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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· · · · IN THE UNITED STATES DISTRICT COURT
`· · · · ·FOR THE SOUTHERN DISTRICT OF NEW YORK
`·2
`· · · · · · · · · · · · - - - - -
`·3
`· · ·KOWA COMPANY, LTD., ET AL.· · CIVIL ACTION NO.
`·4· · · · · · ·Plaintiffs,· · · · ·14-CV-2647(PAC)
`· · · · · · · ·v.
`·5· ·MYLAN, INC., ET AL.,
`· · · · · · · ·Defendant
`·6
`· · · · · · · · · · · · - - - - -
`·7· ·KOWA COMPANY, LTD., ET AL.· · CIVIL ACTION NO.
`· · · · · · · ·Plaintiffs,· · · · ·14-CV-2758(PAC)
`·8· · · · · · ·v.
`· · ·AMNEAL PHARMACEUTICALS, LLC,
`·9· · · · · · ·Defendant
`10· · · · · · · · · · · - - - - -
`11· ·KOWA COMPANY, LTD., ET AL.· · CIVIL ACTION NO.
`· · · · · · · ·Plaintiffs,· · · · ·14-CV-2759(PAC)
`12· · · · · · ·v.
`· · ·ORIENT PHARMA, INC., LTD.,
`13· · · · · · ·Defendant
`14· · · · · · · · · · · - - - - -
`15· ·KOWA COMPANY, LTD., ET AL.· · CIVIL ACTION NO.
`· · · · · · · ·Plaintiffs,· · · · ·14-CV-2760(PAC)
`16· · · · · · ·v.
`· · ·ZYDUS PHARMACEUTICALS (USA)
`17· ·INC., et al.
`· · · · · · · ·Defendants
`18
`· · · · · · · · · · · · - - - - -
`19
`· · ·KOWA COMPANY, LTD., ET AL.· · CIVIL ACTION NO.
`20· · · · · · ·Plaintiffs,· · · · ·14-CV-5575 (PAC)
`· · · · · · · ·v.
`21· ·SAWAI USA, INC., ET AL.,
`· · · · · · · ·Defendants
`22
`· · · · · · · · · · · · - - - - -
`23
`24· ·Video Deposition of ANTHONY PALMIERI III, Ph.D.
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`DTI Court Reporting Solution - BostonDTI Court Reporting Solution - Boston
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· · · · · · · · · · · - - - - -
`·2· ·KOWA COMPANY, LTD., ET AL.· · CIVIL ACTION NO.
`· · · · · · · ·Plaintiffs,· · · · ·14-CV-7394(PAC)
`·3· · · · · · ·v.
`· · ·APOTEX, INC., ET AL.,
`·4· · · · · · ·Defendants
`·5· · · · · · · · · · · - - - - -
`·6· ·KOWA COMPANY, LTD., ET AL.· · CIVIL ACTION NO.
`·7· · · · · · ·Plaintiffs,· · · · ·15-CV-3935(PAC)
`· · · · · · · ·v.
`·8· ·LUPIN LTD, ET AL.,
`· · · · · · · ·Defendants
`·9
`· · · · · · · · · · · · - - - - -
`10
`11· · · · · · ·Wednesday, October 19, 2016
`12
`· · · · · · · · · · · · - - - - -
`13
`14· · · · · · ·Video Deposition of ANTHONY PALMIERI,
`15· ·III, Ph.D., taken at the law offices of Budd
`16· ·Larner, 150 John F. Kennedy Parkway, Short
`17· ·Hills, New Jersey, commencing at 9:09 a.m., by
`18· ·and before Robin L. Clark, Registered
`19· ·Professional Reporter and Notary Public in and
`20· ·for the State of New Jersey.
`21· · · · · · · · · · · - - - - -
`22
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· ·APPEARANCES:
`·2
`· · · · · · · ·MINTZ, LEVIN, COHN, FERRIS, GLOVSKY
`·3· · · · · · ·AND POPEO, P.C.
`· · · · · · · ·BY: THOMAS H. WINTNER, ESQ.
