throbber
Trials@uspto.gov
`571-272-7822
`
`
`
`
`
`
`
`
`
`
` Paper No. 11
`
` Entered: September 9, 2019
`
`
`
`
`
`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`____________
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`____________
`
`NALOX-1 PHARMACEUTICALS, LLC,
`Petitioner,
`
`v.
`
`OPIANT PHARMACEUTICALS, INC.,
`Patent Owner.
`____________
`
`Case IPR2019-00690
`Patent 9,468,747 B2
`____________
`
`
`Before ERICA A. FRANKLIN, ZHENYU YANG,
`and JACQUELINE T. HARLOW, Administrative Patent Judges.
`
`
`YANG, Administrative Patent Judge.
`
`
`
`
`DECISION
`Denying Institution of Inter Partes Review
`35 U.S.C. § 314(a)
`
`
`
`
`
`
`
`
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`
`INTRODUCTION
`Nalox-1 Pharmaceuticals, LLC (“Petitioner”) filed a Petition (Paper 1
`(“Pet.”)), seeking an inter partes review of claims 1–45 of U.S. Patent
`No. 9,468,747 B2 (“the ’747 patent,” Ex. 1001). Opiant Pharmaceuticals,
`Inc. (“Patent Owner”) filed a Preliminary Response. Paper 6 (“Prelim.
`Resp.”).
`For the reasons provided below, we exercise our discretion under
`35 U.S.C. § 314 to deny institution of an inter partes review.
`Related Proceedings
`Petitioner challenges claims 1–45 of the ’747 patent in two other
`concurrently filed petitions. In IPR2019-00688, Petitioner relies on Wyse1
`as the primary reference; and in IPR2019-00689, Petitioner relies on Wang2
`as the primary reference.
`The ’747 patent is one of five patents listed in the Orange Book for
`intranasal naloxone sold under the brand name NARCAN. Pet. 1; Paper 9,
`1. Petitioner also filed petitions for inter partes review, challenging the
`other four patents listed. Pet. 6; Paper 5, 1–2.
`According to the parties, Patent Owner asserted all five Orange-Book-
`listed patents in Adapt Pharma Operations Ltd. v. Teva Pharmaceuticals
`USA, Inc., Case 2:16-cv-07721 (D.N.J.) (consolidated, “the Teva Case”),
`and Adapt Pharma Operations Ltd. v. Perrigo UK FINCO Limited
`
`
`1 Wyse et al., U.S. Patent No. 9,192,570 B2, issued November 24, 2015
`(Ex. 1007).
`2 Wang et al., Chinese Patent Publication No. CN 1575795 A, published
`February 9, 2005 (Ex. 1008).
`
`2
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`Partnership, Case 2:18-cv-15287 (D.N.J.). Pet. 6; Paper 5, 2. Petitioner is
`not involved in those actions. Pet. 6.
`Background of Technology and the ’747 Patent
`Opioid overdose is a crisis in the United States. Ex. 1001, 6:43.
`Naloxone is an opioid receptor antagonist that was initially approved for use
`by injection for the reversal of opioid overdose. Id. at 2:13–14. Naloxone
`hydrochloride injection prevents or reverses the effects of opioids,
`“including respiratory depression, sedation and hypotension.” Ex. 1044,3
`1300.
`
`According to the ’747 patent, administering naloxone via injection
`requires trained medical personnel and imposes the risk of exposure to blood
`borne pathogens through needlestick injury. Ex. 1001, 6:20–32. The
`’747 patent discloses that “it ha[d] been suggested that in view of the
`growing opioid overdose crisis in the US, naloxone should be made
`available over-the-counter (OTC), which would require a device, such as a
`nasal spray device, that untrained consumers are able to use safely.” Id. at
`6:42–46.
`The ’747 patent acknowledges that nasal administration of naloxone
`was known and used by numerous medical services and health departments.
`Ex. 1001, 2:29–6:13, see also id. at 4:39–42 (“Overdose education and nasal
`naloxone distribution (OEND) programs are community-based interventions
`that educate people at risk for overdose and potential bystanders on how to
`prevent, recognize and respond to an overdose.”). It points out, however,
`
`
`3 Physicians’ Desk Reference 2003, entry for NARCAN (Naloxone
`Hydrochloride Injection, USP).
