Histopath findings in unscheduled deaths in male mice
`
`Incidence of Microscopic Observations - Unscheduled Deaths and Sacrifices
`TABLE INCLUDES :
`SEX=ALL:GROUP=1 , 2. 3 . 4 . 5;"EZKSBALL
`DEATH=D. M. A, O; EMBLL; SUBSET=ALL
`
`ORGAN AND FINDING DESCRIPTION
`
`n my or 1.151- "
`DEATH COMMENT
`(DC) ................................... NUMBER BxAMI‘NED:
`3
`NOT REMARKABLB:
`
`SEX: ----------MALE ---------
`-2.
`39
`_
`39
`o
`
`0onoon-omwmoouuumooouuouhnucon
`
`sowaoooasw-ot-aunmouoaooaquuo
`
`u:5
`
`Nuon
`
`0
`
`cocoamu
`
`ma qua
`
`mmcooaowaaaonac0°
`
`nu
`
`Ht»mmawe
`
`Nu
`<7
`
`towmm
`
`HO
`
`sen-unwo
`
`Nu
`
`nu
`
`uauouuueouwwo0°
`
`DU #0
`
`nun
`32
`17
`15
`1
`
`to»:can
`
`u-u—oNoooo
`
`1.:
`
`avNOOOONV‘HKONHONHDOOOMHMDOOcm
`
`muNuoHaoc\IGscumum
`
`Dosouncmwuuoooww"“
`
`nu ~14
`
`mu
`
`r
`
`om
`
`...
`
`ma:mi»
`
`HOmoooacmmoomuowowoooonwmrou
`
`
`1.1-!in»)-lmu!Hoot-IoMunoon
`qt»neowuwmar‘uuowa
`
`00
`
`up
`
`vino
`38
`16
`22
`
`3B
`29
`
`omo-boooo
`
`Hmo
`21
`23
`
`45
`31
`
`oncmoHHl—I
`
`n
`
`noUOOOHouHOOOOOHODHOOHNdNUO
`
`N:-\llfl
`...
`
`a.»06000mu!Huoq
`
`a;no
`
`00
`
`mmcan-aNucooowwooonct—a
`
`rumGun
`19
`
`45
`39
`
`anomooco
`
`Alavi- 66
`
`ancomm
` umowwow
`
`"CARDIOMYOPATHY / OTHER SIGNIFICANT CARDIAC LESIONS
`--GAVRGB-RELATBD DEATH
`-—HIS‘K)DOGICALLY UNDBTBRHINE’D
`“INFLAMHATION, SKIN/SETBCUTIS
`"INFLAMWKTION, UROGENITAL TRACT
`- “INFLKMMRTIDN/INFECTION, OTHER
`~—INFLAMMATION, VASCULAR
`~-IN'I'DSSUSCBE'1‘ION
`“-LIVE'R, DmENERRTION/NBCROSIS
`--N'ECROSIS. BRAIN
`“N'mPLASM, ADRBNAL
`--NEOPLASM, HEMATOPOIETIC
`—-NEOPLASM, KIDNEY
`LIVER
`Lum
`
`SPL‘BE‘N DESTRUCTION, URINARY
`
`
`THRDMBUS, ATRIAL
`TRAUMA
`NEOPLASM. SKE’LEI'AL MUSCLE
`INPLAMMATION, TBSTIS
`N'EDPLASH, SALIVARY GLAND
`NECK-ASH. HBMANGIOSARCOMA
`”NEOPLASM. PENIS
`--FIBROSARCOHA, SKIN/SU'BCUTIS
`
`MARROW, STERNUM (SB)
`...
`
`NumER EXAMIN‘RD:
`NOT WME:
`
`--HYFERPIJ\SIA, MYELOID, MARROW
`-—X-HZMA'IDPOIETIC NEOFLBSIA (SEE 'HBMATO NEOPLASIA" FOR TYPE)
`--PIGMEN1‘, MARROW
`-~N'ECROSIS. MARROW
`BONE, 31“an (SB) .....,............ ..... ............ NUMBEREXAMINBD:
`NOT RENEWABLE:
`
`- - INFLAMMATION. CHRONIC -ACTIVE
`— -INFLAMMATICN, SUBACITJ’E
`- ~ INFLN’MATION. VASCULAR
`- X-H'EMATDPOIETIC NEDPLMM
`--N—CARCINOMA
`(EY)
`
`EYE
`
`. NUMBER EXAMINED:
`NOT mama:
`
`
`
`
`
`- -MID
`- -ANDMM.Y. DEVELOPMENTAL
`--BACTBRIAL WIDNIBS
`DMRNBRATION. LENTICULAR
`DXGWERATION, RETINAI.
`FIBROSIS, CORNEAL
`HYPERPLASIA. EPITHELIAL. CORNEAL
`INFLAMMATION, CHRONIC-RCPIVE
`INFLAMMATION, CHRONIC—ACTIVE, CORNEAL
`I‘NBRMIZATION. CORNEAL
`. INERALIZATIUN.
`IRIS
`
`SYNECHIA. ANTERIOR
`"SYNECHIA, POSTERIOR
`
`ULCBRATION. CORNEAL
`--X-HBM.ATOPOIETIC NEDPLASIA (SEE "EEMA’IO NEOPLRSIA” FOR TYPE)
`NERVE. OPTIC
`(ON)
`..... ............ ...... .............NUHBBRL’X1\MINED:
`NOT mmbfl:
`
`"DESENERATION, Mm!“
`
`ONE EXAMINED
`"VACWLATION. ARTIFACJ'UAL
`NERVE. SCIATIC
`(SN) .................................. NUMBER EXAMINED:
`NOT mums:
`
`--DEGMRATION. AXONRL
`--X-HEMA10POIETIC NEOPLRSIA (SEE ‘flEMWID NBOFLASIN’ FOR TYPE)
`BRAIN (BR) .............. ..... ...... .... .............. NUMBER EXAMINED:
`NOT REMARKAELB:
`
`~-COHPRBSSION. W
`unnammnon, mam.
`--INFILmTE, LYM’PHOHISTIOCYTIC
`"INFLAMMATION, smmx»
`- -MINERALI2M‘ION
`"NECROSIS. FOCAL/WETIFOCAL. UNILATERAL
`"VACUOLATION. WHITE HATER. ARTIPACTUAL
`—-X-H‘BMATOPOIETIC mzopmsm (SEE "mamas mommy FOR TYPE)
`
`

