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`BIOEPIS EX. 1055
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`BIOEPIS EX. 1055
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`BIOEPIS EX. 1055
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`BIOEPIS EX. 1055
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`
`Frontispiece
`
`Ribbon drawing of a human Meg IgG 1 (lambda) immunoglobulin with a hinge
`deletion. The complementarity-determining-regions are marked by spheres in
`appropriate alpha carbon positions at the tips of the Fab arms (only every second
`residue is highlighted). The interchain disulfide bond between the penultimate
`residues of the light chains is represented by a ball and stick model in the space
`between the Fabs. In the CH2 domain on the right, three spheres designate the
`probable region for docking with complement component Clq in antibodies with
`intact hinge regions. The hinge by-pass segment connecting CHI and CH2
`domains is the putative site for attachment to the FcRI receptor of human
`monocytes. Carbohydrate moieties are represented by branched chains between
`the two CH2 domains. The structure of the IgG 1 molecule was determined by
`Luke Guddat and Allen Edmundson at 2.8 Angstrom resolution (model drawn with
`algorithm developed by Mike Carson and Charles Bugg, J. Mol. Graphics, 4, 121-
`122, 1986).
`
`BIOEPIS EX. 1055
`Page 3
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`
`
`SEQUENCES OF
`,,PROTEINS OF
`IMMUNOLOGICAL
`INTEREST
`
`FIFTH EDITION
`
`Tabulation and Analysis of
`Amino Acid and Nucleic Acid Sequences of Precursors,
`V-Regions, C-Regions, J-Chain, T-Cell Receptors for Antigen,
`T -Cell Surface Antigens, ~2-Microglobulins,
`Major Histocompatibility Antigens, Thy-1, Complement,
`C-Reactive Protein, Thymopoietin, lntegrins, Post-gamma Globulin,
`a 2-Macroglobulins, and Other Related Proteins
`
`1991
`
`Elvin A. Kabat*, TaiTe Wu+, Harold M. Perryt,
`Kay S. Gottesman*, and Carl Foel/ert
`
`*Depts. of Microbiology, Genetics and Development, and Neurology, Cancer Center/Institute of
`Cancer Research, College of Physicians and Surgeons, Columbia University, New York, NY
`1 0032 and the National Institute of Allergy and Infectious Diseases, and the Office of the Director
`National Institutes of Health, Bethesda, MD 20892.
`
`+Depts. of Biochemistry, Molecular Biology, and Cell Biology, and Engineering Sciences and
`Applied Mathematics and Biomedical Engineering, Northwestern University, Evanston, IL 60208
`and the Cancer Center, Northwestern University Medical School, Chicago, IL 60611
`
`tsBN Systems and Technologies, 10 Moulton Street, Cambridge, MA 02138
`
`tFormerly with BBN. Present address Laboratory for Applied Research in Academic Information,
`William H. Welch Medical Library, The Johns Hopkins University, Baltimore, Md 21205
`
`The collection and maintenance of this data base is sponsored under grant 5R01 Al-125616 to
`E.A. Kabat of Columbia University by the following components of the National Institutes of
`Health, Bethesda, MD 20892:
`
`Office of the Director
`National Center for Research Resources
`National C~ncer Institute
`National Institute of Allergy and Infectious Diseases
`National Institute of Diabetes, Digestive and Kidney Diseases
`National Institute of General Medical Sciences
`National Library of Medicine
`
`Work with the PROPHET software package is supported by a subcontract from Columbia
`University to BBN Systems and Techologies, Cambridge, MA 02138
`
`U.S. DEPARTMENT OF HEALTH
`AND HUMAN SERVICES
`
`Public Health Service
`National Institutes of Health
`
`NIH Publication No. 91-3242
`
`BIOEPIS EX. 1055
`Page 4
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`
`
`Our listing of sequences will be kept up to date. Investigators are
`invited
`to send additional sequence data when accepted for
`publication. Send two copies of the manuscript together with a
`letter of acceptance £rom a journal to:
`
`Dr. E.A. Kabat
`National Institutes of Health
`Building 8, Room 126
`9000 Rockville Pike
`Bethesda, Maryland 20892
`
`It would be extremely helpful if you can send us your sequence data
`on magnetic tapes or floppy diskettes or a clean copy of the
`sequences. The file formats should be such that they can be read by
`a generic word processor.