`
`3
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`although some studies “reported that the nasal administration of naloxone is
`as effective as the intravenous route in opiate addicts,” others “reported that
`naloxone administered intranasally displays a relative bioavailability of 4%
`only and concluded that the IN [intranasal] absorption is rapid but does not
`maintain measurable concentrations for more than an hour.” Id. at 2:47–55.
`The ’747 patent states
`Thus, there remains a need for durable, easy-to-use, needleless
`devices with storage-stable formulations, that can enable
`untrained individuals to quickly deliver a therapeutically
`effective dose of a rapid-acting opioid antagonist to an opioid
`overdose patient. The therapeutically effective dose should be
`sufficient to obviate the need for the untrained individual to
`administer either a second dose of opioid antagonist or an
`alternative medical intervention to the patient, and to stabilize the
`patient until professional medical care becomes available.
`Id. at 6:52–61.
`According to the ’747 patent, its invention relates to devices adapted
`for nasal delivery of “a therapeutically effective amount of an opioid
`antagonist selected from naloxone and pharmaceutically acceptable salts
`thereof, wherein the device is pre-primed, and wherein the therapeutically
`effective amount, is equivalent to about 2 mg to about 12 mg of naloxone
`hydrochloride.” Id. at 6:63–7:2.
`Illustrative Claims
`Among the challenged claims, claims 1 and 30 are independent, and
`are reproduced below:
`A method of treatment of opioid overdose or a symptom
`1.
`thereof, comprising nasally administering to a patient in need
`thereof a dose of naloxone hydrochloride using a single-use, pre-
`primed device adapted for nasal delivery of a pharmaceutical
`composition to a patient by one actuation of said device into one
`nostril of said patient, having a single reservoir comprising a
`
`4
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`
`pharmaceutical composition which is an aqueous solution of
`about 100 µL comprising:
`about 4 mg naloxone hydrochloride or a hydrate thereof;
`between about 0.2 mg and about 1.2 mg of an isotonicity agent;
`between about 0.005 mg and about 0.015 mg of a compound
`which is at least one of a preservative, a cationic surfactant, and
`a permeation enhancer;
`between about 0.1 mg and about 0.5 mg of a stabilizing agent;
`and
`an amount of an acid sufficient to achieve a pH of 3.5-5.5.
`30. A
`pharmaceutical
`formulation
`for
`intranasal
`administration comprising, in an aqueous solution of not more
`than about 140 µL:
`about 4 mg naloxone hydrochloride or a hydrate thereof;
`between about 0.2 mg and about 1.2 mg of an isotonicity agent;
`between about 0.005 mg and about 0.015 mg of a compound
`which is at least one of a preservative, a cationic surfactant, and
`a permeation enhancer;
`between about 0.1 mg and about 0.5 mg of a stabilizing agent;
`an amount of an acid sufficient to achieve a pH of 3.5-5.5.
`Asserted Grounds of Unpatentability
`Petitioner challenges the patentability of claims 1–45 under 35 U.S.C.
`§ 103 on the following grounds:
`
`5
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`
`Claim(s)
`1–4, 16–24, 30–33
`28–29, 34–39
`40–45
`5–7, 10–14
`8–9
`
`References
`Davies,4 HPE,5 Bahal,6 and Kushwaha7
`Davies, HPE, Bahal, Kushwaha, and Wyse8
`Davies, HPE, Bahal, Kushwaha, and Wyse or
`Wang and Wermeling 20139
`Davies, Djupesland,10 HPE, Bahal, and Kushwaha
`Davies, Djupesland, HPE, Bahal, Kushwaha, and
`the ’291 patent11
`Davies, Djupesland, HPE, Bahal, Kushwaha, and
`Wyse
`Davies, Djupesland, HPE, Bahal, Kushwaha, and
`Wyse or Wermeling 2013 or Wang
`In support of its patentability challenge, Petitioner relies on the
`Declarations of Maureen D. Donovan, Ph.D. (Ex. 1002) and Günther
`Hochhaus, Ph.D. (Ex. 1003).