`

`Incidence of Microscopic Observations
`Unscheduled Deaths and sacrifices
`
`TABLE INCLUDES :
`SEX=ALL; GRODP=1 , 2 , 3 . 4 , 5; WEEKSnALL
`DBATH=D , M, A, O ; PIND=ALL; SUBSET=BLL
`
`SEX: ----------MALE---------
`
`38
`38
`
`45
`45
`
`45
`45
`
`Mon-IQ
`H...
`
`Pmonoooooooowooon
`
`[\lovuuommpomouwaaoumoomouoFDHHNH
`
`u
`
`um
`
`#-
`
`
`wouomwooouumw—oumHMO»
`
`uNonwuuomuooowooumwwomuoucGOOD-'00
`
`,—
`
`m
`
`um
`
`
`uoneqooocn—u—u—uoncnoHmo
`
`HNONUOOOIfihOFOUHOmeUDO-k-OOOcheer-uh
`
`39
`39
`
`.br-IHW
`
`...
`
`UouwuovaHouu-tomw
`
`w
`
`mu:
`
`
`
`unmooummuuuumowwwqouhwoo00000»
`
`N N
`
`32
`32
`4
`
`NUON
`
`2
`
`3
`
`NNr-‘nhOUIOODOOD—‘HHOUU‘
`
`HofiHODmeOHOHNHOhOmHmDOGr-IODODOH
`
`>-
`
`NUMBER:
`ORGAN AND FINDING DESCRIPTION
`KIDNEY
`(1CD)
`. ........................................ . NUMBER EXAMINED:
`NOT REMARKABLE:
`
`- -AMYLOID. GLOMBRULAR/INTBRSTITIAL
`- JUROPHY. UNILATERAL
`- —CAST. PROTEINAC'ZOUS
`- -CYST
`- -DILATATION, PBLVIC
`- -ECTASIA, TUBULAR
`- -I -HRMANGIOSARCOMA
`- -INFARCT
`- ~INFLAMMATION . CHRONIC-ACTIVE
`- -INFIAMMJ\TION, VASCULAR
`- -INPIAMMATION. SUBACUTE
`- M—CARCINOMA, TUBULAR CELL
`- -N-CARCINOMA
`- -NECROSIS
`— -NECROSIS , PAPIDIARY
`- -NEPPDZOPATI-|’Y, CHRONIC
`--ON'B EXAMINED
`- -X -HEMATOPOIETI C NBOPLASIA (SEE “HBMATO NEOPLASIA' FOR TYPE)
`- -M -H’EMANGIOSARCOMA
`
`LIVER
`(LI)
`...
`.. NUMBER EXAMINED:
`NOT REMARKABLE:
`
`INCREASED
`
`- -AM‘1LOID
`- —B-ADENOMA. HEPATOCELLULAR
`- -E -H'EMANGIOHA
`— -CYST, BILIARY
`- -CYSTIC DBGENERATION / H'BMATOMA
`- -DF.GENERATION/NECROSIS , HEPA'IOCBLLULBR
`— -PIBROSIS , PERI PORTAL
`- -FDC'US. ALTERED HBPR'IOCELLULAR , BASOPHILIC
`~ ~FOCUS, ALTZRED HEPATOCELLULAR, EOSINOPHILIC
`- ~GLYCOGm, HBPATOCBLLULAR,
`INCREASED
`- —KEMATOPOIZSIS , BXTRAMEDULMRY
`- -HYPERPIASIA. BILE DUCT
`- -HYPERTROPHY .
`IEPATOCELLUIAR
`INCREASED
`- -MACROPHAGES. PIGMENTvLADRN,
`- - INFILTRATE, LYHPHOHISTIOCYTIC
`- -INPl-AMMATION, CHRONIC-ALTIVE
`- -INPLAMMBTION. VASCULAR
`- -M-CARCINOMA,
`lmPATOCELLImAR
`- -M-HEMANGIOSARCOMA
`- —MINERALIZATION
`- -MITOSIS, HJZPATOCBLLULAR .
`- -N- CARCINOMA
`- -N'ECROSIS , COAGULATIVE
`- -NECROSIS ,
`INDIVIDUAL EEPATOCYTES/MULTIFOCAL
`- -THROM'B‘US
`- -VACUOLATION . HEPATOCELLULAR
`- -V7\CUDLATION . HEPATOCELLULRR , PERIPORTAL
`- -VACWIATION . HEPRTOCELLULAR, LIPID
`- -X-HEMATOPOIET1C NEOPLASIA (SEE “HEMATO NEOFLASIA' FOR TYPE)
`- -ANGIEC'H\SIS , FDCAL/MDLTIFOCAL
`
`GALLBLADDER
`(GB)
`. .
`
`NUMBER EXAMINZD-
`NOT REMARKABLE:
`
`31
`36
`31
`32
`22
`28
`33
`29
`3].
`22
`1
`0
`0
`1
`O
`2
`3
`2
`0
`0
`1
`0
`0
`0
`0
`45
`45
`3B
`39
`32
`32
`2'7
`23
`22
`17
`0
`0
`1
`1
`0
`2
`4
`3
`5
`2
`0
`0
`0
`0
`1
`1
`1
`1
`1
`D
`O
`0
`0
`0
`1
`1
`0
`O
`0
`0
`1
`0
`1
`1
`1
`0
`1
`1
`O
`2
`5
`3
`0
`1
`O
`4
`11
`6
`6
`6
`1
`2
`1
`2
`3
`1
`1
`O
`0
`1
`0
`4
`4
`7
`2
`0
`O
`1
`0
`0
`1
`1
`2
`2
`5
`1
`0
`0
`O
`O
`45
`45
`38
`39
`32
`44
`45
`38
`39
`32
`c
`H
`:1
`o
`- - INFWTION . CHRONIC-ACTIVE
`c
`uto
`vbuI
`.9III
`u m
`ESOPHAG‘US
`(ES)
`. . . A
`NUMBER EXAMINED:
`u q
`um
`a. p
`.po
`NOT mumnz :
`NUtau
`
`- -D1LATATION
`--INFILTRATB. LYMPHOHISTIOCYTIC
`--INSPISSATED MATERIAL. LUMINAL
`(LU) ..... ............. . ...... . ..... ............ NUMBEREXAMIN'ED:
`NOT RBMARKABLE:
`
`'
`
`LUNG
`
`- —AMYIDID
`-—E—ADENOMA. ERONCHIOLAR—ALVEOLAR
`--BACTERIAL COIDNIPS. PLEURAL
`— -BI.DOD, TERMINALLY INHALED
`— -CONGESTION
`- -FIBROSIS, PLEURAL/S’UEPLEURAL
`— «moxmss
`- >HYPERPLASIA, ALVEOLAR / ERONCHIOLAR
`--IN'FILTRATE. LYMPHOHISTIOCTI‘IC
`INFILTRATE. MACROPHKGB. ALVEOLAR
`INFLAMMATION. CHRONIC-ACTIVE
`INFLAWATION, CHRONIC-ACTIVE, DIEDIASTIM
`M-CRRCINOMA, BRONCHIOLAR-ALVEOLAR
`N-CARCINOMA
`X-EBMATOPOIETIC NEOPLASIA (SEE “HEMA'IO NEOPLASIA" FDR TYPE)
`- -N-HBMANGIOSARCOMA
`
`.. ...............
`TRACKEA
`(TR)
`
`
`
`NUMBER EXAMINED:
`NOT MERLE:
`
`- -EACTERIAL COLONIES
`- ~DEGE‘NE‘RATION , MYOFIBER
`- -FOREIGN MATERIAL
`- - INFLAMMATION . CHRONIC -ACIIV'.B
`- -ULCERATION
`
`O‘JNON
`
`owaoo
`
`owooo
`
`I-DvbI-ION
`
`ouuoHo
`
`Alavi- 67
`
`

