Case 1:14-cv-00113-RGA-MPT Document 273-4 Filed 09/21/15 Page 1 of 19 PageID #: 9160
`Case 1:14—cv—OO113—RGA—MPT Document 273-4 Filed 09/21/15 Page 1 of 19 Page|D #: 9160
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`TAB D
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`TAB D
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`Case 1:14-cv-00113-RGA-MPT Document 273-4 Filed 09/21/15 Page 2 of 19 PageID #: 9161
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`CURRICULUM VITAE
`
`Forest Michael White
`
`Work Address:
`Massachusetts Institute of Technology
`77 Massachusetts Ave.
`Building 76-353F
`Cambridge, MA 02139
`Office: (617) 258-8949
`Fax: (617) 258-0225
`Email address: fwhite@mit.edu
`
`
`
`Home Address:
`9 Putnam Hill Road
`Sutton, MA 01590
`(508) 865-6233
`
`
`
`
`
`Education
`
`1993 B.S. Chemistry, Framingham State College, Framingham, Massachusetts
`1997 Ph.D. Analytical Chemistry, Florida State University, Tallahassee, Florida
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`Work Experience
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`1/92-6/93
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`7/14 -
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`Research Assistant, US Army Research and Development Center, Food
`Science Program, Natick, Massachusetts
`Research Assistant, Florida State University, Tallahassee, Florida
`1/94-8/97
`Research Associate, University of Virginia, Charlottesville, Virginia
`9/97-5/99
`Senior Scientist, Proteome Research Institute, Charlottesville, Virginia
`5/99-1/01
`Research Scientist, MDS Proteomics, Inc., Charlottesville, Virginia
`1/01-4/02
`4/02 – 10/02 Senior Research Scientist, MDS Proteomics, Inc.
`10/02 – 6/03 Project Manager and Group Leader, MDS Proteomics, Inc.
`7/03 – 7/07 Assistant Professor, Biological Engineering Division, Massachusetts
`Institute of Technology, Cambridge, MA
`7/07 – 7/14 Associate Professor, Department of Biological Engineering,
`Massachusetts Institute of Technology, Cambridge, MA
`Professor, Department of Biological Engineering, Massachusetts Institute
`of Technology, Cambridge, MA
`
`1)
`
`Kim, H.J.; Ball, D.; Giles, J.; White, F.M. "Analysis of Thermally Produced
`Compounds in Food by Thermospray Liquid Chromatography-Mass
`Spectrometry and Gas Chromatography-Mass Spectrometry", J. Agri. Food
`Chem. 42, 2812-16 (1994).
`2) Marto, J.A.; White, F.M.; Seldomridge, S.; Marshall, A.G. "Structural
`Characterization of Phospholipids by Matrix-Assisted Laser
`Desorption/Ionization Fourier Transform Ion Cyclotron Resonance Mass
`Spectrometry", Anal. Chem. 67, 3979-3984 (1995).
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`Publications
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`JTX-045
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`3)
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`5)
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`Solouki, T.; Marto, J.A.; White, F.M.; Guan, S.; Marshall, A.G. "Attomole
`Biomolecule Mass Analysis by Matrix-Assisted Laser Desorption/Ionization
`Fourier Transform Ion Cyclotron Resonance", Anal. Chem. 67, 4139-4144 (1995).
`4) White, F.M.; Marto, J.A.; Marshall, A.G. "An External Source 7 Tesla FT-ICR
`Mass Spectrometer with Electrostatic Ion Guide", Rapid Commun. Mass
`Spectrom. 10,1845-1849 (1996).
`Senko, M.W.; Hendrickson, C.L.; Pasa-Tolic, L.; Marto, J.A.; White, F.M.;
`Guan, S.; Marshall, A.G. "Electrospray Ionization Fourier Transform Ion
`Cyclotron Resonance at 9.4 Tesla", Rapid Commun. in Mass Spectrom. 10, 1824-
`1828 (1996).
`6) Milgram, K.E.; White, F.M.; Goodner, K.L.; Watson, C.H.; Koppenaal, D.W.;
`Baringa, C.J.; Smith, B.H.; Winefordner, J.D.; Marshall, A.G.; Houk, R.S.;
`Eyler, J.R. "High Resolution Inductively Coupled Plasma Fourier Transform Ion
`Cyclotron Resonance Mass Spectrometry” Anal. Chem. 69, 3714-3721 (1997).
`Jackson, G.S.; White, F.M.; Hammill, C.L.; Clark, R.C.; Marshall, A.G. "Gas
`Phase Dehydrogenation of Saturated and Aromatic Cyclic Hydrocarbons by
`(Ptn)+, n = 1-4", J. Am. Chem Soc. 119, 7567-7572 (1997).
`Emmett, M.R.; White, F.M.; Hendrickson, C.L.; Shi. S.D.-H.; Marshall, A.G.
`“Application of Micro-Electrospray Liquid Chromatography Techniques to FT-
`ICR MS to Enable High-Sensitivity Biological Analysis”, J. Am. Soc. Mass
`Spectrom. 9, 333-340 (1998).
