Submuconal Injection agent for
`lift that
`See it herr
`lasts
`
`Elevieur
`
`New forGi
`endoscopir
`resection_
`
`AD VERT! PAEN
`
`Gastroenterology
`
`AGAJournals.org
`
`I w 111 (cid:9)
`
`0
`
`

`

`...Du sew
`
`3.92
`ATTENUATION OF RESPONSE TO MEILTIPM FtETREATMENT
`D:FL/XIMAII INFUSIONS FOR ACTIVE CROON'S DISEASE
`(CD): POTENTIAL FACTORS THAT MIND,DZE DECREASED
`RESPONSE
`
`lori Y. Cut,Erie A. NoseLanka. hinria T. Men, Dap V. 1-6,4.thl.
`s A'.14Reich, Joanne Goienak, Lk. ROCOSI, Ttroa (cid:9)
`
`Sehitiele.
`Siteinn R. targae, [Wars-Sim Mod. Ca. Loo Angska, CA; Cur.a,
`M.1.1%...14 PA.
`144141 InElin4ca145.2DingfigI [...WM) f 1.i. CD is .resifted
`ai, a 6$41$ yetpothe a(.4. $34$ kini#j6.15 fat 4/ 4 004. HOD44r4r, 114
`offeory. of InlIktirorb IntrealentIn(rns) tan CD ff... I. WWI EMI AIM In.
`study Inc cricwy mad ,eked 4 4'.. 14b.kr,rr11.4 l.9110. 519.01) fee
`recurrein CD. Manodt: 0,40(40}1 4,.41151 iv Cdanw 091 (cid:9)
`16
`CDIF8T24 MM. netwom 11/149! • 110896. 1Int oecoivea
`few COAT >220. 0.113.4 maienthanx ahthiumf (cid:9)
`. 1:mA X
`
`2 (cid:9)4! (cid:9)
`2.4. yrs{ mean:1,1.3 rrx infa~s) I. MAI a rn) WC, pwnn.
`
`11113 were 101:1 3144. Cry 3.:Mol0.114441440 ornoss. 1111.199- Agee
`gyir MAE (cid:9)
`150 were Kir,.
`MUM! ini42an4tg1. 1,2 relx infil (cid:9)
`ch.o in omit were oZowsel. CDAt Noes done in wk R. nod 4 oher sma
`ioiucira. Ripe osn (cid:9)
`I CDA.1070. d oehievemem CDA1 Ina. Ile-
`.CDA1s151.1 Reens: A a goi Aten dEoriiin lend Lc 304041
`4316)440. DOI 04ef11-.18791. la Op I,
`doer rem inh ti.,r eced 0411 (cid:9)
`IIErrap awl kfrIimiEn Dix rho 1.5.21 wide MU. 100p2. road.. 3COM
`after re:141. darned. No 1 in 96 reap and dramas was minimal. frA
`iredian woo CDAls. woos piropromoely lower will rem. One delayed
`1144,.a4la.19.0. rem orclurra.,a etch Gp 1 Et Gni Gp I, on-as P&p No
`reu WO I = 99. Gp mean Nap teremen inf
`$2..onJ raan1.1- .2 =201. 8241. ia Op $ 4,ore tad 1.014
`I Keual (cid:9)
`Mei1A.2.a. or 11TX , 29% a GpL Co.:thine: Coe:tarn( ea of
`CD fl (cid:9) doegt with InfhaimeM Dieror, and easy earcaanenr
`far CD flarra. nty html pearmiel etten.ion of nespease on rrothipfo
`:elusion,/
`
`thom2
`
`nth 1 AM/
`In
`I
`5
`5
`Zo
`764
`ID
`/
`AID
`3044
`204
`2[24
`
`1110.2.
`5
`3
`ffiT
`
`214/1
`
`wiriest
`
`1
`10
`t'a or (cid:9) m.4
`52544
`I14110M41 al
`home 15{2(pn• En
`11111
`1.9 Dil • r* •
`WI
`..A 4
`
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`
`I
`11
`5
`226
`
`AM
`IN)
`
`.2.44
`RAV I norn2
`14
`5
`5
`5
`74
`210
`111
`112
`ago
`4141
`RIO}
`41,1
`
`353$1
`A RANDOM/ZED CONTROLLED TRIAL OF CTIPS71. ...HUMAN-
`IZED ANTIBODY TO TWA, IN MODERATELY TD SEVERELY
`ACTIVE CROWD'S DISEASE,
`William 1. SmaTtern, 912 an R. Tugan, Stephen B. Hanauer. Danoo1 a
`Perim. WO R. 50( and. Mirkucl A.Xvrtim, Doug C. WWI I. P.
