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`EXHIBIT 3
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`EXHIBIT 3
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`STEDMAN1S
`CONCISE
`
`MEDICAL DICTIONARY
`FOR THE HEALTH
`PROFESSIONS
`
`ILLUSTRATED
`4TH EDITION
`
`EDITOR
`John H. Dirckx, M.D.
`Director, University of Dayton
`Student Health Center
`Dayton, Ohio
`
`•
`
`•
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`LIPPINCOTT WILLIAMS [1 WILKINS
`A Wolters Kluwer Company
`Philadelphia • Ballimore • New York · London
`Buenos Aires • Hong Kong • Sydney • Tokyo
`
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`Publisher: Elizabeth Haigh
`Chief Editor & lexicographer: John H. Dirdcx, M.D.
`Project Editor. Beverly Wolpen
`Senior Managing Editor: Vincent Ercolano
`Senior Developmental Editor. Ellen Atwood
`Senior Online Editor. Barbara Ferretti
`Art Direction: Jonathan Dimes, Jennifer Clements
`Associate Editors: Kathy Cadle. Kari Chairet. Trista DiPaula,
`Lisa Fahnestock, Will Howard, Kathryn C. Mason, CMT
`Software Development Manager: Dave Home
`Production Manager. Julie K. Stegman
`Production Coordinator: Kevin Iarossi
`Production Adviser: Brian Smith
`
`Copyright 200 I
`Lippincott Williams & Wilkins
`351 W. Camden Street
`Baltimore, MD 21201-2436 USA
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`All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any
`forrn or by any means, including photocopying, or utilized by any information storage and retrieval sys(cid:173)
`tem without written permission from the copyright owner.
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`Stedman' s is a registered trademark of Lippincott Williams & Wilkins.
`
`Database design by Lexi-Comp, Inc., Hudson, OH
`Printed in the United States of America by Quebecor World, Versailles, KY
`
`First Edition 1987
`Second Edition 1994
`Third Edition 1997
`
`Library of Congress Cataloging-in-Publication Data
`
`illustrated. -4th ed f editor,
`
`Stedman 's concise medical dictionary for the health professions
`John H. Dirckx.
`p. ; cm.
`Includes bibliographical references and index.
`ISBN 0-7817-3012-0
`I. Title: Concise medical dictionary for the health professions.
`l. Medicine--Dictionaries.
`Il Title: Medical dictionary for the health professions.
`ITI. Stedman, Thomas Lathrop,
`1853-1938.
`IV. Dirck.~. John H., 193&-
`I. Medicine-Dictionary- English. W 13 S8 t 25 200 I]
`[DNLM:
`R121 .S8 2001
`6I0'.3-dc21
`
`2001016460
`
`

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`insullnemia
`
`505
`
`interaction
`
`me epidermis, e.g., hairs, nails, sudoriferous and
`blood; usually connOle.~ abnonnaJly large con-
`sebaceous glands. and mammary glands. 2. the
`cent111tions of insulin in the circulating blood.
`rind, capsule, or ~vering of any body or part.
`ln-su-lin-like ac.tiv·l-ty (ILA) a measure of
`SYN integumenrum commune [TA). 1egument.
`substances, usual ly in plasma, that exen biologic
`IL. imegumenlum, a covering, fr. in-tego, to
`effectS similar to those of in$ulin in various bio-
`cover)
`assays; sometimes used as a measure of plasma
`in-leg•U•men•ta•ry (in-teg-yu-men'ta-re) rclat-
`insulin conccntralions; always gi ves higher val-
`ing 10 the integument. su Al.SO cutaneous, der-
`ues lhan immunochemical techniques for the
`mat.
`mea1Urement of insulin.
`inosu·lin-like gn>wth rac.tors (JG•} peptides
`in-teg.u-rnen.tum com-mune (io-ICg-yu-men'
`whose formation is stimulaled by growlh hor·
`tum kO-moo'ne) (TA) SYN integument.
`mone. 'lbese peptide'5 bring about peripheral tis·
`in-tel•le<:•tU•al•i•ta•lion (in-te-lek'choo·l!.1-i-za'
`shun) an unconscious defense mechanism in
`sue effects of that honnone and have high (abou1
`70%} homology to human insulin.
`which reasoning, logic, or focusing on and vcr-
`bali:t.ing imelle,iual minutiae is used in an a1-
`ln-su•lin+i;en•e-si~ (in'sil-lin-O·jen'~··~is) pro·
`duction of insulin. [insulin + G. gene.tis. produc·
`1empt to avoid confrontation with an objection-
`tion)
`ab le impulse, affect, or interpersonal situation.
`(L. in1ellec1us, perception, discemmeot]
`ln.su0Un-o-gen·i~ in-su•lo.gen-ic (in'su-lin-0-
`in-lel·li•gence (in-tel'i-jens) 1. an individua l's
`jen'ilc, in'su-10-jen'ilc:) rel3ling to insulinogenesis.
`aggroga1c capacity to act purposefully, think m-
`in.su.U.no.ma (in'sli-li-no'm3) an islet cell ode-
`tional ly, and deal effec1ively with the environ-
`noma thal secretes insulin. SYN insuloma.