`Rodgers, R.P.; White, F.M.; McIntosh, D.G.; Marshall, A.G. “5.6 Tesla Fourier
`Transform Ion Cyclotron Resonance Mass Spectrometer for Analysis of Volatile
`Complex Mixtures”, Rev. Sci. Inst. 69, 2278-2284 (1998).
`Rodgers, R.P.; White, F.M.; Hendrickson, C.L.; Marshall, A.G.; Andersen, K.V.
`“Resolution, Elemental Composition, and Simultaneous Monitoring by Fourier
`Transform Ion cyclotron Resonance Mass Spectrometry of Organosulfur Species
`Before and After Diesel Fuel Processing", Anal. Chem. 70, 4743-4750 (1998).
`Shabanowitz, J.; Settlage, R.E.; Marto, J.A.; Christian, R.E.; White, F.M.; Russo,
`P.S.; Martin, S.E.; Hunt, D.F. “Sequencing the Primordial Soup”, In Mass
`Spectrometry in Biology and Medicine, A.L. Burlingame, S.A. Carr, and M.A.
`Baldwin, eds. Humana Press, Totowa, N.J. (1999)
`Pierce, R.A.; Field, E.D.; den Haan, J.M.M.; Caldwell, J.A.; White, F.M.; Marto,
`J.A.; Wang, W.; Frost, L.M.; Blokland, E.; Reinhardus, C.; Shabanowitz, J.; Hunt,
`D.F.; Goulmy E.; Engelhard V.H. “Cutting edge: The HLA-A*0101-restricted
`HY minor histocompatibility antigen originates from DFFRY and contains a
`cysteinylated cysteine residue as identified by a novel mass spectrometric
`technique”, J. Immunol. 163, 6360-6364 (1999).
`Crotzer, V.L.; Christian, R.E.; Brooks, J.M.; Shabanowitz, J.; Settlage, R.E.;
`Marto, J.A.; White, F.M.; Rickinson, A.B.; Hunt, D.F.; Engelhard, V.H.
`“Immunodominance among EBV-derived epitopes restricted by HLA-B27 does
`not correlate with epitope abundance in EBV-transformed B-lymphoblastoid cell
`lines”, J. Immunol. 164, 6120-6129 (2000).
`14) Huberman, A.; Aguilar, M.B.; Navarro-Quiroga, I.; Ramos, L.; Fernandez, I.;
`White, F.M.; Hunt, D.F.; Shabanowitz, J. “A hyperglycemic peptide hormone
`from the Caribbean shrimp Penaeus (litopenaeus) schmitti”, Peptides 21, 331-338
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`13)
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`7)
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`17)
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`19)
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`20)
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`15)
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`(2000).
`Zarling, A.L.; Ficarro, S.B.; White, F.M.; Shabanowitz, J.; Hunt, D.F.; Engelhard,
`V.H. “Phosphorylated peptides are naturally processed and presented by MHC
`class I molecules in vivo”, J. Exp. Med. 192, 1755-1762 (2000).
`16) Gimenez-Bonafe, P.; Laszczak, M.; Kassinsky, H.E.; Lemke, M.J.; Lewis, J.D.;
`Iskandar, M.; He, T.; Ikonomou, M.G.; White, F.M.; Hunt, D.F.; Chiva, M.;
`Ausio, J. “Characterization and evolutionary relevance of the sperm nuclear basic
`proteins from stickleback fish”, Mol. Repro. and Dev. 57, 185-193 (2000).
`Luckey, C.J.; Marto, J.A.; Partridge, M.; Hall, E.; White, F.M.; Lippolis, J.D.;
`Shabanowitz, J.; Hunt, D.F.; Engelhard, V.H. “Differences in the expression of
`Human MHC class I alleles and their associated peptides in the presence of
`proteasome inhibitors”, J. Immunol., 167, 1212-1221 (2001).
`18) Nepom, G.T.; Lippolis, J.D.; White, F.M.; Masewicz, S.; Marto, J.A.; Herman,
`A.; Luckey, C.J.; Falk, B.; Shabanowitz, J.; Hunt, D.F.; Engelhard, V.H.
`“Identification and modulation of a naturally processed T-cell epitope from the
`diabetes-associated autoantigen hGAD65”, Proc. Nat. Acad. Sci. 98, 1763-1768
`(2001).
`Ficarro, S.B.; McCLeland, M.L.; Stukenberg, P.T.; Burke, D.J.; Ross, M.M.;
`Shabanowitz, J.; Hunt, D.H.; White, F.M. “Phosphoproteome analysis by mass
`spectrometry and its application to Saccharomyces cerevisiae”, Nat. Biotechnol.
`20, 301-305 (2002).
`Flyer, D.C.; Ramakrishna, V.; Miller, C.; Myers, H.; McDaniel, M.; Root, K.;
`Flournoy, C.; Engelhard, V.H.; Canaday, D.H.; Marto, J.A.; Ross, M.M.; Hunt,
`D.F.; Shabanowitz, J.; White, F.M. “Identification by mass spectrometry of
`CD8+-T-Cell Mycobacterium tuberculosis epitopes within the Rv0341 gene
`product”, Infect. Immun. 70, 2926-2932 (2002).