`Deno a NM on. Mayo
`Bala, Clithicylla (cid:9)
`Waxy. Patric. (cid:9)
`Rodeerer. ).1(4: C.echrg-Simai Med CI. Los Amain. CA: Ifaim of
`PAMIR Sinoi WI of amine. New Tod. NY: Unix
`Clic.opa.Chicua
`of Caw, Caliol.7. AB. 45.,144:%Me" RON 14.43.4Pro. UMW; !Gag-
`a.n.ar9.5r4logy Apes, Jalonth. OAr. Univ 4F Tamale.
`a., AtPmea (cid:9)
`Dmotho.0-.9. Canada: Urtiv How HiMing1.1.1.1niIedKonniorm CelltecIP
`r-hirezionE,Slon)I, United Kingdom; DIM." of WAPICT WIND. Londe%
`ON. CDR.,
`BACKGROUND, Tem. no.,oso Naar (174.9). Er Filo}, a E.:1401D1 41..k 14
`InlInAnnitani of 17411"1ithame 1CDJ ADAM le de(erriae the rif-
`e:x.7 Ind 1441y of the Inomani/ed szai.INPathibody. C.:VP I. for irtac.
`
`ken Jed maidens...of diailwl.irminnxerWent ion..14 with vealcrate ae
`seventy .1ive Crones dims., MEDICOS: 1.159 :Muir patio. with.
`rethlerana to acrerelyr active (cid:9)
`(COAl malt 026-00) *co, ourOard
`.24 0000 40M1040ll ro 404 oNix (cid:9)
`L5CD13521.
`70 raplrg altufeek 0 followed l s 10 mr,iko ,t week, Sam 16:2: CDP521.
`19 repflai al Doolo O. h. Led 164 ly pluk. a, weeks 0.E, and 1$4 4)
`
`CDP571 20nagala a ...all 0 I% lefasel.hy I
`1o.1}..g....rets 0 MA (2; D. 41 plerolTO u we Gond 1Z Cm...
`au DOR held pealed the Ftherodr dose, Dm t3neinia
`iZonI (cid:9)
`
`.,DVERTISEDIENT
`
`New fOr GI en0 oscopic
`resections
`
`See it here r
`
`0444424 acti.nly man 1:CDA I! wore lea &cameo/ se41 thy dhroughot the
`audr Chnithl i044001 110.] trap de44N1 o dee.. i/ Ole [DM 50,413
`Pnnnn here 460 week 4 Mom RESVINS: 0oic4
`it week 2 ECWIllindl I. 75!5 4{27191 of fl.a iffocso /P.M :WU (54%) or
`Cc 19 ANA; prow fp =00051: and 21157 CP%) y1, 3V main warp
`Ip=0.1361. 'tOo onolval cum of arca DO Mthdrawal. dialog Ma 24 weeLe
`may n.as sigaiheam for 1210571 oamplax4 to pinatn fa [hr 12 week
`death; group (ro- 0.012] hump'. the I tusk dMin; group fp .4229). The
`median dirge in cDRI fr.r 14.4.kg 12 weekly dosing .Cup irmarned
`M ,aka of its ilvdY- T.2 of 13
`79 paint, 14,4, Ineal ea Sere (cid:9)
`a5%) of pLacebn tVISAFAS With dra5Dog 0u4,14 envy 4104 ohooDe of
`31- 30/2 of fut4li41 during OK oludy compared with 12321(5014 in Its
`491371 gempa (1,947741 The (amens,. 4 aahlees 40411, PEA) ,'APV
`ate CDP571 end *aim prow., AEJ 401 0.-e brig at infosica
`wets 12% h.n/l,r.plaothaSp = 9.9241e Mader. W1.11 ]tom. v=04214.
`and-CO0571 maiba.frasel,o 0%jp-0.0.6)2.nad nonienelrer ancitedie9
`
`. pl... MONA Tik 016 4.0A.1}.11., (cid:9)
`eam o[lyrop4hons.
`thug Mthend loam. (a &Lye] Inper40t40144 mankira ie me Lady_
`CONCL1,51091$: {IPS 7 I. in etYergi.in in inducing c1inirn1 1,-,PIMW
`wweka in patina, will wwderinflylo segnInLy active Cowhn a r1Dma TPA
`eitmal dose 4. 10 1.44.41;. Duch! 'gm ...en wiL err. Orming and ate
`mairool daring frenaeory every 12 weeks. 7141'571 4110 Siam diroirnos.
`fliethes. COPP I la fee and .41 lolsweel- Swpor4 CelYed9C1f.assisa,- -
`
`11199.
`A RANDOMIZED, DOUITI.E.BLIND, PLACTI504Q0NIROLI,ED.