`
`25–27
`
`15
`
`
`4 Davies et al., PCT Publication WO 00/62757, published October 26, 2000
`(Ex. 1009).
`5 Handbook of Pharmaceutical Excipients, 56–60, 64–66, 78–81, 220–22,
`242–44, 270–72, 441–45, 517–22, 596–98 (Rowe et al. eds., 6th ed. 2009)
`(Ex. 1012).
`6 Bahal et al., U.S. Patent No. 5,866,154, issued February 2, 1999
`(Ex. 1014).
`7 Kushwaha et al., Advances in Nasal Trans-Mucosal Drug Delivery, 01(07)
`J. APPLIED PHARM. Sci. 21–28 (2011) (Ex. 1013).
`8 U.S. Patent No. 9,192,570, issued November 24, 2015 (Ex. 1007).
`9 Wermeling, A Response to the Opioid Overdose Epidemic: Naloxone
`Nasal Spray, 3 DRUG DELIV. & TRANSL. RES. 63–74 (2013) (Ex. 1016).
`10 Djupesland, Nasal Drug Delivery Device: Characteristics and
`Performance in a Clinical Perspective - A Review, 3 DRUG DELIV. &
`TRANSL. RES. 42–62 (2013) (Ex. 1010).
`11 U.S. Patent No. 8,198,291, issued June 12, 2012 (Ex. 1015).
`6
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`
`DISCRETIONARY DENIAL
`Overview
`As explained above, Petitioner has concurrently filed three petitions,
`each of which challenges claims 1–45 of the ’747 patent. Patent Owner
`argues that we should exercise discretion to deny institution of the Davies
`Petition at issue here because it is redundant of the Wyse Petition in
`IPR2019-00688. See Prelim. Resp. 6–9. Patent Owner contends the Davies
`Petition “largely duplicates” the Wyse Petition “merely adding grounds that
`make the same arguments with more-complicated combinations of more
`references.” Id. at 1. Patent Owner points out that “large swaths of text
`[are] word-for-word identical,” and that although the present Petition is
`premised on a different primary reference (i.e., Davies), it “relies extensively
`on the Wyse reference that is the principal reference in Case
`IPR2019-00688.” Id. at 2. According to Patent Owner, the Petition here
`“adds nothing meaningful to Case IPR2019-00688.” Id.
`On August 1, 2019, we issued an order requiring Petitioner to provide
`a Notice identifying:
`(1) a ranking of the three Petitions in the order in which it wishes
`the panel to consider the merits, if the Board uses its discretion
`to institute any of the Petitions, and (2) a succinct explanation of
`the differences between the Petitions, why the differences are
`material, and why the Board should exercise its discretion to
`consider the additional Petitions if it identifies a Petition that
`satisfies Petitioner’s burden under 35 U.S.C. § 314(a).
`Paper 8, 4. We also gave Patent Owner an opportunity to respond. Id. at 5.
`
`Petitioner filed its Notice on August 5, 2019. Paper 9 (“Notice”). In
`that Notice, Petitioner requests that we consider the Wyse Petition first.
`Notice 1. Petitioner further asserts that “[d]ue to different statutory bases for
`
`7
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`invalidity, as well as substantive differences in the[] three primary
`references,” we “should institute review for all three Petitions.” Id. In its
`Response to Petitioner’s Notice, Patent Owner continues its argument that
`the present Petition is redundant, urging “if the Board institutes anything, it
`should institute only the Wyse Petition.” Paper 10, 1 (“Resp.”).
`
`For the reasons explained in our decision instituting review in
`IPR2019-00688, we are instituting inter partes review of claims 1–45 on the
`grounds presented in the Wyse Petition. As explained more fully below, we
`exercise discretion to deny institution of the present Petition under 35 U.S.C.
`§ 314(a) in light of IPR2019-00688.12
`35 U.S.C. § 314(a)
`Under § 314(a), the Director has discretion to deny institution of an
`inter partes review. Cuozzo Speed Techs., LLC v. Lee, 136 S. Ct. 2131,
`2140 (2016) (“[T]he agency’s decision to deny a petition is a matter
`committed to the Patent Office’s discretion.”); SAS Inst. Inc. v. Iancu, 138 S.