`If you have access to the internet you
`can
`send your
`sequence data
`to us via electronic mail
`to
`cfoeller@bbn.com or to tt@ttwu.esam.nwu.edu.
`
`When published, three reprints should be provided.
`
`If any published sequences have been overlooked or if any errors
`are found, please bring them to our attention.
`
`BIOEPIS EX. 1055
`Page 5
`
`
`
`iii
`TABLE OF CONTENTS
`
`INTRODUCTION . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii
`REf.)';RENCES TO INTRODUCTION ........•...•..•..•.......................••......••.•.....•...•....•...•. lxxiii
`\:f
`, .~ ,--7 r
`f !<siGNAL~ SEQUENCES OF LIGHT CHAINS
`
`HUMAN KAPPA CHAINS . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . 1
`HUMAN LAMBDA CHAINS ................••..•...........................•..•....•.••..•••.••.•.•....•..... 5
`
`MOUSE KAPPA CHAINS . . . . . . . . . . . • . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . • . . . . . . • . . . • • . . . • . . 7
`MOUSE LAMBDA CHAINS . . . . . . . . . • • • . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 17
`
`MISCELLANEOUS KAPPA CHAINS . . . . • . . • . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . • . 19
`MISCELLANEOUS LAMBDA CHAINS ........................•...•............••.•.••..•.•.•.••..•.•.•••••.... 21
`
`SIGNAL SEQUENCES OF HEAVY CHAINS
`
`HUMAN . . . . . . . . . . . . . . . . . . . . . • . . • . • . • . • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
`
`MOUSE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • . . . . . . . • . . . . . . 29
`
`MISCELLANEOUS . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40
`
`SIGNAL SEQUENCES OF T-LYMPHOCYTE RECEPTOR
`
`HUMAN ALPHA CHAINS • . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . • . • . . . . . . . . . • . . . • . . . . . . • • . . • . . • . . . • . • 45
`HUMAN BETA CHAINS . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . 4 9
`HUMAN GAMMA CHAINS . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . 53
`HUMAN DELTA CHAINS . . . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . 55
`
`MOUSE ALPHA CHAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 57
`MOUSE BETA CHAINS • . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • . • . • . . . . . 61
`MOUSE GAMMA CHAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 65
`MOUSE DELTA CHAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
`
`MISCELLANEOUS ALPHA CHAINS . . . • . . . . . . . . . . . . . . . . . . . . • . . • • . • . • . • . . . • . . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . • . 69
`MISCELLANEOUS BETA CHAINS ........•.••..•....................•..•.........•...•..•.•.•••.•.••..•....• 71
`
`SIGNAL SEQUENCES OF RELATED PROTEINS
`
`BETA-2-MICROGLOBULINS . . . . . . . . . • . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . • . • 7 3
`
`MAJOR HISTOCOMPATIBILITY ANTIGENS CLASS I . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . • • • . 7 5
`
`I REGION ANTIGENS CLASS I I • . • . • . • . . . . . . . . . . . . . . • . . • . . . • . • . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82
`
`COMPLEMENT . . . • . . . . . . . . . • . . . . . • . . • • . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • 8 9
`
`T-CELL SURFACE ANTIGENS • . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . . . . • 91
`
`INTEGRINS . . . . . . . • • • . . . . . . . . . . . . . . . . . • • • . • • . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . • . . . . . • . . . . . . . . . . . . . . 9 4
`
