`
` UNITED STATES PATENT AND TRADEMARK OFFICE
`
` __________________
`
` BEFORE THE PATENT TRIAL AND APPEAL BOARD
`
` __________________
`
` AMNEAL PHARMACEUTICALS, LLC
`
` Petitioner
`
` vs.
`
` SUPERNUS PHARMACEUTICALS, LLC
`
` Patent Owner
`
` U.S. Patent Nos. 8,394,405,
`
` 8,394,406 and 8.206,740
`
` __________________________
`
` Cases IPR2013-00368, IPR2013-00371,
`
` and IPR2013-00372
`
` __________________________
`
` VIDEO DEPOSITION OF JONES WOODROW BRYAN, JR. Ph.D.
`
` Washington, D.C.
`
` Tuesday, April 29, 2014, 9:20 a.m.
`
`Reported by:
`
`Laurie Bangart, RPR, CRR
`
`Ref. No.: 11687
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
` Video Deposition of
`
` JONES WOODROW BRYAN, JR., Ph.D.
`
`Page 2
`
`Held at the offices of:
`
` Paul Hastings
`
` 875 15th Street, NW
`
` Washington, D.C. 20005
`
` (202)551-1700
`
` Taken pursuant to notice, before
`
` Laurie Bangart, Registered Professional
`
` Reporter, Certified Realtime Reporter and
`
` Notary public in and for the District of
`
` Columbia.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`1
`
`2
`
`3 4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`
`
` A P P E A R A N C E S
`
`Page 3
`
`ON BEHALF OF PETITIONER AMNEAL PHARMACEUTICALS:
`
` Sterne Kessler Goldstein Fox
`
` 1100 New York Avenue, NW
`
` Washington, D.C. 20005
`
` (202)371-2600
`
` By: Eldora L. Ellison, Ph.D.
`
` eellison@skgf.com
`
` R. Wilson Trey Powers, Ph.D.
`
` tpowers@skgf.com
`
`ALSO ON BEHALF OF PATENT OWNER SUPERNUS
`
`PHARMACEUTICALS AND THE WITNESS:
`
` Paul Hastings, LLP
`
` 191 North Wacker Drive, 30th Floor
`
` Chicago, Illinois 60606
`
` (312)499-6064
`
` By: Gregory A. Morris, Ph.D.
`
` gregorymorris@paulhastings.com
`
` Evan Diamond, Esq.
`
` evandiamond@paulhastings.com
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`1
`
`2 3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`
`
`Page 4
`
`(Appearances continued)
`
`ALSO ON BEHALF OF PATENT OWNER SUPERNUS
`
`PHARMACEUTICALS AND THE WITNESS:
`
` Foley & Lardner, LLP
`
` 3000 K Street, NW
`
` Washington, D.C. 20007
`
` (202)672-5413
`
` By: Andrew S. Baluch, Esq.
`
` abaluch@foley.com
`
`ALSO PRESENT:
`
` Kim Johnson, Videographer
`
`1
`
`2 3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
` EXAMINATION INDEX
`
` PAGE
`
`EXAMINATION BY MR. POWERS . . . . . . . . . . 7
`
`Page 5
`
` E X H I B I T S
`
`EXHIBIT DESCRIPTION PAGE
`
`Exhibit 2148 Develpment and Licensing
`
` Agreement . . . . . . . . . . 36
`
`Exhibit 2149 Covance Clinical Study Report 40
`
`Exhibit 2146 Declaration of Jones W. Bryan 43
`
`Exhibit 2036 Development Agreement . . . . 44
`
`Exhibit 2147 Periostat XR Timeline . . . . 62
`
`Exhibit 2150 Shire Labs Monthly Project
`
` Report . . . . . . . . . . . . 126
`
`Exhibit 2154 Email from Jones Bryan
`
`
`
`
`
` . . . . . . . . . 142
`
`Exhibit 2155 Letter to
`
` dated October 23, 2002 . . . . 145
`
`Exhibit 2156 Email from Jennifer Wilson . . 163
`
`Exhibit 2157
`
`
`
` . . . 171
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`1
`
`2
`
`3
`
`4 5 6 7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`20
`
`21
`
`22
`
`23
`
`25
`
`
`
`Page 6
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` P R O C E E D I N G S
`
` THE VIDEOGRAPHER: This is tape
`
` number 1 of the videotaped deposition of
`
` Dr. Jones Bryan, taken in the matter of
`
` Amneal Pharmaceuticals, LLC versus Supernus
`
` Pharmaceuticals, LLC, in the US Patent &
`
` Trademark Office before the Patent Trial &
`
` Appeal Board, case number IPR2013-00368, also
`
` IPR 2013-00371 and IPR 2013-00372.