`Ct. 1348, 1356 (2018) (“[Section] 314(a) invests the Director with discretion
`on the question whether to institute review . . . .” (emphasis omitted));
`Harmonic Inc. v. Avid Tech., Inc., 815 F.3d 1356, 1367 (Fed. Cir. 2016)
`(“[T]he PTO is permitted, but never compelled, to institute an IPR
`proceeding.”).
`Our discretionary determination whether to institute review takes into
`consideration guidance in the Trial Practice Guide Update (July 2019),
`available at https://www.uspto.gov/TrialPracticeGuide3 (referenced in
`
`
`12 Because we exercise discretion to deny institution on this basis, we need
`not make a determination regarding the other arguments presented in Patent
`Owner’s Preliminary Response.
`
`8
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`Office Patent Trial Practice Guide, July 2019 Update, 84 Fed. Reg. 33,926
`(July 16, 2019)) (“TPG July 2019 Update”). The TPG July 2019 Update
`addresses situations where Petitioner has concurrently filed parallel petitions
`challenging the same patent. The TPG July 2019 Update states:
`Based on the Board’s prior experience, one petition should be
`sufficient to challenge the claims of a patent in most situations.
`Two or more petitions filed against the same patent at or about
`the same time (e.g., before the first preliminary response by the
`patent owner) may place a substantial and unnecessary burden
`on the Board and the patent owner and could raise fairness,
`timing, and efficiency concerns. See 35 U.S.C. § 316(b). In
`addition, multiple petitions by a petitioner are not necessary in
`the vast majority of cases.
`TGP July 2019 Update 26.13 The TGP July 2019 Update acknowledges that
`“there may be circumstances in which more than one petition may be
`necessary, including, for example, when the patent owner has asserted a
`large number of claims in litigation or when there is a dispute about priority
`date requiring arguments under multiple prior art references,” but
`characterizes such circumstances as “rare.” Id.
`
`
`13 This is consistent with the guidance previously provided in the August
`2018 update to the Trial Practice Guide Update (August 2018), available at
`https://go.usa.gov/xU7GP (referenced in Office Patent Trial Practice Guide,
`August 2018 Update, 83 Fed. Reg. 39,989 (August 13, 2018)) (“TGP August
`2018 Update”). The TPG August 2018 Update explains that “[t]here may be
`other reasons besides the ‘follow-on’ petition context where the ‘effect . . .
`on the economy, the integrity of the patent system, the efficient
`administration of the Office, and the ability of the Office to timely complete
`proceedings,’ 35 U.S.C. § 316(b), favors denying a petition,” including
`“other proceedings related to the same patent . . . at the Office.” Id. at 10.
`9
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`
`28–29, 34–39
`
`40–45
`
`In addition to the guidance in the Trial Practice Guide, we are also
`mindful to construe our rules to “secure the just, speedy, and inexpensive
`resolution of every proceeding.” 37 C.F.R. § 42.1(b).
`Analysis
`Petitioner’s arguments in the present proceeding are substantially
`similar to those in the Wyse Petition. The table below provides a claim-by-
`claim comparison of the prior art Petitioner asserts in each proceeding.
