`

`
`WO 95/08306
`
`2
`
`PCT/CH94/00184
`
`insertion, enables extremely stable locking between the vertebral bodies without damaging the
`
`surface of the bony cover plate of the vertebral body.
`
`An additional object of the invention is to create an implant for the intervertebral space which
`
`can be put in without using dilators.
`
`The invention achieves the object with an implant for the intervertebral space which exhibits the
`
`features of claim 1.
`
`Additional advantageous embodiments of the invention are characterized in the dependent
`
`claims.
`
`Since the implant according to the invention is equipped with a device for grasping using a tool,
`
`an external force can be exerted on it with relatively little effort, which makes it possible to move
`
`the implant after insertion or take it out again if necessary.
`
`The device for grasping using a tool can be configured as attachment points, so that a rotational
`
`force and/or an axial force and/or a lateral force can be exerted on the implant.
`
`In an advantageous embodiment, these attachment points are shaped at least in such as way as to
`
`allow for the exertion of rotational force on the implant, the implant in this case needing to have
`
`different cross-sectional lengths so that it can be squeezed to a greater or lesser extent as a result
`
`of the rotation of the implant or can even be placed absolutely loosely in its position, so that it
`
`can be inserted with no effort between the vertebral bodies, and have the required positional
`
`locking in another position.
`
`51
`
`

`
`WO 95/08306
`
`3
`
`PCT/CH94/00184
`
`In another embodiment, the body of the implant in one plane has a lens-shaped, cut-to-size
`
`profile which for the most part corresponds to the dual concave shape of the sagittal section
`
`surface of the intervertebral space. In this case, the same body in the other plane has principally
`
`parallel, flat or only slightly curved sides and a rounded end, so that it can be pressed into the
`
`intervertebral space without having to cut away an insert in the vertebral body, and without
`
`damaging the edge of the vertebral body.
`
`The implant is preferably hollow, so that it can be filled with bone material.
`
`To better explain the invention, several examples of advantageous embodiments (to which,
`
`however, the invention is not limited) are described in the following, with references to the
`
`appropriate drawings.
`
`In the drawings:
`
`Fig. 1 is a schematic representation of two vertebral bodies which have been spread out away
`
`from each other using two dilators;
`
`Fig. 2 is a cross section along line II-II of Fig. 1, with a dilator being replaced by a small bone
`
`cuboid;
`
`Fig. 3 is a perspective view of an implant according to the invention with a tool that can be used
`
`with it;
`
`Fig. 4 is a view in the direction of arrow F4 of Fig. 3;
`
`Fig. 5 is a view in the direction of arrow F5 of Fig. 3;
`
`52
`
`

`
`WO 95/08306
`
`4
`
`PCT/CH94/00184
`
`Fig. 6 is a cross section along line VI-VI in Fig. 4;
`
`Fig. 7 is a schematic representation of the implant of Fig. 3 following insertion between two
`
`vertebral bodies;
`
`Fig. 8 is a schematic representation of the implant of Fig. 3 following insertion between two
`
`vertebral bodies and rotation by 90°;
`
`Fig. 9 is a schematic representation of an alternative embodiment of the invention with a tool that
`
`can be used with it;
`
`Fig. 10 is a cross section through an implant according to the invention with one rounding;
`
`Fig. 11 is a cross section through an implant according to the invention with two sides rounded
`
`across the diagonal;
`
`Fig. 12 is a cross section through a pairwise arrangement of two mirror-symmetric implants
`
`according to the invention;
`
`Fig. 13 is a schematic representation of pairwise arranged mirror-symmetric implants according
`
`to the invention with the aid of which the intervertebral disk space can be widened;
`
`Fig. 14 is a schematic representation of two implants lying flat in the intervertebral disk space
`
`which are connected anteriorly by a third implant, before and after rotation into the concave area
`
`of the cover plates of the adjoining vertebral bodies;
`
`53
`
`

