111111111111111111111111111!!!!1!1111!1111111111111111111111111
`
`(12) United States Patent
`Fischkoff et al.
`
`(10) Patent No.:
`(45) Date of Patent:
`
`US 9,017,680 B2
`*Apr. 28, 2015
`
`METHODS OF ADMINISTERING ANTI-TNFa
`ANTIBODIES
`
`Applicant: AbbVie Biotechnology Ltd., Hamilton
`(BM)
`
`Inventors: Steven A. Fischkoff, Short Hills, NJ
`(US); Joachim Kempeni, Neustadt
`(DE); Roberta Weiss, Wynnewood, PA
`(US)
`
`Assignee: AbbVie Biotechnology Ltd., Hamilton
`(BM)
`
`Notice: (cid:9)
`
`Subject to any disclaimer, the term of this
`patent is extended or adjusted under 35
`U.S.C. 154(b) by 0 days.
`
`This patent is subject to a terminal dis-
`claimer.
`
`(21) Appl. No.: 14/542,529
`
`(22) Filed: (cid:9)
`
`Nov. 14, 2014
`
`(65)
`
`Prior Publication Data
`
`US 2015/0071939 Al (cid:9)
`
`Mar. 12, 2015
`
`Related U.S. Application Data
`
`(63) Continuation of application No. 10/163,657, filed on
`Jun. 5, 2002. now Pat. No. 8,889,135.
`
`(60) Provisional application No. 60/296,961, filed on Jun.
`8, 2001.
`
`(51) Int. Cl.
`A 61K 39/395 (cid:9)
`C07K 16/24 (cid:9)
`A61K 39/00 (cid:9)
`(52) U.S. Cl.
`CPC (cid:9)
`
`(2006.01)
`(2006.01)
`(2006.01)
`
`C07K 16/241 (2013.01); CO7K 2317/565
`(2013.01); C07K 2317/21 (2013.01); CO7K
`2317/76 (2013.01); A61K 2039/505 (2013.01);
`A61K 2039/545 (2013.01)
`(58) Field of Classification Search
`None
`See application file for complete search history.
`
`(56)
`
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`
`Felson et al., Arthritis & Rheumatism vol. 41, No. 9, Sep. 1998, pp.
`1564-1570.*
`Wolfe et al. (J Rheumatol. Jun. 2001;28(6):1423-30 which was pre-
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`
`Primary Examiner — Zachary Skelding
`(74) Attorney, Agent, or Firm — Dechert LLP
`
`(57) (cid:9)
`
`ABSTRACT
`
`Methods of treating disorders in which TNFa activity is
`detrimental via biweekly, subcutaneous administration of
`human antibodies, preferably recombinant human antibod-
`ies, that specifically bind to human tumor necrosis factor a
`(hTNFa) are disclosed. The antibody may be administered
`with or without methotrexate. These antibodies have high
`affinity for hTNFa (e.g., Ic=10-8 M or less). a slow off rate
`for hTNFa dissociation (e.g., Kojr10-3 sec-1 or less) and
`neutralize hTNFa activity in vitro and in vivo. An antibody of
`the invention can be a full-length antibody or an antigen-
`binding portion thereof. Kits containing a pharmaceutical
`composition and instructions for dosing, and preloaded
`syringes containing pharmaceutical compositions are also
`encompassed by the invention.
`
`4 Claims, 6 Drawing Sheets
`
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`(cid:9)
`

`

`US 9,017,680 B2
`Page 2
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`

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