`·4· · · · · · ·One Financial Center
`· · · · · · · ·Boston, Massachusetts 02111
`·5· · · · · · ·617-348-1625
`· · · · · · · ·twintner@mintz.com
`·6· · · · · · · · · · · ·For the Plaintiffs
`·7
`· · · · · · · ·MINTZ, LEVIN, COHN, FERRIS, GLOVSKY
`·8· · · · · · ·AND POPEO, P.C.
`· · · · · · · ·BY: KEVIN N. AINSWORTH, ESQ.
`·9· · · · · · ·Chrysler Center
`· · · · · · · ·666 Third Avenue
`10· · · · · · ·New York, New York 10017
`· · · · · · · ·212-935-3000
`11· · · · · · ·kainsworth@mintz.com
`· · · · · · · · · · · · ·For the Plaintiffs
`12
`13· · · · · · ·BUDD LARNER
`· · · · · · · ·BY:· BY: JENNIFER N. SCARPATI, ESQ.
`14· · · · · · ·150 John F. Kennedy Parkway
`· · · · · · · ·Short Hills, New Jersey 07078
`15· · · · · · ·973-379-4800
`· · · · · · · ·jscarpati@buddlarner.com
`16· · · · · · · · · · · ·For the Defendant,
`· · · · · · · ·Amneal Pharmaceuticals, LLC
`17
`18· · · · · · ·MADDOX EDWARDS, PLLC
`· · · · · · · ·BY:· STEVEN MADDOX, ESQ.
`19· · · · · · ·1900 K Street, NW, Suite 725
`· · · · · · · ·Washington, D.C. 20006
`20· · · · · · ·202-830-0238
`· · · · · · · ·smaddox@meiplaw.com
`21· · · · · · · · · · · ·For the Defendant,
`· · · · · · · ·Amneal Pharmaceuticals, LLC
`22
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`DTI Court Reporting Solution - BostonDTI Court Reporting Solution - Boston
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· ·APPEARANCES, continued:
`·2
`· · · · · · · ·WITHERS BERGMAN, LLP
`·3· · · · · · ·BY:· HANS-PETER HOFFMANN, ESQ.
`· · · · · · · ·1700 East Putnam Avenue, Suite 400
`·4· · · · · · ·Greenwich, Connecticut 06870
`· · · · · · · ·203-302-4100
`·5· · · · · hans-peter.hoffmann@withersworldwide.com
`· · · · · · · · · · · · ·For the Defendant,
`·6· · · · · · ·Zydus Pharmaceuticals USA, Inc.
`·7
`· · · · · · · ·ALSTON & BIRD, LLP
`·8· · · · · · ·BY:· NATALIE CLAYTON, ESQ.
`· · · · · · · ·90 Park Avenue
`·9· · · · · · ·New York, New York 10016
`· · · · · · · ·212-210-9573
`10· · · · · · ·natalie.clayton@alston.com
`· · · · · · · · · · · · ·For the Defendant, Orient
`11· · · · · · ·Pharma Co., Ltd.
`12
`· · ·ALSO PRESENT:
`13
`· · · · · · · ·MARCELO RIVERA, Videographer
`14
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· · · · · · · THE VIDEOGRAPHER:· This is
`·2· ·DVD number one of the video deposition
`·3· ·of Dr. Anthony Palmieri in the matter
`·4· ·of Kowa Company, Ltd., et al. versus
`·5· ·Amneal Pharmaceuticals, LLC, et al. in
`·6· ·the United States District Court
`·7· ·Southern District of New York.
`·8· · · · · · · This deposition is being
`·9· ·held at the law offices of Budd Larner
`10· ·located at 150 John F Kennedy Parkway,
`11· ·Short Hills, New Jersey on October 19,
`12· ·2016, at approximately 9:09 p.m.· My
`13· ·name is Marcelo Rivera from DTI Global.
`14· ·The court reporter is Robin Clark in
`15· ·association with DTI Global.· Will
`16· ·present counsel please introduce
`17· ·themselves for the record.