`21) Goeli, D.; Ficarro, S.B.; Kwiek, J.J.; Aaronson, D.; Hancock, M.; Catling, A.D.;
`White, F.M.; Christian, R.E.; Settlage, R.E.; Shabanowitz, J.; Hunt, D.F.; Weber,
`M.J. “Androgen receptor phosphorylation – regulation and identification of the
`phosphorylation sites”, J. Biol. Chem., 277, 29304-29314 (2002).
`Lippolis, J.D.; White, F.M.; Marto, J.A.; Luckey, C.J.; Bullock, T.N.;
`Shabanowitz, J.; Hunt, D.F.; Engelhard, V.E. “Analysis of MHC Class II Antigen
`Processing by Quantitation of Peptides that Constitute Nested Sets”, J. Immunol.
`169, 5089-5097 (2002).
`Ficarro, S.B.; Chertihin, O.; Westbrook, V.A.; White, F.M.; Jayes, F.; Kalab, P.;
`Marto, K.A.; Shabanowitz, J.; Herr, J.C.; Hunt, D.F.; Visconti, P.E.
`“Phosphoproteome of capacitated human sperm”, J. Biol. Chem. 278, 11579-
`11589 (2003).
`Saibil, S.D.; Ohteki, T.; White, F.M.; Luscher, M.; Zakarian, A.; Elford, A.;
`Shabanowitz, J.; Nishina, H.; Hugo, P.; Penninger, J.; Barber, B.; Hunt, D.F.;
`Ohashi, P.S. “Weak agonist self-peptides promote selection and tuning of virus-
`specific T cells”, Eur. J. Immunol. 33, 685-696 (2003).
`Zarling, A.H.; Luckey, C.J.; Marto, J.A.; White, F.M.; Brame, C.J.; Lehner, P. J.;
`Cresswell, P.; Shabanowitz, J.; Hunt, D.F.; Engelhard, V.H. “Tapasin is a
`facilitator, not an editor, of HLA-B8 peptide binding” J. Immunol. 171, 5287-
`5295 (2003).
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`22)
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`26)
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`29)
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`32)
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`33)
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`27)
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`Chen, W.G.; White, F.M. “Proteomic Analysis of Cellular Signaling” Expert Rev.
`Proteomics 1, 343-354 (2004). (Invited Review)
`Zhang, Y; Wolf-Yadlin, A.; Pappin, D.J.; Rush, J.; Lauffenburger, D.A.; White,
`F.M. “Time resolved mass spectrometry of tyrosine phosphorylation sites in the
`EGF receptor signaling network reveals dynamic modules” Mol. Cell. Proteomics
`4, 1240-1250 (2005).
`28) Kim, J.E.; Tannenbaum, S.R.; White, F.M. “Global phosphoproteome of HT-29
`human colon adenocarcinoma cells” J. Proteome Res. 4, 1339-1346 (2005).
`Behr, J.R.; Matsumoto, Y.; White, F.M.; Sasisekharan, R. “Quantification of
`Isomers from a Mixture of twelve heparin and heparan sulfate disaccharides using
`tandem mass spectrometry” Rapid Commun. in Mass Spectrom. 19, 2553-2562
`(2005).
`30) Moser, K.; White, F.M. “Phosphoproteomic Analysis of Rat Liver by High
`Capacity IMAC and LC-MS/MS” J. Proteome Res. 5, 98-104 (2006).
`31) Kim, J.E.; White F.M. “Quantitative Analysis of Phosphotyrosine Signaling
`Networks triggered by CD3 and CD28 co-stimulation in Jurkat cells” J. Immunol.,
`176, 2833-2843 (2006).
`Brar, G.A.; Kiburz, B.M.; Zhang, Y.; Kim, J.E.; White, F.M.; Amon, A. “Rec8
`phosphorylation and recombination promote the stepwise loss of cohesions in
`meiosis” Nature, 441, 532-536 (2006)
`Schmelzle, K.; Kane, S.; Gridley, S.; Lienhard, G.E.; White, F.M. “Temporal
`Dynamics of Tyrosine Phosphorylation in Insulin Signaling” Diabetes, 55, 2171-
`2179 (2006).
`Schmelzle, K.; White, F.M. “Proteomic approaches to elucidate cellular signaling
`networks” Current Opin. Biotechnol. 17, 406-414 (2006) (Invited Review)
`35) Wolf-Yadlin, A.; Kumar, N.; Zhang, Y.; Hautaniemi, S.; Zaman, M.; Kim, H.-D.;
`Grantcharova, V.; Lauffenburger, D.A.; White, F.M. “Quantitative
`Phosphoproteomic Analysis of HER2-overexpression effects on Cell Signaling
`Networks governing proliferation and migration” Mol. Systems Biol. 2, 54 (2006).
`36) Albeck, J.G.; MacBeath, G.; White F.M.; Sorger, P.K.; Lauffenburger, D.A.;
`Gaudet, S. “Collecting and organizing systematic sets of protein data” Nat. Rev.