`

`»_ --------- MALE ---------
`.1.
`.2.
`-4.
`.5.
`32
`39
`45
`45
`32
`39
`45
`44
`38
`28
`31
`40
`
`Incidence of Microscopic Observations
`Unscheduled Deaths and Sacrifices
`
`TABLE INCLUDES :
`SEX=ALL;GROUP=1,2,3,4,5;WEEKS=ALLI
`DEATH: D, M. A . 0: FIND=ALL ; SUBSET=ALL
`
`SEX:
`GROUP:
`NUMBER-
`ORGAN AND FINDING DESCRIPTION
`
`THYROID
`(TY) ................. ......... . ..... ,........NUM'BEREXAMINED:
`NOT REMARKAELE:
`
`- -MTYI.OID
`- —CYST, FOLLICULAR
`— -CYST. THYROGIDSSAL
`- -FIBROSIS
`- — INFILTRATE , LYMPHOHISTIOCYTIC
`- - INFLAMMATION, CHRONIC-ACTIVE
`- ammmnnou , VASCULAR
`— —ONB EXAMINED
`- -X-HEMATOPOIETIC NEOPLASIA (SEE ‘H'EMA’IO NEOPLASIA" FOR TYPE)
`- -N-CARCINOMA
`PmTl-IYROID (PT) ................. .. .................. NUMBER EXAMINED:
`NOT REMARWLE:
`
`- —AMYIDID
`
`HEART
`
`(HT) ......... ............... ......... . ....... ”NUMBEREXAM'INED:
`NOT REMARKRBLE:
`
`
`
`- JAM-DID
`CARDIOMYOPATH‘I
`INFILTRATE. LYMPHOHISTIOCYTIC
`INmHMATION, CHRONIC—ACTIVE
`INWATION. VASCULAR
`HINERALIZATION, EPICARDIU'M
`--N-CARCINOMA
`
`~-NBCROSIS. MYOCARDIAL. WITH HEMORRHAGB
`THROMBUS, ATRIAL
`‘
`——X-HEMATOPOIETIC NEOPLASIA (SEE “HEMA'IO NEOPLASIA' FOR TYPE)
`MUSCLE. SKELETAL
`(SM) ................................ NUMBER EXAMINBD:
`NOT REMARIOXELE:
`
`- -ATROPKY, MYOFIBER
`
`
`DmmRATION/NECROSIS
`HBMORRHAGB
`
`INFLAMMATXON . CHRONIC-ACTIVE
`
`—}EMATOPOIETIC NEOPLASIA (SEE “HEMA'ID NEOPLASIA” FOR TYPE)
`- -M ~FIBROSARCOMR
`- -M—HBMANGIOSARCOMA
`TONGUE
`(TO) .....,.,..................
`
`
`.. NUMBER EXAMINED:
`NOT REMARKRBLE :
`
`.....
`
`........ ........NUMBEREXAMINED:
`NOTRBMARmLz:
`
`- -AM'YIDID
`- -B-PAPIl-LOMA, SQUAHOUS CELL
`- - INFILTRATION, LYMPHOHISTIOCYTIC
`- -IN'ELAM'W\TION. CHRONIC-ACEIVZ
`- ~1'NFLAM'MATION. VASCULAR
`SPLEm (SP)
`- -AMYIDID
`
`B~HEMANGIOMA
`
`DEPLBTION. LYMPHOCYTIC
`
`FIBROSIS , CAPSULAR
`HEMATOPOIESIS. EXTRAMEDULLARY ,
`HYPERFLASIA, LY‘MPHORETICUUAR
`N“HBMANGIOSARCOMA
`
`NECROSIS . LYMPHOCYTIC
`PIGMENT.
`INCREASED
`— -X-HEMA'N)POIETIC NEOPLASIA (SEE “immm NEOPLASIA” FOR TYPE)
`
`THYM'US
`(TH) ..........
`. . NUMBER EXAMINED:
`NOT REMARKABLE:
`
`INCREASED
`
`- -CYST
`~ ~DBPLETION, LYMPHOC‘ITIC
`- -FOREIGN MATERIAL . MEDIASTINAL
`— ~H’YPERPLASIA. LYMPHORETICULAR
`- - INFLAMMATION, CHRONIC-ACEIV'B, MEDIASTINAL
`- -H-HEMANGIOSARCOMA
`- ~HINERALIZATION
`'
`- -NECROSIS . LYMPHOCYTIC
`- -X— HEMA'IOPOIETIC NBOPLASIA (SEE ‘I-EEMA’R) NBOPLASIA” FOR TYPE)
`LN, MESENTERIC
`(MS) ..................... . ........ .. ,. NUMBER ZXAMINED:
`NOT REMARKABLE:
`
`- -AMYLOID
`- <ANGIECTASIS
`- ~CONGESTION
`- -CYST
`- —DEPLETION. LYMEHOCYTIC
`- -ECTOPIC IN'IESTINAL EPITHELIUM , ADJACENT MESENTERY
`- JEUATOPDIESIS, EXTRAMEDULLARY
`- >HEMORRHAGB
`- ~HYPERPLASIA, LYMPHORETICULAR
`- -HYPERPLASIA. RETICULOENDOTH‘HLIAL
`- -INPILTRATE , MACROPHAGE, PIGMBNTED
`- VINPLAMMATION . CHRONIC ~AL‘I‘IVE
`"THROMBUS
`—-X—HEMA'I‘0POIETIC NEOPLASIA (SEE “PEMA’IO NEOPLASIA” FOR TYPE)
`
`onwwocooua
`
`MN0nun-
`
`n-‘uQM
`
`UNOOHH‘FHQO
`
`mo
`
`N
`
`>-
`
`umot-toonoooowcurd00°00
`
`
`FM.30Hwouéwooowooa»br-HOHOHQD
`
`HOOOHHOOUIU
`
`NMmu
`
`OOOOHI—‘Oouw
`
`tau9:~10
`
`nu
`
`mu
`
`Hm
`
`NOOHoHvr-ImuNW
`5:20OHOOQOaw
`NHHHcououI-INbug00000
`tornmacaocomo
`
`N...owooonuotw-uauu
`
`H
`
`mm
`
`Nu
`
`ugm:1oooooo
`
`HHHHH
`
`H“ mm
`
`MNOCOOHObb-Icam“OOHDV‘OHHN
`
`
`noHoocuooqowuu
`
`Nuout
`
`OHOONOHHUO
`
`mm9mm
`
`ab0qu
`
`uooooouoqo
`
`HHHOH-FFD‘OOmmOoh-10°
`wooomaoqomu
`
`NU
`
`u»mu
`
`wwwohuooooon
`
`QOOGOODODH
`
`wwNu
`H
`
`to»0'0!
`
`.5»HUIUIOOOHOHUUIOU
`
`Hoooop000000
`HHMto.»HNOHHOHNOumHNOHquHcI—lmu:
`HOwaowpumoncu
`
`uh
`
`Alavi— 68
`
`

