`
`PubMed
`
`Display Settings: Abstract
`
`J Int Acad Periodontol. 2000 Jan;2(1):3-8.
`Effects on the clinical indices and gingival crevicular fluid enzyme activities of the
`cyclical regimen of low-dose doxycycline therapy for adult periodontitis.
`Alptekin NO, Kurtoglu F, Serpek B, Duran I, Gözlü M.
`Department of Periodontology, Faculty of Dentistry, Selçuk University, Konya, Turkey. alptekin@karatay1cc.selcuk.edu.tr
`
`Abstract
`The purpose of this study was to determine the effect of cyclic regimen of low dose doxycycline (20 mg) or
`placebo therapy following scaling and root planing on clinical parameters and crevicular fluid alkaline
`phosphatase, aspartate aminotransferase, alanine aminotransferase and elastase activities. Fifteen adults (13
`males, 2 females) with moderate to advanced adult periodontitis were recruited for the study. The LDD-treated
`group (n = 8 subjects) self administered low dose doxycycline b.i.d. (20 mg, p.o.) from time (treatment) to 2
`months and then no drug from 2 to 4 months and finally low-dose doxycycline b.i.d. from 4 to 6 months (i.e.
`"cyclical" regimen). The placebo-treated group (n = 7 subjects) was asked to take placebo capsules (containing
`inactive filler; i.e. starchflour) b.i.d. according to the same "cyclical" regimen. No differences were found between
`LDD- and placebo-treated groups regarding any of the clinical parameters and gingival crevicular fluid enzyme
`activities. The relative attachment gain was significantly improved in both groups. The "cyclical" regimen of low-
`dose doxycycline was not found to reduce alkaline phosphatase, aspartate aminotransferase, alanine
`aminotransferase and elastase activities in gingival crevicular fluid of the adult periodontitis patients over a 6-
`month time period.
`
`PMID: 12666979 [PubMed - indexed for MEDLINE]
`
`Publication Types, MeSH Terms, Substances
`
`LinkOut - more resources
`
`Page 1 of 1
`
`(cid:38)(cid:68)(cid:83)(cid:86)(cid:88)(cid:74)(cid:72)(cid:79)(cid:3)(cid:40)(cid:91)(cid:75)(cid:76)(cid:69)(cid:76)(cid:87)(cid:3)(cid:20)(cid:19)(cid:20)(cid:21)
`
`6/5/2013
`
`
Accessing this document will incur an additional charge of $.
After purchase, you can access this document again without charge.
Accept $ Charge
Still Working On It
This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.
Give it another minute or two to complete, and then try the refresh button.
A few More Minutes ... Still Working
It can take up to 5 minutes for us to download a document if the court servers are running slowly.
Thank you for your continued patience.
This document could not be displayed.
We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.
Your account does not support viewing this document.
You need a Paid Account to view this document. Click here to change your account type.
Your account does not support viewing this document.
Set your membership
status to view this document.
With a Docket Alarm membership, you'll
get a whole lot more, including:
- Up-to-date information for this case.
- Email alerts whenever there is an update.
- Full text search for other cases.
- Get email alerts whenever a new case matches your search.
One Moment Please
The filing “” is large (MB) and is being downloaded.
Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.
Your document is on its way!
If you do not receive the document in five minutes, contact support at support@docketalarm.com.
Sealed Document
We are unable to display this document, it may be under a court ordered seal.
If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.
Access Government Site