`18· · · · · · · MR. WINTNER:· Tom Wintner
`19· ·from Mintz Levin in Boston on behalf of
`20· ·the Kowa and Nissan plaintiffs.· Also
`21· ·with me today is Kevin Ainsworth from
`22· ·the New York offices of Mintz Levin.
`23· · · · · · · MS. SCARPATI:· Jennifer
`24· ·Scarpati of Budd Larner, PC
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· ·representing defendant, Amneal
`·2· ·Pharmaceuticals, LLC.
`·3· · · · · · · MS. CLAYTON:· Natalie
`·4· ·Clayton with Austin and Bird
`·5· ·representing defendant, Orient
`·6· ·Pharmaceuticals.
`·7· · · · · · · MR. MADDOX:· Steven Maddox
`·8· ·from Maddox Edwards, PLLC representing
`·9· ·Amneal as well.
`10· · · · · · · MR. HOFFMANN:· Peter
`11· ·Hoffmann for Zydus with Withers.
`12· · · · · · · THE VIDEOGRAPHER:· Will the
`13· ·court reporter please swear in the
`14· ·witness.
`15· · · · · · · MS. CLARK:· Do you want to
`16· ·raise your right hand, please?· Do you
`17· ·swear the testimony you are about to
`18· ·give in this deposition will be the
`19· ·truth, the whole truth, and nothing but
`20· ·the truth, so help you God?
`21· · · · · · · THE WITNESS:· Yes.
`22· · · · · · · - - - - -
`23· · · ·ANTHONY PALMIERI, III, Ph.D.,
`24· ·having been duly sworn, was examined
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· ·I think to a person such as myself, an
`·2· ·enantiomer would be one, a stereospecific
`·3· ·confirmation of a compound.
`·4· · · · · Q.· ·And you say that you think that
`·5· ·would be the definition to a person such as
`·6· ·yourself.· Would that also be the same
`·7· ·definition that would be understood by a person
`·8· ·of ordinary skill in the art?
`·9· · · · · A.· ·I believe so, yes.· As I recall
`10· ·sitting here today, yes.
`11· · · · · Q.· ·What's your definition,
`12· ·Dr. Palmieri of the term "diastereomer"?
`13· · · · · A.· ·As I recall sitting here today and
`14· ·of course, I would confirm it, it is where
`15· ·there are two configurations, but that's
`16· ·sitting here today off the top of my head.
`17· · · · · Q.· ·Where there are two configurations
`18· ·of what?
`19· · · · · A.· ·Two configurations of the way the
`20· ·atoms are oriented in the molecule, the
`21· ·isomers.
`22· · · · · Q.· ·What's the difference between an
`23· ·enantiomer and a diastereomer?
`24· · · · · A.· ·I don't recall sitting here today,
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· ·I'm sorry.
`·2· · · · · Q.· ·You have no opinion?
`·3· · · · · · · · · · · MS. SCARPATI:· Objection.
`·4· · · · · · · · · · · THE WITNESS:· That's not
`·5· · · · · ·what I said.· I don't recall sitting
`·6· · · · · ·here today.· I think like any good
`·7· · · · · ·scientist would do, they would go to a
`·8· · · · · ·reference to be certain that their
`·9· · · · · ·opinion or their definition is what is
`10· · · · · ·generally accepted.
`11· ·BY MR. WINTNER:
`12· · · · · Q.· ·So sitting here as an expert
`13· ·witness today, you would need to consult with a
`14· ·reference in order to tell me what the
`15· ·difference between a diastereomer and an
`16· ·enantiomer is?
`17· · · · · · · · · · · MS. SCARPATI:· Object to the
`18· · · · · ·form.
`19· · · · · · · · · · · THE WITNESS:· That's not
`20· · · · · ·what I said.· What I said was although
`21· · · · · ·I have a general understanding, sitting
`22· · · · · ·here today or a person of ordinary
`23· · · · · ·skill of the art would say, yes, I
`24· · · · · ·believe I know what it is, but I want
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`·1· ·ester, but not a lactone?