`

`Incidence of Microscopic Observations
`Unscheduled Deaths and Sacrifices
`
`TABLE INCLUDES:
`-
`SEX:
`SBX=ALL;GROUP-1.2,3,4,5;WEEKS=ALL
`DBATH=D.M.A»°:FIND=ALL18UBSBT=ALL
`
`"1111110113
`--ATROPHY, coR'rICAL
`--13-ADzNonA, smacnpsmn (221.1.
`--DEGENERATION, LIPOFUSCIN,
`INNER 1:011sz
`--1zcro121c 1mm
`--11YRRRPLA31A,
`51211111113 can.
`"11121111111113. LYMIPHOCYTIC
`"INE'LAMMATZON, mRONIC-Acrrvz
`--1NFLAmATION. VASCULAR
`"MINERALIZATION
`——ONB EXAMINER
`ummmsm, coR'rICAI.
`"HYPBRTROPHY, com-1cm. CELL
`"11132110515. COAGULAT'IVP.
`"X‘HEMA'KOPOIBTIC NzopLAsxA (S1323 ‘HEMATO NEOPLASIA" FOR TYPE)
`--B-FH.'EOCKRDMOCmHA
`«mam-11011. LIPOF'USCIN
`HVPBRPLASIA. MEDULLARY
`-INFILTRATB. Lmnonrsuocn'xc
`
`"MINERALIZATION
`"01113 21111111111313
`
`.. NUMBER BXAMINED:
`11011111
`(A0)
`..
`NOT mmm:
`
`"moms:
`--INmeATION. CHRONIC-ACTIVE
`—-1NF1.AM11ATION. VASCULAR
`--N-CARCINOMA. ADJAcm-r 11.55172
`“I-EEMATO NEDPLASIA' ROR TYPE)
`—-X-l-EMA’IOPOIBTIC 1113021115111 (5111;
`prrurmzv
`(91) ..... . ................................. NUMBER EXAMINED:
`NOT REMARKABLE:
`
`»n—AD2N0HA
`"cvs'r
`
`"HEMORRHRGB
`1MBR1=1A51A
`
`INFLAmATION. CHRONIC-ACTIVE
`--x-113MAmPom1'Ic NzopLAsm (3122 “112111110 NEOPLASIA” FOR TYPE)
`"PARS. TN'I'BRMEDIA
`PANCREAS
`(9A) ......
`
`
`.
`.mznzxmmzn:
`NOT REMARKABLB:
`
`4s
`45
`3s
`39
`32
`NUMBER:
`ORGAN AND FINDING DESCRIPTION
`—=— —-.
`--— _—.
`........................................................................ .u.
`44
`15
`37
`311
`mm. 00111131:
`(AC)
`..... ...........ND111313R EXAMINER:
`31
`16
`21
`9
`14
`NOT REHARKABLE:
`13
`2
`11
`4
`5
`1
`o
`n
`3
`1
`o
`o
`o
`o
`1
`0
`19
`113
`13
`10
`11
`o
`1
`o
`o
`0
`5
`5
`9
`5
`5
`1
`u
`1
`o
`o
`1
`a
`o
`1
`a
`o
`1
`o
`o
`o
`1
`a
`o
`o
`o
`3
`2
`3
`6
`3
`1
`1
`1
`o
`1
`1
`2
`1
`1
`2
`1
`a
`o
`o
`o
`o
`1
`1
`1
`2
`0
`0
`0
`1
`0
`1
`1
`o
`1
`1
`1
`o
`o
`a
`1
`o
`o
`1
`o
`o
`o
`1
`o
`o
`o
`5
`6
`a
`7
`2
`45
`44
`39
`36
`31
`43
`43
`37
`35
`26
`o
`o
`o
`o
`1
`1
`o
`1
`o
`1
`o
`1
`o
`o
`a
`1
`o
`o
`o
`0
`o
`o
`1
`1
`4
`45
`44
`38
`33
`32
`1
`5
`1
`2
`4
`1
`1
`o
`o
`o
`2
`1
`o
`2
`a
`o
`o
`1
`o
`o
`o
`o
`1
`o
`o
`o
`o
`1
`o
`o
`o
`o
`o
`1
`1
`44
`39
`37
`35
`23
`15
`45
`39
`35
`32
`27
`31
`23
`26
`21
`a
`o
`1
`o
`o
`1
`o
`o
`o
`o
`o
`o
`:1
`2
`o
`1
`o
`o
`o
`o
`o
`o
`1
`o
`0
`n
`1
`a
`o
`o
`11
`o
`o
`o
`1
`1
`o
`o
`o
`o
`1
`1
`1
`1
`3
`15
`12
`12
`9
`7
`45
`45
`39
`3a
`32
`27
`33
`23
`19
`13
`3
`1
`3
`2
`o
`o
`o
`o
`1
`o
`o
`1
`o
`2
`o
`3
`0
`3
`1
`1
`1
`0
`2
`1
`3
`7
`4
`9
`7
`5
`0
`1
`0
`D
`-D
`o
`1
`o
`a
`o
`12
`9
`9
`9
`11
`o
`1
`3
`1
`o
`o
`1
`1
`o
`11
`a
`o
`o
`1
`u
`1
`o
`o
`o
`o
`o
`o
`1
`o
`o
`o
`1
`o
`o
`o
`1
`1
`1
`1
`4
`45
`45
`39
`33
`32
`44
`42
`3s
`37
`25
`a
`1
`o
`o
`o
`a
`o
`o
`1
`0
`1
`2
`3
`1
`2
`o
`1
`1
`1
`o
`u
`1
`1
`o
`o
`o
`o
`o
`o
`1
`'41
`41
`36
`35
`31
`40
`41
`33
`33
`27
`1
`o
`2
`2
`1
`-~A1\m.om
`o
`o
`o
`o
`1
`"EDEMA
`o
`o
`o
`o
`1
`13211111311111.
`--11v1>z1u=LAs1A.
`
`o
`o
`1
`n
`o
`"magnum
`o
`o
`2
`x-nmmmrmrc NzopLAsxA (SEE “1113111110 NEOPLASIA" FOR m2)
`o
`o
`___———————————____——————————____.——_____________________________________________________________
`
`"EDEMA
`"IBMATOPOTBSIS. EXTRAMBDULLARY
`—-INRIL1'RA113. memsuocv‘nc
`--INFLAMMA1'ION, CHRONIC-ACTIVE
`-—INFLAMMATIO'N, CHRONIC, ADJACENT CONNECTIVR 11551113
`--1N1:LAM11A'1'ICN, suaAcm'B
`—-INPLAM11A'1‘10N, VASCULAR
`--N-CARcm0MA
`--X-HBMATOPOIETIC NEORLASIA (SEE “1113111170 NEOPLASIA- FOR ME)
`-—ZYMOGBN. chmszp
`
`.. ....... .. NUMBER BXAHINED:
`SNMACH. CI.
`(51')
`..
`NOT RI‘MARKABLE:
`
`"AMYLOID
`—-B~ADEN0MA
`--CONGBSTION
`"ms-1‘s. BPITH'BLIAL. sumcosA/TUNICA muscumms
`111111 INTRAC‘ISTIC CELLULAR 01251215
`-—DBGENERATION / “zcnoszs, MUCOSAL GLAN'DS
`MAY INCLUDE 13111111111011
`--1zcrAsrA. GASTRIC GLANDs
`--EROSION
`~-1113110RR11AGB
`~-HYPERTROPHY / HYPERPLASIA. mcosm.
`"mum-11011, CHRONIC-Acrm
`—-1NFLA1~1MA1'10N, suaAcm-a
`--1N1'1.AMMATION, VASCULAR
`"mum-1'13, LYMPHOHISTIOCYTIC
`"bl—CARCINOMA
`--NECROSIS
`--x-111311Am20121'1c NEoPLASIA (5132 ‘HEMAN NEOPLASIA" FOR m3)
`510mm.
`1101161.
`(511)
`........ .............N1711513RBXAMIN'BD:
`NOT REMARKABLE:
`
`--ch1', sommous
`"212051011
`--HYPERIGZRATOSIS. NONGLANDULAR MUCOSA
`~—IN'1=LAM11A'1'10N, CHRONIC-Acrrvz
`--ULCERBTION
`~-X—HBMATOPOIETIC N'EOPLASIA (.5213 .112111111) 1113021113111" FOR TYPE)
`1:001:13an
`(DU)
`........ . ........................... NUMBER EXAMINED:
`NOT RmARXABLR:
`
`Alavi- 69
`
`

`

`Incidence of Microscopic observations
`Unscheduled Deaths and Sacrifices
`TABLE INCLUDES :
`szx=Amezoup=1 .2 , 3 ,4 , smazksam.
`DEATH-D, Mm. 0;FIND=ALL;SUBSET-ALL
`
`53x: ----------HALE.........
`
`ORGAN AND FINDING DESCRIPTION
`mi (-72) ....... ........... ..... A.
`
`NUMBER-
`
`. NUMBER EXAMINED:
`
`NOT RBMARXABLB:
`
`"AMYLOID
`“HBMORRHAGE
`--X-HWTOPOIBTIC NEOPLHSIA (SEE ‘HEMAN N'EOPLASIR' FOR TYPE)
`ILBVM (IL) ........................................... NUMBER EXAMINED:
`
`NOT WWI; .
`--X-HRMA’IOPOIETIC NEOPLASIA (SEE "HZMATO NEOPLASIA' FOR ME)
`--AHYIDID
`CBCUM (CB)
`. . . . . ...................................... NUMBER EXAMINED:
`NOT WWLE:
`
`--AMYLOID
`--H'YPERPLASIA. GMT (GUT ASSOCIATED LYHPHOID TISSUE)
`--X—H’BMATOPOIETTC N'EOPLASIA (SEE “YEMTO NEOPLASIA” FOR ME)
`COLON
`(CO) ............... . ........................... NUMBER EXAMINED:
`NOT RBMARKABLE:
`
`"RYPERFLASIA. EPI'fiiELIAL
`--X-HEMA'(OPOIBTIC NEOPLASIA (SEE "REMATO NBOPLASIA' FOR TYPE)
`LN, MANDIBULAR
`(MN) .......... . ....................... NUMBER BXAMINED:
`NOT mmLE:
`
`--CYST
`~~HYPERPLASIA, LYHPHOFLASMAC‘ITIC
`--HYPERFIJ\SIR, LYHPHORETICULRR
`—-ON'B EXAMINRD
`--X-HBMATOPOIETIC NEOPLASIA (SEE "HEMATO NBOPLASIA‘ FOR TYPE)
`
`.. NUMBER EXAMINED:
`SALIV 8L. MANDIB
`(SG)
`NOT WWI/B:
`
`--AMleD
`(PRESENT IN HANDme AND/0R CHER SALIVARY GLANDS IN SECTION)
`"HEMORRHAGE
`--INFILTRATB. LYMPHOHISTIOCYTIC
`"INFLAMMATION. CHRONIC-ACTIVE
`--M-GARCINOMR
`——SECRETORY GRANULES, DECREASE
`--X-HBMATOPOIBTIC NEOPLASIA (323 ‘HBMA'IO NPDPLASIA‘ FOR TYPE)
`HARDBRIAN GLAND
`(HG) ................................. “WEEK EXAMINED:
`NOT mmLB:
`- -ATROPHY
`- -B~ADENOMA
`- -E(.'I'ASIA. DUCTAL
`- -HYPXRFLRSIA, GLANDULAR
`~ - INPILTRATB . LYMPHOHISTIDCYTIC
`- ‘ INFLAMMATION, CHRONIC-ACTIVE
`- ~PIGMHIT.
`IM’RADUCTRL.
`INCREASED
`- -X-NB'MATOPOIETIC NEOPLASIA (532 "1412mm NEOP’LASIA” FOR TYPE)
`- -M-CARCINQ\1A
`SKIN (SK) .......... ......... ....... ......... .........NUHBEREXAMINBD:
`NOT REMARIGELE:
`
`- -ACANTHOSIS/HYPERKERATOSIS
`- -B-HISTIOCY1’OMA
`~ -B-PAPILLOMA, SOUAMOUS CELL
`- -COLONY. BACTERIAL
`- -CYST. SQmMOUS
`- -EDBMA
`- ~PIBROSI5
`--FORBIGN MATERIAL
`"INPILTRA‘PB, LYMPHOHISTIOCYTIC
`- -INFLAHMATION, CHRONIC -A(.TIVB
`- -INFLAMMATIM, CHRONIC
`- >INFLAMATION, 51mm
`- vM-FIBROSARCOHR
`- -SU‘PERFICIA!. CRUSTING
`- JIMWTIDN
`- -X-H'EMA'IOPOIETIC N'BDPLASIA (SEE ‘HEHAN NEOPLASIA' FOR TYPE)
`MANNY, HALE
`(m)
`. .................................. NUMBER BXAHIN'BD:
`NOT REMARKNBL'B:
`
`32
`30
`27
`1
`0
`2
`29
`26
`2
`1
`26
`24
`O
`1
`1
`29
`28
`0
`1
`32
`15
`D
`4
`0
`10
`5
`32
`27
`0
`
`32
`23
`
`NUumHana-no
`oowow-o-t-uo
`
`mun-noOcmaobwouoob
`
`39
`33
`29
`2
`2
`0
`35
`27
`1
`7
`31
`29
`1
`0
`1
`34
`34
`O
`0
`37
`25
`0
`5
`D
`6
`1
`39
`29
`Iu
`
`nuouuumn—aaua4mHHHNbD—I
`
`>0nmmoaauuapuununm
`
`tauum
`
`um
`
`HMuluwe
`
`
`
`HNHOOOOF'm—oaowmcwu
`
`anH»-
`
`an
`
`nuum
`
`
`
`uhflflv—Ou'nw<¢~mnwu$aao
`
`"BCIASIA. DUCTAL
`--X-HH’IATOPOIETIC NEOPLASIR (SEE 'I'EBMATO NEOPLASIA" FUR M!)
`URINARY BLADDER
`(U3) ........................ . .
`.
`. . .
`.
`.
`. NWBER EXAMINED:
`NOT REMARKABLE:
`- -AMYIDID
`“BACTERIAL COLONI‘BS
`- -CDNGSSTION
`. -DILATATION
`- —EDEMA
`- -PXBROSIS
`- -mORRHAGE
`- -mmpmsm. TRANSITION”. C‘BLL
`- -H'Y'PERTROPHY. SMOOTH MUSCLE
`--INEILTRATE, LYMPHOHISTIOCYTIC
`- leFLAMMATION. CHRONIC-ACTIVE
`- -INPIAMHATION, SUEACUTB
`— - INFLAHMATION , VASCULAR
`- -M»CA_RCINQ\1A, TRANSITIO‘NAI. CELL
`- -PROTEINACBOUS MATERIAL. LUMINAL
`- -ULCERATIDN
`- -VBCEDLATION, TRANSITION“ EPITHZLIDM
`--X-HEMA10POIETIC NEOPLASIA (SEE ‘H'BMATO NEOPLASIA' FOR ME)
`——_————.—.——__.—__._____—___
`
`BB
`35
`33
`2
`0
`fl
`34
`27
`0
`7
`33
`33
`0
`0
`0
`35
`36
`D
`D
`36
`25
`D
`4
`D
`6
`2
`3E
`25
`w
`
`HODDB‘IO
`
`45
`39
`39
`0
`O
`0
`35
`36
`1
`1
`39
`38
`O
`0
`1
`41
`39
`1
`1
`42
`25
`I
`6
`0
`10
`1
`44
`33
`to
`
`unoumo
`
`45
`40
`40
`0
`D
`O
`35
`33
`0
`2
`37
`36
`0
`1
`0
`41
`41
`o
`0
`43
`25
`O
`6
`l
`12
`1
`4-1
`34
`o
`
`uoonqo
`
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`um
`
`Nu”\l
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`
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`
`Alavi- 70
`
`