`Mol. Cell Biol., 7, 803-812 (2006)
`Tannenbaum, S.R.; White F.M. “Regulation and specificity of S-nitrosylation and
`denitrosylation” ACS Chem. Biol., 1, 615-618 (2006)
`38) Kumar, N.; Wolf-Yadlin, A.; White F.M.; Lauffenburger, D.A. “Modeling HER2
`effects on cell behavior from mass spectrometry phosphotyrosine data” PLOS
`Comp. Biol., 3, e4 (2007).
`39) Wilker, E.W.; van Vugt, M.; Artim, S.A.; Huang, P.H.; Petersen, C.P.; Reinhardt,
`H.C.; Feng, Y.; Sharp, P.A.; Sonenberg, N.; White, F.M.; Yaffe, M.B. “14-3-3s
`controls mitotic translation to facilitate cytokinesis” Nature, 446, 329-332 (2007).
`40) Yaffe, M.B.; White F.M. “Signaling netwErks get the global treatment” Genome
`Biol. 8, 202 (2007).
`41) Wolf-Yadlin, A.; Hautaniemi, S.; Lauffenburger, D.A.; White, F.M. “Multiple
`reaction monitoring for robust quantitative analysis of cellular signaling
`networks” Proc. Nat. Acad. Sci. 104, 5860-5865 (2007).
`Zhang, Y.; Wolf-Yadlin, A.; White, F.M. “Quantitative Proteomic Analysis of
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`49)
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`Phosphotyrosine-Mediated Cellular Signaling Networks” Methods Mol. Biol.,
`359, 203-212 (2007) (Invited Book Chapter)
`43) Huang, P.H.; Mukasa, A.; Bonavia, R.; Flynn, R.A.; Brewer, Z.E.; Cavenee,
`W.K.; Furnari, F.B.; White, F.M. “Quantitative analysis of EGFRvIII cellular
`signaling networks reveals a combinatorial therapeutic strategy for glioblastoma”
`Proc. Nat. Acad. Sci. 104, 12867-12872 (2007).
`44) White F.M. “On the iTRAQ of kinase inhibitors” Nat. Biotechnol. 25, 994-996
`(2007).
`45) Huang, P.H.; Cavenee, W.K.; Furnari, F.B.; White F.M. “Uncovering therapeutic
`targets for glioblastoma: a systems biology approach” Cell Cycle 6, 2750-2754
`(2007).
`46) Apgar, J.F.; Toettcher, J.E.; Endy D.; White F.M.; Tidor B. “Stimulus design for
`model selection and validation in cell signaling” PLoS Comput Biol. 4, e30
`(2008).
`47) White, F.M. “Quantitative phosphoproteomic analysis of signaling network
`dynamics” Current Opin. Biotechnol. 19, 404-409 (2008) (Invited Review)
`48) Huang, P.H.; White F.M. “Phosphoproteomics: Unraveling the Signaling Web”
`Mol. Cell. 31, 777-781 (2008)
`Tedford, N.C.; White F.M.; Radding, J.A. “Illuminating signaling network
`functional biology through quantitative phosphoproteomic mass spectrometry”
`Brief Funct Genomic Proteomic. 7, 383-394 (2008) (Invited Review).
`50) Nita-Lazar, A.; Saito-Benz, H.; White F.M. “Quantitative phosphoproteomics by
`mass spectrometry: Past, present, and future.” Proteomics 8, 4433-4443 (2008)
`(Invited Review).
`Joughin B.A.; Naegle K.M.; Huang P.H.; Yaffe M.B.; Lauffenburger D.A.; White
`F.M. “An integrated comparative phosphoproteomic and bioinformatic approach
`reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing
`glioblastoma cells.” Mol Biosyst. 5, 59-67 (2009).
`Stevens A.L.; Wishnok J.S.; White F.M.; Grodzinsky A.J.; Tannenbaum S.R.
`“Mechanical injury and cytokines cause loss of cartilage integrity and upregulate
`proteins associated with catabolism, immunity, inflammation, and repair.” Mol
`Cell Proteomics 8, 1475-1489 (2009)
`53) Morel C.; Carlson S.M.; White F.M.; Davis R.J. “Mcl-1 integrates the opposing
`actions of signaling pathways that mediate survival and apoptosis.” Mol Cell
`Biol., 29, 3845-3852 (2009)
`54) Nichols A.M.; White F.M. “Manual validation of peptide sequence and sites of
`tyrosine phosphorylation from MS/MS spectra” Methods Mol. Biol., 492, 143-160
`(2009) (Invited Book Chapter)
`55) Huang P.H.; Xu A.M.; White F.M. “Oncogenic EGFR signaling in glioma” Sci
`Signal., 8, re6 (2010)
`56) Del Rosario A.M.; White F.M. “Quantifying oncogenic phosphotyrosine signaling
`networks through systems biology” Curr. Opin. Genet. Dev. 20, 23-30 (2010)
`Iwai L.K.; Benoist, C.; Mathis, D.; White F.M. “Quantitative phosphoproteomic
`analysis of T cell receptor signaling in diabetes prone and resistant mice” J.