`
`WO 95/08306
`
`5
`
`PCT/CH94/00184
`
`Fig. 15 is a perspective view of an implant according to the invention with a longitudinal cut to
`
`admit spongy bone material or osteoconductive or osteoinductive material, and transverse
`
`perforation of the walls for bone growth;
`
`Fig. 16 is a perspective view of an implant according to the invention with longitudinally toothed
`
`contact surfaces between implant and bone, the longitudinal toothing being configured such that
`
`rotation of the implant into the concave space of the cover plates is possible only in one
`
`direction;
`
`Fig. 17 is a perspective view of an implant according to the invention with transversely toothed
`
`contact surfaces between implant and bone, the transverse toothing being configured such that
`
`one toothing prevents translational motion in the anterior direction, while the other toothing
`
`prevents translational motion in the posterior direction. The prevention of translational motion in
`
`the anterior direction results in the removal of pressure from the remaining annulus, which,
`
`according to the latest research, is innervated and may therefore react with pain signals to
`
`anterior pressure.
`
`The invention and additional embodiments of the invention are described in the following in
`
`even greater detail using the partially schematic diagrams of numerous configurational examples.
`
`Using Figs. 1 and 2, the known technique will first be described.
`
`When an intervertebral disk is removed, as Fig. 1 shows, the two adjoining vertebral bodies 1
`
`and 2 are spread as far away from each other as possible, so that dilators 3 can be inserted. After
`
`vertebral bodies 1 and 2 are at the desired distance, dilators 3, as shown in Fig. 2, are replaced by
`
`54
`
`

`
`WO 95/08306
`
`6
`
`PCT/CH94/00184
`
`the bone grafts 4. Following the cutting away of a recess in vertebral bodies 1and 2, these bone
`
`grafts 4 must be grafted between the vertebral bodies using a pressure element 5. It is evident
`
`that this technique has the disadvantages identified in the introduction to the description.
`
`The implant according to the invention depicted in Figs. 3-6 overcomes these disadvantages,
`
`permitting it to be inserted quickly and, in addition, if necessary, enabling it to be locked
`
`between two vertebral bodies by applying force. The implant 6 essentially consists of a body 7
`
`with a device 8 to allow grasping using a tool 9. The devices 8 for grasping using a tool 9 is so
`
`configured that rotational, axial and/or lateral force can be exerted on the implant 6, preferably in
`
`all directions.
`
`Preferably, as depicted in Figs. 3-6, the devices 8 are configured such that at least a rotational
`
`force R can be exerted on it and, in connection with that, the implant is so configured that it has
`
`differing diameters or cross-sectional lengths, so that by turning at the cited devices 8, the body 7
`
`of the implant 6 can be inserted between the vertebral bodies 1 and 2 at greater or lesser
`
`distances.
`
`In the configuration in Figs. 3-6, the devices 8 consist of a recess made on the rear axial end 10
`
`of implant 6, in the inner side of body 7. This recess enables a tool 9 to be inserted. As shown,
`
`the recess may consist of an axially many-sided (such as hexagonal) opening, it being necessary
`
`here to use a tool 9 that is equipped with a hexagonal end 11 in the form of a socket wrench.
`
`The use of an opening made in the inner side for inserting a tool 9, i.e., the above-mentioned
`
`recess, offers the advantage that the implant 6 has no protruding disturbing parts.
`
`55
`
`

`
`WO 95/08306
`
`7
`
`PCT/CH94/00184
`
`Preferably, the body 7 has a particular shape with one or more of the following characteristics:
`
`– the front axial end 12 of the body 7 should be configured to be rounded or wedge-shaped, since
`
`this facilitates insertion into the intervertebral space 25;
`
`– the rounding 13 on the front axial end 12 of the body 7 preferably runs only along a cross
`
`section parallel to the smaller diameter D1 – see Fig. 4 – and not along the cross section that is at
`
`a right angle to it, as depicted in Fig. 5;
`
`– the sides 14 and 15 through which the smaller diameter runs are preferably parallel and flat,
`
`except for the rounding 13;
`
`– when viewed from the side, the body 7, as depicted in Fig. 5, has a rounded-off, lens-shaped
`
`profile, and thus a profile that matches the natural dual concave form possessed by an
`
`intervertebral space in the sagittal section. The transitions between the sides 14 and 15 and the
`
`sides 16 and 17 are rounded off;
`
`– the sides 16 and 17 are preferably at least partially flat, and better if completely flat, along a
`
`cross section; the fact that the sides 17 and 18 are at least partially flat in a transverse direction
`
`offers the advantage that they offer stability against tilt in their locked-in state;
`
`– the body 7 has one or more openings or recesses for filling with graft material; as per Figs. 3 to
`
`6, a straight-through opening 18, extending from side 16 to side 17, is preferred; the opening 18
`
`preferably consists of an elongated slit with parallel walls 19 and 20. The abovementioned recess
`
`8 can extend to opening 18 if desired;
`
`– the implant consists of titanium or a titanium alloy suitable for implants;
`
`56
`
`

`
`WO 95/08306
`
`8
`
`PCT/CH94/00184
`
`– the opening 18 or the slit in the body 7 of the implant of Fig. 3 can be made by drilling several
`
`vertical boreholes into the body 7 and milling away the intermediate walls;
`
`– preferably, the im