`MULT243ENTE42 TRIAL OF THE ENGLNLEP.1.13 liLMAN
`BODY TO 754.(CDP37T) FOR STEROID SPARING AND MAIN-
`TE22ANCE fJP REMISSION IN nsnErn-.6 5597/1 40PR0TD.DR4
`PENDENT CROHN.S DISEASE
`Bolo, G. Feapn. 1Yil Faun 1. Sandpprn.l.P-134.11.. F. Com:me:IL Lloyd
`Sah.c11,4 C. n RPM. DIAKE SaLthers„.h. Aerlumhan. Chute, N.
`Bertolein. G. R. Liel-Asnowin. Parkin R. Hark S{spbee P. Hama,
`lseelan. CI. 1,4.14 Bawd% Group, [erode, ON. Caned.: Fitor Clip.
`1.010 Unix of Toronto. Toro.. ON. COD9:91 Ulry of Virginne.
`Charloolcswille. VA: Univ of Calgary. Calgary, AD. Canada, leis 4
`414440.0 Dirminghan. Birmingham. AL' A111011 anarorreerolm AS-
`S.% Ananta. GAL Vein of Mod-Kraal, Monyeal. 40, Canada: Shoo of
`Pelnairces. Wirmipm/ NIB. Caaula: Ural. (cid:9)
`Pren$714.a4do.
`PA: tetheth Thersaralin /ne. Slough, 52nired Ringderre Uth4 o(Chicogo
`Heepask Ctirmo, IL
`BACKERID4A413: Thoo . setreois. f•ch10114FOr ph> a piamal thle ii
`IFICinllommobon.o43nahr.'sdieenie (CDJAVedaermined.thaeMemy Ind
`nifty of horn/Mud anthITIF mtholly. 630$71 fen 0lee44aming4
`maimeana of remiosion in patienD W 14 atavidaienerAleal CA t•P1-
`(IDS' '2] Fiat, 140 sremiel-depre2tht CD {CDAI (cid:9)
`150. AND a
`predniiorc clam cif 12-40 theday a a Bedewed, drat 9a144d42 For
`80404x, AND a 4il4 vamps co rempreionoor or badmen& whine
`wean) Nora email:4 Into a 16 W.14.4 eM rondoma MILO age dmu
`[14401ELl54 1)304171 20 ragtag al week D 1 411..1 In ink; at week
`S; 2) Plneebo ea 104414 0 and E. Piedahene vem deeremed Donn the week
`11 dean by 5 nnyrownle lo a dole of 10 dykley. and then by 7.5. eatA...aek
`11424 0114441. Ehaleseerian tom eeeteth(41 Rem 9 11414y m I
`rnecnor It. 3 wool, 3 med., for 3 was. and Dm, 41.14.0¢04111
`5....kinkmea1;c1.1141, panne anOrr.a.Lka 3.11 rEcthofteronc wort held
`MIAMI' 11 the Fe.sady dose_ The primary auto.. 1404 401.1.41.04.1
`%Wmpid irithahooni anhour a Imo or CD (irorDase in CLIA3 l4 41 220
`P4mol-REELITS: 19 peens osxived 3M71 and )2 rselovel
`Slade-mm.4*k oLarreitOces of the FARM, soars 144 diffrent w ihr the
`0.Kin. Al we& 41 17199 C.13.4%) of Wen, .Arlja. nmeiveel CDP5.71
`remthoedfreo of a dureoe Mao as comaand with only 1.51 (219 %) of
`1114 h4 004,.4rd plaerho (cid:9)
`0.0491 C04571 them
`HA-med./90 44.11 infthion nacrlaeas wax FT/ambled. Swan Adoeree
`groats vec.rrsel a 122%of pegenta 'salvia; pl.riabe and 49.90x. of dye.
`aleigood roamioe 01‘21..-111: the "OHO. of Ilk. IMO dlisava related and
`IOU WCR A.41.01 t4 CDP171 Ihairpy. 'Pay OW {Ow( I2.0141
`aped detterahle mottaly eo CDP$71. 6.776 4 poromte developed eth-
`doubliDstrsdEd DMA omt.iboliev.. No duos of lupus a 1/Eaphoon
`CONCLUSIONS: CDP571 it Do drEram airaloy 014icS Ca.lioatto
`Drill drawn! dr onethvenneith U Muhl with 0140040 nrmiC 114241 1]l CD.
`
`Tt, cos py w9.1CDPS71 ;a...eta:Rd a.;11., a leek im,ideme Madversetaeou.
`A LOW rale of auto-anolcdy fornitio.O wet Need 84141 (cid:9)
`10
`CDP371. oromod Wm/D.1r.
`
`© 2000 American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.
`
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