`
` This deposition is being held at
`
` Paul Hastings located at 875 15th Street,
`
` Northwest, Washington, D.C. on April 29, 2014
`
` at approximately 9:20. My name is Kim
`
` Johnson. I am the legal video specialist.
`
` The court reporter is Laurie Bangart, both in
`
` association with TransPerfect Legal
`
` Solutions.
`
` Will counsel please introduce
`
` yourselves and state whom you represent.
`
` DR. POWERS: Sure. My name is Trey
`
` Powers. I'm from the law firm of Sterne,
`
` Kessler, Goldstein & Fox on behalf of Amneal.
`
` DR. ELLISON: Eldora Ellison also
`
` from Sterne Kessler Goldstein & Fox on behalf
`
` of Amneal.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 7
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` DR. MORRIS: Gregory Morris from
`
` Paul Hastings on behalf of Supernus and the
`
` witness.
`
` MR. DIAMOND: Evan Diamond of Paul
`
` Hastings on behalf of Supernus and the
`
` witness.
`
` MR. BALUCH: Andrew Baluch from
`
` Foley & Lardner on behalf of Supernus and the
`
` witness.
`
` THE VIDEOGRAPHER: Would the court
`
` reporter please swear in the witness.
`
` JONES WOODROW BRYAN, JR., Ph.D.,
`
` having been first duly sworn, testified
`
` upon his oath as follows:
`
` EXAMINATION BY COUNSEL FOR AMNEAL
`
`BY DR. POWERS:
`
` Q Good morning, Dr. Bryan.
`
` A Good morning.
`
` Q Thank you for being here with us today
`
`morning.
`
` Would you state your full name for the
`
`record?
`
` A Jones Woodrow Bryan, Jr.
`
` Q Okay, and have you been deposed before?
`
` A I have, yes.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 8
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` Q So you understand that you're being
`
`questioned under oath today?
`
` A I do.
`
` Q It's important that you give us audible
`
`answers, because as you can see, the court
`
`reporter will be transcribing your testimony, so
`
`we ask that instead of nodding your head or
`
`shaking your head, you say yes or no. It's also
`
`better if you don't say "uh-huh" or "huh-uh," as
`
`opposed to -- or instead of that, just say yes or
`
`no.
`
` A Okay.
`
` Q It's also important that we don't talk
`
`over each other. I'll try to let you finish your
`
`answer, and if you'd try to let me finish my
`
`question, it will be a lot easier for the court
`
`reporter.
`
` A Good.
`
` Q And if you don't understand a question
`
`that I ask, would you please ask for
`
`clarification. If you go forward with your
`
`answer, I'll be -- I'll presume that you
`
`understood the question.
`
` A Right.
`
` DR. ELLISON: Can you also speak up
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 9
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` a little bit, please.
`
`BY MR. POWERS:
`
` Q You are very soft spoken, so if you
`
`would please speak up a little bit when you give
`
`an answer, that would be great.
`
` A Okay.
`
` Q So we can take regular breaks as long as
`
`there are no pending questions. Anytime you need
`
`a break, just let me know. As long as there's not
`
`a question pending, I'll be happy to take a break.
`
` A Will do.
`
` Q So this deposition in the IPR context is
`
`a little different than a deposition in a
`
`litigation. This deposition is meant to be really
`
`a conversation between me and you, and your
`
`attorney may object, but you can answer the
`
`question unless instructed not to.