`Proteome Res. 4, 3135-3145 (2010)
`58) Huang PH, Miraldi ER, Xu AM, Kundukulam VA, Del Rosario AM, Flynn RA,
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`62)
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`63)
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`65)
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`59)
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`Cavenee WK, Furnari FB, White FM. “Phosphotyrosine signaling analysis of site-
`specific mutations on EGFRvIII identifies determinants governing glioblastoma
`cell growth.” Mol Biosyst. 15, 1227-1237 (2010)
`Spangler JB, Neil JR, Abramovitch S, Yarden Y, White FM, Lauffenburger DA,
`Wittrup KD. “Combination antibody treatment down-regulates epidermal growth
`factor receptor by inhibiting endosomal recycling.” Proc. Natl. Acad. Sci. USA
`107, 13252-13257 (2010)
`60) Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB,
`Lauffenburger DA, White FM. “PTMScout: A web resource for analysis of high-
`throughput post-translational proteomic studies.” Mol Cell Proteomics 9, 2558-
`2570 (2010)
`61) Apgar JF, Witmer DK, White FM, Tidor B. “Sloppy models, parameter
`uncertainty, and the role of experimental design.” Mol Biosyst. 6, 1227-1237
`(2010)
`Pines G, Huang PH, Zwang Y, White FM, Yarden Y. “EGFRvIV: a previously
`uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism.”
`Oncogene, 29, 5850-5860 (2010)
`Lahesmaa-Korpinen AM, Carlson SM, White FM, Hautaniemi S. “Integrated data
`management and validation platform for phosphorylated tandem mass
`spectrometry data.” Proteomics 10, 3515-3524 (2010)
`Carlson SM, White FM. “Using small molecules and chemical genetics to
`interrogate signaling networks.” ACS Chem Biol. 6, 75-85 (2011)
`Liu H, Ong SE, Badu-Nkansah K, Schindler J, White FM, Hynes RO. “CUB-
`domain-containing protein 1 (CDCP1) activates Src to promote melanoma
`metastasis.” Proc. Natl. Acad. Sci. USA 108, 1379-1384 (2011)
`66) White FM, “The potential cost of high-throughput proteomics” Sci. Signal. 4, pe8
`(2011)
`67) Naegle KM, Welsch RE, Yaffe MB, White FM, Lauffenburger DA. “MCAM:
`multiple clustering analysis methodology for deriving hypotheses and insights
`from high-throughput proteomic datasets” PLoS Comput Biol. 7, e1002119 (2011)
`Carlson SM, Chouinard CR, Labadorf A, Lam CJ, Scmelzle K, Fraenkel E, White
`FM. “Large-scale discovery of ERK2 substrates identifies ERK-mediated
`transcriptional regulation by ETV3” Sci Signal. 4, rs11 (2011)
`69) Hackel BJ, Neil JR, White FM, Wittup KD. “Epidermal growth factor receptor
`downregulation by small heterodimeric binding proteins” Protein Eng. Des. Sel.
`25, 47-57 (2012).
`Jun HJ, Acquaviva J, Chi D, Lessard J, Zhu H, Woolfenden S, Bronson RT,
`Pfannl R, White F, Housman DE, Iyer L, Whittaker CA, Boskovitz A, Raval A,
`Charest A. “Acquired MET expression confers resistance to EGFR inhibition in a
`mouse model of glioblastoma multiforme.” Oncogene 31, 3039-50 (2012)
`Jun HJ, Johnson H, Bronson RT, de Feraudy S, White F, Charest A. “The
`Oncogenic Lung Cancer Fusion Kinase CD74-ROS Activates a Novel
`Invasiveness Pathway Through E-Syt1 Phosphorylation.” Cancer Res. 72, 3764-
`3774 (2012)
`72) Vidal M, Chan DW, Gerstein M, Mann M, Omenn GS, Tagle D, Sechi S,
`Apweiler R, Bader J, Barnes S, Bettauer R, Chan MM, Coon J, Dolinski K,
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`74)
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`75)
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`76)
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`78)
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`73)
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`Dowell BL, Edmonds CG, Gaudet S, Gerszten R, Kagan J, Mazurchuk R,
`McShane L, Moritz RL, Palmer-Toy D, Pandey A, Polanski M, Quackenbush J,
`Sheeley D, Skates S, Srivastava S, Wang W, Weng Z, White F. “The human
`proteome - a scientific opportunity for transforming diagnostics, therapeutics, and
`healthcare” Clin Proteomics. 9, 6 (2012).
`Carlson SM, White FM. “Expanding applications of chemical genetics in signal
`transduction” Cell Cycle, 11, 1903-1909 (2012).
`Carlson SM, White FM. “Labeling and identification of direct kinase substrates”
`Sci Signal. 5, pI3 (2012).
`Johnson H, White FM. “Toward quantitative phosphotyrosine profiling in vivo”
`Semin Cell Dev Biol., 23, 854-862 (2012).
`Bryson BD, White FM. “Signaling for death: tyrosine phosphorylation in the
`response to glucose deprivation”, Mol. Sys. Biol., 8, 591, (2012)
`77) Naegle KM, White FM, Lauffenburger DA, Yaffe MB. “Robust co-regulation of
`tyrosine phosphorylation sites on proteins reveals novel protein interactions” Mol
`Biosyst. 8, 2771-2782 (2012).
