(cid:38)(cid:68)(cid:83)(cid:86)(cid:88)(cid:74)(cid:72)(cid:79)(cid:3)(cid:40)(cid:91)(cid:75)(cid:76)(cid:69)(cid:76)(cid:87)(cid:3)(cid:20)(cid:19)(cid:21)(cid:21)
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`Page 1 of 3
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`Patented July as, 1931
`
`1,815,902
`
`UNITED STATES-
`
`PATENT OFFICE
`
`£300 15'. ELIZEY, OI BUFFALO, NEW YORK. ”SIG-NOB- II'O NATIONAL mm ‘7
`CHEMICAL COMPANY, INC" OF NEW YORK, N. Y, A CORPORATION 01' NEW YORK
`
`DEVICE FOR ADHINISTEBINQ 1113131st
`
`Application filed July 18, Elli”. Earls] Ho. $08.18!.
`
`This invention relates to an. improved
`composite pellet for the oral administration
`of such medicamentsas are sensitive to the
`contents of the stomach, and more particu-
`5 larly, for the administration of tetraiodo-
`henolphthalein in a form capable of assimi-
`ljation y the walls of the duodenum.
`.
`The oral administration of ,tetraiodo-
`phenolphthalein, which substance is valu-
`10 able in cholecysto a-phy, has been accom~
`panied by many
`ifliculties, because of its
`reaction with the acids of the stomach.
`The sodium salt of tetraiodophenolphtha-
`lein is readily soluble in water but in the
`15 presence of mineral acids, such as hydro-
`chloric acid, the free acid of the tetraiodo-
`phenolphthalein - which is 'very insoluble in
`water, is iormed. If the sodium salt is ad-
`.ministered orally as for example in a plain
`20 gelatin capsule, the acid gastric juice of the
`_ stomach permeates the capsule and converts
`the salt into the insoluble free acid, a film of
`which forms around the periphery of the
`d c. This film retains the general contour
`25 o the capsule and is quite hard in consist-
`ency. Upon passing into the duodenum, these
`capsule "shaped'masses of the free acid are
`' not all changed into the soluble salt by the
`alkaline intestinal juices, only a very small
`an amount of the free acid being converted and
`available for absorption.
`-
`It has 'been found that the difficulties in
`administering such substances may be sub-
`stantially eliminated by the use of a' double
`walled shell or capsule as shown in the ac-
`companying drawmgs, in which
`Fig. 1 is a cross-section of one form of the
`invention,
`\
`-
`Fig. .2 a crow section of another form of
`the invention, and
`Fig. 3 a horizontal section on the line 3-—3
`of Fig. 2-.
`-In the drawings, wherein like reference
`figures designate corresponding parts, 1 is a
`capsule containing a medicament 2 and sur-
`rounded by a second ca sule 3. In the stom-
`ach, capsule 3 may be-
`issolved but the inner
`capsule 1 will pass in to the intestines sub-
`stantiall unaltered.
`If a p ysiologically harmless alkaline ma-
`
`85
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`Page 2 of 3
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`70
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`76
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`terial is placed in the annular space between
`the inner capsule 1 and the outer calpsule 3,
`as shown at 4, Fi
`. 2 and 3, still fort er pr
`tection is afiorde the medicament contained
`in the inner capsule. The layer of alkaline
`material surrounding the inner or central
`core or capsule containing the medicament is
`adapted to maintain it in an unaltered condi-.
`tion by preventin
`or hindering the acid
`gastric juice of t e stomach from disin-
`tegrating it, and in consequence the capsule
`asses on to the intestinal tract where it is
`issolved by the alkaline intestinal fluids.
`As suitable alkaline material placed in the
`space between the inner and outer capsule
`may be mentioned, for example, the alkali—
`metal carbonates such as sodium bicarbonate
`and other compounds such as sodium borate,
`magnesium oxide, etc.
`The capsules may be made of gelatine or
`any other material which is physiologically
`harmless and dissolves or disintegrates in the
`digestive-tract, such as starch, and any desir-
`able shapje or' form of capsule may be used. .
`. It is o vious that changes in size, propor~
`tion, material and minor points may be made
`without departing from the spirit-and scope
`of the a pended claims.
`It wi
`be obvious that any suitable in-
`testinal medicaments may be em loyed in
`accordance with the invention in pill-ice ofthe
`specific material above referred-to.
`Byway of further example, other organic
`intestinal medicaments which might be used,
`einb dying my invention, are:
`A 1i metal salts of benzoic acid.
`Alkali metal salts of salicylic acid.
`Oincophen.
`Pancreatin._
`Other materials or medicaments which-We
`might be used in accordance with my inven-
`tion will be apparent to physicians and others
`skilled in the art without further illustration
`I claim:
`'
`1. An improved composite pellet for oral
`administration of organic medicaments for
`intestinal treatment which are alterable by
`the fluids of the stomach which comprises an
`inner 'shell of a material soluble in the in-
`testinal fluid containing the intestinal organic
`
`80
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`'85
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`Ill}
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`Page 2 of 3
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`

`2
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`1,515,909;
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`'
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`'
`
`medicament and an innocuous alkaline ma-
`terial surroundin the shell of suflicient thick-
`ness to protect t e capsule dunng its pas-
`sage through the stomach. .
`2. An improved composite pellet for oral
`administration of organic medicaments for
`intestinal treatment which are alterable by
`the fluids of thostomach which com rises a 5
`double shell eafisnle of a-material so able in
`10 the intestinal
`nid, having the inner shell
`containing the hatestinal organic medicament
`and an innocuous alkaline material soluble
`in the stomach fluids between the shells of
`sufficient thickness to protect the inner shell
`15 durin its passage through the stomach.
`3.
`n improved composite pellet for oral
`administration of intestinal organic medica-'
`meats which are alterable by the fluids of the
`stomach which comprises an inner shell
`20 soluble in the intestinal fluid containin a
`sodium compound of tetraiodophenolpht a-
`lein and a layer of sodium bicarbonate sur-
`rounding said shell of sufficient thickness
`to protect the inner shell during its pas-
`gfl sag-although the stomach.
`testimony whereof I aflix my si
`ESCO F. E
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`-
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`_
`
`ature.
`Y:
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`(5
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`P ge3of3
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`Page 3 of 3
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