`
` Do you understand?
`
` A I do.
`
` Q Okay.
`
` Is there any reason you can't give full
`
`and truthful testimony today, like medications
`
`you're on or anything like that?
`
` A No.
`
` Q Okay. Thank you.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 10
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` So let's talk a little bit about your
`
`educational background. Where did you attend
`
`college?
`
` A Undergraduate degree from Clemson
`
`University, and then a Ph.D. in pharmaceutical
`
`sciences from the Medical University of South
`
`Carolina.
`
` Q What did you major in at Clemson?
`
` A Zoology.
`
` Q Okay, and what year did you graduate?
`
` A 1986.
`
` Q '86, and you mentioned you had -- you
`
`have a Ph.D. from the Medical University of South
`
`Carolina.
`
` A That's correct.
`
` Q What was your discipline?
`
` A Pharmaceutical sciences.
`
` Q Pharmaceutical sciences, and what years
`
`did you attend that university?
`
` A 1986 through the end of 1990.
`
` Q Okay, and then what did you do after
`
`that, after you left the University of -- sorry --
`
`the Medical University of South Carolina?
`
` A I was employed by Schering-Plough
`
`Pharmaceuticals.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 11
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` Q Okay.
`
` What year did you start at Schering?
`
` A 1991.
`
` Q So what did you do between leaving the
`
`Medical University of South Carolina and starting
`
`with Schering?
`
` A I, I finished my, my educational work at
`
`MUSC at the end of 1990, so I started early in
`
`1991.
`
` Q I see, and what was your title at
`
`Schering?
`
` A I'll have to look back. It was senior
`
`scientist I believe was my first official title.
`
` Q Okay, and what were your
`
`responsibilities at Schering as a senior
`
`scientist?
`
` A I did initial formulation development
`
`work. It was actually in support of the
`
`veterinary medicine division of Schering-Plough.
`
` Q Okay.
`
` What type of -- what kind of dosage
`
`forms were you working on at Schering?
`
` A I worked on immediate release dosage
`
`forms for companion animals.
`
` Q All right, and after you left
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 12
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`Schering -- so how long were you at Schering?
`
` A I was there until 1993.
`
` Q Okay, and where did you go after that?
`
` A AAI.
`
` Q Okay. What is AAI?
`
` A It's a contract pharmaceutical services
`
`firm.
`
` Q Okay. Where is that located?
`
` A Wilmington, North Carolina.
`
` Q What kind of pharmaceuticals -- what was
`
`your role at AAI?
`
` A I was a manager of a formulation
`
`development group.
`
` Q Okay.
`
` Did you work on business development at
`
`that time?
`
` A When I initially joined, I was working
`
`on formulation development, and I transitioned
`
`into a technical director position, which was a
`
`business development function. So I left the
`
`project-related formulation group and became
`
`really a presenter, business development person
`
`representing the formulation development group.
`
` Q So why did you -- I'm sorry. Were you
`
`finished?
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 13
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` A There was a transition from, from a
`
`project-oriented formulation development
`
`responsibility to a business development
`
`responsibility.
`
` Q So when you say "business development
`
`responsibility," what does that entail?
`
` A Talking with prospective customers of
`
`AAI.
`
` Q Okay.
`
` A Presenting the capabilities of the
`
`company.
`
` Q Selling the company's services?
`
` A Right, mm-hmm.
`
` Q And why did you leave AAI?
`
` A Well, over the ensuing several years at
`
`AAI, I continued in business development and
`
`developed an expertise in business development and
`
`licensing, and joined Shine Pharmaceuticals in
`
`January of 2000 to fulfill very much the same
`
`role. Shire had formulation drug delivery
`
`technology expertise, and I was hired to be their
`
`business development person for that function.
`
` Q So what was your title when you got to
`
`Shire?
`
` A Senior director of business development.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 14
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` Q Okay, and you said "very much the same
`
`role" at Shire. Does that mean talking to
`
`potential customers?
`
` A Yes.
`
` Q Selling the company's services?
`
` A Right.