`Johnson H, Del Rosario AM, Bryson BD, Schroeder MA, Sarkaria JN, White FM.
`“Molecular Characterization of EGFR and EGFRvIII Signaling Networks in
`Human Glioblastoma Tumor Xenografts” Mol Cell Proteomics. 11, 1724-1740
`(2012)
`79) Winter GE, Rix U, Carlson SM, Gleixner KV, Grebien F, Gridling M, Müller AC,
`Breitwieser FP, Bilban M, Colinge J, Valent P, Bennett KL, White FM, Superti-
`Furga G. “Systems-pharmacology dissection of a drug synergy in imatinib-
`resistant CML” Nat Chem Biol. 905-912 (2012).
`Johnson H, Lescarbeau RS, Gutierrez JA, White FM. “Phosphotyrosine Profiling
`of NSCLC Cells in Response to EGF and HGF Reveals Network Specific
`Mediators of Invasion” J. Proteome. Res. 12, 1856-1867 (2013)
`Curran TG, Bryson BD, Reigelhaupt M, Johnson H, White FM. “Computer aided
`manual validation of mass spectrometry-based proteomic data” Methods 61, 219-
`26 (2013)
`82) Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran
`TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK,
`Neel BG, Saghatelian A, White FM. “Molecular network analysis of
`phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice” Integr
`Biol 5, 940-963 (2013)
`Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD,
`Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC,
`Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM,
`Chen CC, White FM, Bradner JE, Yaffe MB. “The bromodomain protein Brd4
`insulates chromatin from DNA damage signalling.” Nature 498, 246-50 (2013)
`84) Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, White FM, Kamm RD,
`Lauffenburger DA. “Vascular endothelial growth factor (VEGF) and platelet (PF-
`4) factor 4 inputs modulate human microvascular endothelial signaling in a three-
`dimensional matrix migration context.” Mol Cell Proteomics 12, 3704-18 (2013).
`Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, Brar
`GA, Xu Y, Xiao C, Futcher B, Weissman JS, White FM, Amon A. “A
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`developmentally regulated translational control pathway establishes the meiotic
`chromosome segregation pattern.” Genes Dev. 27, 2147-63 (2013).
`86) Arneja A, Johnson H, Gabrovsek L, Lauffenburger DA, White FM. “Qualitatively
`different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical
`dependences on receptor signal strength and duration.” J Immunol. 192, 123-35
`(2014).
`87) Gajadhar AS, White FM. “System level dynamics of post-translational
`modifications.” Curr Opin Biotechnol. 28, 83-7 (2014).
`Johnson H, White FM. “Quantitative analysis of signaling networks across
`differentially embedded tumors highlights interpatient heterogeneity in human
`glioblastoma.” J Proteome Res. 13, 4581-93 (2014).
`Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, Chambers MC, Zimmerman LJ,
`Shaddox KF, Kim S, Davies SR, Wang S, Wang P, Kinsinger CR, Rivers RC,
`Rodriguez H, Townsend RR, Ellis MJ, Carr SA, Tabb DL, Coffey RJ, Slebos RJ,
`Liebler DC; NCI CPTAC. “Proteogenomic characterization of human colon and
`rectal cancer.” Nature. 513, 382-7 (2014).
`90) Haley J, White FM. “Adaptive protein and phosphoprotein networks which
`promote therapeutic sensitivity or acquired resistance.” Biochem Soc Trans. 42,
`758-64 (2014).
`Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N,
`White FM, Sassone-Corsi P, Guarente L. “SirT1 is required in the male germ cell
`for differentiation and fecundity in mice.” Development. 141, 3495-504 (2014).
`Curran TG, Zhang Y, Ma DJ, Sarkaria JN, White FM. “MARQUIS: a multiplex
`method for absolute quantification of peptides and posttranslational
`modifications.” Nat Commun. 6, 5924 (2015).
`Bryson BD, Del Rosario AM, Gootenberg JS, Yaffe MB, White FM. “Engineered
`bromodomains to explore the acetylproteome.” Proteomics. 15, 1470-5 (2015).
`94) Gajadhar AS, Johnson H, Slebos RJ, Shaddox K, Wiles K, Washington MK,
`Herline AJ, Levine DA, Liebler DC, White FM; Clinical Proteomic Tumor
`Analysis Consortium. “Phosphotyrosine signaling analysis in human tumors is
`confounded by systemic ischemia-driven artifacts and intra-specimen
`heterogeneity.” Cancer Res. 75, 1495-503 (2015).