`MISCELLANEOUS PROTEINS . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . • . . . • . . . . . • . . . . . . . . . . . • . . . . . . 96
`
`VARIABLE REGION LIGHT CHAIN SEQUENCES
`
`HUMAN KAPPA CHAINS
`HUMAN KAPPA CHAINS
`HUMAN KAPPA CHAINS
`HUMAN KAPPA CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I ••.••................•.••......................•.•.•..••.•.••..•...... 103
`II . . • . . . . • . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . • . . . . . • • • . . . . . . . . . . . . . . . . . 113
`III. . . • . . . . . . . . • . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 118
`IV . • • . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . • . . • . . . . • . . • . • . • . . . . . . . . . . . . . . . 128
`
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I . . . . . . . . . . . . • • . . . . . . . . . . . . . • . . . . . . • • . . • . . . . . . . . . . . . . . . . . • . . . . • . . . • • . • 131
`II ..........••....................•••..••......................•.••••• 135
`III . • . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . • . . . . . . . . . • . . . • . . . . . . . . . . . 139
`IV . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • • . . . . . . . . . . . . . . . _ .....•••. 144
`v ..................................................................... 146
`VI . . . . . . . . . . • . . . • . . . . . . . . . . . . . • . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . • • • • • . • 148
`
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I . • . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . • . 151
`II . . . . . . . . . . • . • • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . • • . • . . . • . . . . . . . 163
`III ...•.....•......•...•..•..••..•....................••.••••.......... 190
`IV . • . • • • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . • . . . . • • • . • . • . . . . . . . . . . . . . . . . . . . 201
`v .................. '• ................................................... 208
`VI. . . . . . . . . . . . . . • . . . . . . . . . . . . . . . • . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • • 239
`VII. . . . . . • . . • . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • • . . . . • • . 257
`
`MISCELLANEOUS MOUSE KAPPA CHAINS . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . • . • . . • . • . . . . . . . . . . . . . . . . . . . • . • . . . 259
`
`MOUSE LAMBDA CHAINS . . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . • . . . . . . . . • . . . . • . . . . . . . . . . . . • . . . . 2 63
`
`RAT KAPPA CHAINS . . . • . . . • . . . . . . . . . . . . . . . . • . . • • . . . . . . . . . . . . . . . . . . . • • . • . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
`
`RAT LAMBDA CHAINS . • • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . • • . • . • . . • . • • • . . • . . . • . 274
`
`RABBIT KAPPA CHAINS •.......••.....•................•......•........................•....••.•••.•.•. 276
`
`RABBIT LAMBDA CHAINS ....••..•...••.•....•.....................•.•.••..•.......................•..•. 290
`
`CHICKEN LAMBDA CHAINS . . . . . . . . • . . . . . . • . . . . . . . . . . . . • . . . . . . . . • . . • . • . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . • 2 93
`
`MISCELLANEOUS KAPPA CHAINS . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . • • . . . . . . . . . . . . 303
`
`MISCELLANEOUS LAMBDA CHAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . • • . . • . . • . . . . • . . . . 306
`
