`
`Stephen M. Orlofsky
`David C. Kistler
`New Jersey Resident Partners
`BLANK ROME LLP
`301 Carnegie Center, 3d Floor
`Princeton, NJ 08540
`Telephone: (609) 750-7700
`
`William C. Jackson
`BOIES, SCHILLER & FLEXNER LLP
`5301 Wisconsin Ave, NW
`Washington, DC 20015
`
`Douglas Carsten
`WILSON SONSINI GOODRICH & ROSATI
`12235 El Camino Real
`Suite 200
`San Diego, CA 92130
`
`
`IN THE UNITED STATES DISTRICT COURT
`FOR THE DISTRICT OF NEW JERSEY
`
`
`
`Civil Action No. 3:14-cv-5499
`(PGS)(LHG)
`
`
`
`DECLARATION OF ROBERT
`DELAFIELD IN SUPPORT OF
`PLAINTIFF’S OPENING CLAIM
`CONSTRUCTION BRIEF
`
`
`
`
`
`UNITED THERAPEUTICS
`CORPORATION,
`
`Plaintiff,
`
`
`
`
`v.
`
`
`
`SANDOZ, INC.,
`
`Defendant.
`
`
`
`
`
`
`
`
`
`
`
`
`
`Case 3:14-cv-05499-PGS-LHG Document 42-1 Filed 07/07/15 Page 2 of 5 PageID: 583
`
`I, Robert A. Delafield II, declare the following:
`
`1.
`
`I am an attorney at Wilson Sonsini Goodrich & Rosati, counsel to Plaintiff United
`
`Therapeutics Corporation (“United Therapeutics”). I submit this Declaration in support of United
`
`Therapeutics’ Opening Claim Construction Brief.
`
`2.
`
`Attached hereto as Exhibit 1 is a true and correct copy of U.S. Patent No. 8,497,393,
`
`bearing Bates numbers UTC_REM_II_000003353 – UTC_REM_II_000003369.
`
`3.
`
`Attached hereto as Exhibit 2 is a true and correct copy of an excerpt from Zumdahl,
`
`Chemistry, p. A26 (1986), bearing Bates numbers UTC_REM_II_000001645 –
`
`UTC_REM_II_000001647.
`
`4.
`
`Attached hereto as Exhibit 3 is a true and correct copy of an excerpt from Aulton,
`
`Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, pp. 338-341 (3rd ed. 2007),
`
`bearing Bates numbers UTC_REM_II_000001755 – UTC_REM_II_000001758.
`
`5.
`
`Attached hereto as Exhibit 4 is a true and correct copy of an excerpt from Richet, The
`
`Physical Basis of Thermodynamics with Application to Chemistry, pp. 285-286 (2001), bearing
`
`Bates numbers UTC_REM_II_000005495 – UTC_REM_II_000005498.
`
`6.
`
`Attached hereto as Exhibit 5 is a true and correct copy of an excerpt from Brown, et
`
`al., Chemistry: The Central Science, p. G-1 (9th ed. 2003), bearing Bates numbers
`
`UTC_REM_II_000001584 – UTC_REM_II_000001586.
`
`7.
`
`Attached hereto as Exhibit 6 is a true and correct copy of an excerpt from March, et
`
`al., March’s Advanced Organic Chemistry, pp. 327-332 (5th ed. 2001), bearing Bates numbers
`
`UTC_REM_II_000001587 – UTC_REM_II_000001594.
`
`
`
`-2-
`
`
`
`Case 3:14-cv-05499-PGS-LHG Document 42-1 Filed 07/07/15 Page 3 of 5 PageID: 584
`
`8.
`
`Attached hereto as Exhibit 7 is a true and correct copy of an excerpt from Rayner-
`
`Canham, et al., Descriptive Inorganic Chemistry, pp. 121-134 (2nd ed. 1996), bearing Bates
`
`numbers UTC_REM_II_000001595 – UTC_REM_II_000001610.
`
`9.
`
`Attached hereto as Exhibit 8 is a true and correct copy of an excerpt from Loudon, et
`
`al., Organic Chemistry, pp. 87-112 (3rd ed. 1995), bearing Bates numbers
`
`UTC_REM_II_000001611 – UTC_REM_II_000001638.
`
`10.
`
`Attached hereto as Exhibit 9 is a true and correct copy of an excerpt from Bettelheim,
`
`et al., Introduction to General, Organic & Biochemistry, p. G-2 (6th ed. 2001), bearing Bates
`
`numbers UTC_REM_II_000001639 – UTC_REM_II_000001641.
`
`11.
`
`Attached hereto as Exhibit 10 is a true and correct copy of an excerpt from Suchocki,
`
`et al., Conceptual Chemistry, p. G-1 (2001), bearing Bates numbers UTC_REM_II_000001642 –
`
`UTC_REM_II_000001644.
`
`12.
`
`Attached hereto as Exhibit 11 is a true and correct copy of file history for U.S. Patent
`
`No. 8,497,393, bearing Bates numbers UTC_REM_II_000003371 – UTC_REM_II_000003575.
`
`13.