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`Invited Talks
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`1)
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`2)
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`2001 Keystone Symposium on Systems Approach to Plant Biology, Big Sky, MT,
`“Proteome Analysis by Mass Spectrometry”, 1/30/01
`2002 Keystone Symposia on Protein Phosphorylation and Mechanisms of Cellular
`Recognition, Taos, NM, “Phosphoproteome Analysis by Mass Spectrometry”,
`3/09/02
`ISSX North American Meeting, Providence, RI, ‘Application of FTMS to the
`Analysis of Cell Signaling Pathways’ 10/14/03
`4) New England Biotechnology Symposium, Cambridge, MA ‘Phosphoproteome
`Analysis by Mass Spectrometry’ (Plenary Lecture), 10/17/03
`Joslin Diabetes Center, Boston, MA, ‘Phosphoproteome Analysis by Mass
`Spectrometry’, 10/21/03
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`3)
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`5)
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`6)
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`7)
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`8)
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`9)
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`10)
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`12)
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`15)
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`17)
`18)
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`Applied Biosystems, Framingham, MA ‘Phosphoproteome Analysis by Mass
`Spectrometry’, 10/30/03
`Japan-America Frontiers of Engineering, Irvine, CA ‘Proteomic Analysis of
`Cellular Signaling’, 11/21/03
`Greater Boston Area Mass Spectrometry Discussion Group, Waltham, MA
`‘Phosphoproteome Analysis by Mass Spectrometry’, 12/09/03
`Computational and Systems Biology Initiative Symposium, Cambridge, MA
`‘Phosphoproteomics – Global Analysis of Cellular Signaling’, 1/08/04
`Cell Signaling Technology, Beverly, MA ‘Phosphoproteome Analysis by Mass
`Spectrometry’, 01/29/04
`11) ABRF, Portland, OR ‘Phosphoproteome Analysis’ (Host, Roundtable
`Discussion), 2/29/04
`6th World Congress on Trauma, Shock, Inflammation, and Sepsis, Munich,
`Germany, ‘Mapping the Phosphoproteome’ 3/03/04
`13) Dartmouth College, Hanover, NH ‘Mapping the Phosphoproteome’ 3/36/04
`14)
`Barnett Institute, Northeastern University ‘Mapping the Phosphoproteome’
`4/02/04
`Protein Phosphorylation Drug Discovery, La Jolla, CA ‘Mapping the
`Phosphoproteome’ 4/21/04
`16) Hamilton Symposium, UCSF, San Francisco, CA ‘Mapping the
`Phosphoproteome’ 5/21/04
`Pfizer, San Diego, CA ‘Mapping the Phosphoproteome’ 6/03/04
`Sino-American Pharmaceutical Professionals Association-New England,
`Cambridge, MA ‘Mapping the Phosphoproteome’ 6/26/04
`19) Altana Pharmaceuticals, Waltham, MA ‘Mapping the Phosphoproteome’ 8/06/04
`7th International ISSX Meeting, Vancouver, Canada ‘Mapping of Human and
`20)
`Yeast Phosphoproteomes’ 9/02/04
`15th International Symposium in Regulatory Peptides, Toulouse, France
`‘Elucidation of Signaling Cascades by Phosphoproteome Analysis’ 9/20/04
`3rd Annual AACR International Conference on Frontiers in Cancer Prevention
`Research, Seattle, WA ‘Mapping the Phosphoproteome as a Key to Cellular
`Signaling’ 10/16/04
`23) Applied Biosystems Proteomics Symposium, Cambridge, MA ‘Elucidation of
`Cellular signaling Cascades’ 10/18/04
`24) Whitehead Institute High School Science Teachers Lecture, Cambridge, MA
`‘Mapping the Phosphoproteome’ 11/01/04
`2005 Keystone Conference on Proteomics and Bioinformatics, Keystone, CO,
`‘Phosphoproteomic Analysis of Cellular Signaling’ 4/11/05
`Eli Lilly, Indianapolis, IN, ‘Quantitative Proteomic Analysis of Cellular Signaling
`Networks’ 5/20/2005
`27) Dept. of Microbiology and Immunology, Vanderbilt University, Nashville, TN,
`‘Quantitative Proteomic Analysis of Cellular Signaling Networks’ 5/24/05
`Epitome Biosystems, Waltham, MA ‘Quantitative Proteomic Analysis of Cellular
`Signaling Networks’ 6/03/05
`2005 Gordon Conference on Toxicogenomics, New London, NH ‘Quantitative
`Proteomic Analysis of Cellular Signaling Networks’ 6/06/05
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`21)
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`22)
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`25)
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`26)
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`28)
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`29)
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` 9170
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`30)
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`31)
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`33)
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`34)
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`35)
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`37)
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`Summer course: “Theory and Practice in Molecular and Physiological
`Technologies”, Joslin Diabetes Center, Boston, MA, ‘Phosphoproteomics’
`7/12/05
`Lecture and Lab course on Phosphoproteomics, Cold Spring Harbor Laboratory,
`Cold Spring Harbor, NY, 7/19/05