`
` Q Okay, and so what does that, what does
`
`that mean, talking to potential customers?
`
` A At Shire it was specific to identifying
`
`companies that had a need for the application of
`
`drug delivery technologies that Shire possessed,
`
`and, and discussing a business relationship on how
`
`to collaborate on, on working together on product
`
`concepts using the Shire drug delivery technology
`
`platforms.
`
` Q Okay, and what year was that when you
`
`got to Shire?
`
` A January of 2000.
`
` Q Okay, and were you promoted over the --
`
` A I was promoted a few years later. I
`
`don't remember the exact time frame, but yes, I
`
`was promoted.
`
` Q Promoted to what?
`
` A Vice president of business development,
`
`right.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 15
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` Q Were you vice president there at around
`
`2002/2003?
`
` A I don't remember the specific date. It
`
`was sometime between 2000 and end of 2005.
`
` Q Okay, and how many vice presidents were
`
`there at Shire at the time you were promoted?
`
` A I have no idea. Shire, Shire
`
`Pharmaceuticals was a growing organization. I
`
`don't recall how many specific vice presidents
`
`were there.
`
` Q More than five?
`
` A I don't remember a specific number.
`
` Q Was it around -- can you give me a
`
`ballpark?
`
` A It was more than one.
`
` Q More than one. Well, yeah, so do you
`
`know how the vice presidents were broken up into
`
`categories, types of vice presidents that were
`
`there?
`
` A I certainly was aware of certain
`
`departments where there were vice presidents, but
`
`I can't recite the organizational chart to you.
`
` Q Okay, that's fine.
`
` Was there a vice president, for example,
`
`of research and development?
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 16
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` A Yes.
`
` Q Who was that person; do you remember?
`
` DR. MORRIS: Objection. Outside
`
` the scope.
`
` THE WITNESS: I mean that's not
`
` part of my declaration today, but I mean not
`
` to recall individuals 14 years ago . . .
`
`BY DR. POWERS:
`
` Q Do you remember who the person was?
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: Not specifically. I
`
` know individuals that were there during that
`
` period of time. I can't -- what particular
`
` time frame were you referring to if you can
`
` point me to that?
`
`BY DR. POWERS:
`
` Q Yeah, let's go to 2002.
`
` A I don't specifically recall who was head
`
`of development at that time.
`
` Q Okay.
`
` So you said you were promoted to VP at
`
`Shire sometime between 2000 and 2005, I think.
`
` A That's correct.
`
` Q What happened after that? Are you still
`
`employed at Shire?
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 17
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` A I'm no longer with Shire.
`
` Q Okay.
`
` So what happened in your career after
`
`let's say 2005? What happened?
`
` A The division of Shire that I was working
`
`for was spun out of the Shire organization to form
`
`a stand-alone organization.
`
` Q And what's that organization called?
`
` A Supernus Pharmaceuticals.
`
` Q Okay, and do you own any stock in
`
`Supernus?
`
` A I do.
`
` Q How much stock?
`
` A I, I don't think it's pertinent to this
`
`discussion. It's not part of my declaration.
`
` Q Well, sir, today I get to ask the
`
`questions, so if you would please answer mine, I
`
`would appreciate it.
`
` How much stock do you own in Supernus?
`
` DR. MORRIS: Objection, counsel.
`
` Outside the scope of this deposition.
`
` DR. POWERS: Noted.
`
` THE WITNESS: You can find it.
`
` It's public record. You can find SEC
`
` filings.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 18
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`BY DR. POWERS:
`
` Q Okay. Well, I'm asking you.
`
` A I don't recall the specific number of
`
`shares I have at the moment.
`
` Q Can you give me a ballpark?
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: I don't have a number
`
` off the top of my head at the moment.
`
`BY DR. POWERS:
`
` Q All right. So would you say it's more
`
`than 5,000 shares?
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: I don't recall
`
` specific numbers. I'm not --
`
`BY DR. POWERS:
`
` Q But I'm not asking for a specific
`
`number. I'm just asking a ballpark.
`
` How many shares do you own in Supernus?