`MISCELLANEOUS LIGHT CHAINS • . • . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • . . . . • . . • . • • . . . . . . . . . . . . . . . . . . • . . • 308
`
`BIOEPIS EX. 1055
`Page 6
`
`
`
`iv
`
`TABLE OF CONTENTS (cont'ct>
`
`VARIABLE REGION HEAVY CHAIN SEQUENCES
`
`HUMAN
`HUMAN
`HUMAN
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I .•........•.•••.....••.....•••••......••........•.....••...•.•.........•.•••....•.. 310
`II . . . . . . . . . • . . . . . . . . . • . . . . . . • . • . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . . . . . . . . . . . • . . . . . . . 317
`III . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . • • . . . . • • • . . . . • . • . . 324
`
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`(A) .......••.....•.•.....••••........•..••..•.....•.•......••....••.....•....•••.. 339
`I
`(B) .....•.......•........•.................•..............•...........•.....••••.. 362
`I
`II (A) ...•.•.......•.••............................................••.....••...••..• 375
`II (B) .....•••.......•.•..............•.•..................•••....•.......•....•.•.. 398
`II (C) •.••......••.......•••.....••.......•.•.....•................•..••.....•....•. 421
`III (A) . . . . • • . . . . . . . • . . . . . . . . . • . . . . . . . • . • . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . • . . . . 430
`III (B) ..•.....••.•.......•.........•......•....................................•.... 451
`III (C) ....••........••................•..............................••...•......•. 458
`III (D) ••......•••..•....••.......................•.•......••.....••.....•......•... 464
`V
`(A) . . • . . . . . . . • . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 475
`V(B) .....•.•.•....••.•.......•.•.......•........•.............•.....•••....••...... 494
`
`MOUSE MISCELLANEOUS .........•.......•••......•••• : . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . • . 498
`
`RAT ...•.••.....•••.......•••.•....•..•....•••........................•.........•....•......•......• 512
`
`RABBIT • . . . . . . . . . . • . . . . . . . . • . . . . . . . . • • • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . . . . • . . . . . • . . . . . . . . . . . . . . 514
`
`GUINEA PIG .....•.......•.•......•..•.....•................... · ........•.....•.......•...........••.. 521
`
`CAT ..••.•........•.•.•.....•••.....•••......•.................•......•.......•....••......••...••.• 523
`
`DOG .......••.........•.....•...••..•...••..•....•......•..................•.....•......••......••.. 525
`
`CHICKEN ....•••••.•.......•.•......•....•..•••......•.......•........•.............•......•......•.. 527
`
`SHARK .......•••.........•••.......••......•••..............................••...•..•......•.....•.. 530
`
`MISCELLANEOUS .....•........••••......••......••.......•.......•........•........................... 533
`
`VARIABLE REGION T-LYMPHOCYTE RECEPTOR (TCR) FOR ANTIGEN
`
`HUMAN ALPHA
`HUMAN ALPHA
`HUMAN ALPHA
`HUMAN ALPHA
`
`CHAINS
`CHAINS
`CHAINS
`CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I. ..•••.................•............................•.......••...•.... 540
`II ...••......•..•................................•.....•....•.•.....•.. 543
`III ..••.......•..................•......•......•.....•••....•.......... 546
`MISCELLANEOUS .••....•.............•..............•......•......•....•.. 548
`
`HUMAN BETA
`HUMAN BETA
`HUMAN BETA
`
`CHAINS
`CHAINS
`CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I ..••......••••.......•...............•......•.......•.................. 552