`32) Molecular Oncology Group, Royal Victoria Hospital, McGill University,
`Montreal, Quebec, Canada, ‘Quantitative Proteomic Analysis of Cellular
`Signaling Networks’ 9/06/05
`Biochemistry Department, Boston University School of Medicine, Boston, MA,
`‘Quantitative Proteomic Analysis of Cellular Signaling Networks’ 9/27/05
`32nd Federation of Analytical Chemistry and Spectroscopy Societies, Quebec
`City, Canada, ‘Quantitative Proteomic Analysis of Cellular Signaling Networks’
`10/10/05
`Receptor Tyrosine Kinase (RTK) Consortium Symposium at the ICSB
`conference, Boston, MA ‘Quantitative Proteomic Analysis of Cellular Signaling
`Networks’, 10/23/05
`36) MIT Biology Dept. IAP Series on Proteomics and Protein Technologies,
`Cambridge, MA ‘Quantitative Proteomic Analysis of Cellular Signaling
`Networks’, 1/11/06
`2006 Gordon Conference on Reversible Associations in Structural and Molecular
`Biology, Ventura, CA ‘Quantitative Proteomic Analysis of Cellular Signaling
`Networks’, 1/18/06
`38) Applied Biosystems Seminar Series, Cambridge, MA ‘Quantitative Proteomic
`Analysis of Cellular Signaling Networks’, 1/31/06
`39) Applied Biosystems Seminar Series, Philadelphia, PA ‘Quantitative Proteomic
`Analysis of Cellular Signaling Networks’, 2/02/06
`Proteomics Seminar Series sponsored by Mellon Biomarker Discovery Lab and
`the Keck Biomedical Mass Spectrometry Lab, University of Virginia,
`Charlottesville, VA, ‘Quantitative Proteomic Analysis of Cellular Signaling
`Networks’, 3/14/06
`97th Annual American Association for Cancer Research (AACR) Meeting,
`Washington, DC, ‘Quantitative Proteomic Analysis of Cellular Signaling
`Networks’, 4/05/06
`42) MIT Graduate Alumni Convocation, MIT, Cambridge, MA, ‘Quantitative
`Proteomic Analysis of Cellular Signaling Networks’, 4/22/06
`Protein Research Group, University of Southern Denmark, Odense, DK,
`‘Quantitative Proteomic Analysis of Cellular Signaling Networks’, 4/24/06
`Center for Biological Sequence Analysis, Danish Technical University,
`Copenhagen, DK ‘Quantitative Proteomic Analysis of Cellular Signaling
`Networks’, 4/25/06
`Pfizer, Cambridge, MA ‘Quantitative Proteomic Analysis of Cellular Signaling
`Networks’, 5/2006
`Roswell Park Cancer Institute, Buffalo, NY, ‘Quantitative Proteomic Analysis of
`ErbB Signaling Networks’, 6/2006
`Boston Biomedical Research Institute, Boston, MA, ‘Quantitative Proteomic
`Analysis of ErbB Signaling Networks’, 6/2006
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`47)
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`40)
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`48)
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`49)
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`51)
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`52)
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`54)
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`55)
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`57)
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`56)
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`Lecture and Lab course on Phosphoproteomics, Cold Spring Harbor Laboratory,
`Cold Spring Harbor, NY, 7/2006
`2006 Gordon Research conference on Growth Factor Signaling, Connecticut
`College, New London, CT ‘Quantitative Proteomic Analysis of Receptor
`Tyrosine Kinase Signaling Networks’, 07/20/2006
`50) AstraZeneca, Alderly Park, UK, ‘Quantitative Proteomic Analysis of Receptor
`Tyrosine Kinase Signaling Networks’, 07/2006
`Enabling Technologies for Alzheimer’s Disease VI, Bar Harbor, ME, ‘Network
`Activity Relationships’, 08/04/2006
`28th Annual International conference IEEE Engineering in Medicine and Biology
`Society (EMBS), New York, NY, ‘Cell system perturbation for time-resolved
`quantification of tyrosine phosphorylation in complex samples’, 08/2006
`53) Applied Biosystems Seminar Series, Cambridge, MA, ‘Highly Reproducible
`Quantitative Analysis of Cellular Signaling Networks’ 11/14/2006
`RECOMB Systems Biology and Computational Proteomics Satellite Conference,
`San Diego, CA, ‘Quantitative Analysis of Cellular Signaling Network Activity
`Relationships’, 12/03/2006
`PDL BioPharma, Fremont, CA, ‘Quantitative Analysis of Growth Factor Receptor
`Signaling Networks’, 12/04/2006
`Thermo FisherScientific, San Jose, CA, ‘Quantitative Analysis of Growth Factor
`Receptor Signaling Networks’, 12/05/2006
`46th Annual Meeting of The American Society for Cell Biology, San Diego, CA,
`‘Quantitative Analysis of Growth Factor Receptor Signaling Networks’,
`12/09/2006
`58) Karmanos Cancer Institute, Detroit, MI, ‘Quantitative Analysis of ErbB Signaling
`Networks’, 01/09/2007
`59) Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA ‘Quantitative
`Analysis of Receptor Tyrosine Kinase Signaling Networks’, 01/23/2007
`Chemistry in Cancer Research: A Vital Partnership, AACR-ACS joint
`conference, San Diego, CA ‘Quantitative Proteomic analysis of Receptor
`Tyrosine Kinase signaling Networks’ 02/05/07
`Tango Lessons for Brain Cancer Research, Cordoba, Argentina ‘Quantitative
`Analysis of Cell Signaling Networks as a Drug Target Discovery Tool’ 02/28/07
`2007 Keystone Conference on Cell Signaling and Proteomics, Steamboat Springs,
`CO ‘Quantitative Analysis of ErbB Cellular signaling Networks’ 03