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: Again, it's public
`
` record, you know. You can find what the
`
` specific numbers are. No need to speculate.
`
`BY DR. POWERS:
`
` Q So will you tell me, though, if it's
`
`over 5,000 shares? I'm just asking for a ballpark
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 19
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`figure of the number of shares you own in
`
`Supernus.
`
` DR. MORRIS: Same objection and
`
` objection to form.
`
` THE WITNESS: Again, it's public
`
` record. If you're curious about what I own,
`
` it's public record. Anyone can go and take a
`
` look at it.
`
`BY DR. POWERS:
`
` Q Do you have an approximate dollar value?
`
` A No.
`
` Q You don't know or you're refusing to
`
`answer the question or --
`
` A I don't have a particular dollar value.
`
` Q Do you have a ballpark for the dollar
`
`value of shares you own in Supernus?
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: I do not.
`
`BY DR. POWERS:
`
` Q You have no idea the value of the shares
`
`that you own in Supernus?
`
` A It's not something I think about day to
`
`day, and so no, I don't have an accurate number at
`
`the moment.
`
` Q Do you have a ballpark number?
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 20
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: I do not.
`
`BY DR. POWERS:
`
` Q Is it more than $20,000 worth of
`
`Supernus stock?
`
` A I don't have a specific number for you.
`
` Q That's not the question that I asked. I
`
`asked if it's more than $20,000 worth of Supernus
`
`stock.
`
` A I don't see the need to speculate on any
`
`dollar amount. I mean, you know, again, it's
`
`public record. It's not like I'm sharing anything
`
`with you that you can't calculate on your own.
`
` Q So at this time here today, you're not
`
`willing to tell us if you own more than $20,000
`
`worth of Supernus stock?
`
` DR. MORRIS: Objection to form.
`
` THE WITNESS: I'm here to talk
`
` about what's in my declaration for this
`
` proceeding, and I don't recall -- in fact, if
`
` I could see a copy of my declaration, you
`
` could point me to where in the declaration
`
` this is a pertinent topic. I'll be glad to
`
` address whatever is in the declaration.
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 21
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`BY DR. POWERS:
`
` Q Dr. Bryan, I'm actually allowed to ask
`
`you about things that go to many issues related to
`
`your declaration, one of which is bias. Your
`
`ownership of Supernus stock goes to that issue,
`
`and I find it strange that you aren't willing to
`
`share with us the ballpark number of Supernus
`
`stock that you own.
`
` DR. MORRIS: Objection to form.
`
` Argumentative.
`
` THE WITNESS: I don't see the point
`
` of me speculating on what the actual number
`
` is when you can see it in public record.
`
` It's an official record.
`
`BY DR. POWERS:
`
` Q It seems as though you're unwilling to
`
`give me any kind of a ballpark number of the
`
`shares of Supernus that you own.
`
` A Because I can't give you the specific
`
`number accurately.
`
` Q I'm not asking for specifics. I'm not
`
`asking for specifics.
`
` A I'm unwilling to share anything that's
`
`unspecific when it's something that you can find
`
`publicly that is specific.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 22
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` Q So are you unable to answer whether or
`
`not you own more than $20,000 worth of Supernus
`
`stock?
`
` A I am unprepared to give you a specific
`
`number, and I'm unwilling to talk about
`
`categorical amounts of stock I own and certainly
`
`any dollar value associated with that.
`
` Q So sitting here today, you're saying
`
`you're unwilling to say whether or not you have
`
`$20,000 worth of Supernus stock or more?
`
` DR. MORRIS: Objection to form.
`
` THE WITNESS: I don't see the point
`
` of understanding and speculating what the
`
` dollar amount is or the number of shares is
`
` when, again, it could be verified by public
`
` record and be absolutely accurate.
`
`BY DR. POWERS:
`
` Q So is it possible that you own $50,000
`
`worth of Supernus stock or more?
`
` A I've answered your question.
`
` Q No, you haven't answered my question.