`II ..••......•..........•....•................••......•.......•....•..... 55 9
`MISCELLANEOUS . . . . . . . . . . . . . . . · . . . . . . . . . . . . . . • . . . . . . . . . . . • . . . . . • . . . . . · .•..•. 562
`
`HUMAN GAMMA CHAINS ..••......•••......•••....•.•...............•........•......•............•....... 566
`
`HUMAN DELTA CHAINS . . • . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . • • . . . . . . . • . . . . . . . . . . . . . . • . . . . . . . . . . . . . • . . . . • • . . 570
`
`MOUSE ALPHA
`MOUSE ALPHA
`MOUSE ALPHA
`MOUSE ALPHA
`
`CHAINS
`CHAINS
`CHAINS
`CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I ....•.......•................•.....•.•......•.....•.....•••......•...• 575
`II. .....••....•..•.....•........•......•....................•....•.••.. 579
`III ......•......•.............................•......••.....••....•.•.. 582
`MISCELLANEOUS . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . • . . . . . . • . . . . • • . . . . . . . 585
`
`MOUSE BETA
`MOUSE BETA
`MOUSE BETA
`MOUSE BETA
`
`CHAINS
`CHAINS
`CHAINS
`CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • • . . . . . • • . . . . . • . . . . . . . . 590
`I I. .....••....•.......•......•.•.....•........•.......•.....••...•...... 5 95
`III ...•......•.......•.....•................••.............•....••...... 598
`MISCELLANEOUS .........•.....................•.......••••.....•......•... 600
`
`MOUSE GAMMA CHAINS ...•.......•........•.........•.••.•......•...............•.....•... , ..•......... 611
`
`MOUSE DELTA CHAINS •.....•.......•.......•.......•.....••.......................•......•...•.•...... 616
`
`RAT ALPHA CHAINS SUBGROUP II ..••.....••.......••.....................•..............•....•••....••. 628
`
`I ••.....••......•......•.......•.......•................•....•.••...•.•... 630
`RAT BETA CHAINS SUBGROUP
`RAT BETA CHAINS SUBGROUP II . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . . . . • . . . . . . . . . . . . . • . . 632
`RAT BETA CHAINS SUBGROUP MISCELLANEOUS ......•.......•....•.•.......•......•.....••......•••...•••.. 634
`
`RABBIT ALPHA CHAINS SUBGROUP I ...••....•.•..............••........•.....••.....•......••........... 636
`
`RABBIT BETA CHAINS SUBGROUP I . . . . . . • . . . . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . . . . . . • . . 638
`
`BOVINE ALPHA CHAINS SUBGROUP I ..•......••......••.........•......•............•.•......••.....••... 640
`BOVINE ALPHA CHAINS SUBGROUP III .••..............•......••......•........•.............•........•.. 642
`BOVINE ALPHA CHAINS SUBGROUP MISCELLANEOUS •.................................•.....•....•••....•••.. 644
`
`CONSTANT REGION SEQUENCES
`
`KAPPA LIGHT CHAINS •....••............•....•..........•.....................•.•...•........•.....•.. 64 7
`
`LAMBDA LIGHT
`
`CHAINS............................................... . ......•.•....•......••.....•... 653
`
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`
`CH1 REGION .....•••......••...•..........•.............•.............•............•.•.. 661
`HINGE REGION ....••......•......•..•....................•.......•......•...........•... 670
`CH2 REGION . . . . • . • . . . . . . . • . . . . . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . 67 9
`CH3 REGION •...•..••......•....•...•..................•..............•.•.....••.....••. 688
`EXTRA LONG CH3 REGION ..•.•.•.••...............•.......•.......•.....••.............•.. 697