`·2· · · · · Q.· ·Do you know what a lactone is,
`·3· ·Dr. Palmieri?
`·4· · · · · A.· ·Sitting here today, I have a
`·5· ·recollection of it, but as any good
`·6· ·pharmaceutical scientist would, I would refer
`·7· ·back to a reference.
`·8· · · · · Q.· ·And sitting here today, what is
`·9· ·your recollection of what a lactone is?
`10· · · · · A.· ·I don't, I don't recall.· It's
`11· ·irrelevant to my, my conclusions in my reports.
`12· ·I don't address that in my report.· It's -- I
`13· ·don't think it's relevant and at the same time,
`14· ·sitting here today, in this environment, I
`15· ·don't recall.· I'd go back to a reference.
`16· ·It's that simple.· Any good scientist would go
`17· ·back to a reference.
`18· · · · · Q.· ·If you don't know sitting here
`19· ·today what a lactone is, Dr. Palmieri, how is
`20· ·it that you can offer an opinion as to whether
`21· ·or not the compound depicted in claim 1 of the
`22· ·'953 patent could be converted to a lactone?
`23· · · · · · · · · · · MS. SCARPATI:· Object to the
`24· · · · · ·form.· Mischaracterizes.
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`Page 185
`·1· · · · · A.· ·As I recall, I believe that to be
`·2· ·correct, yes.
`·3· · · · · Q.· ·And did you make your own
`·4· ·determination as to what the priority date of
`·5· ·the Roth '995 patent, Exhibit 12, is?
`·6· · · · · A.· ·I don't recall.· I recall
`·7· ·discussing it with, I may have discussed it
`·8· ·with counsel, but I don't recall.· It states
`·9· ·here that it gives me the date of July 12,
`10· ·1989.
`11· · · · · · · · · · · MS. SCARPATI:· I believe you
`12· · · · · ·mean the 21st.
`13· · · · · · · · · · · THE WITNESS:· Excuse me,
`14· · · · · ·July 21st of 1989.· Good catch.
`15· ·BY MR. WINTNER:
`16· · · · · Q.· ·Thank you.· I would like you to
`17· ·turn to Exhibit 12, the '995 patent.· And in
`18· ·particular, I'd like you to turn to the Scheme
`19· ·1 that's shown in columns three and four of
`20· ·that patent.
`21· · · · · A.· ·Yes.
`22· · · · · Q.· ·Are you with me, Dr. Palmieri?
`23· · · · · A.· ·I see Scheme 1, which is below
`24· ·columns 3 and 4 of the '995 patent, yes.
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`ANTHONY PALMIERI, III, PH.D. - 10/19/2016ANTHONY PALMIERI, III, PH.D. - 10/19/2016
`Page 186
`·1· · · · · Q.· ·And do you see in Scheme 1, that
`·2· ·there's a reaction and there's a molecule on
`·3· ·the left that is treated with phenethylamine to
`·4· ·form the molecule on the right?
`·5· · · · · A.· ·I believe that's correct, yes.
`·6· · · · · Q.· ·Okay.· And the molecule on the
`·7· ·right under Scheme 1 after step A, would you
`·8· ·describe that molecule as an amide or a salt?
`·9· · · · · A.· ·As an amide or a salt?· Sitting
`10· ·here today, I don't recall.· I certainly see a
`11· ·nitrogen in that.· Whether or not one would
`12· ·call it a salt or not, I believe it to be a
`13· ·free acid.· But I'm not exactly sure.
`14· · · · · Q.· ·So --
`15· · · · · A.· ·I'm not sure, I'm just not sure
`16· ·looking at it again today.
`17· · · · · Q.· ·You can put that document away.· In
`18· ·paragraph 40 of your reply expert report.
`19· · · · · A.· ·I just wanted to make sure it was
`20· ·off.· That's all.
`21· · · · · Q.· ·Is everything okay, Mr. Palmieri?
`22· · · · · A.· ·Yes, I just wanted to make sure my
`23· ·phone was off so it did not interrupt our
`24· ·discussions.
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