`

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`
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`
`v»-
`
`Incidence of Microscopic observations
`Unscheduled DeathE and Sacrifices
`
`TABLE INCLUDES :
`SWML;GROUP-:1.2.3.4,5;HBEKS=ALL
`DBATH=D,M,A;O:PIND-ALL:SUESETIALL
`
`SEX:
`GROUP:
`
`NUMBER:
`ORGAN AND FINDING DESCRIPTION
`PROSTATE
`(PR)
`. . . ........................... . . . . ...... NUMBER BXAMINED:
`NOT RBMARKABLE:
`- -BDEMA
`- 4125101021935!
`-—INPILTRATE. LY‘MFHOHIS’L’IOCYTIC
`--INPLM4W\TION. CHRONIC-ACTIVE
`- >INFIAMHRTION, VASCULAR
`"X-HEMATOPOIBTIC NZDPLESIA (SEE "HBMR'IO NZOPLASIA' FOR TYPE)
`SEMINAL VESICL'B
`(5V) .......... . ............ . . . ....... NUMBER EXAMINED:
`NOT REMARKRBLE :
`— <FIBROSIS
`- -HYPBRPLASIA/HYPERTROFHY . MESOTH'BLIAL
`- — INFILTRATB , LYMPHOHISTIOCYTIO
`- -INFLAMMATION, CHRONIC
`- -INPLAMMATION. CHRONIC-ACTIVE
`— -INFLAMMATION, SUBACDTB
`- -INFLMTION, SUPPURATIVE
`- -ONB EXAMINED
`- —SBCRETION.
`INCREASED
`« -X>HBMA‘IOPOIBTIC NEOPLBSIA (SEE “HERETO NECK-ASIA“ FOR TYPE)
`TESTIS
`(TE) ..... ...... ....... ..... ........... ..... ...NUMBEREXAMINBD:
`NOT REMARKRBLB :
`-—AMYLOID
`—-ATROPKY / DEGENBRATION. UNILA’fi-IRAL
`-—ATROPHY / DEGENBRATION, BILATBRAL
`--B-SERTOLI CELL TUMOR
`—-GRANUI»OMJ\, SPERM
`‘-HYPERPLAS!A.
`INI'ERSTITIAL CELL (LE‘IDIG CELL)
`--1NFLN’NATION, CHRONIC-ACTIVE.
`- -MINERALIZATION
`- -THROMBU8
`-—X-H’EMATOPOIETIC NEOPLASIA (SEE ‘HBMATO N'EDPLASIA' FOR TYPE)
` . . NUMBER BXAMINED:
`NOT REMARKABLB:
`EPIDIDYMIS
`(2P) ...............
`
`- -ATROPHY
`--ECTASIA. DUCTAI;
`Gm. SPERM
`HEMA'IDPOIESIS. EXTRAM‘EDULLARY
`HMORRHAGB
`
`HYPOSPERMIA
`IX‘MATD'RE SPERM FORMS
`INFILTRATB. LYMPHOHISTIOC‘ITIC
`
`INFILTRATB, MACROPHAGE. PIGMENTBD, ADJACENT
`INFLAMMATION. CHRONIC-ACTIVE
`
`M-PIBROSRRCOMA
`MTNERALIZRTION
`--X-HWATOPOIBTIC NEOPLASIA (SEE 'HEMA’KO NEOPLASIA” FOR TYPE)
`HEHATO NEOPMSIA (KN)
`.
`. .
`. . . ....... . .................. NUMBER BXAHINBD:
`NOT REMARKABLE :
`- -M-LYMP‘HOMA
`- -M—SARCOMA. HISTIOCYTIC
`
`PAS STAIN (P1)
`..
`
`............. NUMBER EXAMIN'BD:
`NOT REMARKABLE:
`
`— -HEMATOPOIESIS, BXTRAMEDULLARY
`
`....... ............... NUMBER BXAMINED:
`131mm (m)
`..
`NOT RBMARKABLB:
`
`- -ACANTHOSIS/HYPBRKERATOSIS
`- -COLONY. BACL'ERIAL
`- —FIB‘ROSIS
`- -INFIAMWATTON, CHRONIC -ACTIV'B
`- ~U'LCBRATION
`——SUPERPICIAL CRUSTING
`- -B-PAPILLOMA, SOUAMOUS CELL
`HILLARY ........ NUMBER EXAMINED:
`NOT REJARKABLE:
`
`LN.
`
`~ -INP1LTRATE. LYMPHOFIASMACYTIC
`—- ~NECROSIS . LYMPHOCYTIC
`- -INPILTRATZ. HISTIOCYTIC
`- ‘HBMATOPOIESIS . EXTRAMEDULLARY
`PRBPUTIAL GLAND
`(PG)
`. . .. ............................. NUMBER EXAMINED'
`NOT RBMARKABLB:
`
`- -EL‘I'ASIA, DUCTAL
`~ -HYPERPIASIA
`- ~1NFLAMMRTION. CHRONIC
`- -HEMORRHAGE
`- - INFUIMMA'IION. CHRONIC -ACTIVE
`- -BACTBRIAL COMNIBS
`LUMBAll/ILIAC
`(LN) .......... . . . ..... .
`
`. . . .
`
`.
`
`.
`
`.
`
`. ..... NUMBER EXAMINBD-
`NOT REMARKABLB:
`
`“HYPERPLASIA, LYMPHOPLASMACYTIC
`_
`- —INFLAMMI\TIDN, CHRONIC—ACTIVE
`
`coco
`X -HEMATOPOIETIC NEOPLRSIA (5113 "HEMATO NEOPLASIA" FOR TYPE)
`» -HEMATOPOIESIS , mmmv
`_______________________.———————-————-
`
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`
`Alavi- 71
`
`