`CH4 REGION ...••.....••......••................•.........................•.......•.•... 700
`EXTRA LONG CH4 AND MEMBRANE BOUND REGIONS ....................•.••...•.....•••.....•... 709
`
`BIOEPIS EX. 1055
`Page 7
`
`
`
`v
`
`TABLE OF CONTENTS (cont'ctl
`
`MAJOR HISTOCOMPATIBILITY ANTIGENS CLASS I SEQUENCES
`
`HUMAN A-LOCUS OF THE ALPHA-1 REGION .•••.•.........•.••...................•..••••••.•••••••...•..... 724
`HUMAN A-LOCUS OF THE ALPHA-2 REGION ..............................•...••••...•............••..•.•••• 727
`HUMAN A-LOCUS OF THE ALPHA-3 REGION ..•.•..••...... · ........•.•.•..................•.•..••••••....... 730
`HUMAN A-LOCUS OF THE MEMBRANE REGION ••••••...........••.•...............•..•.•••.•••••........•.... 733
`HUMAN A-LOCUS OF THE CYTOPLASMIC REGION .•.••...........•.•.•..................••••.•.•...•.......•. 735
`
`HUMAN B-LOCUS OF THE ALPHA-1 REGION ....••.•••.........•..•.•.•................•...•••.••..•....•..• 738
`HUMAN B-LOCUS OF THE ALPHA-2 REGION .......•••...............•.•.....................•••••.•.•••.•.• 741
`HUMAN B-LOCUS OF THE ALPHA-3 REGION ..•...•..............•.•..•..•.......•.....•...•.•.•............. 744
`HUMAN B-LOCUS OF THE MEMBRANE REGION .......•.•.•..........•...••...•.........•.•.••.••.•......•••.. 747
`HUMAN B-LOCUS OF THE CYTOPL!I.SMIC REGION .•.•••..............•..•...............•••.•••••.••...•.•.•. 749
`
`HUMAN C-LOCUS OF THE ALPHA-1 REGION ••••.•...........•............•.••••..••.••...............•..•.. 752
`HUMAN C-LOCUS OF THE ALPHA-2 REGION ...........•••.........•.••....•..........•.•...•.••.......•..•. 754
`HUMAN C-LOCUS OF THE ALPHA-3 REGION ...•..•.•.............••......•..••...•.•............•........•. 756
`HUMAN C-LOCUS OF THE MEMBRANE REGION .........•........••.••......•...•.•.•••••••................... 758
`HUMAN C-LOCUS OF THE CYTOPLASMIC REGION ......•.•...........................•..•••.•................ 759
`
`HUMAN MISCELLANEOUS LOCUS OF THE ALPHA-1 REGION ...•................••.••........•...••.•.•••••.••.• 761
`HUMAN MISCELLANEOUS LOCUS OF THE ALPHA-2 REGION ................•...••.•............•....••....•.••• 763
`HUMAN MISCELLANEOUS LOCUS OF THE ALPHA-3 REGION ••••..............•.................•••••....••..•.. 765
`HUMAN MISCELLANEOUS LOCUS OF THE MEMBRANE REGION ..............•......•.....•.....•.•..•............ 767
`HUMAN MISCELLANEOUS LOCUS OF THE CYTOPLASMIC REGION ...................•.............••.••.•........ 768
`
`MOUSE K-LOCUS OF THE ALPHA-1 REGION ........................•..........•...•••.•..............•....• 770
`MOUSE K-LOCUS OF THE ALPHA-2 REGION ••.........•..............................•••••.• .' .......•...... 772
`MOUSE K-LOCUS OF THE ALPHA-3 REGION •.•...........••...........•................••••.•••.........•.. 774
`MOUSE K-LOCUS OF THE MEMBRANE REGION .....•............•.............••...............••.•...•••.... 776
`MOUSE K-LOCUS OF THE CYTOPLASMIC REGION ..........•.•.........•...•..................•....•.......•. 777
`
`MOUSE D-LOCUS OF THE ALPHA-1 REGION ...•••........................•...••..............•.•.•....•.... 779
`MOUSE D-LOCUS OF THE ALPHA-2 REGION ..•........................•.•.•••.•............•.•...•....•.... 781
`MOUSE D-LOCUS OF THE ALPHA-3 REGION .........•........••.............•.•••..........•.••••.......... 783
`MOUSE D-LOCUS OF THE MEMBRANE REGION ...........•.•............•..•...........•.•..•..•....•••..•••• 785
`MOUSE D-LOCUS OF THE CYTOPLASMIC REGION . . . . . . • . . . . . . . . . . . • . . . . . . . . . . . . . . . • • . . . . . . . . . . . . . . . . . • . . • . . . 786