`
`Attached hereto as Exhibit 12 is a true and correct copy of an excerpt from Zumdahl,
`
`Chemistry, pp. A25, A36 (1986), bearing Bates numbers UTC_REM_II_000001763 –
`
`UTC_REM_II_000001766.
`
`14.
`
`Attached hereto as Exhibit 13 is a true and correct copy of an excerpt from Brown, et
`
`al., Chemistry: The Central Science, pp. G-2, G-10 (9th ed. 2003), bearing Bates numbers
`
`UTC_REM_II_000001759 – UTC_REM_II_000001762.
`
`15.
`
`Attached hereto as Exhibit 14 is a true and correct copy of an excerpt from Webster’s
`
`New Collegiate Dictionary, pp. 29, 901, 910-911 (Springfield, MA, G. & C. Merriam Co. 1981),
`
`bearing Bates numbers UTC_REM_II_000001782 – UTC_REM_II_000001787.
`
`
`
`-3-
`
`
`
`Case 3:14-cv-05499-PGS-LHG Document 42-1 Filed 07/07/15 Page 4 of 5 PageID: 585
`
`16.
`
`Attached hereto as Exhibit 15 is a true and correct copy of an excerpt from Suchocki,
`
`et al., Conceptual Chemistry, p. G-6 (2001), bearing Bates numbers UTC_REM_II_000001767 –
`
`UTC_REM_II_000001769.
`
`17.
`
`Attached hereto as Exhibit 16 is a true and correct copy of Williams, et.al.,
`
`“Asymmetric, Stereocontrolled Total Synthesis of Paraherquamide A,” J. Am. Chem. Soc.,
`
`125:12172-178 (2003), bearing Bates numbers UTC_REM_II_000001741 –
`
`UTC_REM_II_000001747.
`
`18.
`
`Attached hereto as Exhibit 17 is a true and correct copy of Williams, et.al.,
`
`“Stereocontrolled Total Synthesis of (+)-Paraherquamide B”, J. Am. Chem. Soc., 118:557-579
`
`(1996), bearing Bates numbers UTC_REM_II_000001718 – UTC_REM_II_000001740.
`
`19.
`
`Attached hereto as Exhibit 18 is a true and correct copy of Williams, et.al., “Synthetic
`
`Studies on Et-743. Assembly of the Pentacyclic Core and a Formal Total Synthesis,” J. Org.
`
`Chem., 73(24):9594-9600 (2008), bearing Bates numbers UTC_REM_II_000001748 –
`
`UTC_REM_II_000001754.
`
`20.
`
`Attached hereto as Exhibit 19 is a true and correct copy of Heathcock, et.al., “Further
`
`Studies of the Daphniphyllum Alkaloid Polycyclization Cascade,” J. Org. Chem., 66:450-454
`
`(2001), bearing Bates numbers UTC_REM_II_000001670 – UTC_REM_II_000001689.
`
`21.
`
`Attached hereto as Exhibit 20 is a true and correct copy of Heathcock, et.al.,
`
`“Daphniphyllum Alkaloids. 12. A Proposed Biosynthesis of the Pentacyclic Skeleton. Proto-
`
`Daphniphylline,” J. Org. Chem., 57:2554-2566 (1992), bearing Bates numbers
`
`UTC_REM_II_000001657 – UTC_REM_II_000001669.
`
`
`
`-4-
`
`
`
`Case 3:14-cv-05499-PGS-LHG Document 42-1 Filed 07/07/15 Page 5 of 5 PageID: 586
`
`22.
`
`Attached hereto as Exhibit 21 is a true and correct copy of Buchwald, et.al., “An Air-
`
`Stable Catalyst System for the Conversion of Esters to Alcohols,” J. Org. Chem., 57:3753-3755
`
`(1992), bearing Bates numbers UTC_REM_II_000001648 – UTC_REM_II_000001650.
`
`23.
`
`Attached hereto as Exhibit 22 is a true and correct copy of Buchwald, et.al., “A
`
`Practical Titanium-Catalyzed Synthesis of Bicyclic Cyclopentenones and Allylic Amines,” J.
`
`Org. Chem., 61:2713-2718 (1996), bearing Bates numbers UTC_REM_II_000001651 –
`
`UTC_REM_II_000001656.
`
`24.
`
`Attached hereto as Exhibit 23 is a true and correct copy of an excerpt from Hawley’s
`
`Condensed Chemical Dictionary, pp. 34, 221 (14th ed. 2001), bearing Bates numbers
`
`UTC_REM_II_000001770 – UTC_REM_II_000001774.
`
`25.
`
`Attached hereto as Exhibit 24 is a true and correct copy of an excerpt from Loudon, et
`
`al., Organic Chemistry, pp. 454-455 (3rd ed. 1995), bearing Bates numbers
`
`UTC_REM_II_000001700 – UTC_REM_II_000001703.
`
`I declare under penalty of perjury under the laws of the United States of America that the
`
`foregoing is true and correct.
`
`Executed this 7th day of July, in Austin, Texas.
`
`
`
`
`
`
` Robert A. Delafield II
`
`
`
`-5-