`

`
`
`Incidence of Microscopic Observations
`Unscheduled Deaths and Sacrifices
`
`TABLE INCLUDES:
`SEX=ALL;GROUP=1 , 2 , 3 , 4 , 5,-HBBKS=ALL
`DEATH=D, M,A, 0,‘FIND=ALL: SUBSET-ALL
`
`ORGAN AND FINDING DESCRIPTION
`
`LN, OTHER
`
`(LN) ............................ ........... NUMBER EXAMINED:
`NOT WWLE:
`
`--x-Hmnm1>omnc NEOPLASIA (SEE ‘H'BMATO NBOPLASIA" FOR TYPE)
`"INFLAMMATION, CHRONIC-ACTIVE
`"HYPERPLASIA. LYMPHOPLASMACYTIC
`
`.................... .. NUMBER EXAMIN'ED;
`(RL)
`LN, RENAL
`NOT REMARKABLB:
`--mmpmsm, LmPHopLAsmcv'rIc
`--IN'FLAMMATION, CHRONIC-ACTIVE
`"consume“
`--X-HEMATOPOIBTIC momsm [SEE “92mm NBOPLASIA” FOR TYPE)
`
`URETER
`(DB)
`....NUMBEREXAMINED:
`nor REMARKABLB:
`- -DILATATION
`- -INFLAMMATIW, CHRONIC-ACTIVE
`" -ONB EWINED
`- -INFILTRATB. LYMPHOHISTIOCYTIC
`
`(ML) ...... . .......................... mam 2mm»:
`no'r REMAanLB:
`
`LN, MRDIASTINAL
`--N-CARCINOMA
`—-x-m'mpomnc mzopLAsm (snz "HEMATO unopmsm" FOR TYPE)
`INGD'INAL (IN) ..... . ..... . ........ NUMBER minimum
`NOT WWII:
`--HYPERPLASIA, LYMPHOPLASMACYTIC
`
`
`LN,
`
`....
`(PE)
`PENIS
`- -INFLAMMATION. CHRONIC-ACTIVE
`- ~CONGESTION
`- ~ECTASIR. VASCULAR
`- -ULCERATION
`- VM-FIBROSARCOMA
`- -BXUDATE, BPIDERMAL
`
`......... NUMBER EXAMINED:
`NOT RBMARKABLE:
`
`CAVITY, ABDOM (PC)
`--FIBROSIS
`--INFILTRATE, MACROPHAGE. PIGMENTBD
`--INE‘LAMMATIUN. CHRONIC-ACTIVE
`
`. . . . ..... . . . . . . .............. . ..... NUMBER EXAMINED:
`NOT RBMARKABLE:
`
`
`(TB) ......... ............,.... .n... NUMBER EXAMINED
`LN, TRACHEOERON
`--HYPRRPLASIA, PLASMACYTIC
`--ONE EXAMINED
`--x-mmpomnc NEOPLASIR (SEE “HEMATO NEOPLASIA” FOR TYPE)
`
`(TI) .........
`........................ NUMBER EXAMINED:
`NOT REMARKABLE:
`- - INPLAMMATION , CHRONIC
`- —AmNT1-IOSIS / HYPERIGRATOSIS
`~ -ULCERATION
`--EXUDATE BPIDBRML
`- -INFLAMMATION. SUEACUTB. ADNEXAL/PERIADNBXAL
`~ -NECROS IS , DISTAL
`
`TAIL
`
`
`(17E) . NUMBER BXAMINED:
`BONE, FEMUR
`NOT REMARMBLE:
`- -HZMORRHAGE
`- -FIBROSIS
`--IN'FLAMMATION. CHRONIC-ACTIVE
`- -FRACI‘UR.B
`
`(CG) .. ...... . ........ NU'MBEREXAMINED:
`COAGULATING GL
`NOT REMARKABLE .-
`- -ONE EXAMINED
`- -SECRETION INCREASED
`- -INFLAMMATION , CHRONIC -ACTIVB
`
`
`CAVITY, THORACIC
`
`(TA)
`
`. . . . .
`
`.
`
`. NUMBER EXAMINBD:
`NOT REMARKABLE :
`
`--X—HEMA’IOPOIETIC NEOPLASIA (SEE “EEMA'ID NEOPLASIA” FOR TYPE)
`SBLIV GL,PAROTID
`(PV)
`......... . ......... ........ NUMBER BXAMINBD:
`NOT REMARKABLE:
`--INFLRMMATION. CHRONIC-ACTIVE
`1" END OF LIST *"
`
`ODD-IN
`
`OI»OOOHOH00¢09
`I-IOOOHHHHONHH01OOOOOOI:
`
`GO
`
`ONOOO
`OOOHHONH
`
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`
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`
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`OH00OOHot-Amcm
`OODOOONOolu
`
`H
`
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`
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`HOHHOH
`
`OO
`
`ON000::
`OOOOO0”“
`
`O
`
`
`
`a»:HI-IHon:vOOQQDHOHOOO0000Doors:ONHOHHonFHOOH
`
`OHoopwu»OHwoo
`
`HHHH
`
`ocoOOOcc
`
`0:!
`
`OMOHONONDHHODHOOH
`
`ODOD-lid
`OOOHOOMu
`
`OOOOOOOOOI-IHOHOOOO0
`
`0000OO
`00N00on
`
`NUO
`H
`
`coal-
`NW
`
`OHOOONO
`OOOOHH
`
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`
`0OOOOOOOOO000ODOOO
`
`OOOO
`
`o»000OO
`
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`O
`
`Alavi- 72
`
`