`Challenged
`IPR2019-00688
`IPR2019-00690
`Claim(s)
`(Wyse Petition)
`(Davies Petition)
`1–3, 16–24,
`Davies, HPE, Bahal, and
`Wyse and HPE
`30–33
`Kushwaha
`Wyse, Djupesland, and
`Davies, HPE, Bahal, and
`4
`HPE
`Kushwaha
`Davies, HPE, Bahal,
`Wyse and HPE
`Kushwaha, and Wyse
`Davies, HPE, Bahal,
`Kushwaha, and Wyse or
`Wang and Wermeling 2013
`Davies, Djupesland, HPE,
`5–7, 10–14 Wyse, Djupesland, and
`Bahal, and Kushwaha
`HPE
`Davies, Djupesland, HPE,
`Wyse, Djupesland,
`Bahal, Kushwaha, and the ’291
`HPE, and the ’291
`patent
`patent
`Davies, Djupesland, HPE,
`Wyse, Djupesland, and
`Bahal, Kushwaha, and Wyse or
`HPE
`Wermeling 2013 or Wang
`Davies, Djupesland, HPE,
`Wyse, Djupesland, and
`Bahal, Kushwaha, and Wyse
`HPE
`As can be seen from the table above, the main difference between the
`petitions is that here Petitioner relies on Davies, as opposed to Wyse, as the
`primary reference for its obviousness combinations. More specifically, in
`the Wyse Petition, Petitioner relies on Wyse for its teaching of intranasal
`naloxone formulations in a single-use, pre-primed device, whereas here
`
`Wyse and HPE
`
`8, 9
`
`15
`
`25–27
`
`10
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`Petitioner relies on Davies for the same teaching. Compare Pet. 23, 27–36,
`with Wyse Pet. 26, 29–35. In both proceedings, Petitioner relies on HPE,
`Djupesland, and the ’291 patent as secondary references for essentially the
`same disclosure. Compare Pet. 30–31 (HPE), 51 (Djupesland), 55–56 (the
`’291 patent), with Wyse Pet. 33–34 (HPE), 49–50 (Djupesland), 56–57 (the
`’291 patent). Moreover, Petitioner relies on the same declarations to support
`its arguments in the Davies Petition that it does in the Wyse Petition.
`
`The additional secondary references asserted in the Davies Petition do
`not substantively distinguish Petitioner’s arguments from those in the Wyse
`Petition. These references relate to limitations that Petitioner contends are
`taught by Wyse, but acknowledges are not taught by Davies. It is apparently
`for this reason that Petitioner decided not to rely on them to supplement the
`teachings of the primary reference in its grounds in the Wyse Petition.
`Indeed, Petitioner has not identified any differences relating to these
`secondary references that it contends materially distinguish its arguments
`here from those in the Wyse Petition. See generally Notice 1–3.
`
`To the contrary, Petitioner’s arguments in the Davies Petition largely
`rely on the teachings in Wyse, just as they do in the Wyse Petition. As
`shown in the table above, several of Petitioner’s grounds in the Davies
`Petition expressly rely on Wyse. Moreover, Petitioner presents essentially
`the same argument concerning the “about 4 mg naloxone” limitation of
`claim 1 in this proceeding that it does in the Wyse Petition. In both
`Petitions, Petitioner contends that the primary reference discloses an
`overlapping dosage range and relies on the same evidence, including data
`from Table 4 of Wyse, to argue “[a] POSA . . . would have been motivated
`to deliver a naloxone dose of about 4-6 mg.” Compare Pet. 17, with Wyse
`
`11
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`Pet. 19–20. Thus, even for those grounds in the Davies Petition that do not
`expressly include Wyse in the stated combination of references, Petitioner
`nevertheless relies on Wyse as evidence for its argument that a 4 mg dose
`would be obvious. Indeed, significant portions of the arguments in the
`present Petition are substantively identical to those presented in the Wyse
`Petition. Compare Pet. 12–20, 30–31, with Wyse Pet. 15–23, 33–34.
`
`None of the “differences” Petitioner identifies in its Notice warrant
`institution of a second IPR. See Notice 3 (table summarizing alleged
`“differences”). First, Petitioner contends that because Wyse “is prior art
`under § 102(a)(2),” whereas Davies is prior art under § 102(a)(1), “Patent
`Owner may seek to remove Wyse as prior art under an exception under
`§ 102(b)(2), but will be unable to do so for Davies.” See Notice 1–2. Patent
`Owner has stipulated that it will not dispute that both Wyse and Davies are
`prior art. Resp. 1. Thus, there is no dispute as to Wyse’s status as prior art
`that could justify the burden of instituting an additional inter partes review
`to consider what are essentially the same arguments, but premised on a
`different primary reference. Cf TPG July 2019 Update 26 (noting that a
`second proceeding may be necessary if there “is a dispute about priority date
`requiring arguments under multiple prior art references”).