`
` A My answer is that I'm unwilling to give
`
`an estimate when there is specific information
`
`that is publicly available that you can go in,
`
`anyone can go in and determine it themselves, and
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 23
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`it's not a number that I have specific that I pay
`
`attention to day to day.
`
` Q Do you own more than $5 worth of
`
`Supernus stock?
`
` A I'm sure I do. I don't have a specific
`
`number, though.
`
` Q Do you own more than $5,000 worth of
`
`Supernus stock?
`
` A You've asked this question several
`
`times, and I've given you my answer.
`
` Q I haven't asked this question. Do you
`
`own more than $5,000 worth of Supernus stock?
`
` A I don't know the exact dollar amount
`
`that I own.
`
` Q Sir, do you own more than $5,000 worth
`
`of Supernus stock? Yes or no, or I don't know,
`
`which is a fine answer, too.
`
` A I don't know. I don't know specifically
`
`what I own.
`
` Q But you don't know if you own more than
`
`$5,000?
`
` A I don't know the specific dollar amount
`
`of what I own. It's not something I do day to
`
`day.
`
` Q Okay.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 24
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` So while you were at Shire, did you play
`
`a role in formulation development?
`
` A Not directly, no.
`
` Q Did you ever interpret data related to
`
`formulation development?
`
` A No, not directly.
`
` Q Did you make decisions about strategy
`
`related to formulation development?
`
` DR. MORRIS: Object to form.
`
` THE WITNESS: No.
`
`BY DR. POWERS:
`
` Q Did you play a role in preclinical
`
`formulation decisions?
`
` DR. MORRIS: Object to the form. I
`
` just want to instruct the witness to slow
`
` down a little bit so I can make my
`
` objections.
`
` THE REPORTER: I did not hear the
`
` answer.
`
` THE WITNESS: The answer is no.
`
`BY DR. POWERS:
`
` Q Did you play a role in making regulatory
`
`decisions while you were at Shire?
`
` DR. MORRIS: Objection to form.
`
` THE WITNESS: No.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 25
`
`BY DR. POWERS:
`
` Q Did you play a role in drug feasibility
`
`decisions while you were at Shire?
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: No.
`
`BY DR. POWERS:
`
` Q Did you make decisions about drug
`
`feasibility and strategy?
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: No.
`
`BY DR. POWERS:
`
` Q Did you play a role in dosage form
`
`development decisions?
`
` DR. MORRIS: Same objections.
`
` THE WITNESS: No.
`
`BY DR. POWERS:
`
` Q Did you ever interpret data on dosage
`
`form development and discuss strategy forward with
`
`the scientists?
`
` DR. MORRIS: Same objection.
`
` THE WITNESS: I was not responsible
`
` for interpreting data. I received their
`
` expert opinion on strategy as a result of
`
` their evaluation and generation of data.
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 26
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`BY DR. POWERS:
`
` Q Okay.
`
` Did you ever work on accelerated
`
`stability projects?
`
` DR. MORRIS: Same objection.
`
`BY DR. POWERS:
`
` Q In a scientific role?
`
` A No.
`
` Q While you were at Shire, did you ever
`
`work on the validation of analytical methods?
`
` A No.
`
` Q Did you ever work on any of the
`
`preparation of any regulatory documents while you
`
`were at Shire?
`
` A No.
`
` Q Did you ever help oversee the
`
`manufacture of GMP batches while you were at
`
`Shire?
`
` A No.
`
` Q Have you ever helped formulate a
`
`doxycycline product at any time?
`
` DR. MORRIS: Objection. Form.
`
` THE WITNESS: Not that I recall.
`
`BY DR. POWERS:
`
` Q Did you know Rong-Kun Chang?
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 27
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` A Yes.
`
` Q And he also went by "Richard," right?
`
` A Yes.
`
` Q How did you know him?
`
` A He was a formulator at Shire when I
`
`joined, and he worked, worked at Shire, Shire Labs
`
`while I was also employed by Shire Labs.
`
` Q And how long did you know him? Do you
`
`still know him?
`
` DR. MORRIS: Objection. Form.
`
`BY DR. POWERS:
`
` Q Let me just clarify that question.