`
`MOUSE MISCELLANEOUS LOCUS OF THE ALPHA-1 REGION . . . . . . . . . . • . . . . . . . . . . . . . . • • . . . . . . . . . . . . . . • . . . • . . . . . . 788
`MOUSE MISCELLANEOUS LOCUS OF THE ALPHA-2 REGION ........•.•............•••...•..........•.•.•.•.•... 791
`MOUSE MISCELLANEOUS LOCUS OF THE ALPHA-3 REGION .........•..........•..•..•........•...•••.•...•.... 794
`MOUSE MISCELLANEOUS LOCUS OF THE MEMBRANE REGION ....•....••.........•••••••............•••.•••..... 7 97
`MOUSE MISCELLANEOUS LOCUS OF THE CYTOPLASMIC REGION ....••.............•..•..•.•........•••••....... 799
`
`MISCELLANEOUS ALPHA-1 REGION .•........................•.•............•...•••...............•••..•.. 802
`MISCELLANEOUS ALPHA-2 REGION . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . . . 805
`MISCELLANEOUS ALPHA-3 REGION .•.•..........................................•.•...............•••.••. 808
`MISCELLANEOUS MEMBRANE REGION ..•.••........•...•...........•.•...•................•.....•.......... 811
`MISCELLANEOUS CYTOPLASMIC REGION ..................•...•.•.........•.•••.•..•.............. · .••.••••• 813
`
`I REGION GENE PRODUCTS CLASS II SEQUENCES
`
`HUt-'I.AN A-CHAIN DR-LOCUS OF THE ALPHA-1 REGION ...•.............•••••.•••..•............•..•••••...... 816
`HUMAN A-CHAIN DR-LOCUS OF THE ALPHA-2 REGION .............•••.................•..••.•.............•• 817
`HUMAN A-CHAIN DR-LOCUS OF THE MEMBRANE REGION .............•.••..................•••.•.........•.••• 818
`
`HUMAN A-CHAIN DQ-LOCUS OF THE ALPHA-1 REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . . • . . . • • • 820
`HUMAN A-CHAIN DQ-LOCUS OF THE ALPHA-2 REGION .......................•...•.............•.••••......•. 823
`HUMAN A-CHAIN DQ-LOCUS OF THE MEMBRANE REGION .....•.....•..............•••..••.........••••...••... 826
`
`HUMAN A-CHAIN DP-LOCUS OF THE ALPHA-1 REGION .............................•••.••.............•.•.•.• 830
`HUMAN A-CHAIN DP-LOCUS OF THE ALPHA-2 REGION ..........•...............•...•••.....•.....•...••.•••. 831
`HUMAN A-CHAIN DP-LOCUS OF THE MEMBRANE REGION ....................•••.••....•.......••..•.•......... 832
`
`HUMAN A-CHAIN MISCELLANEOUS LOCUS OF THE ALPHA-1 REGION .......•.•.••................•.•.••........• 834
`HUMAN A-CHAIN MISCELLANEOUS LOCUS OF THE ALPHA-2 REGION .........•...•...............•••..•....•.... 835
`HUMAN A-CHAIN MISCELLANEOUS LOCUS OF THE MEMBRANE REGION . . . . . . • . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . 836
`
`MOUSE A-CHAIN A-LOCUS OF THE ALPHA-1 REGION •....•...............•••.•.•.•...........•.•.•.•••...... 838
`MOUSE A-CHAIN A-LOCUS OF THE ALPHA-2 REGION .....••..............••..••••.•.•.............•.•....... 840
`MOUSE A-CHAIN A-LOCUS OF THE MEMBRANE REGION .•...............•••......................•••.•........ 842
`
`MOUSE A-CHAIN E-LOCUS OF THE ALPHA-1 REGION .......•.•.............•..•..••.•..•.............••••... 845
`MOUSE A-CHAIN E-LOCUS OF THE ALPHA-2 REGI,ON .......••.........................••.•............•••.•. 846
`MOUSE A-CHAIN E-LOCUS OF THE MEMBRANE REGION ....•.•...................•.•••••................••.... 847
`
`MISCELLANEOUS A-CHAIN OF THE ALPHA-1 REGION .•......................•.•..••.•............•..•..•.•.. 849
`MISCELLANEOUS A-CHAIN OF THE ALPHA-2 REGION ..............•.......•.............•....•.•••.•........ 850
`MISCELLANEOUS A-CHAIN OF THE MEMBRANE REGION . . . . • . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . 851