`

`Histopath findings in unscheduled dead female mice
`Incidence of Microscopic observations
`Unscheduled Deaths and sacrifices
`
`TABLE INCLUDES:
`saxammnouvag.3.4.s;wszl<s=.un .
`DEATH-D,H,A,01PIND=ALL:SUBSET-ALL
`
`sax: ---------FEMALE--------
`GROUP: —1— —2-
`-3- —4-
`-5-
`
`
`
`4d47(DC) H... ............ ....... ........... NUMBER EXAMINED: 4 oo
`
`
`
`NUMBER:
`
`47
`
`44
`
`40
`
`ORGAN AND FINDING DESCRIVI’ION
`" TOP 01’ LIST "
`BEND-X COMMENT
`
`- -FIBROSARm
`"GAME-RELATED DEATH
`
`maxim-mes
`HISTOLOGICALLY mmnnm‘an
`
`INPMWATXON/NECRDSIS. mm
`INFLRMMATION/NBCROSIS. MULTIFOCAL
`mm’nm, sxm/smacuns
`
`~-Iwmmumn, \mscmAR
`"1.1m DEGBNBRATION/NECROSIS
`“MAMMARY mss
`~-MESOTHELI0MA
`--1=ramus osmonvsmom
`--N'BCROSIS, BRAIN
`“mum. Amman
`--N'EOPU\SM. GASTRom-rzsnm 'nuc'r
`--N'BOPLBSM, mum“ GLAND
`"NEOPLASM. WTOPOIETIC
`"wot-mm, LUNG
`--mpmsn, PITUITARY
`--mm, REPRODUCTIVE TRACT
`(mm m 511mm smcom)
`umpmsu, SK/so
`"NEH-mommy / mom -
`--mRonucuvs may LESIONS
`--schom, ENDOMETRIAL snow
`— -THROM‘E‘US . ATRIAL
`- —DILATATION . ESOPHAGD‘S
`- -OBSTRUC1‘ION, URINARY
`- ~GASTROTN1'BSTINAL TRACT LESIONS
`NOT REMARKAELE:
`MARROW, STERNU'H
`(SE) .............. .................. . NUMBEREXAMINED:
`- -HYPERPLASIA, MYELOID. MARROW
`- —X-HEHNIDPOIBTIC N‘BOPLASIA (533 “113mm NEOPUXSIA' FOR TYPE)
`— ~HYPOCEU-Uhm. MARROW
`— -PIG|VBNT.
`INCREASED
`- -HYPERPIASIA, MEGAKARYOCYTIC, MARROW
`- -MYBLOPHTHISIS
`- -HYPBRPU\5IA. BRYTHROID. MARROW
`— -N-REMANGIOSARCOMA
`
`oowcuownoonoou
`
`
`uamp-lounuoHow-boa
`DOHHONI-lm
`
`NWtow
`
`QObOOhOD-‘O
`uouauoowcovv-
`
`cocawuua
`
`1
`
`apnmoowooooaoaoumwuu
`
`
`
`oooaclaus-
`
`upon
`
`u»0-:-
`
`uomu
`3.:-umcoco
`
`onyx-w
`
`m:-4;.owns-no
`
`o.»
`45
`N~l
`
`0.1
`
`u.»an»
`
`on
`40
`u v
`
`NOT REMARKRBLE:
`BONE. STERN'UM (SB) ................... . . . . . . .......... NUMBER EXAMINBD:
`--05TEODYSTROPHY, FIBROUS
`—-RCUTB INFLBHHATICN. SKELETAL MUSCLE WITH N'ECROSIS
`
`..... NUMBER EXAMINED:
`(13‘!) .......... ................ . ..... .
`NOT REHARKAELB:
`
`BY!
`
`44
`:-
`
`cvh
`
`45
`:-
`
`cu!
`
`wowwoou
`
`
`
`aunt-JPl—t-‘DHOONOOOHD
`
`N.“
`
`mucoal-I
`uHOOr—H—Imm
`
`.h-hnu
`
`HH
`
`«u:a»
`
`--ATROPHY
`”DEGENERATIO‘N. L‘B'NTICULAR
`"DEGENZRATION. RETINRL
`,--FIBROSIS. CORNEAL
`"mymmuon. CHRONIC-ACTIVE
`--INE~’LM1HATION, SUBACUTE
`“HDTBRALIZATION. CORNER
`“MUERALIZATIW.
`IRIS
`"NINERALIZATION. mm, FOCAL/MULTIFOCAL
`"ONE WEED
`"SYNBCHIA. POSTZRIOR
`--ULCERJ\TION, CORNEAL
`--X-FlEHAmPOX‘BTIC NEOP‘LASIA (SEE ‘H'BMNKJ NPDPIASIA” FOR TYPE)
`
`NOT REHARKABLE :
`NERVE, OPTIC (0N)
`. ........... NUMBER memzm
`—-ATROPHY
`--ONB BXAHINED
`one
`aux-4
`Hun:
`—-X-W1OPOIBTIC N'BOPLASIA (SEE "BEHATO NEON-ASIA” FOR TYPE)
`
`
`
`
` 19141919NOT REMARKABLE: 21
`
`NERVB. SCIATIC
`(SN)
`. NUMBER EXAMINBD:
`‘15
`43
`40
`44
`45
`>-DK32NERATION, MONAL
`23
`21
`23
`26
`24
`--INPI!.TRATB, LYMPHOHISTIOCYTIC
`1
`3
`3
`3
`O
`--X~HEMA10POIBTIC NEOFLASIA (SEE 'HEM‘ATO NEOPLASIA' FOR TYPE)
`3
`l
`2
`l
`l
`
`BRAIN
`(ER) ..u......’.
`........
`
`.. ........... NUMBER EXAMIN'BD:NOT REMARWLB:
`
`4733
`
`4!30
`
`4028
`
`GA28
`
`4534
`
`oouwauoooonwcmpoqouw
`
`
`
`I—QONHnuo
`
`u»will
`
`DOONHNU
`ahHt]!0
`0-»
`
`up
`
`oommoowouauul
`
`abONO0Ncoo
`
`hoOUou-DHOOOOO
`
`a....
`uul
`
`Houoouuaooomu
`
`u
`l..-
`
`mu
`
`woououa
`
`i-IUINcooou
`
`uu
`
`away-wove:
`uhcuewHNHHOH
`
`”COMPRESSION. VENTRAL
`"ECI‘OPIC ARTERIOLES , FOCAL
`WITH GLIOSIS
`—-GLIOSIS. FOCAL
`--INFILTRATB. LYMPHOHISTIOCYTIC
`- -MINERALIZATION
`—-NECR.DSIS, FOCAL/MULTIFOQL. UNILATBRAL
`- -VACUOU§TION, WHITE m'rnm ARTTFRCTUAL
`- ~X—H'EMATOPDIBTIC NEOPLASIA (SEE ‘HEMA’HJ NEOPIASIA" FOR TYPE)
`
`1
`0
`1
`0
`1
`O
`12
`1
`
`2
`0
`O
`0
`2
`0
`11
`2
`
`l
`0
`0
`1
`0
`1
`10
`D
`
`2
`D
`1
`2
`1
`4
`10
`0
`
`1
`1
`0
`D
`0
`D
`9
`0
`
`Alavi- 73
`
`