`
` A I knew him then and I know him now. I
`
`know of him.
`
` Q When is the last time that you spoke to
`
`Dr. Chang?
`
` A When he was employed with Shire Labs.
`
` Q Do you remember when that was, about?
`
` A I really don't, but he's been gone a
`
`number of years.
`
` Q And what about Arash Raoufinia? I have
`
`trouble with that name.
`
` A As do I.
`
` Q Raoufinia. Did you know him?
`
` A I did, yes.
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 28
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` Q And how did you know him?
`
` A He worked within the formulation drug
`
`delivery sciences group at Shire when I was there
`
`for a period of time.
`
` Q About how long did you know him?
`
` A I couldn't say specifically. He was, he
`
`was part of our team in that, somewhere in the
`
`time frame between the January 2000 and 2005, but
`
`I can't tell you specifically the dates he was
`
`there.
`
` Q When was the last time that you spoke to
`
`Dr. Raoufinia?
`
` A Whenever he left the organization. I
`
`haven't really remained in contact with him.
`
` Q Did you leave at the same time when
`
`Shire was spun out?
`
` A I don't recall whether he made the
`
`transition from Shire over to Supernus with us or
`
`not.
`
` Q Same question for Dr. Chang. Was that
`
`about the time frame --
`
` A He did make a transition from Shire to
`
`Supernus, and so he was with Supernus for some
`
`period of time post-spinout from Shire, yes. I
`
`can't recall how long that was, but he did, he did
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 29
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`stay with the organization, the new organization.
`
` Q Gotcha, and what about Niraj Shah; did
`
`you know him?
`
` A I know the name and I remember him. I,
`
`I don't recall what time frame. Again, he was, he
`
`was at Shire Labs during that period of time, but
`
`I don't remember the, the longevity of how long he
`
`was with the organization.
`
` Q Do you remember what his role was at
`
`Shire?
`
` A Not specifically, no.
`
` Q Do you remember generally what
`
`Dr. Shah's role was at Shire?
`
` A I know he worked closely with the drug
`
`delivery sciences group. In what specific
`
`capacity, I don't remember.
`
` Q Okay.
`
` When, about, was the last time you spoke
`
`to Dr. Shah?
`
` A I truly don't recall. It would have
`
`been the same sort of time frame where Shire Labs
`
`separated from and became Supernus.
`
` Q Okay.
`
` So it's fair to say you haven't seen any
`
`of these gentlemen lately?
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 30
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` A Yes, that would be correct.
`
` Q Okay.
`
` Do you know where they work now, any,
`
`any of them?
`
` A I really don't, no.
`
` Q Okay.
`
` Have you had any communication with
`
`Dr. Chang in the past few years since he left
`
`Shire?
`
` A I haven't. Not that I recall.
`
` Q And how about with Dr. Raoufinia; have
`
`you had any communication with him since he left
`
`Supernus or Shire?
`
` A Again, not that I recall, no.
`
` Q And same question for Dr. Shah.
`
` A Not that I recall.
`
` Q Dr. Bryan, what did you do in preparing
`
`for this deposition today?
`
` And let me just be clear. I'm not
`
`trying to get to any kind of privileged
`
`communication between you and your counsel.
`
` DR. MORRIS: Objection. I'm going
`
` to instruct the witness not to answer on the
`
` basis of attorney/client privilege.
`
` DR. POWERS: Not to answer the
`
`TransPerfect Legal Solutions
`212-400-8845 - Depo@TransPerfect.com
`
`
`
`Page 31
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
` question at all, counsel?
`
` DR. MORRIS: Yeah, if you want to
`
` ask more specific questions, I'll let him
`
` answer, but that's a broad question and could
`
` get into privileged information.
`
`BY DR. POWERS:
`
` Q Dr. Bryan, what documents did you review
`
`in preparation for your deposition today?
`
` DR. MORRIS: Again, I'm going to
`
` instruct the witness not to answer on the
`
` basis of attorney/client privilege. If you
`
` want to ask him about a specific document, if
`
` he reviewed it, then that would be fine, but
`
` having him char