`
`HUMAN B-CHAIN DR-LOCUS OF THE BETA-1 REGION . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . 853
`HUMAN B-CHAIN DR-LOCUS OF THE BETA-2 REGION . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . • • . . • . • . . . . . . . . . . . . . • . . . 861
`HUMAN B-CHAIN DR-LOCUS OF THE MEMBRANE REGION . • . . . . . . . . . . . . . . . . . . . . • . • . • . . . . . . . . . . . . . . . . . . . . • . . . • . . 870
`
`HUMAN B-CHAIN DQ-LOCUS OF THE BETA-1 REGION . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 881
`HUMAN B-CHAIN DQ-LOCUS OF THE BETA-2 REGION ......•...•....................•....•••.•....•.•.•.••.•• 888
`HUMAN B-CHAIN DQ-LOCUS OF THE MEMBRANE REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 895
`
`HUMAN B-CHAIN DP-LOCUS OF THE BETA-1 REGION . . . . . . . . . . . • . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 905
`HUMAN B-CHAIN DP-LOCUS OF THE BETA-2 REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 909
`HUMAN B-CHAIN DP-LOCUS OF THE MEMBRANE REGION . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 913
`
`HUMAN B-CHAIN MISCELLANEOUS LOCUS OF THE BETA-1 REGION ......................•.....•.•.....••.•.••.. 919
`HUMAN B-CHAIN MISCELLANEOUS LOCUS OF THE BETA-2 REGION .....•.•.•..••••••••.••••.•.•.•.••...•.•..... 920
`HUMAN B-CHAIN MISCELLANEOUS LOCUS OF THE MEMBRANE REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • 921
`
`BIOEPIS EX. 1055
`Page 8
`
`
`
`vi
`
`TABLE OF CONTENTS (cont'ctl
`
`I REGION GENE PRODUCTS CLASS II SEQUENCES (cont'd)
`
`MOUSE B-CHAIN A-LOCUS
`MOUSE B-CHAIN A-LOCUS
`MOUSE B-CHAIN A-LOCUS
`
`OF THE
`OF THE
`OF THE
`
`BETA-1 REGION ..............•.••...••....•.........•.•.••••.••••.••.••• 923
`BETA-2 REGION .....................••.•••.•••.•.•.•.•.................. 927
`MEMBRANE REGION ................•...•.......••.••..•.•.•.......•....... 931
`
`MOUSE B-CHAIN E-LOCUS
`MOUSE B-CHAIN E-LOCUS
`MOUSE B-CHAIN E-LOCUS
`
`OF THE
`OF THE
`OF THE
`
`BETA-1 REGION .............•...•....•......•..•••..•..•...•.•.......... 937
`BETA-2 REGION . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 939
`MEMBRANE REGION • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 941
`
`MISCELLANEOUS B-CHAIN
`MISCELLANEOUS B-CHAIN
`MISCELLANEOUS B-CHAIN
`
`OF THE
`OF THE
`OF THE
`
`BETA-1 REGION ...................•.....•...•.•••.......•............... 944
`BETA-2 REGION . . . • . . . . . . . . . . . . . . . . . . • . . . • . . . • . . . • . . . • . . . . . . . . . . . . . . . . . . 94 6
`MEMBRANE REGION ..•..•..••••.•.•.................•••••.•.•.•••.•....••. 94 8
`
`SEQUENCES OF RELATED PROTEINS
`
`J CHAIN .................•••.••.•.•.•••...•.•.•.••••••.•••.•.•.•............................•..•.•.• 951
`
`BETA-2-MICROGLOBULINS ..•...•..•.......•........•.................•..........•••.••..•..•........... 953
`
`THY-1 ANTIGENS ..•.......••..•...•..........................•.....••..•.••.•.•...•.•.••..•.......... 956
`
`HUMAN COMPLEMENT COMPONENTS .•..•.•••••••.••.•..•..........•..........................•..••••.•.•.•. 959
`
`OTHER COMPLEMENT COMPONENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 981
`
`T-LYMPHOCYTE RECEPTOR FOR ANTIGEN CONSTANT REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . 1004
`
`T-CELL SURFACE ANTIGENS . . . . . . • . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • 1019
`
`INTEGRINS .••...•.••.••.••••.•.•.•.••••.••..••..•.•.•. , .....•...•....•...•.•.•......•.............. 1034
`
`MISCELLANEOUS HUMAN PROTEINS ASSOCIATED WITH THE IMMU