`

` 43
`19
`44
`43
`
`A
`
`u.»
`.-,..
`
`H,5can
`
`45
`
`45
`21
`45
`45
`
`inpmon
`
`5-:
`
`b
`
`on
`
`bl)!
`
`.t-
`
`.NUOOMOODOHOF‘UO
`
`u5-Dcmaobuuqmuwuwomwnooaa
`
`.4
`
`lb
`
`uvooamwowwooowu
`Mecca-Jonubp
`omwuuowumocnuo
`
`nu
`
`uamoonuomoocpn
`MOPP‘NOwe
`HmoHHcOuboHOL-vo
`
`b H
`
`NH
`
`.—
`
`,.
`
`4
`
`.bq
`
`uONOHMOHDHHHHO
`NooooauouunowNmHmnooun»
`
`,—
`
`Incidence at Micraacopic Observations
`unscheduled Deaths and Sacrifices
`
`TABLE INCLUDES:
`SEX=ML;GROUP=1 . 2 ,3 , 4 . 5; WEEKSMMJ.
`DEATHHD, M,A. 0:?mD-ALL:SUBSBT=ALL
`
`SEX:
`GROUP:
`
`NUMBER-
`
`
`ORGAN AND FINDING DESCRIPTION
`" FROM PREVIOUS PAGE ‘*
`
`NERVE. SCIATIC
`(SN)
`.v.... .................. ......... NUMEBRBXRHINED:
`NOTRBMARKABLR:
`
`..............................NUMBERBXAHINED:
`SPINALCORD (SC)
`NOT RBMARKABLB :
`--NBCROSIS, WHITE MATTER
`--X~WPOIETIC NEOPLASIA (SEE 'HEMNIO NEON-ASIA" FOR TYPE)
`
`KIDNEY
`(KD)
`.. ..................... NUMBER EXAMINED:
`NOT nmmoxsnz:
`- -AMYLOID, GLOMERD‘LAR/INTERSTITIRL
`- -DILATA'HON. PBLVIC
`- ~BCEASIA. TUBULAR
`- -I —M'BSDTHKLIOMA
`- - INPLAMMATION. CHRONIC-ACTIVE. SUBCAPSUIAR
`- -INPLABMTION, SIERCD'I'E. PBLVIC
`~ -MIN'BRALX ZATION, TUBULAR, PAPILIIARY
`- N-CARCINOMA
`- -N'ECROSIS
`- -NBP‘H'ROPATHY, Cl-DIONIC
`- -ON'B BXANINED
`- ~INFLWTION, VASCUIM
`~ -x-HEHAmPOIBTIC NEOPLASIA (SEE ‘PEWX'ID NEOPLASIA" FOR TYPE)
`- -HYALIN'B DROPIIBTS. TUBULAR BPITRBLIDM
`
` LIVER (LI) .................
`--ADH'ESION
`"AMYLOID
`"CYST, BILIARY
`"FOCUS, ALTZRE) HEPATOWLLULAR, BASOPHILIC
`"61910062", FIBPA'KJCBLLULAR,
`INCREASED
`"MTOPOIESIS, EXTRAMEDULLARY
`- -HYPERTROPHY. HEPATOCELLULAR
`- -I ~MBSOTFIELIOMA
`- - INFILTRATE . LYMPHOKISTIDCVTIC
`- -INFLAMMATION. CHRONIC-ACIIVE
`- ~MACROPHAGES, PIGMENT-LADEN. Immsxp
`- -N-CARCINOMA
`- -N2CROSIS , COAGULATIVB, FOCAL/HUB“FOCAL
`- -NECROSIS ,
`INDIVIDUAL HBPA‘IDCYTES/HULTIEOCAL
`- —LEUKOCYTOSIS , SIN'USDIDAL
`- -MITOSIS, HBPATOCKLLULAR,
`INCREASED
`~ -THROMBUS
`- —VACUOIJ\TION, ' HEPATOCELL‘DLAR . CENTRILOBULAR
`- -VACDOLATION, HEPATOCBLLULAR. DIFFUSB
`
`N—HEMANGIOSARCOWA
`- ~X-HEMA’IOPOIBTIC NEOPLASIA (BBB “HBMA'I’O “ROFL-ASIA” FOR TYPE)
`— -M -HEMANGIOSARCCMA
`
`. ...... .. NUMBER EXAMIN'BD:
`NOT REMARKABI‘B:
`
`(GB)
`
`. . .......... . . . . . . . ....... . .......... "WEEK EXAMINBD:
`NOT REMARWLB:
`
`GALLBLADDER
`- ~CYST
`
`DILATATION
`- < I 'HBSOTHRIJOMR
`- -INFI!.TRATB, LYMPHOHISTIOCYTIC
`- -INPLAMHRTION , CHRONIC~ACFIVB
`— -X-H2MJ\TOPOTETIC NEOPLASIA (8E3 "HRMA'KJ NEOPLASIA' FOR TYPE)
`
`LUNG
`(LU) ..........
`......NUHBEREXAHIN'BD:
`NDTREMARKABLB:
`- -AMYIDID
`“ASPIRATION. WITH INTRALESIONAL FEED MATERIAL
`- B~ADBNOHA. BRONCHIOLAR-ALVEOLAR
`--BLOOD. TERMINALLY INHALED
`~ {ONES'H’GN
`--FIBROSIS, PLEURRlu/SD'BPLEURAL
`"memes. SUBACUTB
`- —H’YPBRPLASIA, BRONCHIAL/BRONCHIOLAR
`—-mznpmsm, meomrc. unranonmzouR/pznmsmn
`--r-nzsom}zmom
`--INFILTRATB. menopause. uvzomuz
`-—INFLNMTION. CHRONIC-ACTIVE. mus-um
`- M-cmcmom
`- N-cmcmom
`"memosnxcom
`"Hmnmmzmmn. 32m
`unmamrzmxon. mmmm, FOCAL
`--NECROSIS
`--X-SRRCOMA, HISTIOCYTIC
`--X-HBMA'IDPOIBTIC NEOFLASIA (SEE ‘HEMR’IO NEOPLRSIA" FOR TYPE)
`
`. . NUMBER EXAMINED:
`NOT REMARKABLB:
`
`(TR) .......... . . ........... , . .
`TRACKER
`- ~INFLWTION, CHRONXC -RCIIV2
`"ULCBRATION. MUCOSR
`-—X—HEM}\10POIBTIC NBOPLASIA (SEE ‘REMTO NEON-ASIA” FOR TYPE)
`BSOPHAGUS
`(F5) ................... . .......... . . . . . . . . . NUMBER EXAMINBD:
`NOT RBMARKABLE:
`— -BACTBRIAL COLONIES
`- ~GRANULOMA, FOCAL
`- -II\‘FLAMTION, CHRONIC -ACPIV‘B, ADVENTI’A‘IA
`WI‘l'H INTRALESXONAL FEED MATERIAL AND BACTERIRL COLDNIES
`-~DBGENERATION. MYOPIBER
`--N'ECROSIS, ADIPOSE TISSUE, RWTITIA
`--x-Hmnmpomnc NROPLASIA (SEE "HEMA'ID NEOPLASIA" FDR TYPE)
`"INFLAMTION, SD'BRCUTE
`"DILATATION, ESOPHAG'US
`
`uuMm
`
`MOHOOH
`
`Hamt-
`
`,..cmonooou»~louc~oopuu—~
`
`,0Houooo
`
`Ha
`
`...oucocu—n-unmcouooounon
`
`u»
`
`up-‘U'll-lb-Ianoaq
`
`H
`
`was.No”AdcNNooonwmv-qoaot-Iuhoua
`
`u.-
`
`44
`40
`
`.bo
`36
`
`Comp-IOmoo
`
`...
`
`HHNOH
`
`was:uq
`
`you
`count;
`
`mmmm
`
`Nah-con
`
`Huhma
`
`)1Haunponuuuomnaoooao»
`
`#0
`
`HH0no
`
`9-:-"-5
`
`come:one
`
`uu
`
`.h
`
`uaoaooova
`
`am
`
`A:
`
`
`
`D#Hownu:omoouenumnowaonaoaoo
`
`ahIuUI
`
`oooowNOD
`
`AIavi- 74
`
`

`

`Incidence of Microscopic Observations
`Unscheduled Deaths and Sacrifices
`
`TABLE mcwozs =
`SEX=ALL:GROU‘P=1. 2 . 3 . 4 . 5,- wmzxsamx.
`DEATH:
`.M,A,o,~Em=A1.L;snasm-=m
`
`sax: ---------FEMALE————————
`
`45
`45
`36
`
`OUIONOH
`
`twp
`
`NUNUIHOD-IquaDI-l
`
`NMOODD—‘U‘lflmN
`
`u:-
`
`.b
`
`anmu'Ioooomulkumuoouomu!
`
`
`
`aououacoHon-Io
`
`mounequwoooaooo
`
`b
`7.-
`
`wk:
`
`H
`
`Alavi- 75
`
`44
`44
`31
`
`ououou
`
`a»
`
`up
`
`N»m»OHHummo
`mHoI-‘cv-‘mulmn
`“HOOHOONO~13:
`1““-ncooMe.
`
`mmmonooooomop-Ir-
`H00HOGUb‘OOOOUII‘NH
`
`I!“
`
`:-
`
`N
`
`u
`
`5-.
`
`44
`43
`31
`
`DNDNHb
`
`An»
`
`to»
`
`)hU‘DOOOD-‘Ulwb~3-ooNWHup
`
`up
`
`mu
`
`uwoouowuo
`
`a»no
`
`oar-aw
`d»:-
`
`.h
`
`uu
`so
`
`
`aouuawoo(=on
`
`umpHOOUIOOOOOU‘OOM
`
`40
`40
`29
`
`HOOD—0V0
`~10Ha
`DON
`
`N»
`
`FILE DC
`
`u:-
`
`.bwwcHNHmt-Im
`NHOOOOOHI—Ime
`
`u.»
`
`mo
`
`H.»
`
`Nonuoo
`
`boooooooOoh-m
`H”aHI-Iodoocflowooowon
`
`u
`
`47
`NUMBER:
`ORGAN AND FINDING DESCRIPTION
`
`NUMBER RXAMINBD:
`46
` THYROID (TY)
`
`NOT RBMARKABLE:
`31
`4
`- -AMY!.OID
`- -B—ADBNOMA, FOLLICULAR CELL
`1
`- -C‘IST, FOLLICULAR
`1
`- -BCIOPIC THYM'US
`1
`- - INF ILTRATE . LYMPHOPLASMACYTIC
`20
`- -INFLM’MATION, G‘IRONIC-ACI‘IV'B
`- om: EXAMINED
`-—x—meop01m1c NEOPLASIA (szz “Ingram mpmsm- FOR n92)
`PARATHYROID
`(PT) .......... .
`.
`‘
`. . . . . ................... NUMBER EXAMINED:
`NOT RBMARKABLB:
`
`D6
`
`mu
`
`3
`3
`
`7 NUMBER BXAMINED:
`NOT RBMARKABLE:
`
`
`- -INFILTRATB , LYMPHOHISTIOC'YTIC
` HEART (MT) ...
`
`
`- -AMYLOID
`- -CARDIOMYOPATHY
`- - INFILTRATB , LYMPHOHIS