`We are likewise not persuaded by Petitioner’s argument that a second
`IPR is warranted because the Wyse Petition relies on “the Declaration of
`Dr. Donovan to support the position that a POSA would not have considered
`Wyse to teach away from the use of BAC [i.e., benzalkonium chloride],”
`whereas the Davies Petition “do[es] not rely [on] Wyse for the teaching of
`BAC, but instead for its other teachings.” Notice 2–3. To the extent
`Petitioner is suggesting that the alleged teaching away in Wyse is not at
`
`12
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`issue here, Petitioner is wrong. Patent Owner raises exactly the same
`teaching away argument in response to the Davies Petition that it does in
`response to the Wyse Petition. Compare Prelim. Resp. 48–58, with
`IPR2019-00688 Prelim. Resp. 49–59. Moreover, Petitioner relies on the
`same testimony from Dr. Donovan in support of the Davies Petition. See
`Pet. 61 (citing Dr. Donovan’s testimony in support of Petitioner’s argument
`that a POSA “would not have properly concluded that Wyse taught away
`from using BAC with naloxone”). It makes no difference that the grounds in
`the Davies Petition only rely on Wyse’s “other teachings” (Notice 3)
`because “[a] reference must be considered for everything that it teaches,”
`which here includes Wyse’s statements regarding the use of BAC in a
`naloxone intranasal formulation. See In re Applied Materials, Inc., 692 F.3d
`1289, 1298 (Fed. Cir. 2012). Moreover, Petitioner’s arguments regarding
`the BAC limitation are similar in both petitions and largely rely on the same
`secondary reference (HPE) to support Petitioner’s argument that the claimed
`inclusion of BAC would have been obvious. See Pet. 30–31; Wyse Pet.
`33–34.
`None of the other “differences” Petitioner identifies weigh in favor of
`instituting a second inter partes review. See Notice 3 (table). For example,
`Petitioner asserts that Wyse “[a]nticipates” certain limitations that Davies
`does not. Id. If anything, that suggests the grounds premised on Wyse as
`the primary reference present a stronger argument for unpatentability than
`the grounds in the Davies Petition. It does not demonstrate a need for an
`additional IPR to consider essentially the same arguments, but involving a
`larger set of references to account for limitations that Petitioner
`acknowledges Davies does not expressly teach.
`
`13
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`
`In sum, having considered the parties’ arguments and evidence in both
`proceedings, we determine that instituting inter partes review on the Davies
`Petition would result in an essentially duplicative proceeding running
`concurrently with the proceeding on the Wyse Petition. Such a proceeding
`“would place a substantial and unnecessary burden on the Board and the
`patent owner and could raise fairness, timing, and efficiency concerns.” See
`TGP July 2019 Update 26. We have considered Petitioner’s preference that
`the Wyse Petition be instituted first and determined that institution on that
`petition is appropriate. Thus, all of the claims of the ’747 patent are subject
`to inter partes review of the Wyse Petition. On the record before us, we do
`not find the differences between the references and arguments in the Davies
`Petition and those in the Wyse Petition to be sufficiently material to
`outweigh the inefficiencies and costs of instituting an additional proceeding
`brought by the same Petitioner on the same claims of the same patent.
`Accordingly, we exercise our discretion to deny instituting review of the
`Davies Petition.
`
`CONCLUSION
`For the foregoing reasons, based on the circumstances of this case, we
`exercise discretion under 35 U.S.C. § 314 and deny the present Petition
`requesting institution of inter partes review of claims 1–45 of the
`’747 patent.
`
`ORDER
`
`Accordingly, it is
`ORDERED that Petitioner’s request for an inter partes review of
`claims 1–45 of the ’747 patent is denied and no inter partes review is
`instituted.
`
`14
`
`

`

`IPR2019-00690
`Patent 9,468,747 B2
`
`PETITIONER:
`Yelee Kim
`Richard Berman
`Christopher Yaen
`Janine Carlan
`Bradford Frese
`ARENT FOX LLP
`Yelee.kim@arentfox.com
`Richard.berman@arentfox.com
`Chirstopher.yaen@arentfox
`Janine.carlan@arentfox.com
`Bradford.frese@arentfox.com
`
`
`PATENT OWNER:
`Robert Green
`Jessica Mackay
`GREEN, GRIFFITH & BORG-BREEN, LLP
`rgreen@greengriffith.com
`jmackay@greengriffith.com
`
`
`
`15
`
`

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