`in..~u.lin re.cep.tor sub-strate-.1 (IRS-)) a cy-
`men1. especially in meeting challenges and solv-
`ing problems. 2 PSYCIJOLOOY an individual's rcl-
`loplasmic protein ll1at is a direct substrate of the
`a1ive standing on two quanlitative indices, mea-
`activa1cd insulin receptor kinase. Insulin expo-
`sure rcsull• in its rapid phosphorylation at multi·
`sured int.elligcnce and effectivene.% of adaptive
`betuivior; a quantii.ativc score or similar index on
`pie tyrosine residues. )IS phosphorylalcd sires as-
`both indices constitutes lhe operational definition
`sociate with high affinity 10 ccnain cellular pro-
`of in1elligence. IL i1ttelligentia)
`teins. IRS- I thus ac1S as an adap1or molecule that
`lillks the receptor kinase to various cellular activ·
`in-tel-Ji.gcnce quo•tient (IQ) lhe psychologist's
`index of intelligence as one pan of a iwo-pan
`ities regulated by insulin. lRS-1 is also phospho-
`determination. the other pan being an index of
`rylatcd after s1imulalion by insulinlike growth
`odaptivc behavior. IQ is ordinarily expressed as o.
`factor- I and several interleukins.
`ratio between the person's score on a given 1est
`in.su 0lln re.slsobnce diminished effec1ivencss
`and the score which the average individual of
`of insulin in lowering blood sugar levels; arbi-
`trarily defined as requiring 200 units or more of
`oomparoblc age attained on the same 1est.
`in·te n-sl.ty (in-tco'sHc'!) marked tension; great
`insulin per day 10 prevent hyperglycemia or keto-
`ac1iviry ; often used simply to denote a measure
`si.~ usual ly due to insul in binding by antibodie.~.
`of the degree or amount of some quality. (L. in-
`bu! abnonnalitie.~ in insulin rcccp1ors on cell sur-
`undo, pp. -tensus, 10 stretch out)
`faces also occur; associated with obesity, ke1oac-
`in-ten.sive care U•Dit (ICU) a hospital facility
`idosis, infection, and certain rare conditions.
`in.su.Un shtX:k severe hypoglycemia produced
`for provision of intensive nursing. and medical
`care of critically ill pa1ien1s, charactttiicd by
`by adminislJation of insulin, manifested by
`high quality and quantity of continuous nursing
`sweating, tremor. anx.iety, vertigo, and d iplopia,
`and medical supervision and by use of sophisti-
`. followed by delirium, convulsions, and collapse.
`llloSU-11.tis (in'sil-b-tis) inOammation of the is-
`ca1ed monitoring and resuscitative equipmen1;
`may be organized for the care of specific patient
`lands of Langerhans, with lyrnphocyiic infi.ltra-
`groups, e.g., neonatal or newborn ICU. 11curo-
`lion which mav result from viral infection and be
`logical ICU, pulmonary ICU. SYN crilical care
`lhe initial lesion of insulin-dependent diabetes
`. meltitus. (L. insula. island, + -itis. inflammation)
`unil.
`in•ltn•tion (in-ten'shun) I, an objective. 2. SVR·
`ID·SU·lo.ma (in-su-11'.>'mll) SYN insulinoma.
`(L.
`CE.llY a process or operation. {L. inten1io. a
`iltswla, island.+ ·omo, tumor]
`inoSUlt (in'stllt) an injury, anack. or trauma. (LL.
`stretching out; intention)
`. 1ruul1us. fr L. insu/10, tu spring upon)
`in.ten•tion spasm a spasmodic contraction of the
`muscles occwriog when a voluntary movement
`lll•sus.cep0 tl·bil•i•lY (in'sli-scp'ti-bil'i· te) SYN
`1rnmuni1y. (L. suscipio, pp. -ceptus, 10 take upon
`is anempted .
`. one, fr. sub. under. + capio. 10 lake)
`in•ttn•tioo-t~treat an.aJ.y.sis method of ana-
`ly1.ing results of a randomized controlled trial
`~te.gra.tion (in-1e-grli'shun) I. 1he st.ale of be-
`•ng combined, or the process of combining, imo
`lha1 includes in the analysis all tbe cases that
`shoul<l have received a treatment regimen but for
`a complete and hannonioui; whole. 2. PHYs101.wv
`Ille process of building up. as by accretion. anal>-
`whatever reason did n0t do so. All cases allo-
`catcd to each arm of the aial are analyzed to-
`ohsm, elc. 3. M11ntEMATICS the p rocess of ascer-
`g e thcr as representing that rrcatmenr arm,
`laining a function from its differential. 4. MOt.EC·
`whethcr or not they received or completed the
`UIJ,R BlOl.OC.Y a recombination event in which a
`generic element is inserted. IL. inregro, pp. -atus,
`prescribed regimen .
`. 10 make whole, fr. in1eger, whole)
`in•lm-tion tn:m-or a tremor !hat occurs during
`'11•1cg • .;.1y (in-1eg'ri-1e) soundness o r complete-
`the pcrfonnance of precise voluntary move-
`ness of strncturc; a sound or unimpafred condi-
`menu, caused by d isorders of the cerebellum or
`its connections. SYN voli1ional tremor (2).
`. hon.
`'"'teg.u.ment (in-1eg'yu- mcnt) I. the enveloping r'.:.linter - among. between. IL in/er, between]
`in.t.er•ac.tion (in1'er-ak'shun) 1. the reciprocal
`m<mbrane of the body; inchxlcs. in addition to
`1~ epidermis and Jennis. a.II of the derivatives of
`ac1ion berween two entities in a common envi-
`
`